Vemurafenib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Vemurafenib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0838065
SLTM SAFB-like, transcription modulator 0.0682212
FAM13A family with sequence similarity 13, member A 0.0441559
EGFR epidermal growth factor receptor 0.0422728
ELL2 elongation factor, RNA polymerase II, 2 0.03035
SPAG9 sperm associated antigen 9 0.024768
ANO6 anoctamin 6 0.0239249
CES1 carboxylesterase 1 0.0238965
ARRDC3 arrestin domain containing 3 0.0234757
TXNRD1 thioredoxin reductase 1 0.0230322
RUNX1 runt-related transcription factor 1 0.0228554
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0224684
ADAM9 ADAM metallopeptidase domain 9 0.0220754
SMAD3 SMAD family member 3 0.0220435
NAMPT nicotinamide phosphoribosyltransferase 0.0207718
AGO2 argonaute RISC catalytic component 2 0.0205885
ZNF638 zinc finger protein 638 0.0201303
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0201206
NGLY1 N-glycanase 1 0.0197906
RICTOR RPTOR independent companion of MTOR, complex 2 0.0196425
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0193809
TBC1D22A TBC1 domain family, member 22A 0.0193049
SOD2 superoxide dismutase 2, mitochondrial 0.0191204
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0187511
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0182193
PAPOLA poly(A) polymerase alpha 0.017971
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0172133
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.017199
USP9X ubiquitin specific peptidase 9, X-linked 0.0170616
ZNF292 zinc finger protein 292 0.0169276
CEMIP cell migration inducing protein, hyaluronan binding 0.0167165
HSPA8 heat shock 70kDa protein 8 0.0161691
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0160129
MYOF myoferlin 0.0159309
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0156741
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.014291
TES testin LIM domain protein 0.0142796
OGA O-GlcNAcase 0.0140229
ZC3H11A zinc finger CCCH-type containing 11A 0.0140177
TMCO3 transmembrane and coiled-coil domains 3 0.0139543
DTNA dystrobrevin, alpha 0.0138506
ATP13A3 ATPase type 13A3 0.0137745
NCKAP1 NCK-associated protein 1 0.0137699
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0137336
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0137242
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0136072
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0133072
TMEM165 transmembrane protein 165 0.0132833
RNF145 ring finger protein 145 0.0132657
HELZ helicase with zinc finger 0.0132246
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0131996
PUM2 pumilio RNA-binding family member 2 0.0131619
JMJD1C jumonji domain containing 1C 0.0130836
SLC35F5 solute carrier family 35, member F5 0.0128011
KDM2A lysine (K)-specific demethylase 2A 0.0124943
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0124139
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0123584
TSC22D2 TSC22 domain family, member 2 0.0123218
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.012208
MYO5B myosin VB 0.0121815
EP300 E1A binding protein p300 0.0116863
GLS2 glutaminase 2 (liver, mitochondrial) 0.011681
DSCAM Down syndrome cell adhesion molecule 0.0116616
UBA6 ubiquitin-like modifier activating enzyme 6 0.0115319
USP34 ubiquitin specific peptidase 34 0.0114321
ARGLU1 arginine and glutamate rich 1 0.0113705
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0112851
RBM39 RNA binding motif protein 39 0.0111471
GCLC glutamate-cysteine ligase, catalytic subunit 0.0110515
YTHDC1 YTH domain containing 1 0.0109355
ZBTB1 zinc finger and BTB domain containing 1 0.0107433
USP53 ubiquitin specific peptidase 53 0.0107428
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0105295
MYO1B myosin IB 0.0104967
JAK1 Janus kinase 1 0.0102944
MKI67 marker of proliferation Ki-67 0.0102856
CUL4A cullin 4A 0.0102734
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0102502
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0101934
LYST lysosomal trafficking regulator 0.0101912
MXI1 MAX interactor 1, dimerization protein 0.0101708
RNF213 ring finger protein 213 0.00998828
PRELID2 PRELI domain containing 2 0.00994316
FNIP1 folliculin interacting protein 1 0.00989352
SUCO SUN domain containing ossification factor 0.00988969
KANSL1 KAT8 regulatory NSL complex subunit 1 0.00988002
GRB10 growth factor receptor-bound protein 10 0.00984258
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00981942
AFF1 AF4/FMR2 family, member 1 0.00967195
DENND4A DENN/MADD domain containing 4A 0.00956879
KMT5B lysine methyltransferase 5B 0.00956356
KIAA1217 KIAA1217 0.00948689
YEATS2 YEATS domain containing 2 0.00943644
HBP1 HMG-box transcription factor 1 0.00929369
CYLD cylindromatosis (turban tumor syndrome) 0.00928585
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.00923591
FTH1 ferritin, heavy polypeptide 1 0.00921594
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00917473
CSNK1A1 casein kinase 1, alpha 1 0.00917449
PYGL phosphorylase, glycogen, liver 0.0091465

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.153746
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0910213
PTMA prothymosin, alpha -0.0890174
ACTG1 actin gamma 1 -0.0754226
PTPRM protein tyrosine phosphatase, receptor type, M -0.0671597
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0644827
S100A10 S100 calcium binding protein A10 -0.0588531
ASPH aspartate beta-hydroxylase -0.0550632
CST3 cystatin C -0.0534958
TPT1 tumor protein, translationally-controlled 1 -0.0531801
EGR1 early growth response 1 -0.052877
FTL ferritin, light polypeptide -0.0459003
RPL35A ribosomal protein L35a -0.0448233
THSD4 thrombospondin, type I, domain containing 4 -0.0393489
PKM pyruvate kinase, muscle -0.0383132
MCL1 myeloid cell leukemia 1 -0.0363768
AKR1C1 aldo-keto reductase family 1, member C1 -0.0356672
IFI6 interferon, alpha-inducible protein 6 -0.0353558
KRT7 keratin 7, type II -0.034918
EFNA5 ephrin-A5 -0.0345607
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0343632
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0338198
INTS6 integrator complex subunit 6 -0.0335827
CAV1 caveolin 1, caveolae protein, 22kDa -0.0325201
RPS24 ribosomal protein S24 -0.0323103
RPLP1 ribosomal protein, large, P1 -0.0313553
RPL37A ribosomal protein L37a -0.0313369
RPS25 ribosomal protein S25 -0.0310195
KRT18 keratin 18, type I -0.0308571
AREG amphiregulin -0.029558
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0289718
RPL31 ribosomal protein L31 -0.0289256
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0284342
ENO1 enolase 1, (alpha) -0.0280678
S100A11 S100 calcium binding protein A11 -0.0271525
CCND1 cyclin D1 -0.0268263
HLA-B major histocompatibility complex, class I, B -0.0266415
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0266201
TPM4 tropomyosin 4 -0.0259629
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0259487
SEC61G Sec61 gamma subunit -0.02572
RPL34 ribosomal protein L34 -0.0249079
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0247603
SLC38A1 solute carrier family 38, member 1 -0.0245498
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0244889
CUX1 cut-like homeobox 1 -0.0243586
LPP LIM domain containing preferred translocation partner in lipoma -0.0242525
B2M beta-2-microglobulin -0.0240356
RPS27A ribosomal protein S27a -0.0239991
S100A9 S100 calcium binding protein A9 -0.0237228
VCL vinculin -0.0235229
PATJ PATJ crumbs cell polarity complex component -0.0229808
RPS29 ribosomal protein S29 -0.022949
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0226688
S100P S100 calcium binding protein P -0.0221117
KPNB1 karyopherin (importin) beta 1 -0.0220326
ANXA2 annexin A2 -0.0218466
IER3 immediate early response 3 -0.0217599
KRT8 keratin 8, type II -0.0215616
RPL11 ribosomal protein L11 -0.0215393
STC1 stanniocalcin 1 -0.0212796
RPS8 ribosomal protein S8 -0.0206338
S100A6 S100 calcium binding protein A6 -0.0206238
RPS23 ribosomal protein S23 -0.0201958
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0200816
RPS27 ribosomal protein S27 -0.0199687
ZMYND8 zinc finger, MYND-type containing 8 -0.0197485
RPS6 ribosomal protein S6 -0.0189752
FBXO11 F-box protein 11 -0.0187963
MAML3 mastermind-like 3 (Drosophila) -0.0187508
RPL37 ribosomal protein L37 -0.0187494
IGFBP5 insulin-like growth factor binding protein 5 -0.0186431
RPS3 ribosomal protein S3 -0.0186014
FLNB filamin B, beta -0.0182399
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0181061
RPL19 ribosomal protein L19 -0.0180005
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0179812
KRT19 keratin 19, type I -0.0177962
RPL23 ribosomal protein L23 -0.0175368
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0174863
RPLP2 ribosomal protein, large, P2 -0.0174855
RPS19 ribosomal protein S19 -0.0174539
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0172649
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0171588
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0170334
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.016824
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0167907
SCEL sciellin -0.0167094
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0164557
SLC38A2 solute carrier family 38, member 2 -0.0164196
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0163506
PDE4D phosphodiesterase 4D, cAMP-specific -0.0163497
LRP1B low density lipoprotein receptor-related protein 1B -0.0162952
WSB1 WD repeat and SOCS box containing 1 -0.0162685
TNS3 tensin 3 -0.0162489
AHNAK AHNAK nucleoprotein -0.0161201
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0160322
MYO1D myosin ID -0.0159326
TRIM56 tripartite motif containing 56 -0.0158824
CTSL cathepsin L -0.0158571