| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vemurafenib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vemurafenib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.253744 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.115554 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.113969 |
| GRAMD1B | GRAM domain containing 1B | 0.109439 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.109406 |
| TXNRD1 | thioredoxin reductase 1 | 0.083772 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0815676 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0592925 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.058232 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0576651 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0452226 |
| IER3 | immediate early response 3 | 0.0415965 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.036895 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0365408 |
| NRG1 | neuregulin 1 | 0.0359471 |
| FAM107B | family with sequence similarity 107, member B | 0.0355774 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0355006 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0354403 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.03506 |
| NAV3 | neuron navigator 3 | 0.0345715 |
| STC1 | stanniocalcin 1 | 0.0343598 |
| ASPH | aspartate beta-hydroxylase | 0.0317577 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0305707 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0298361 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.029071 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0282191 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0271042 |
| FMNL2 | formin-like 2 | 0.0269579 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0260474 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0257997 |
| WDR43 | WD repeat domain 43 | 0.0254753 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0246603 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0239436 |
| KLF6 | Kruppel-like factor 6 | 0.0236524 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0230192 |
| BMP6 | bone morphogenetic protein 6 | 0.0228866 |
| OSMR | oncostatin M receptor | 0.0228606 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0223506 |
| RBM39 | RNA binding motif protein 39 | 0.0223057 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0221208 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.022087 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0219537 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0218542 |
| MCL1 | myeloid cell leukemia 1 | 0.0215197 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0212112 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0210242 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0207924 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0204231 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0197495 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.019733 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0197221 |
| NUMB | numb homolog (Drosophila) | 0.0195848 |
| YME1L1 | YME1-like 1 ATPase | 0.0195115 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0194504 |
| CDCP1 | CUB domain containing protein 1 | 0.0193368 |
| FLNB | filamin B, beta | 0.0193141 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0193115 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0187258 |
| SPAG9 | sperm associated antigen 9 | 0.0185915 |
| GOLGA4 | golgin A4 | 0.0185344 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0185159 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0184224 |
| SNX9 | sorting nexin 9 | 0.0183853 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0180071 |
| IL6 | interleukin 6 | 0.017904 |
| LAMC2 | laminin, gamma 2 | 0.017881 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0178054 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0177897 |
| ACTG1 | actin gamma 1 | 0.0176987 |
| S100A6 | S100 calcium binding protein A6 | 0.0175948 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0175472 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0175073 |
| VMP1 | vacuole membrane protein 1 | 0.0174353 |
| PFDN2 | prefoldin subunit 2 | 0.0170972 |
| KIF5B | kinesin family member 5B | 0.0170872 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0168227 |
| COG5 | component of oligomeric golgi complex 5 | 0.0167726 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.016763 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0166215 |
| NCKAP1 | NCK-associated protein 1 | 0.0160861 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0160553 |
| TMSB10 | thymosin beta 10 | 0.0158423 |
| ITGB5 | integrin, beta 5 | 0.0158308 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0157983 |
| PTK2 | protein tyrosine kinase 2 | 0.0156647 |
| TOP1 | topoisomerase (DNA) I | 0.0156045 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0155 |
| TMEM131 | transmembrane protein 131 | 0.0154763 |
| SNX14 | sorting nexin 14 | 0.0154397 |
| DSE | dermatan sulfate epimerase | 0.0153926 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0153779 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0153589 |
| LDHA | lactate dehydrogenase A | 0.0152834 |
| TPD52 | tumor protein D52 | 0.01484 |
| EZR | ezrin | 0.0148277 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0148126 |
| NOP58 | NOP58 ribonucleoprotein | 0.0146796 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0146251 |
| GLIS3 | GLIS family zinc finger 3 | 0.0145411 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0143156 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | -0.0836172 |
| FTL | ferritin, light polypeptide | -0.0819747 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0491281 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.039736 |
| FGB | fibrinogen beta chain | -0.0352964 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0301188 |
| NEGR1 | neuronal growth regulator 1 | -0.0297792 |
| RAD51B | RAD51 paralog B | -0.0248207 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0227582 |
| EFNA5 | ephrin-A5 | -0.0218048 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0206622 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0204025 |
| TPM1 | tropomyosin 1 (alpha) | -0.0198912 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0190838 |
| RPS8 | ribosomal protein S8 | -0.0184891 |
| ZFHX3 | zinc finger homeobox 3 | -0.0175321 |
| TNS3 | tensin 3 | -0.0170918 |
| FGA | fibrinogen alpha chain | -0.0165867 |
| PTMA | prothymosin, alpha | -0.0158565 |
| RPL23 | ribosomal protein L23 | -0.0151798 |
| RPS29 | ribosomal protein S29 | -0.0149493 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0145467 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0142882 |
| PDE8A | phosphodiesterase 8A | -0.0142629 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0140114 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0139651 |
| B2M | beta-2-microglobulin | -0.0137655 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0134846 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0131791 |
| PRR16 | proline rich 16 | -0.0129915 |
| JUP | junction plakoglobin | -0.0129616 |
| VIM | vimentin | -0.0127353 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0126882 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0126228 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.012597 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0120198 |
| NEBL | nebulette | -0.0120191 |
| THSD7A | thrombospondin, type I, domain containing 7A | -0.0119157 |
| CUX1 | cut-like homeobox 1 | -0.0118194 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0118054 |
| RPL37A | ribosomal protein L37a | -0.0116518 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0113386 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0111807 |
| RORA | RAR-related orphan receptor A | -0.0111357 |
| RPL19 | ribosomal protein L19 | -0.0109344 |
| UTRN | utrophin | -0.0109023 |
| LMNA | lamin A/C | -0.0108644 |
| HLA-A | major histocompatibility complex, class I, A | -0.0106381 |
| GPC6 | glypican 6 | -0.0105016 |
| RPLP1 | ribosomal protein, large, P1 | -0.0104772 |
| RPS19 | ribosomal protein S19 | -0.0103807 |
| NFIB | nuclear factor I/B | -0.0103039 |
| GNAS | GNAS complex locus | -0.0100549 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0100406 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.00997913 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.00982494 |
| RPL35A | ribosomal protein L35a | -0.00972944 |
| RPL31 | ribosomal protein L31 | -0.00971221 |
| NCOA2 | nuclear receptor coactivator 2 | -0.00957659 |
| FGG | fibrinogen gamma chain | -0.00927949 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.00899107 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.00896835 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.00861098 |
| RPS12 | ribosomal protein S12 | -0.00851068 |
| CFAP73 | cilia and flagella associated protein 73 | -0.00846478 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.00846373 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.00844529 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00840522 |
| RPS21 | ribosomal protein S21 | -0.00840079 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.00836538 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.00833681 |
| VCL | vinculin | -0.00832453 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.00821352 |
| RPS25 | ribosomal protein S25 | -0.00814912 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.00812863 |
| PDE10A | phosphodiesterase 10A | -0.0080611 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.00800039 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.00785896 |
| LAMA5 | laminin, alpha 5 | -0.0077538 |
| RPS20 | ribosomal protein S20 | -0.00773984 |
| RPS27 | ribosomal protein S27 | -0.00766881 |
| RPS27A | ribosomal protein S27a | -0.00763095 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.00755804 |
| ZNF644 | zinc finger protein 644 | -0.00748689 |
| FRMD5 | FERM domain containing 5 | -0.00744612 |
| HLA-B | major histocompatibility complex, class I, B | -0.00737474 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.00728251 |
| PCNX4 | pecanex 4 | -0.00716573 |
| RPL13A | ribosomal protein L13a | -0.00712432 |
| MYO1E | myosin IE | -0.00711103 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.00703961 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.00703371 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.00700367 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.00698234 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.00694594 |
| RPL8 | ribosomal protein L8 | -0.006889 |
| FN1 | fibronectin 1 | -0.00683698 |
| YY1 | YY1 transcription factor | -0.0068053 |
| CANX | calnexin | -0.00677981 |
| ENO1 | enolase 1, (alpha) | -0.00673848 |
