| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vemurafenib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vemurafenib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.0743724 |
| KYNU | kynureninase | 0.0557807 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0535091 |
| FN1 | fibronectin 1 | 0.0454555 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0445114 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0442439 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0434641 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0408005 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0377688 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0371602 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.03669 |
| VIM | vimentin | 0.0364667 |
| GLIS3 | GLIS family zinc finger 3 | 0.0339136 |
| LMO7 | LIM domain 7 | 0.0337481 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0337459 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0332245 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0323016 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0319518 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0318866 |
| EGFR | epidermal growth factor receptor | 0.0317184 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0316706 |
| CD44 | CD44 molecule (Indian blood group) | 0.031178 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0309844 |
| RUNX1 | runt-related transcription factor 1 | 0.0309553 |
| GPHN | gephyrin | 0.0303006 |
| ASPH | aspartate beta-hydroxylase | 0.0298467 |
| RPS6 | ribosomal protein S6 | 0.0289855 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0286876 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0281485 |
| RPLP1 | ribosomal protein, large, P1 | 0.0276942 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0274756 |
| INHBA | inhibin, beta A | 0.0274668 |
| NTN4 | netrin 4 | 0.0272835 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0271936 |
| PTK2 | protein tyrosine kinase 2 | 0.0270287 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0270127 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0256365 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.025397 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0253409 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0247523 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0245044 |
| ACTG1 | actin gamma 1 | 0.0242166 |
| MYO6 | myosin VI | 0.0235149 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0234257 |
| HMGA2 | high mobility group AT-hook 2 | 0.0233269 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0227952 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.022716 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0224995 |
| RND3 | Rho family GTPase 3 | 0.0223989 |
| RPL35A | ribosomal protein L35a | 0.0223051 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0221825 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0214825 |
| TJP1 | tight junction protein 1 | 0.0211108 |
| FUS | FUS RNA binding protein | 0.0209303 |
| RPS8 | ribosomal protein S8 | 0.0208015 |
| DSPP | dentin sialophosphoprotein | 0.0207191 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0206732 |
| CDH13 | cadherin 13 | 0.0206017 |
| RPLP2 | ribosomal protein, large, P2 | 0.0198696 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0198286 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0197561 |
| UBC | ubiquitin C | 0.019669 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0195604 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0195365 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0194865 |
| JAK1 | Janus kinase 1 | 0.0194243 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0193944 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.01935 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0193106 |
| ATXN1 | ataxin 1 | 0.0192404 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0189456 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0188663 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0183701 |
| RPL23 | ribosomal protein L23 | 0.0183625 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0182071 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0181814 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0180932 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0180622 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0178955 |
| FRMD5 | FERM domain containing 5 | 0.017825 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0177847 |
| FNIP1 | folliculin interacting protein 1 | 0.0177485 |
| RNF145 | ring finger protein 145 | 0.0173425 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.017177 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0171277 |
| RAB7A | RAB7A, member RAS oncogene family | 0.017116 |
| RPS20 | ribosomal protein S20 | 0.0169809 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0167739 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0167424 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.016734 |
| RAI14 | retinoic acid induced 14 | 0.0167265 |
| RAD51B | RAD51 paralog B | 0.0166595 |
| KRT17 | keratin 17, type I | 0.0164825 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0164799 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0163161 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0162354 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0160023 |
| SON | SON DNA binding protein | 0.0159445 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0158605 |
| DST | dystonin | 0.0158495 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | -0.0543866 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0535411 |
| LAMB3 | laminin, beta 3 | -0.0428628 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0412882 |
| NDRG1 | N-myc downstream regulated 1 | -0.0406817 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0397348 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0388064 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0377869 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0375848 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0372958 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0315509 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0315097 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0311841 |
| AUTS2 | autism susceptibility candidate 2 | -0.0307985 |
| NEBL | nebulette | -0.0305679 |
| RUFY1 | RUN and FYVE domain containing 1 | -0.0300321 |
| AHNAK | AHNAK nucleoprotein | -0.0297124 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0288014 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0284399 |
| PERP | PERP, TP53 apoptosis effector | -0.0281722 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0281705 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0275779 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0271513 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0271468 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0263808 |
| SUCO | SUN domain containing ossification factor | -0.0261555 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0260812 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.025987 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0259839 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0259674 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0258051 |
| LNPEP | leucyl/cystinyl aminopeptidase | -0.0257162 |
| KIAA1217 | KIAA1217 | -0.0251064 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0247706 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0247479 |
| PDE10A | phosphodiesterase 10A | -0.0246134 |
| HELZ | helicase with zinc finger | -0.0243387 |
| PARD3 | par-3 family cell polarity regulator | -0.0242452 |
| PHF21A | PHD finger protein 21A | -0.0241173 |
| FMNL2 | formin-like 2 | -0.0235328 |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase | -0.0234335 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0231827 |
| WDR45B | WD repeat domain 45B | -0.0229438 |
| NBEA | neurobeachin | -0.0229155 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.022749 |
| CDCP1 | CUB domain containing protein 1 | -0.0227425 |
| TMEM41B | transmembrane protein 41B | -0.022617 |
| CYTH1 | cytohesin 1 | -0.0225982 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0225656 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | -0.022547 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0222106 |
| DENND1A | DENN/MADD domain containing 1A | -0.0221541 |
| PRELID2 | PRELI domain containing 2 | -0.0221052 |
| MORF4L1 | mortality factor 4 like 1 | -0.0212686 |
| KIAA1671 | KIAA1671 | -0.0212618 |
| NGLY1 | N-glycanase 1 | -0.0212146 |
| CDC42 | cell division cycle 42 | -0.0212055 |
| EHF | ets homologous factor | -0.0211432 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0210688 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0206616 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0206488 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.020499 |
| RASAL2 | RAS protein activator like 2 | -0.0204889 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0204445 |
| PKP4 | plakophilin 4 | -0.0203479 |
| OGA | O-GlcNAcase | -0.0202452 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0201922 |
| RIGI | RNA sensor RIG-I | -0.0201214 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0200566 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0199148 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0196886 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0196423 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0195983 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0195163 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | -0.0193681 |
| SEC24D | SEC24 family member D | -0.0192951 |
| RNGTT | RNA guanylyltransferase and 5'-phosphatase | -0.0192708 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0192378 |
| ARF4 | ADP-ribosylation factor 4 | -0.0190362 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0188611 |
| CFDP1 | craniofacial development protein 1 | -0.0188341 |
| MTSS1 | metastasis suppressor 1 | -0.0188271 |
| HEBP2 | heme binding protein 2 | -0.0186909 |
| XRN1 | 5'-3' exoribonuclease 1 | -0.0184486 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.018404 |
| RB1 | retinoblastoma 1 | -0.0183044 |
| MALT1 | MALT1 paracaspase | -0.0181791 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0180766 |
| SCEL | sciellin | -0.0179407 |
| FBXO34 | F-box protein 34 | -0.0177719 |
| NBEAL1 | neurobeachin-like 1 | -0.0176325 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.017621 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0175157 |
| STAG2 | stromal antigen 2 | -0.0174068 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0173452 |
| SETD5 | SET domain containing 5 | -0.0172485 |
| INSIG2 | insulin induced gene 2 | -0.0172472 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0172446 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0172408 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0172116 |
