Vemurafenib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 0.0410701
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0297247
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0286586
HSPA8 heat shock 70kDa protein 8 0.0284227
CAMTA1 calmodulin binding transcription activator 1 0.0273948
INTS6 integrator complex subunit 6 0.0273833
MACF1 microtubule-actin crosslinking factor 1 0.0264795
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.026094
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0260124
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0257544
DST dystonin 0.0254679
ANO6 anoctamin 6 0.0251669
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0249466
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0236834
COPA coatomer protein complex, subunit alpha 0.0236592
SPAG9 sperm associated antigen 9 0.0230528
RAB7A RAB7A, member RAS oncogene family 0.0228377
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0225717
BZW1 basic leucine zipper and W2 domains 1 0.0221572
ELL2 elongation factor, RNA polymerase II, 2 0.0219405
ZFC3H1 zinc finger, C3H1-type containing 0.0218693
MARCHF4 membrane associated ring-CH-type finger 4 0.0215
TM4SF1 transmembrane 4 L six family member 1 0.0211252
ZCCHC7 zinc finger, CCHC domain containing 7 0.0208906
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0204841
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.019408
OGA O-GlcNAcase 0.0190004
GPHN gephyrin 0.0189982
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0180678
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0179412
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0178801
HOMER1 homer scaffolding protein 1 0.0174874
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0171055
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0170994
CRY1 cryptochrome circadian clock 1 0.0169297
CLTC clathrin, heavy chain (Hc) 0.0168306
KDM7A lysine (K)-specific demethylase 7A 0.0168263
GOLGB1 golgin B1 0.0163448
FNIP1 folliculin interacting protein 1 0.0162828
JMJD1C jumonji domain containing 1C 0.0162623
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0161943
USP9X ubiquitin specific peptidase 9, X-linked 0.016039
FMNL2 formin-like 2 0.0157615
WNT2B wingless-type MMTV integration site family, member 2B 0.0155424
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0153788
TRIO trio Rho guanine nucleotide exchange factor 0.015345
USP15 ubiquitin specific peptidase 15 0.0152536
CAPRIN2 caprin family member 2 0.0151043
CUL3 cullin 3 0.0149048
PRELID2 PRELI domain containing 2 0.0142984
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0142941
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0142246
UBAP2L ubiquitin associated protein 2-like 0.0141347
WNK1 WNK lysine deficient protein kinase 1 0.0140982
PMM2 phosphomannomutase 2 0.0140236
NIPBL Nipped-B homolog (Drosophila) 0.0137493
KDM3A lysine (K)-specific demethylase 3A 0.013715
CHD1 chromodomain helicase DNA binding protein 1 0.0136192
RB1CC1 RB1-inducible coiled-coil 1 0.0135054
NCKAP1 NCK-associated protein 1 0.0133831
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0133124
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0130815
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0128866
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0127761
SEC31A SEC31 homolog A (S. cerevisiae) 0.0126699
PLCB4 phospholipase C, beta 4 0.0124869
SFPQ splicing factor proline/glutamine-rich 0.0124254
ESYT2 extended synaptotagmin-like protein 2 0.0123875
STK4 serine/threonine kinase 4 0.0123853
EXOC6B exocyst complex component 6B 0.0121619
DCLK1 doublecortin-like kinase 1 0.0120546
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0120515
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0119725
COPB1 coatomer protein complex, subunit beta 1 0.0118636
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0117167
RAB1A RAB1A, member RAS oncogene family 0.0115503
SPIRE1 spire-type actin nucleation factor 1 0.0114012
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.0113571
ZNF800 zinc finger protein 800 0.0111946
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0111925
PHF3 PHD finger protein 3 0.0111555
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0110164
DIDO1 death inducer-obliterator 1 0.0109579
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0108333
PDIA5 protein disulfide isomerase family A, member 5 0.0108137
CAMKMT calmodulin-lysine N-methyltransferase 0.0107513
NDEL1 nudE neurodevelopment protein 1-like 1 0.0107168
PRPF8 pre-mRNA processing factor 8 0.0106046
TRA2A transformer 2 alpha homolog (Drosophila) 0.0105584
ATF6 activating transcription factor 6 0.0105365
RICTOR RPTOR independent companion of MTOR, complex 2 0.010431
USP47 ubiquitin specific peptidase 47 0.010404
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0103302
WDR43 WD repeat domain 43 0.010292
SND1 staphylococcal nuclease and tudor domain containing 1 0.0102449
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.010226
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.010199
MON2 MON2 homolog (S. cerevisiae) 0.0101704
GOLT1B golgi transport 1B 0.0101062
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.010083

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.191079
TMSB10 thymosin beta 10 -0.116228
PTMA prothymosin, alpha -0.093052
GRAMD1B GRAM domain containing 1B -0.0864997
VIM vimentin -0.0851257
RPS27 ribosomal protein S27 -0.0607885
IFI6 interferon, alpha-inducible protein 6 -0.0599749
YBX3 Y box binding protein 3 -0.0591492
HLA-B major histocompatibility complex, class I, B -0.0572627
RPS3 ribosomal protein S3 -0.0532678
RPS8 ribosomal protein S8 -0.0532191
RPL35A ribosomal protein L35a -0.0531931
RPS21 ribosomal protein S21 -0.0513077
RPL37 ribosomal protein L37 -0.0510012
EGR1 early growth response 1 -0.050224
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0494627
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0488799
PDE10A phosphodiesterase 10A -0.0483498
RPS19 ribosomal protein S19 -0.0476748
MCL1 myeloid cell leukemia 1 -0.0472783
PDE4D phosphodiesterase 4D, cAMP-specific -0.0469498
RPL37A ribosomal protein L37a -0.046688
RPL23 ribosomal protein L23 -0.0464269
RPS6 ribosomal protein S6 -0.0436936
DENND5B DENN/MADD domain containing 5B -0.0432146
FTL ferritin, light polypeptide -0.0412579
PFN1 profilin 1 -0.0411306
AKAP12 A kinase (PRKA) anchor protein 12 -0.0407312
RPS29 ribosomal protein S29 -0.0402974
RPLP1 ribosomal protein, large, P1 -0.0396935
RPS12 ribosomal protein S12 -0.0394796
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0381393
BASP1 brain abundant, membrane attached signal protein 1 -0.0378722
MT2A metallothionein 2A -0.0366645
NCOA7 nuclear receptor coactivator 7 -0.0363504
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0347689
TPM4 tropomyosin 4 -0.0338816
TPI1 triosephosphate isomerase 1 -0.0337796
RPL31 ribosomal protein L31 -0.0335749
RPL11 ribosomal protein L11 -0.0332606
TPM2 tropomyosin 2 (beta) -0.0328433
ZBTB20 zinc finger and BTB domain containing 20 -0.0319303
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0309197
RAD51B RAD51 paralog B -0.0304843
ENO1 enolase 1, (alpha) -0.030484
RPLP2 ribosomal protein, large, P2 -0.0303384
RPL19 ribosomal protein L19 -0.0303342
RPL8 ribosomal protein L8 -0.0298063
RPL36A ribosomal protein L36a -0.0296207
GNAS GNAS complex locus -0.0295696
RPL36 ribosomal protein L36 -0.028897
LOC102724023 ES1 protein homolog, mitochondrial -0.0288654
RPS10 ribosomal protein S10 -0.0288327
PTMS parathymosin -0.0284241
RPL34 ribosomal protein L34 -0.0277106
RPL26 ribosomal protein L26 -0.0275825
RPS27A ribosomal protein S27a -0.0273644
ZMYND8 zinc finger, MYND-type containing 8 -0.0272955
EML4 echinoderm microtubule associated protein like 4 -0.0271243
LATS2 large tumor suppressor kinase 2 -0.0271215
RPS15 ribosomal protein S15 -0.0270144
RPS14 ribosomal protein S14 -0.0269258
VCL vinculin -0.0266996
TPT1 tumor protein, translationally-controlled 1 -0.0263035
RNF213 ring finger protein 213 -0.0260639
KTN1 kinectin 1 (kinesin receptor) -0.0254715
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0253536
FNDC3B fibronectin type III domain containing 3B -0.0251657
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0250825
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0249724
POTEF POTE ankyrin domain family, member F -0.0247494
WSB1 WD repeat and SOCS box containing 1 -0.0247168
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0242512
RPS23 ribosomal protein S23 -0.023063
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0229283
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0229003
RPL12 ribosomal protein L12 -0.0227914
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0227847
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0227242
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0225742
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0225631
RIMS2 regulating synaptic membrane exocytosis 2 -0.0223125
IGF1R insulin-like growth factor 1 receptor -0.0222154
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0222073
RPS25 ribosomal protein S25 -0.02213
OSMR oncostatin M receptor -0.022032
RPL35 ribosomal protein L35 -0.0220215
THSD4 thrombospondin, type I, domain containing 4 -0.0215113
WWOX WW domain containing oxidoreductase -0.021452
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0211716
RSF1 remodeling and spacing factor 1 -0.02097
RPL32 ribosomal protein L32 -0.020756
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0204231
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0203639
SMIM44 small integral membrane protein 44 -0.0203178
FLOT1 flotillin 1 -0.0202478
B2M beta-2-microglobulin -0.0201649
RPL28 ribosomal protein L28 -0.0201635
RPS17 ribosomal protein S17 -0.0201075
RYR3 ryanodine receptor 3 -0.0200249