| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vemurafenib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vemurafenib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.137837 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.101851 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0991638 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0933335 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0918225 |
| ACTG1 | actin gamma 1 | 0.0813214 |
| NDRG1 | N-myc downstream regulated 1 | 0.077493 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0751537 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0716801 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0649821 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0638318 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0623326 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0593829 |
| EZR | ezrin | 0.0564227 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0553312 |
| FAM13A | family with sequence similarity 13, member A | 0.0552695 |
| LAMC2 | laminin, gamma 2 | 0.0552439 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0548328 |
| TOP1 | topoisomerase (DNA) I | 0.0546886 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0518258 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0515368 |
| AHNAK | AHNAK nucleoprotein | 0.0514274 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0503667 |
| DTNA | dystrobrevin, alpha | 0.0492036 |
| DSPP | dentin sialophosphoprotein | 0.0473132 |
| UBC | ubiquitin C | 0.0470083 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0469435 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0462171 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0450166 |
| EGR1 | early growth response 1 | 0.0447059 |
| TMSB4X | thymosin beta 4, X-linked | 0.0445278 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0418777 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.041875 |
| PLEC | plectin | 0.0411673 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0383435 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0372723 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0371231 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0368805 |
| LDHA | lactate dehydrogenase A | 0.036872 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0358145 |
| LMNA | lamin A/C | 0.0351755 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0347923 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.034038 |
| COPA | coatomer protein complex, subunit alpha | 0.0340306 |
| RYBP | RING1 and YY1 binding protein | 0.0338406 |
| RHOA | ras homolog family member A | 0.0333194 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0332843 |
| RLF | rearranged L-myc fusion | 0.033154 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0330779 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0326398 |
| RCOR1 | REST corepressor 1 | 0.0324116 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0321402 |
| S100A6 | S100 calcium binding protein A6 | 0.032062 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0320435 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0319455 |
| MAP1B | microtubule-associated protein 1B | 0.0314114 |
| NUMB | numb homolog (Drosophila) | 0.0308614 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0306891 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0306751 |
| SDC4 | syndecan 4 | 0.0298905 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0298686 |
| KRT7 | keratin 7, type II | 0.0297416 |
| TPM3 | tropomyosin 3 | 0.0296156 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0294196 |
| LAMB3 | laminin, beta 3 | 0.0292612 |
| CANX | calnexin | 0.0290692 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0288751 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0282084 |
| MSN | moesin | 0.0281426 |
| RBM39 | RNA binding motif protein 39 | 0.0279383 |
| POTEF | POTE ankyrin domain family, member F | 0.0277682 |
| G0S2 | G0/G1 switch 2 | 0.0273525 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0271797 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0268736 |
| CALR | calreticulin | 0.0268073 |
| PUM1 | pumilio RNA-binding family member 1 | 0.026194 |
| MXD1 | MAX dimerization protein 1 | 0.0261776 |
| PTK2 | protein tyrosine kinase 2 | 0.0256877 |
| ANXA2 | annexin A2 | 0.0255883 |
| SPAG9 | sperm associated antigen 9 | 0.0254752 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0254133 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0253957 |
| PRRC2C | proline-rich coiled-coil 2C | 0.024824 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0244652 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0244643 |
| HMGB2 | high mobility group box 2 | 0.0244565 |
| RREB1 | ras responsive element binding protein 1 | 0.0243895 |
| USP3 | ubiquitin specific peptidase 3 | 0.0242842 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0242683 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0242487 |
| FLNB | filamin B, beta | 0.0240254 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0240209 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0239751 |
| YME1L1 | YME1-like 1 ATPase | 0.0238279 |
| TMSB10 | thymosin beta 10 | 0.0237524 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0235029 |
| ARRDC3 | arrestin domain containing 3 | 0.0233718 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0232024 |
| RBM25 | RNA binding motif protein 25 | 0.0231033 |
| SLMAP | sarcolemma associated protein | 0.0229981 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.111333 |
| FN1 | fibronectin 1 | -0.0894476 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0678227 |
| ASPH | aspartate beta-hydroxylase | -0.0663081 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0615736 |
| TXNIP | thioredoxin interacting protein | -0.0567646 |
| EFNA5 | ephrin-A5 | -0.0559409 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0526947 |
| RPL37A | ribosomal protein L37a | -0.0425211 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0404938 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0403961 |
| RBM47 | RNA binding motif protein 47 | -0.0391251 |
| RPS29 | ribosomal protein S29 | -0.0375875 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0370497 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0363834 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0360744 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0332269 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0328113 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0306166 |
| FBXO32 | F-box protein 32 | -0.0300481 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0291388 |
| PGBD5 | piggyBac transposable element derived 5 | -0.0284821 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0281896 |
| ETV6 | ets variant 6 | -0.0274494 |
| RPL35A | ribosomal protein L35a | -0.0271063 |
| HMGA1 | high mobility group AT-hook 1 | -0.0266873 |
| LMO7 | LIM domain 7 | -0.0260351 |
| OSMR | oncostatin M receptor | -0.0259702 |
| VCL | vinculin | -0.0246901 |
| RPL31 | ribosomal protein L31 | -0.0241565 |
| BPTF | bromodomain PHD finger transcription factor | -0.0237593 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0236031 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.023591 |
| RPL11 | ribosomal protein L11 | -0.023349 |
| ATXN1 | ataxin 1 | -0.0231241 |
| RPS27 | ribosomal protein S27 | -0.0231104 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0230634 |
| RPS12 | ribosomal protein S12 | -0.0229552 |
| OCLN | occludin | -0.0229255 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.022906 |
| CD109 | CD109 molecule | -0.0226993 |
| NTN4 | netrin 4 | -0.0226651 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0224543 |
| RAD51B | RAD51 paralog B | -0.0223046 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0223044 |
| DSCAM | Down syndrome cell adhesion molecule | -0.022127 |
| FBXO34 | F-box protein 34 | -0.0220276 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0218969 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0218677 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0218293 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0215648 |
| RPS25 | ribosomal protein S25 | -0.0213828 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.021323 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.021177 |
| RPS13 | ribosomal protein S13 | -0.0208337 |
| RPS6 | ribosomal protein S6 | -0.0204657 |
| GLCCI1 | glucocorticoid induced 1 | -0.0201155 |
| SVIL | supervillin | -0.0196521 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0195882 |
| EGFR | epidermal growth factor receptor | -0.0194583 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0194121 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | -0.0193575 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0193128 |
| CPNE8 | copine VIII | -0.0191766 |
| PHF3 | PHD finger protein 3 | -0.0189406 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.018881 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0187542 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0187306 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0184274 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0183616 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0182459 |
| FAM3C | family with sequence similarity 3, member C | -0.0178793 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0178499 |
| CEP350 | centrosomal protein 350kDa | -0.0178348 |
| PALLD | palladin, cytoskeletal associated protein | -0.0176489 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0176211 |
| PCNX4 | pecanex 4 | -0.017531 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0173218 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0172983 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.0171504 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.016955 |
| RPS3 | ribosomal protein S3 | -0.0169267 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.016862 |
| FHIT | fragile histidine triad | -0.0167438 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.016546 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0163656 |
| ERBIN | erbb2 interacting protein | -0.0162491 |
| FRMD5 | FERM domain containing 5 | -0.0162365 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0160468 |
| THRB | thyroid hormone receptor, beta | -0.0160246 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0156208 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0154732 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0154686 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0152839 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | -0.0152362 |
| HDAC8 | histone deacetylase 8 | -0.0152047 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0150717 |
| EXOC4 | exocyst complex component 4 | -0.0150048 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0149315 |
| FNIP1 | folliculin interacting protein 1 | -0.0147998 |
