Vemurafenib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.360799
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.11139
CDH13 cadherin 13 0.0897299
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0759748
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0743115
VIM vimentin 0.0733566
PSD3 pleckstrin and Sec7 domain containing 3 0.0675912
PRKN parkin RBR E3 ubiquitin protein ligase 0.0578317
MAML3 mastermind-like 3 (Drosophila) 0.0578184
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0561902
SMAD2 SMAD family member 2 0.0556102
SMOC1 SPARC related modular calcium binding 1 0.050432
EEF2 eukaryotic translation elongation factor 2 0.0498411
PDE4D phosphodiesterase 4D, cAMP-specific 0.0461946
CREB5 cAMP responsive element binding protein 5 0.0448207
AGTPBP1 ATP/GTP binding protein 1 0.0441427
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0411028
LSAMP limbic system-associated membrane protein 0.0393977
EXT1 exostosin glycosyltransferase 1 0.03929
DOCK4 dedicator of cytokinesis 4 0.0391885
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0380994
MAP7 microtubule-associated protein 7 0.0369071
CD44 CD44 molecule (Indian blood group) 0.036258
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0351295
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0328865
PTPRM protein tyrosine phosphatase, receptor type, M 0.0323532
P3H2 prolyl 3-hydroxylase 2 0.0306295
DST dystonin 0.0304365
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0303641
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0302425
AUTS2 autism susceptibility candidate 2 0.0298653
CUX1 cut-like homeobox 1 0.0296122
RAD51B RAD51 paralog B 0.0294953
SQSTM1 sequestosome 1 0.0285716
THSD4 thrombospondin, type I, domain containing 4 0.0279981
DENND1A DENN/MADD domain containing 1A 0.027807
NRXN3 neurexin 3 0.0274594
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0270399
AKAP13 A kinase (PRKA) anchor protein 13 0.0269976
WARS1 tryptophanyl-tRNA synthetase 1 0.0266672
SH3KBP1 SH3-domain kinase binding protein 1 0.025737
XYLT1 xylosyltransferase I 0.0247069
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0246245
NCKAP5 NCK-associated protein 5 0.0245532
BZW1 basic leucine zipper and W2 domains 1 0.0242382
HMGA2 high mobility group AT-hook 2 0.0238192
FNDC3A fibronectin type III domain containing 3A 0.0238003
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0234284
ESM1 endothelial cell-specific molecule 1 0.0230656
ZSWIM6 zinc finger, SWIM-type containing 6 0.022865
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0227788
CLIP1 CAP-GLY domain containing linker protein 1 0.0222844
PDLIM5 PDZ and LIM domain 5 0.0217803
ABLIM1 actin binding LIM protein 1 0.0216279
INTS6 integrator complex subunit 6 0.0214918
FTH1 ferritin, heavy polypeptide 1 0.021393
PRELID2 PRELI domain containing 2 0.0212181
SOX9 SRY (sex determining region Y)-box 9 0.0209382
NALF1 NALCN channel auxiliary factor 1 0.0209354
SFTPA2 surfactant protein A2 0.0207107
FNIP1 folliculin interacting protein 1 0.0206343
INHBA inhibin, beta A 0.0205762
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0202369
ACTG1 actin gamma 1 0.0201392
AADAC arylacetamide deacetylase 0.0200925
DNER delta/notch-like EGF repeat containing 0.0200036
FAM107B family with sequence similarity 107, member B 0.0199414
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0198827
TTC28 tetratricopeptide repeat domain 28 0.0197257
BMP6 bone morphogenetic protein 6 0.0193712
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0192344
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0191499
LOC102724023 ES1 protein homolog, mitochondrial 0.0190455
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0188926
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0188273
SVIL supervillin 0.0187589
ATXN1 ataxin 1 0.0186184
RASAL2 RAS protein activator like 2 0.0182381
HDAC9 histone deacetylase 9 0.0181886
FMNL2 formin-like 2 0.0180781
PCDH9 protocadherin 9 0.0180358
AKAP12 A kinase (PRKA) anchor protein 12 0.0177321
GRB10 growth factor receptor-bound protein 10 0.0173353
CTIF CBP80/20-dependent translation initiation factor 0.0173225
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0170324
KIF16B kinesin family member 16B 0.0163731
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0163351
PRKCA protein kinase C, alpha 0.0162873
RAB7A RAB7A, member RAS oncogene family 0.0162235
RANBP17 RAN binding protein 17 0.016188
ANXA2 annexin A2 0.0161854
MACF1 microtubule-actin crosslinking factor 1 0.0160682
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0158116
RNF213 ring finger protein 213 0.0157613
NTSR1 neurotensin receptor 1 (high affinity) 0.0156651
RPS4X ribosomal protein S4, X-linked 0.0154743
LDHA lactate dehydrogenase A 0.015355
TENM2 teneurin transmembrane protein 2 0.0153203
RHCG Rh family, C glycoprotein 0.0152657
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0151608

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.21594
EFNA5 ephrin-A5 -0.146317
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.121279
TXNRD1 thioredoxin reductase 1 -0.114243
RTN4 reticulon 4 -0.0871373
NEK7 NIMA-related kinase 7 -0.0865953
GDA guanine deaminase -0.0848785
ASPH aspartate beta-hydroxylase -0.0813678
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0693235
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0688376
LIMCH1 LIM and calponin homology domains 1 -0.068742
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0639174
GRAMD1B GRAM domain containing 1B -0.06261
NAP1L1 nucleosome assembly protein 1-like 1 -0.060551
RBM39 RNA binding motif protein 39 -0.0600526
MFF mitochondrial fission factor -0.0596046
OGA O-GlcNAcase -0.0583749
PTMA prothymosin, alpha -0.0577061
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0562131
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0555389
MYOF myoferlin -0.054847
ELL2 elongation factor, RNA polymerase II, 2 -0.0542776
AGFG1 ArfGAP with FG repeats 1 -0.0521736
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0516885
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0513582
COL5A2 collagen, type V, alpha 2 -0.0504219
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0502373
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0501477
TNPO1 transportin 1 -0.0499732
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.049363
TRIO trio Rho guanine nucleotide exchange factor -0.0489452
RGS2 regulator of G-protein signaling 2 -0.0482817
TGFBI transforming growth factor, beta-induced, 68kDa -0.048232
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0473698
TM4SF1 transmembrane 4 L six family member 1 -0.047079
TFPI2 tissue factor pathway inhibitor 2 -0.0468158
PTGR1 prostaglandin reductase 1 -0.0438332
ENAH enabled homolog (Drosophila) -0.0430594
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0429754
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.042587
PRRC2C proline-rich coiled-coil 2C -0.0419188
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0403245
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0400984
CTSC cathepsin C -0.0388835
FLNB filamin B, beta -0.0388789
FTL ferritin, light polypeptide -0.0388233
ARHGAP29 Rho GTPase activating protein 29 -0.0380003
CENPF centromere protein F, 350/400kDa -0.0376111
RPS2 ribosomal protein S2 -0.0362878
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0354761
SRGN serglycin -0.035297
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0352679
BDNF brain-derived neurotrophic factor -0.0352231
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0350011
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0349559
TMX4 thioredoxin-related transmembrane protein 4 -0.0347526
KTN1 kinectin 1 (kinesin receptor) -0.0347347
XPO1 exportin 1 -0.0345947
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.034235
WDFY2 WD repeat and FYVE domain containing 2 -0.0335489
MATR3 matrin 3 -0.0334952
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0329533
GOLGA4 golgin A4 -0.0327386
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0323735
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0322855
KMT2C lysine (K)-specific methyltransferase 2C -0.0321904
ZNF292 zinc finger protein 292 -0.0321145
B2M beta-2-microglobulin -0.0319822
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0317034
PUM2 pumilio RNA-binding family member 2 -0.0312968
PHF20 PHD finger protein 20 -0.0311399
AVL9 AVL9 homolog (S. cerevisiase) -0.0308722
ANKRD28 ankyrin repeat domain 28 -0.0308094
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0307934
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0305467
PNISR PNN-interacting serine/arginine-rich protein -0.0305143
SLF1 SMC5-SMC6 complex localization factor 1 -0.0299831
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0297282
BRWD3 bromodomain and WD repeat domain containing 3 -0.0291837
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.0291706
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.029068
BCAR3 breast cancer anti-estrogen resistance 3 -0.0289828
ZFC3H1 zinc finger, C3H1-type containing -0.028822
TPR translocated promoter region, nuclear basket protein -0.0287852
BIRC6 baculoviral IAP repeat containing 6 -0.0286602
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0286558
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0285502
CFLAR CASP8 and FADD-like apoptosis regulator -0.0284798
PHIP pleckstrin homology domain interacting protein -0.0282299
ESYT2 extended synaptotagmin-like protein 2 -0.0282012
USP3 ubiquitin specific peptidase 3 -0.0280087
SRPK2 SRSF protein kinase 2 -0.0278695
WSB1 WD repeat and SOCS box containing 1 -0.0278457
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0275383
TRA2A transformer 2 alpha homolog (Drosophila) -0.027524
MED13L mediator complex subunit 13-like -0.0275173
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0273276
DPY19L1 dpy-19-like 1 (C. elegans) -0.0272757
SFPQ splicing factor proline/glutamine-rich -0.0272605
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.027026