Vemurafenib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.187926
EXT1 exostosin glycosyltransferase 1 0.154406
IGF2 insulin-like growth factor 2 0.139331
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.100496
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.09908
SAMD4A sterile alpha motif domain containing 4A 0.0939091
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0918592
ASPH aspartate beta-hydroxylase 0.0907211
PNISR PNN-interacting serine/arginine-rich protein 0.0907203
SVIL supervillin 0.0905885
FNDC3B fibronectin type III domain containing 3B 0.0903389
TBC1D22A TBC1 domain family, member 22A 0.0895052
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0852209
RNF213 ring finger protein 213 0.0846926
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0824164
RPL37 ribosomal protein L37 0.0819128
ESYT2 extended synaptotagmin-like protein 2 0.0796606
EZR ezrin 0.0789288
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0765718
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0761224
FTL ferritin, light polypeptide 0.0754003
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0729924
LMO7 LIM domain 7 0.0726465
RPS19 ribosomal protein S19 0.0724968
INTS6 integrator complex subunit 6 0.071887
KLF6 Kruppel-like factor 6 0.0717216
ANKRD17 ankyrin repeat domain 17 0.0711288
LPP LIM domain containing preferred translocation partner in lipoma 0.0694409
EEF2 eukaryotic translation elongation factor 2 0.0684924
HDLBP high density lipoprotein binding protein 0.0669408
AKAP12 A kinase (PRKA) anchor protein 12 0.0662372
RPLP2 ribosomal protein, large, P2 0.0661267
FAT1 FAT atypical cadherin 1 0.0653367
JUN jun proto-oncogene 0.065209
PTPRK protein tyrosine phosphatase, receptor type, K 0.064963
ANKRD11 ankyrin repeat domain 11 0.0644241
SPTBN1 spectrin, beta, non-erythrocytic 1 0.064395
ENO1 enolase 1, (alpha) 0.063164
IGFBP3 insulin-like growth factor binding protein 3 0.0604184
RPS6 ribosomal protein S6 0.0590315
BACE2 beta-site APP-cleaving enzyme 2 0.058073
RPL35A ribosomal protein L35a 0.0572503
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0569445
SQSTM1 sequestosome 1 0.0564321
TMSB10 thymosin beta 10 0.0557999
SMAD3 SMAD family member 3 0.0554347
PRRC2C proline-rich coiled-coil 2C 0.0542464
RACK1 receptor for activated C kinase 1 0.0538544
RPL34 ribosomal protein L34 0.0533818
RPLP0 ribosomal protein, large, P0 0.0528881
TAOK1 TAO kinase 1 0.0517604
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0480775
MYO1E myosin IE 0.0478884
BPTF bromodomain PHD finger transcription factor 0.0465371
EPS8 epidermal growth factor receptor pathway substrate 8 0.0461268
MACF1 microtubule-actin crosslinking factor 1 0.0450245
AKAP9 A kinase (PRKA) anchor protein 9 0.0449479
RPL11 ribosomal protein L11 0.0448216
RPL37A ribosomal protein L37a 0.0423146
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0416875
MED13L mediator complex subunit 13-like 0.0407579
LRP1B low density lipoprotein receptor-related protein 1B 0.0402747
POTEF POTE ankyrin domain family, member F 0.0401114
GOLGA4 golgin A4 0.0396187
TPT1 tumor protein, translationally-controlled 1 0.0377082
B2M beta-2-microglobulin 0.0367742
SMYD3 SET and MYND domain containing 3 0.034158
RERE arginine-glutamic acid dipeptide (RE) repeats 0.033581
EFNA5 ephrin-A5 0.0332056
ATXN1 ataxin 1 0.0328152
CTBP2 C-terminal binding protein 2 0.031974
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0307147
CTNND1 catenin (cadherin-associated protein), delta 1 0.0306799
NPEPPS aminopeptidase puromycin sensitive 0.0302921
ANKRD12 ankyrin repeat domain 12 0.0298256
HOOK2 hook microtubule-tethering protein 2 0.0297613
DLG1 discs, large homolog 1 (Drosophila) 0.0295505
RPLP1 ribosomal protein, large, P1 0.02926
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0262448
MED13 mediator complex subunit 13 0.0257779
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0253061
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0246242
NDRG1 N-myc downstream regulated 1 0.0240689
ZCCHC7 zinc finger, CCHC domain containing 7 0.0239695
ACTG1 actin gamma 1 0.0204607
OGA O-GlcNAcase 0.01965
MAML3 mastermind-like 3 (Drosophila) 0.0195395
AKAP13 A kinase (PRKA) anchor protein 13 0.0189485
PARD3 par-3 family cell polarity regulator 0.0166312
ZBTB20 zinc finger and BTB domain containing 20 0.0164981
GLS2 glutaminase 2 (liver, mitochondrial) 0.0161386
SETD5 SET domain containing 5 0.0154044
RPL12 ribosomal protein L12 0.0151275
GCLC glutamate-cysteine ligase, catalytic subunit 0.0141924
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0130559
RPL31 ribosomal protein L31 0.0114528
TJP1 tight junction protein 1 0.0106041
DST dystonin 0.00983488
EIF1 eukaryotic translation initiation factor 1 0.00954547
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.00928147

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.20464
PTMA prothymosin, alpha -0.136463
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122501
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.12014
NKD1 naked cuticle homolog 1 (Drosophila) -0.109309
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.10433
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0996465
LAMA4 laminin, alpha 4 -0.0964683
NUP58 nucleoporin 58 -0.0940301
PKM pyruvate kinase, muscle -0.0878712
RLF rearranged L-myc fusion -0.0846309
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0827021
FN1 fibronectin 1 -0.0825706
VIM vimentin -0.0803057
RB1CC1 RB1-inducible coiled-coil 1 -0.0792872
PIBF1 progesterone immunomodulatory binding factor 1 -0.0778623
CLTC clathrin, heavy chain (Hc) -0.077434
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0752983
RSF1 remodeling and spacing factor 1 -0.0744383
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0743187
JARID2 jumonji, AT rich interactive domain 2 -0.0715613
PGK1 phosphoglycerate kinase 1 -0.0715178
LMAN1 lectin, mannose-binding, 1 -0.0713351
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0706957
RAB7A RAB7A, member RAS oncogene family -0.0703712
KDM6A lysine (K)-specific demethylase 6A -0.0684671
SEC31A SEC31 homolog A (S. cerevisiae) -0.0668846
NAMPT nicotinamide phosphoribosyltransferase -0.0656865
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0653873
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0643205
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0642816
SMC5 structural maintenance of chromosomes 5 -0.0633319
ELL2 elongation factor, RNA polymerase II, 2 -0.063162
RPL23 ribosomal protein L23 -0.0618161
MYH9 myosin, heavy chain 9, non-muscle -0.0609411
KDM3A lysine (K)-specific demethylase 3A -0.0608009
FAM13A family with sequence similarity 13, member A -0.0597366
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.058467
PDE4D phosphodiesterase 4D, cAMP-specific -0.0573002
PTK2 protein tyrosine kinase 2 -0.0571668
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0566862
RTN4 reticulon 4 -0.0544917
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0521704
FNDC3A fibronectin type III domain containing 3A -0.0515349
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0513556
PRELID2 PRELI domain containing 2 -0.0494625
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.048219
UBC ubiquitin C -0.0465888
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0460137
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0458518
PDE8A phosphodiesterase 8A -0.044731
ADAM9 ADAM metallopeptidase domain 9 -0.0443314
CCNI cyclin I -0.0425741
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0420447
AFF4 AF4/FMR2 family, member 4 -0.0408318
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0403186
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.040185
ACTN4 actinin, alpha 4 -0.0399621
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0384903
KTN1 kinectin 1 (kinesin receptor) -0.0358909
GPHN gephyrin -0.0352063
CALU calumenin -0.0351651
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0345099
SLTM SAFB-like, transcription modulator -0.0342722
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0342188
PDLIM5 PDZ and LIM domain 5 -0.0331207
FNIP1 folliculin interacting protein 1 -0.0326428
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0324522
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0310628
ANXA2 annexin A2 -0.0310375
GARS1 glycyl-tRNA synthetase 1 -0.0284803
SRPK2 SRSF protein kinase 2 -0.0274802
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0272807
RPL15 ribosomal protein L15 -0.0267007
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0264626
GSK3B glycogen synthase kinase 3 beta -0.0260198
NIPBL Nipped-B homolog (Drosophila) -0.0241591
SBF2 SET binding factor 2 -0.0235997
GOLGB1 golgin B1 -0.0214935
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0213335
ZNF292 zinc finger protein 292 -0.0207779
SRRM2 serine/arginine repetitive matrix 2 -0.0205919
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0189204
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0176909
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0176815
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.016886
LDHA lactate dehydrogenase A -0.016884
RPS27A ribosomal protein S27a -0.0160846
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0155984
SPAG9 sperm associated antigen 9 -0.0154727
RBM39 RNA binding motif protein 39 -0.0150028
JAK1 Janus kinase 1 -0.0149158
FMN1 formin 1 -0.0142128
TXNRD1 thioredoxin reductase 1 -0.0140111
MYO6 myosin VI -0.0136316
KMT2C lysine (K)-specific methyltransferase 2C -0.0134655
SLC38A1 solute carrier family 38, member 1 -0.0133062
BHLHE40 basic helix-loop-helix family, member e40 -0.0120631
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0117821
DSCAM Down syndrome cell adhesion molecule -0.0108673