Vemurafenib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.230342
ERBB4 erb-b2 receptor tyrosine kinase 4 0.179788
CDH10 cadherin 10, type 2 (T2-cadherin) 0.156358
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.14767
CADM2 cell adhesion molecule 2 0.144495
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.13206
PCLO piccolo presynaptic cytomatrix protein 0.130044
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0887485
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0867195
LRRC4C leucine rich repeat containing 4C 0.0800807
TENM3 teneurin transmembrane protein 3 0.0779023
PCDH9 protocadherin 9 0.0719592
ADGRV1 adhesion G protein-coupled receptor V1 0.0709159
FOXP2 forkhead box P2 0.0706043
ADGRL2 adhesion G protein-coupled receptor L2 0.0690015
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0658859
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0633292
SLIT2 slit homolog 2 (Drosophila) 0.0555511
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0553962
CDH19 cadherin 19, type 2 0.0532239
DOCK5 dedicator of cytokinesis 5 0.0529609
COL5A2 collagen, type V, alpha 2 0.049404
NTM neurotrimin 0.0492137
HDAC9 histone deacetylase 9 0.0487271
SAMD4A sterile alpha motif domain containing 4A 0.0481868
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0455363
PARD3B par-3 family cell polarity regulator beta 0.0449431
RAD51B RAD51 paralog B 0.0442409
FNDC3B fibronectin type III domain containing 3B 0.0422618
ANK2 ankyrin 2, neuronal 0.041995
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0416306
NCAM2 neural cell adhesion molecule 2 0.0415855
ZEB2 zinc finger E-box binding homeobox 2 0.0402278
TAS2R14 taste receptor, type 2, member 14 0.0402253
MED13L mediator complex subunit 13-like 0.0383699
PDE4D phosphodiesterase 4D, cAMP-specific 0.0380174
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0368322
JMJD1C jumonji domain containing 1C 0.0363663
DST dystonin 0.0362706
RASAL2 RAS protein activator like 2 0.0357359
TTC28 tetratricopeptide repeat domain 28 0.0355721
CSMD3 CUB and Sushi multiple domains 3 0.0340331
TNRC6B trinucleotide repeat containing 6B 0.0338238
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0335515
MAML2 mastermind-like 2 (Drosophila) 0.0333545
NEBL nebulette 0.0323118
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0311526
USP9X ubiquitin specific peptidase 9, X-linked 0.0310142
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0309464
SYT1 synaptotagmin I 0.0296362
ANKRD33B ankyrin repeat domain 33B 0.029276
PHIP pleckstrin homology domain interacting protein 0.0291492
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 0.0290545
HMGA2 high mobility group AT-hook 2 0.0289404
PRTG protogenin 0.0281406
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0280107
TRAK1 trafficking protein, kinesin binding 1 0.0276826
GREB1L growth regulation by estrogen in breast cancer-like 0.0275766
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0275347
USP34 ubiquitin specific peptidase 34 0.027466
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0273149
BMPR1A bone morphogenetic protein receptor, type IA 0.0269433
GARRE1 granule associated Rac and RHOG effector 1 0.0268207
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0265993
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.026329
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0262726
MED12L mediator complex subunit 12-like 0.0259318
SREBF2 sterol regulatory element binding transcription factor 2 0.0256975
ZC3H12B zinc finger CCCH-type containing 12B 0.0255483
NHSL1 NHS-like 1 0.0254887
ATXN1 ataxin 1 0.0252636
DSCAM Down syndrome cell adhesion molecule 0.0251713
RCOR1 REST corepressor 1 0.0251424
INTS6 integrator complex subunit 6 0.0248847
GSE1 Gse1 coiled-coil protein 0.0247092
ADGRL3 adhesion G protein-coupled receptor L3 0.0245611
RBM20 RNA binding motif protein 20 0.0245168
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0243308
SMYD3 SET and MYND domain containing 3 0.0240419
MPG N-methylpurine-DNA glycosylase 0.0239807
PRELID2 PRELI domain containing 2 0.023294
ZNF638 zinc finger protein 638 0.0228669
SRRM2 serine/arginine repetitive matrix 2 0.022597
DMD dystrophin 0.0224822
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0224652
MEIS2 Meis homeobox 2 0.0223607
CUX1 cut-like homeobox 1 0.0220088
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0219611
CLIC4 chloride intracellular channel 4 0.0216739
CCDC102B coiled-coil domain containing 102B 0.0212221
TJP1 tight junction protein 1 0.0210123
DOK6 docking protein 6 0.0209377
TRPS1 trichorhinophalangeal syndrome I 0.020803
ZBTB20 zinc finger and BTB domain containing 20 0.0202358
RABGAP1L RAB GTPase activating protein 1-like 0.0201443
PRKD1 protein kinase D1 0.0198938
PCDH7 protocadherin 7 0.0198715
CSRNP3 cysteine-serine-rich nuclear protein 3 0.0197965
PLPP1 phospholipid phosphatase 1 0.0196444
HMCN1 hemicentin 1 0.0195632

decreased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.14805
VIM vimentin -0.126768
PTMA prothymosin, alpha -0.107192
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0851636
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0774513
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.076715
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0756112
TOP2A topoisomerase (DNA) II alpha 170kDa -0.072176
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0667169
TMSB4X thymosin beta 4, X-linked -0.0654047
TSC22D2 TSC22 domain family, member 2 -0.0608643
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0557518
ATP5F1B ATP synthase F1 subunit beta -0.0556311
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0521887
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0497947
MKI67 marker of proliferation Ki-67 -0.0497058
CENPF centromere protein F, 350/400kDa -0.0489815
POTEF POTE ankyrin domain family, member F -0.0486345
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0466174
YBX1 Y box binding protein 1 -0.0458039
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.042579
RTN4 reticulon 4 -0.0421898
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0414935
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0399426
NAP1L1 nucleosome assembly protein 1-like 1 -0.0397079
RPS16 ribosomal protein S16 -0.0395532
H1-4 H1.4 linker histone, cluster member -0.0389057
RPS6 ribosomal protein S6 -0.0368701
SFRP4 secreted frizzled-related protein 4 -0.0361329
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0356993
TPX2 TPX2, microtubule-associated -0.0352076
FXR1 fragile X mental retardation, autosomal homolog 1 -0.035201
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0351638
RHEB Ras homolog enriched in brain -0.034673
NOP58 NOP58 ribonucleoprotein -0.0341558
SRP54 signal recognition particle 54kDa -0.0341404
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.033919
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0335552
SET SET nuclear proto-oncogene -0.0330644
ZNF292 zinc finger protein 292 -0.0321812
PDCD5 programmed cell death 5 -0.0316261
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0314841
CLTC clathrin, heavy chain (Hc) -0.0312687
ANXA2 annexin A2 -0.0309705
PFN1 profilin 1 -0.0306963
RPS2 ribosomal protein S2 -0.0298313
KIF4A kinesin family member 4A -0.0296737
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.02962
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0294715
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0287253
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0286933
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0283631
RPS8 ribosomal protein S8 -0.0280662
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0275469
CKAP5 cytoskeleton associated protein 5 -0.0274586
RPS12 ribosomal protein S12 -0.027276
HMGB2 high mobility group box 2 -0.0270434
RBM25 RNA binding motif protein 25 -0.0269954
RPL19 ribosomal protein L19 -0.0268879
ADAM9 ADAM metallopeptidase domain 9 -0.0266861
NAMPT nicotinamide phosphoribosyltransferase -0.0266422
USP3 ubiquitin specific peptidase 3 -0.0265312
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0265052
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0264668
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0263302
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0262612
TPM3 tropomyosin 3 -0.0262447
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0259595
ANLN anillin, actin binding protein -0.0256764
QKI QKI, KH domain containing, RNA binding -0.0256667
SMC4 structural maintenance of chromosomes 4 -0.025462
MATR3 matrin 3 -0.0254407
PCBP2 poly(rC) binding protein 2 -0.0254109
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0250827
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0250085
KPNB1 karyopherin (importin) beta 1 -0.0249959
LDHB lactate dehydrogenase B -0.0248467
ZC3H15 zinc finger CCCH-type containing 15 -0.0247952
RAD21 RAD21 homolog (S. pombe) -0.0243534
RPLP1 ribosomal protein, large, P1 -0.0242492
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0242079
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.023899
MYL12B myosin, light chain 12B, regulatory -0.0237702
CENPE centromere protein E, 312kDa -0.023589
CANX calnexin -0.0235569
NUSAP1 nucleolar and spindle associated protein 1 -0.023524
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.0234214
CSDE1 cold shock domain containing E1, RNA-binding -0.0232768
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.0229877
ANXA1 annexin A1 -0.0229803
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0227756
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0227746
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0226825
RPL7 ribosomal protein L7 -0.0226817
SERBP1 SERPINE1 mRNA binding protein 1 -0.022567
RPL6 ribosomal protein L6 -0.0225374
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0224665
CAPN2 calpain 2, (m/II) large subunit -0.0224102
EMP1 epithelial membrane protein 1 -0.0221415
EIF4A1 eukaryotic translation initiation factor 4A1 -0.022022