Vemurafenib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vemurafenib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vemurafenib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.0502943
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0433645
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0377505
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0364511
FAT1 FAT atypical cadherin 1 0.0337787
SUCO SUN domain containing ossification factor 0.0326251
FAM13A family with sequence similarity 13, member A 0.0283233
RICTOR RPTOR independent companion of MTOR, complex 2 0.0281266
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0274516
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0267355
ELL2 elongation factor, RNA polymerase II, 2 0.0224874
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0208152
SOD2 superoxide dismutase 2, mitochondrial 0.020515
HELZ helicase with zinc finger 0.0197008
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.017897
CTBP2 C-terminal binding protein 2 0.0177034
RNF145 ring finger protein 145 0.0176375
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.017503
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0163782
DOCK5 dedicator of cytokinesis 5 0.0162007
NDRG1 N-myc downstream regulated 1 0.0160529
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0158275
COG5 component of oligomeric golgi complex 5 0.0157915
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0153985
LCORL ligand dependent nuclear receptor corepressor-like 0.0153557
UBA6 ubiquitin-like modifier activating enzyme 6 0.0152611
ANO6 anoctamin 6 0.0147027
TENT2 terminal nucleotidyltransferase 2 0.0145542
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0144063
ZSWIM6 zinc finger, SWIM-type containing 6 0.0141226
KDM3A lysine (K)-specific demethylase 3A 0.0140015
PICALM phosphatidylinositol binding clathrin assembly protein 0.0139746
ARRDC3 arrestin domain containing 3 0.0138655
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0136843
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0136199
RLF rearranged L-myc fusion 0.0135928
CDC73 cell division cycle 73 0.0134977
COPA coatomer protein complex, subunit alpha 0.0132144
NUP58 nucleoporin 58 0.0130067
QKI QKI, KH domain containing, RNA binding 0.0129928
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0127674
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0127082
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0125625
CD109 CD109 molecule 0.012533
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0124834
NUMB numb homolog (Drosophila) 0.012399
WAC WW domain containing adaptor with coiled-coil 0.0123928
GOLGA4 golgin A4 0.0121693
HSPA8 heat shock 70kDa protein 8 0.0119392
EREG epiregulin 0.0118314
MTSS1 metastasis suppressor 1 0.0118253
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.011806
NEK7 NIMA-related kinase 7 0.011714
TRA2A transformer 2 alpha homolog (Drosophila) 0.0116903
KMT2C lysine (K)-specific methyltransferase 2C 0.0115764
NIPBL Nipped-B homolog (Drosophila) 0.0115442
SEC23A Sec23 homolog A (S. cerevisiae) 0.0114533
SLTM SAFB-like, transcription modulator 0.0114198
CLINT1 clathrin interactor 1 0.0113711
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0113621
RAB8B RAB8B, member RAS oncogene family 0.0113604
ANKRD28 ankyrin repeat domain 28 0.0113461
USP15 ubiquitin specific peptidase 15 0.0113245
ZCCHC7 zinc finger, CCHC domain containing 7 0.0112362
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0111447
SMAD3 SMAD family member 3 0.0111268
ZC3H12C zinc finger CCCH-type containing 12C 0.0110159
NBAS neuroblastoma amplified sequence 0.0109599
ESYT2 extended synaptotagmin-like protein 2 0.0109344
EMP1 epithelial membrane protein 1 0.0108904
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0108884
PAPOLA poly(A) polymerase alpha 0.0107405
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0105851
SEC24D SEC24 family member D 0.0105175
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0104896
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0104832
TFG TRK-fused gene 0.0104818
BIRC3 baculoviral IAP repeat containing 3 0.0104171
TFPI2 tissue factor pathway inhibitor 2 0.0103677
ZC3H11A zinc finger CCCH-type containing 11A 0.0103522
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0102741
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0101466
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0101191
OGA O-GlcNAcase 0.0100537
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.00989814
ZNF292 zinc finger protein 292 0.00989215
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00982644
SLAIN2 SLAIN motif family, member 2 0.00971258
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0096891
FOXO3 forkhead box O3 0.00968341
KDM5B lysine (K)-specific demethylase 5B 0.00967444
MARCHF6 membrane associated ring-CH-type finger 6 0.00956812
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00952344
ELOVL5 ELOVL fatty acid elongase 5 0.00946609
FAM107B family with sequence similarity 107, member B 0.00945268
SRP54 signal recognition particle 54kDa 0.00933973
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.00931956
TMF1 TATA element modulatory factor 1 0.00926579
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.00922521
ZFC3H1 zinc finger, C3H1-type containing 0.00920863

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.186091
NRG1 neuregulin 1 -0.162876
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.145413
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.117509
IFI27 interferon, alpha-inducible protein 27 -0.0939097
TMSB10 thymosin beta 10 -0.0797643
PTMA prothymosin, alpha -0.0773465
FTL ferritin, light polypeptide -0.0690361
HLA-B major histocompatibility complex, class I, B -0.068831
SQSTM1 sequestosome 1 -0.0651035
VCL vinculin -0.0609393
S100A6 S100 calcium binding protein A6 -0.0589076
TMEM156 transmembrane protein 156 -0.0547041
VIM vimentin -0.0545372
HMGA2 high mobility group AT-hook 2 -0.0527801
B2M beta-2-microglobulin -0.0512181
ASPH aspartate beta-hydroxylase -0.0506882
SOX4 SRY (sex determining region Y)-box 4 -0.0466768
SYT1 synaptotagmin I -0.0462004
GLIS3 GLIS family zinc finger 3 -0.0449672
LOC102724023 ES1 protein homolog, mitochondrial -0.0427324
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0380439
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0378321
ENO1 enolase 1, (alpha) -0.0377243
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0373281
ENO2 enolase 2 (gamma, neuronal) -0.0366418
MT2A metallothionein 2A -0.0361822
PLIN2 perilipin 2 -0.03556
NRP1 neuropilin 1 -0.0355393
ETV1 ets variant 1 -0.0354993
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0352725
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0349936
TMSB4X thymosin beta 4, X-linked -0.0347561
IFI6 interferon, alpha-inducible protein 6 -0.0336752
KLHL5 kelch-like family member 5 -0.0332169
TPT1 tumor protein, translationally-controlled 1 -0.0331682
PKM pyruvate kinase, muscle -0.0315009
HLA-A major histocompatibility complex, class I, A -0.0312114
ITGA1 integrin, alpha 1 -0.0308978
POTEF POTE ankyrin domain family, member F -0.0306113
NTN4 netrin 4 -0.0303349
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0303295
PDE4D phosphodiesterase 4D, cAMP-specific -0.0302045
EXT1 exostosin glycosyltransferase 1 -0.0298516
RPL35A ribosomal protein L35a -0.0290471
MAP1B microtubule-associated protein 1B -0.0285087
ZBTB20 zinc finger and BTB domain containing 20 -0.0284934
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0284849
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0281099
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0276525
TPI1 triosephosphate isomerase 1 -0.0272983
RNF213 ring finger protein 213 -0.0271509
EGR1 early growth response 1 -0.0270881
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0260793
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0260648
RPS6 ribosomal protein S6 -0.025334
DNAH5 dynein, axonemal, heavy chain 5 -0.0250752
ACTG1 actin gamma 1 -0.0250461
LRMDA leucine rich melanocyte differentiation associated -0.0246666
RPL37A ribosomal protein L37a -0.0244644
LY6E lymphocyte antigen 6 complex, locus E -0.0234971
ZMYND8 zinc finger, MYND-type containing 8 -0.0233687
LOC112694756 uncharaterized LOC112694756 -0.0233231
RPS21 ribosomal protein S21 -0.0233047
WSB1 WD repeat and SOCS box containing 1 -0.0227776
TSC22D1 TSC22 domain family, member 1 -0.0222453
OSMR oncostatin M receptor -0.0220528
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0218294
HMGA1 high mobility group AT-hook 1 -0.0217014
RPLP1 ribosomal protein, large, P1 -0.021665
TPM4 tropomyosin 4 -0.0214748
RPL31 ribosomal protein L31 -0.0207316
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0206708
GLUL glutamate-ammonia ligase -0.0206042
LMNA lamin A/C -0.020486
RPS27 ribosomal protein S27 -0.0203945
MBD5 methyl-CpG binding domain protein 5 -0.0200766
MX2 MX dynamin-like GTPase 2 -0.0198019
IFI16 interferon, gamma-inducible protein 16 -0.0195597
RPS19 ribosomal protein S19 -0.0193489
NXN nucleoredoxin -0.0192552
S100A9 S100 calcium binding protein A9 -0.0192285
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0192278
RAD51B RAD51 paralog B -0.0191866
FOXP1 forkhead box P1 -0.019116
TENM4 teneurin transmembrane protein 4 -0.0191033
CENPF centromere protein F, 350/400kDa -0.0189163
SFRP1 secreted frizzled-related protein 1 -0.0188507
MKI67 marker of proliferation Ki-67 -0.0183808
BPTF bromodomain PHD finger transcription factor -0.0183547
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0182567
SFTPA2 surfactant protein A2 -0.0182267
AEBP2 AE binding protein 2 -0.01782
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0174414
RAI14 retinoic acid induced 14 -0.0174398
IFITM1 interferon induced transmembrane protein 1 -0.0173595
RPS8 ribosomal protein S8 -0.0171715
CTSD cathepsin D -0.0171474
RACK1 receptor for activated C kinase 1 -0.0170735
TTC28 tetratricopeptide repeat domain 28 -0.0170458