Verapamil_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.256042
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.187138
MT2A metallothionein 2A 0.174485
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.166826
TMSB10 thymosin beta 10 0.159089
PTMA prothymosin, alpha 0.142236
B2M beta-2-microglobulin 0.129897
ZFP36L1 ZFP36 ring finger protein-like 1 0.121042
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.12051
VIM vimentin 0.113785
AKAP12 A kinase (PRKA) anchor protein 12 0.108603
TRIO trio Rho guanine nucleotide exchange factor 0.0968108
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0940654
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0922257
PODXL podocalyxin-like 0.0895474
DLG1 discs, large homolog 1 (Drosophila) 0.0864281
CSTB cystatin B (stefin B) 0.0824741
PLAUR plasminogen activator, urokinase receptor 0.0778213
ANXA2 annexin A2 0.0733001
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0629987
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0625331
SQSTM1 sequestosome 1 0.0609891
FTL ferritin, light polypeptide 0.0589567
ENO1 enolase 1, (alpha) 0.0566425
IFITM3 interferon induced transmembrane protein 3 0.0565303
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0553915
S100A10 S100 calcium binding protein A10 0.0512265
LMNA lamin A/C 0.0510172
NDRG1 N-myc downstream regulated 1 0.0503999
SETD5 SET domain containing 5 0.0500033
RPS3 ribosomal protein S3 0.0497411
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0491638
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0490382
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0478243
GOLGA4 golgin A4 0.0478103
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0474045
RPL37A ribosomal protein L37a 0.045259
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0446124
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0445516
S100A11 S100 calcium binding protein A11 0.043335
ZNF292 zinc finger protein 292 0.0428803
TNIP1 TNFAIP3 interacting protein 1 0.0419583
SOX9 SRY (sex determining region Y)-box 9 0.0417696
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0415768
RTN4 reticulon 4 0.04126
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0407276
ANKRD11 ankyrin repeat domain 11 0.0405562
WSB1 WD repeat and SOCS box containing 1 0.0400844
MXI1 MAX interactor 1, dimerization protein 0.0400795
DST dystonin 0.0387557
KLF6 Kruppel-like factor 6 0.0379629
GPBP1 GC-rich promoter binding protein 1 0.037372
ELL2 elongation factor, RNA polymerase II, 2 0.0367631
DDIT4 DNA-damage-inducible transcript 4 0.0363252
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0361593
HILPDA hypoxia inducible lipid droplet-associated 0.0360806
NAMPT nicotinamide phosphoribosyltransferase 0.0355401
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0355219
FMNL2 formin-like 2 0.0353767
KMT2E lysine (K)-specific methyltransferase 2E 0.0352724
CYLD cylindromatosis (turban tumor syndrome) 0.0351905
HELZ helicase with zinc finger 0.0344191
IFI6 interferon, alpha-inducible protein 6 0.0341262
ABI1 abl-interactor 1 0.033984
MSI2 musashi RNA-binding protein 2 0.0338344
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0333573
ADM adrenomedullin 0.0331151
EIF1 eukaryotic translation initiation factor 1 0.0323641
PARP14 poly (ADP-ribose) polymerase family, member 14 0.031602
IFIH1 interferon induced with helicase C domain 1 0.0312294
FNDC3B fibronectin type III domain containing 3B 0.0312212
RPL12 ribosomal protein L12 0.0312154
PGK1 phosphoglycerate kinase 1 0.0311153
RPS8 ribosomal protein S8 0.0310605
RNF24 ring finger protein 24 0.0310436
ANXA1 annexin A1 0.0307697
RPS19 ribosomal protein S19 0.030447
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0302301
COL8A1 collagen, type VIII, alpha 1 0.029746
RPS2 ribosomal protein S2 0.029684
KDM3A lysine (K)-specific demethylase 3A 0.0296815
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0296667
FSTL1 follistatin-like 1 0.0295143
VCL vinculin 0.0294985
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0289268
HLA-A major histocompatibility complex, class I, A 0.0287254
MB21D2 Mab-21 domain containing 2 0.0284818
RAI1 retinoic acid induced 1 0.0283889
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0283847
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0278682
FOSL1 FOS-like antigen 1 0.0278273
FAM13A family with sequence similarity 13, member A 0.027809
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0275404
SEC61G Sec61 gamma subunit 0.0273383
STC1 stanniocalcin 1 0.0270203
FAM107B family with sequence similarity 107, member B 0.0270059
MYOF myoferlin 0.0268389
RAB1A RAB1A, member RAS oncogene family 0.0264561
CTBP2 C-terminal binding protein 2 0.026399
ESYT2 extended synaptotagmin-like protein 2 0.0261727

decreased expression

Symbol Name Standardized Value
LOX lysyl oxidase -0.101849
NAV1 neuron navigator 1 -0.0888647
IGFBP3 insulin-like growth factor binding protein 3 -0.0865138
COL5A1 collagen, type V, alpha 1 -0.064317
COL1A2 collagen, type I, alpha 2 -0.0482987
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0414805
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0403536
MYADM myeloid-associated differentiation marker -0.0381808
GLIS3 GLIS family zinc finger 3 -0.0376149
LOC112694756 uncharaterized LOC112694756 -0.0369493
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0355993
SUCNR1 succinate receptor 1 -0.035436
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0340121
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.032809
TAPBP TAP binding protein (tapasin) -0.0315827
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0310251
FBN1 fibrillin 1 -0.0292836
RNF213 ring finger protein 213 -0.0291655
EXOC6B exocyst complex component 6B -0.0290031
CDH13 cadherin 13 -0.0279613
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0264145
CCND1 cyclin D1 -0.0258251
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0241423
BPTF bromodomain PHD finger transcription factor -0.0233265
EGFR epidermal growth factor receptor -0.0232992
RASA3 RAS p21 protein activator 3 -0.0218635
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0212475
SLFN5 schlafen family member 5 -0.0208746
SOD2 superoxide dismutase 2, mitochondrial -0.0206732
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0205955
VEGFA vascular endothelial growth factor A -0.0203676
FLNA filamin A, alpha -0.0199887
PLSCR1 phospholipid scramblase 1 -0.019986
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0199658
LAMA5 laminin, alpha 5 -0.0198857
ZNF217 zinc finger protein 217 -0.0191202
ANTXR1 anthrax toxin receptor 1 -0.018868
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0188237
SLF2 SMC5-SMC6 complex localization factor 2 -0.0187895
COL6A1 collagen, type VI, alpha 1 -0.0185606
BBS9 Bardet-Biedl syndrome 9 -0.0184769
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0184416
MRPS6 mitochondrial ribosomal protein S6 -0.0179896
PLAT plasminogen activator, tissue -0.0178271
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0176622
PBX3 pre-B-cell leukemia homeobox 3 -0.0175639
PLEC plectin -0.0173617
THBS2 thrombospondin 2 -0.0170254
C1D C1D nuclear receptor corepressor -0.016908
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0167951
AFF3 AF4/FMR2 family, member 3 -0.0167918
SMAD3 SMAD family member 3 -0.0166407
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0166402
EHBP1 EH domain binding protein 1 -0.016623
NCOR2 nuclear receptor corepressor 2 -0.01648
PXDN peroxidasin -0.0164472
CDC16 cell division cycle 16 -0.016242
NECTIN3 nectin cell adhesion molecule 3 -0.0161904
LENG8 leukocyte receptor cluster (LRC) member 8 -0.0161281
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -0.016093
COL6A2 collagen, type VI, alpha 2 -0.0160626
DPYSL2 dihydropyrimidinase-like 2 -0.0160243
GSE1 Gse1 coiled-coil protein -0.016
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0159159
TPM1 tropomyosin 1 (alpha) -0.0159083
CEP112 centrosomal protein 112kDa -0.0158547
MPRIP myosin phosphatase Rho interacting protein -0.0158308
SMIM44 small integral membrane protein 44 -0.0156977
TBCA tubulin folding cofactor A -0.0153315
OSMR oncostatin M receptor -0.0152007
COL5A2 collagen, type V, alpha 2 -0.0151151
MX2 MX dynamin-like GTPase 2 -0.0150565
FTH1 ferritin, heavy polypeptide 1 -0.0150402
FRMD4A FERM domain containing 4A -0.0149932
MON2 MON2 homolog (S. cerevisiae) -0.0149511
RC3H2 ring finger and CCCH-type domains 2 -0.0148728
NAV2 neuron navigator 2 -0.0148483
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0148057
RNF144A ring finger protein 144A -0.0147253
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0146882
TUT7 terminal uridylyl transferase 7 -0.0146453
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.014506
DPYSL3 dihydropyrimidinase-like 3 -0.0143872
CCM2 cerebral cavernous malformation 2 -0.0143619
TMCO3 transmembrane and coiled-coil domains 3 -0.0143582
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0142671
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0142458
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0142206
FBXL7 F-box and leucine-rich repeat protein 7 -0.0142142
NIBAN2 niban apoptosis regulator 2 -0.0142079
NSD1 nuclear receptor binding SET domain protein 1 -0.0141245
RABGAP1L RAB GTPase activating protein 1-like -0.0139592
NSD2 nuclear receptor binding SET domain protein 2 -0.0138877
ZNF207 zinc finger protein 207 -0.0138693
VMP1 vacuole membrane protein 1 -0.013779
DOCK5 dedicator of cytokinesis 5 -0.0137633
SRRM2 serine/arginine repetitive matrix 2 -0.0136726
RAB22A RAB22A, member RAS oncogene family -0.0136535
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0136116
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF -0.0135455