Verapamil_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.0965538
TMSB10 thymosin beta 10 0.0854438
RPS12 ribosomal protein S12 0.0805779
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0733112
FTL ferritin, light polypeptide 0.0671056
RPS3 ribosomal protein S3 0.0636448
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0602172
YAP1 Yes-associated protein 1 0.060194
RRM2 ribonucleotide reductase M2 0.0560209
AREG amphiregulin 0.0557972
ACTG1 actin gamma 1 0.0544738
RPL37A ribosomal protein L37a 0.0532736
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0518168
RPS2 ribosomal protein S2 0.0485545
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0476601
PDE4D phosphodiesterase 4D, cAMP-specific 0.046521
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0464386
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0461902
RPL12 ribosomal protein L12 0.0425942
RPS19 ribosomal protein S19 0.041668
CNRIP1 cannabinoid receptor interacting protein 1 0.0416114
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0415739
ENO1 enolase 1, (alpha) 0.0410827
RPL23 ribosomal protein L23 0.0405238
TAS2R14 taste receptor, type 2, member 14 0.0398953
EPHA6 EPH receptor A6 0.0392219
PUM2 pumilio RNA-binding family member 2 0.0389478
RPS8 ribosomal protein S8 0.0383402
RPS6 ribosomal protein S6 0.0381324
HMGA2 high mobility group AT-hook 2 0.0351871
CCNL1 cyclin L1 0.0348425
WWOX WW domain containing oxidoreductase 0.0341897
PRELID2 PRELI domain containing 2 0.0325429
ATAD2 ATPase family, AAA domain containing 2 0.0310057
NAP1L1 nucleosome assembly protein 1-like 1 0.0299591
PCDH9 protocadherin 9 0.0298292
RACK1 receptor for activated C kinase 1 0.0295109
BIRC2 baculoviral IAP repeat containing 2 0.0285214
RPL36 ribosomal protein L36 0.0281604
MKI67 marker of proliferation Ki-67 0.0279983
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.027811
RPS29 ribosomal protein S29 0.0276645
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0274635
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0270175
EIF1 eukaryotic translation initiation factor 1 0.0269436
RPL9 ribosomal protein L9 0.026571
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0258898
ERRFI1 ERBB receptor feedback inhibitor 1 0.0258467
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0254188
RAD51B RAD51 paralog B 0.025384
HELLS helicase, lymphoid-specific 0.0251879
PDIA6 protein disulfide isomerase family A, member 6 0.0250185
MBD5 methyl-CpG binding domain protein 5 0.0247572
LPP LIM domain containing preferred translocation partner in lipoma 0.0245631
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0245166
RPL6 ribosomal protein L6 0.0244825
SETD5 SET domain containing 5 0.0244647
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0243408
LRMDA leucine rich melanocyte differentiation associated 0.0242254
STMN1 stathmin 1 0.0241112
RPS23 ribosomal protein S23 0.0240907
RPL4 ribosomal protein L4 0.0232007
RPLP2 ribosomal protein, large, P2 0.023181
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0231111
SMC4 structural maintenance of chromosomes 4 0.0229894
S100A10 S100 calcium binding protein A10 0.0229238
RPS27A ribosomal protein S27a 0.02278
RPL18 ribosomal protein L18 0.0225015
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0224498
RPL31 ribosomal protein L31 0.022421
VMP1 vacuole membrane protein 1 0.0221185
H1-4 H1.4 linker histone, cluster member 0.0219145
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0218746
RPS10 ribosomal protein S10 0.0218035
VCL vinculin 0.0217855
SDK1 sidekick cell adhesion molecule 1 0.0215953
SNX14 sorting nexin 14 0.0215051
YBX3 Y box binding protein 3 0.0210374
PDIA3 protein disulfide isomerase family A, member 3 0.0208048
NALF1 NALCN channel auxiliary factor 1 0.0207953
RPL37 ribosomal protein L37 0.0207665
CLTC clathrin, heavy chain (Hc) 0.0206652
RPL19 ribosomal protein L19 0.0205555
H1-0 H1.0 linker histone 0.0199702
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0199525
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0199448
HSPA8 heat shock 70kDa protein 8 0.0196683
NDUFA4 NDUFA4, mitochondrial complex associated 0.0196146
RPL3 ribosomal protein L3 0.0192501
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.019101
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0190919
LDHB lactate dehydrogenase B 0.018907
HDAC9 histone deacetylase 9 0.0187295
CDK17 cyclin-dependent kinase 17 0.0187141
TBK1 TANK-binding kinase 1 0.0185023
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0184233
SERINC1 serine incorporator 1 0.0181717
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0181659
NFE2L1 nuclear factor, erythroid 2-like 1 0.0181586
RPS7 ribosomal protein S7 0.0181086

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.181572
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.153774
BIRC3 baculoviral IAP repeat containing 3 -0.108169
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.108022
DPYD dihydropyrimidine dehydrogenase -0.100586
ZBTB20 zinc finger and BTB domain containing 20 -0.0974248
MMP12 matrix metallopeptidase 12 -0.095729
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.095493
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0891919
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0873445
CELF2 CUGBP, Elav-like family member 2 -0.0832946
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0785282
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0757986
RASAL2 RAS protein activator like 2 -0.0733935
USP34 ubiquitin specific peptidase 34 -0.0733115
SLC38A2 solute carrier family 38, member 2 -0.0729132
CCN2 cellular communication network factor 2 -0.0706212
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0703292
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0694756
TXNRD1 thioredoxin reductase 1 -0.0669711
BIRC6 baculoviral IAP repeat containing 6 -0.0669114
MARCHF4 membrane associated ring-CH-type finger 4 -0.0657292
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0634776
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0634602
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0620355
EDN1 endothelin 1 -0.0603127
EHBP1 EH domain binding protein 1 -0.060019
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0552951
CARD16 caspase recruitment domain family, member 16 -0.0524916
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0521706
DLC1 DLC1 Rho GTPase activating protein -0.0518117
SBF2 SET binding factor 2 -0.0515283
DST dystonin -0.0498394
CMIP c-Maf inducing protein -0.047919
ERBIN erbb2 interacting protein -0.0478343
BPTF bromodomain PHD finger transcription factor -0.0463042
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0451222
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0414622
ANKRD28 ankyrin repeat domain 28 -0.0398557
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0387344
NF1 neurofibromin 1 -0.0387163
PLK2 polo-like kinase 2 -0.038349
AHNAK AHNAK nucleoprotein -0.0360877
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0359067
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0356298
PCDH7 protocadherin 7 -0.0355562
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0353747
HMGA1 high mobility group AT-hook 1 -0.0349288
SPAG9 sperm associated antigen 9 -0.0348507
CLDN1 claudin 1 -0.0342826
PRKCI protein kinase C, iota -0.0341163
NEBL nebulette -0.0338395
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0336571
EEF2 eukaryotic translation elongation factor 2 -0.0336514
EXOC6B exocyst complex component 6B -0.0334706
ANKRD12 ankyrin repeat domain 12 -0.033019
YBX1 Y box binding protein 1 -0.0325767
TSC22D2 TSC22 domain family, member 2 -0.0324576
LMO7 LIM domain 7 -0.0322451
EZR ezrin -0.0319994
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -0.0318927
CSNK1A1 casein kinase 1, alpha 1 -0.0317971
KIF5B kinesin family member 5B -0.0316304
EGFR epidermal growth factor receptor -0.0316195
U2SURP U2 snRNP-associated SURP domain containing -0.0313268
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0312872
ZNF804A zinc finger protein 804A -0.0312531
ADGRG6 adhesion G protein-coupled receptor G6 -0.0307628
RABGAP1L RAB GTPase activating protein 1-like -0.0303967
ATP5F1B ATP synthase F1 subunit beta -0.0302745
MGAT4C MGAT4 family, member C -0.0299991
SYT1 synaptotagmin I -0.0298873
NCOR1 nuclear receptor corepressor 1 -0.0295937
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -0.0295027
GJA1 gap junction protein, alpha 1, 43kDa -0.0292142
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0287204
LOC112694756 uncharaterized LOC112694756 -0.0285987
MON2 MON2 homolog (S. cerevisiae) -0.0285518
CCND1 cyclin D1 -0.0285069
MYL12B myosin, light chain 12B, regulatory -0.0281071
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0280462
FSTL5 follistatin-like 5 -0.0277781
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0277357
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0274103
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0273979
FNBP4 formin binding protein 4 -0.0273697
PICALM phosphatidylinositol binding clathrin assembly protein -0.0270198
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0268835
VDAC1 voltage-dependent anion channel 1 -0.0268617
TSPAN5 tetraspanin 5 -0.0268224
TRIO trio Rho guanine nucleotide exchange factor -0.0266252
NECTIN3 nectin cell adhesion molecule 3 -0.0262338
KIF1B kinesin family member 1B -0.0262112
FER fer (fps/fes related) tyrosine kinase -0.0261934
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.026178
PDCD10 programmed cell death 10 -0.0260262
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.025773
FBXL2 F-box and leucine-rich repeat protein 2 -0.0257141
ELP4 elongator acetyltransferase complex subunit 4 -0.0256586
OSBPL8 oxysterol binding protein-like 8 -0.0253268