Verapamil_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.12164
HELZ helicase with zinc finger 0.105703
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0964653
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.078265
ZNF292 zinc finger protein 292 0.065242
NAMPT nicotinamide phosphoribosyltransferase 0.0641282
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0553473
KMT2C lysine (K)-specific methyltransferase 2C 0.0546556
NDRG1 N-myc downstream regulated 1 0.0506524
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.049213
WDR45B WD repeat domain 45B 0.0484062
KDM3A lysine (K)-specific demethylase 3A 0.048011
PTMA prothymosin, alpha 0.0467313
NPEPPS aminopeptidase puromycin sensitive 0.0463681
WAC WW domain containing adaptor with coiled-coil 0.0461529
ZMYM2 zinc finger, MYM-type 2 0.0459864
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.044204
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0438773
SSBP2 single-stranded DNA binding protein 2 0.0434078
QKI QKI, KH domain containing, RNA binding 0.0433279
PKM pyruvate kinase, muscle 0.0411816
DTNA dystrobrevin, alpha 0.0410808
RNF145 ring finger protein 145 0.0398644
HILPDA hypoxia inducible lipid droplet-associated 0.0387622
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0382132
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0374989
FNDC3B fibronectin type III domain containing 3B 0.0363818
RFX7 regulatory factor X, 7 0.0363645
ANXA2 annexin A2 0.0347038
NUP58 nucleoporin 58 0.0331051
RTN4 reticulon 4 0.0327721
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0325059
MED13L mediator complex subunit 13-like 0.0318952
PNISR PNN-interacting serine/arginine-rich protein 0.0310373
SLMAP sarcolemma associated protein 0.0309201
MSMO1 methylsterol monooxygenase 1 0.0306868
AKAP12 A kinase (PRKA) anchor protein 12 0.0305918
USP3 ubiquitin specific peptidase 3 0.0302952
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0302151
CCNL1 cyclin L1 0.0302079
CD36 CD36 molecule (thrombospondin receptor) 0.0301543
KDM6A lysine (K)-specific demethylase 6A 0.0301197
PGK1 phosphoglycerate kinase 1 0.029785
FXR1 fragile X mental retardation, autosomal homolog 1 0.0297113
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0296562
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0294448
LCORL ligand dependent nuclear receptor corepressor-like 0.0291921
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0290367
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0285401
KMT2E lysine (K)-specific methyltransferase 2E 0.0284364
CDC27 cell division cycle 27 0.0279974
WSB1 WD repeat and SOCS box containing 1 0.0278269
HMBOX1 homeobox containing 1 0.0276341
PDS5B PDS5 cohesin associated factor B 0.0276312
RYBP RING1 and YY1 binding protein 0.0273758
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0267069
ECT2 epithelial cell transforming 2 0.0264845
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0263547
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0261654
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0258228
PDE8A phosphodiesterase 8A 0.0258121
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0257386
TTK TTK protein kinase 0.0255778
TENT5A terminal nucleotidyltransferase 5A 0.0253173
SOX9 SRY (sex determining region Y)-box 9 0.0252782
PIAS1 protein inhibitor of activated STAT, 1 0.0252637
SEPTIN9 septin 9 0.024861
TM9SF3 transmembrane 9 superfamily member 3 0.0248313
EIF4A3 eukaryotic translation initiation factor 4A3 0.0246094
MYOF myoferlin 0.0244438
SREBF2 sterol regulatory element binding transcription factor 2 0.0243478
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0239603
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0234923
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0234589
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0232584
CXXC5 CXXC finger protein 5 0.0230937
FEM1C fem-1 homolog c (C. elegans) 0.022823
GOLGA4 golgin A4 0.0228004
FAM162A family with sequence similarity 162, member A 0.0227441
POU2F1 POU class 2 homeobox 1 0.0226471
HMGB2 high mobility group box 2 0.0224965
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0224927
ZNF148 zinc finger protein 148 0.0223457
ZNF451 zinc finger protein 451 0.0222789
USP8 ubiquitin specific peptidase 8 0.0219397
NFYA nuclear transcription factor Y, alpha 0.0219259
NUMB numb homolog (Drosophila) 0.0218203
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0218046
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0217441
FTL ferritin, light polypeptide 0.021705
AFDN afadin, adherens junction formation factor 0.0216957
ADAM17 ADAM metallopeptidase domain 17 0.0215058
UBA2 ubiquitin-like modifier activating enzyme 2 0.0213885
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0212596
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0211573
NEK7 NIMA-related kinase 7 0.0211381
PUM2 pumilio RNA-binding family member 2 0.0210095
RPL6 ribosomal protein L6 0.0209269
NIPBL Nipped-B homolog (Drosophila) 0.0206757
BRD4 bromodomain containing 4 0.0205388

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.263447
NRG1 neuregulin 1 -0.204223
LSAMP limbic system-associated membrane protein -0.12169
NALF1 NALCN channel auxiliary factor 1 -0.100257
PTPRD protein tyrosine phosphatase, receptor type, D -0.0970666
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0920664
FRMD4A FERM domain containing 4A -0.0818534
EXT1 exostosin glycosyltransferase 1 -0.080882
LIMCH1 LIM and calponin homology domains 1 -0.0748144
ZBTB20 zinc finger and BTB domain containing 20 -0.0746429
SYT1 synaptotagmin I -0.0740397
BPTF bromodomain PHD finger transcription factor -0.0721655
THSD4 thrombospondin, type I, domain containing 4 -0.0711403
FMN1 formin 1 -0.0703484
PLAT plasminogen activator, tissue -0.0694984
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0653905
ANTXR1 anthrax toxin receptor 1 -0.0648946
RNF213 ring finger protein 213 -0.0636119
MBD5 methyl-CpG binding domain protein 5 -0.0541221
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0540587
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0535494
PDE4D phosphodiesterase 4D, cAMP-specific -0.0526101
NREP neuronal regeneration related protein -0.0525072
KLHL13 kelch-like family member 13 -0.0505532
BCAS3 breast carcinoma amplified sequence 3 -0.0501909
RPL23 ribosomal protein L23 -0.0501688
CEMIP cell migration inducing protein, hyaluronan binding -0.0496231
COL4A5 collagen, type IV, alpha 5 -0.0493895
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0481986
TRIO trio Rho guanine nucleotide exchange factor -0.0479981
DNAH14 dynein, axonemal, heavy chain 14 -0.0471176
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0467946
SOS1 son of sevenless homolog 1 (Drosophila) -0.0445294
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0433156
MAPK10 mitogen-activated protein kinase 10 -0.0431205
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0429828
VCL vinculin -0.0406852
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0400631
VMP1 vacuole membrane protein 1 -0.0393691
ACTG1 actin gamma 1 -0.0392263
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0391483
TAS2R14 taste receptor, type 2, member 14 -0.0382938
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0375258
PRKCA protein kinase C, alpha -0.0374306
NCAM2 neural cell adhesion molecule 2 -0.0369653
COL3A1 collagen, type III, alpha 1 -0.036448
SLIT2 slit homolog 2 (Drosophila) -0.0360394
GREM2 gremlin 2, DAN family BMP antagonist -0.035518
DPH6 diphthamine biosynthesis 6 -0.0347524
PCDH9 protocadherin 9 -0.0347256
ZNF804A zinc finger protein 804A -0.0345807
DGKH diacylglycerol kinase, eta -0.034494
DLC1 DLC1 Rho GTPase activating protein -0.0338959
FOXP1 forkhead box P1 -0.0337544
UNC5C unc-5 homolog C (C. elegans) -0.0336366
PTPRE protein tyrosine phosphatase, receptor type, E -0.0335998
NPAS2 neuronal PAS domain protein 2 -0.0332003
COL4A2 collagen, type IV, alpha 2 -0.0331285
AUTS2 autism susceptibility candidate 2 -0.033041
PTPRK protein tyrosine phosphatase, receptor type, K -0.0328999
EPAS1 endothelial PAS domain protein 1 -0.0327338
PRKCE protein kinase C, epsilon -0.0327117
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0321851
AEBP2 AE binding protein 2 -0.031975
RIGI RNA sensor RIG-I -0.031385
MCL1 myeloid cell leukemia 1 -0.0313024
EGR1 early growth response 1 -0.0305212
AKAP9 A kinase (PRKA) anchor protein 9 -0.0303676
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0302179
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0296948
MBTD1 mbt domain containing 1 -0.0296481
PCNX4 pecanex 4 -0.0294307
SIK2 salt-inducible kinase 2 -0.0292106
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.0291332
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0288597
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.02865
TPM1 tropomyosin 1 (alpha) -0.0283435
RPTOR regulatory associated protein of MTOR, complex 1 -0.0282834
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0281243
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0281042
CADM2 cell adhesion molecule 2 -0.027769
PTPRM protein tyrosine phosphatase, receptor type, M -0.0277426
FAM120B family with sequence similarity 120B -0.0273818
NPAS3 neuronal PAS domain protein 3 -0.0273099
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0272505
RAD51B RAD51 paralog B -0.027133
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0270297
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0270159
SMYD3 SET and MYND domain containing 3 -0.0269031
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0264418
NF1 neurofibromin 1 -0.0262694
TBC1D19 TBC1 domain family, member 19 -0.0260601
TPST1 tyrosylprotein sulfotransferase 1 -0.0258909
MYO9A myosin IXA -0.0257566
ITGA1 integrin, alpha 1 -0.0254089
N4BP1 NEDD4 binding protein 1 -0.0253832
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0251657
TLE4 transducin-like enhancer of split 4 -0.0248141
AFF3 AF4/FMR2 family, member 3 -0.0245787
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0242912