Verapamil_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0760238
BTBD9 BTB (POZ) domain containing 9 0.069254
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0611986
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0608882
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0564466
MCTP2 multiple C2 domains, transmembrane 2 0.0564033
PRKCA protein kinase C, alpha 0.0515662
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0510277
AHI1 Abelson helper integration site 1 0.0507328
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0477127
ATXN1 ataxin 1 0.0473172
RAB1A RAB1A, member RAS oncogene family 0.0446505
RUNX1 runt-related transcription factor 1 0.0442227
METTL15 methyltransferase like 15 0.0432573
ARHGAP5 Rho GTPase activating protein 5 0.0429801
ERRFI1 ERBB receptor feedback inhibitor 1 0.0427943
GMDS GDP-mannose 4,6-dehydratase 0.0416257
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0404191
SEC24D SEC24 family member D 0.0392477
TRIM2 tripartite motif containing 2 0.0391643
SREBF2 sterol regulatory element binding transcription factor 2 0.0389155
GSK3B glycogen synthase kinase 3 beta 0.0381778
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0367862
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.035884
RNF149 ring finger protein 149 0.0358547
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0354038
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0346779
KMT2C lysine (K)-specific methyltransferase 2C 0.0346221
ESYT2 extended synaptotagmin-like protein 2 0.0340857
FNIP1 folliculin interacting protein 1 0.0340114
NDRG1 N-myc downstream regulated 1 0.0334183
H1-0 H1.0 linker histone 0.0333414
TMEM263 transmembrane protein 263 0.0330411
GCLC glutamate-cysteine ligase, catalytic subunit 0.0319134
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.031839
KIF16B kinesin family member 16B 0.0312315
STK24 serine/threonine kinase 24 0.0305341
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0302936
ANKRD11 ankyrin repeat domain 11 0.0298911
NPTN neuroplastin 0.0296445
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0296247
SKIC3 SKI3 subunit of superkiller complex 0.0294548
GPBP1 GC-rich promoter binding protein 1 0.0291953
FANCI Fanconi anemia, complementation group I 0.0290664
TM9SF3 transmembrane 9 superfamily member 3 0.0289932
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0289275
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0289224
DLG1 discs, large homolog 1 (Drosophila) 0.0285296
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0283952
ANKIB1 ankyrin repeat and IBR domain containing 1 0.02804
ARHGAP32 Rho GTPase activating protein 32 0.0278376
TASP1 taspase, threonine aspartase, 1 0.0278215
HELZ helicase with zinc finger 0.0276582
PRELID2 PRELI domain containing 2 0.0273191
ACSL3 acyl-CoA synthetase long-chain family member 3 0.027199
PATJ PATJ crumbs cell polarity complex component 0.0271394
ZNRF3 zinc and ring finger 3 0.0269728
KDM6A lysine (K)-specific demethylase 6A 0.0267725
ARRDC3 arrestin domain containing 3 0.0266966
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0259248
RBM26 RNA binding motif protein 26 0.0257554
SOS1 son of sevenless homolog 1 (Drosophila) 0.0255269
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0253526
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0252496
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0244888
CDK19 cyclin-dependent kinase 19 0.0243383
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0242815
CDK6 cyclin-dependent kinase 6 0.024049
RNF145 ring finger protein 145 0.0240185
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0238582
FDPS farnesyl diphosphate synthase 0.0238337
TENT5A terminal nucleotidyltransferase 5A 0.0237914
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0236682
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0236296
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0236171
PFKP phosphofructokinase, platelet 0.0235235
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0234286
SRP54 signal recognition particle 54kDa 0.0233956
NRIP1 nuclear receptor interacting protein 1 0.0233789
CDC42SE2 CDC42 small effector 2 0.0233521
NIPSNAP2 nipsnap homolog 2 0.0233494
JMJD1C jumonji domain containing 1C 0.0233347
KAZN kazrin, periplakin interacting protein 0.0232881
MED13L mediator complex subunit 13-like 0.0232133
NCKAP1 NCK-associated protein 1 0.0231554
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0231533
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 0.0230837
ZNF644 zinc finger protein 644 0.0230291
OGA O-GlcNAcase 0.0228548
SBF2 SET binding factor 2 0.02266
TUBGCP3 tubulin, gamma complex associated protein 3 0.0225827
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0224281
A1CF APOBEC1 complementation factor 0.022306
PICALM phosphatidylinositol binding clathrin assembly protein 0.0222524
BABAM2 BRISC and BRCA1 A complex member 2 0.0222474
MSMO1 methylsterol monooxygenase 1 0.0221526
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0219401
RAB20 RAB20, member RAS oncogene family 0.0219263
NFXL1 nuclear transcription factor, X-box binding-like 1 0.021848
PNISR PNN-interacting serine/arginine-rich protein 0.0218442

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.115993
PERP PERP, TP53 apoptosis effector -0.109415
LCN2 lipocalin 2 -0.106597
INTS6 integrator complex subunit 6 -0.100403
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0994056
EGR1 early growth response 1 -0.0939971
TPT1 tumor protein, translationally-controlled 1 -0.0918088
EPSTI1 epithelial stromal interaction 1 (breast) -0.0914351
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0817514
HLA-B major histocompatibility complex, class I, B -0.076702
MAP7 microtubule-associated protein 7 -0.0764219
NCKAP5 NCK-associated protein 5 -0.0735307
EZR ezrin -0.0721916
TRIO trio Rho guanine nucleotide exchange factor -0.0705238
RNF213 ring finger protein 213 -0.0705008
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.065445
SQSTM1 sequestosome 1 -0.0627679
ANXA2 annexin A2 -0.0623404
EXT1 exostosin glycosyltransferase 1 -0.0617814
IRF1 interferon regulatory factor 1 -0.0614652
TSC22D1 TSC22 domain family, member 1 -0.0609169
PKM pyruvate kinase, muscle -0.0574861
UBC ubiquitin C -0.0543544
LOC112694756 uncharaterized LOC112694756 -0.0528178
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0521048
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0513723
HLA-C major histocompatibility complex, class I, C -0.0505995
XAF1 XIAP associated factor 1 -0.0498175
IRS2 insulin receptor substrate 2 -0.0496154
ACTN4 actinin, alpha 4 -0.0491403
C6ORF132 chromosome 6 open reading frame 132 -0.0489179
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0480368
SP100 SP100 nuclear antigen -0.047818
LYZ lysozyme -0.0474505
RAB7A RAB7A, member RAS oncogene family -0.0474074
RIGI RNA sensor RIG-I -0.0463024
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0459881
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0441551
FTH1 ferritin, heavy polypeptide 1 -0.043531
VCL vinculin -0.043459
TXNIP thioredoxin interacting protein -0.0432764
RPLP1 ribosomal protein, large, P1 -0.0422161
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0413508
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0411658
SETX senataxin -0.0402709
KRT19 keratin 19, type I -0.0401697
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0401405
CTSB cathepsin B -0.0398633
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0398408
ACTG1 actin gamma 1 -0.0395377
PLSCR1 phospholipid scramblase 1 -0.0394818
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0394301
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0393358
MAML2 mastermind-like 2 (Drosophila) -0.0386111
HLA-E major histocompatibility complex, class I, E -0.0381973
TMC5 transmembrane channel-like 5 -0.0380778
TSHZ2 teashirt zinc finger homeobox 2 -0.0380031
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0378441
BLZF1 basic leucine zipper nuclear factor 1 -0.0367741
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0349613
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0345931
RPL35A ribosomal protein L35a -0.0342738
RPLP0 ribosomal protein, large, P0 -0.03398
VDAC1 voltage-dependent anion channel 1 -0.0338437
MX1 MX dynamin-like GTPase 1 -0.033677
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0336226
HM13 histocompatibility (minor) 13 -0.0335542
SDCBP syndecan binding protein (syntenin) -0.0325322
S100A6 S100 calcium binding protein A6 -0.0324811
ITGA6 integrin, alpha 6 -0.0318253
ZNF609 zinc finger protein 609 -0.0313859
MCL1 myeloid cell leukemia 1 -0.0309919
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0308377
POU2F2 POU class 2 homeobox 2 -0.0305904
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0305375
EPCAM epithelial cell adhesion molecule -0.0303815
MYO1E myosin IE -0.0299719
SOD2 superoxide dismutase 2, mitochondrial -0.0299708
HBP1 HMG-box transcription factor 1 -0.0299558
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0298903
EEF2 eukaryotic translation elongation factor 2 -0.029598
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0295873
SDC4 syndecan 4 -0.0295817
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0292847
PLSCR2 phospholipid scramblase 2 -0.0289552
PHF3 PHD finger protein 3 -0.0288964
RBM47 RNA binding motif protein 47 -0.0287535
STS steroid sulfatase (microsomal), isozyme S -0.0285191
SLC38A2 solute carrier family 38, member 2 -0.0284986
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.028356
FAT1 FAT atypical cadherin 1 -0.02829
KRT8 keratin 8, type II -0.0281668
MX2 MX dynamin-like GTPase 2 -0.0280392
AKAP13 A kinase (PRKA) anchor protein 13 -0.0277782
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0277167
NT5C2 5'-nucleotidase, cytosolic II -0.027516
KLF5 Kruppel-like factor 5 (intestinal) -0.027475
RPL23 ribosomal protein L23 -0.0271283
TMSB4X thymosin beta 4, X-linked -0.0270285
RPL7L1 ribosomal protein L7-like 1 -0.0268875