Verapamil_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.146737
PTMA prothymosin, alpha 0.0963191
FAM13A family with sequence similarity 13, member A 0.0848407
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0824869
ARHGAP32 Rho GTPase activating protein 32 0.072984
RPS3 ribosomal protein S3 0.0703696
H1-0 H1.0 linker histone 0.0700738
GARS1 glycyl-tRNA synthetase 1 0.0690397
ERRFI1 ERBB receptor feedback inhibitor 1 0.0558308
GOLGA4 golgin A4 0.0514359
ESRP1 epithelial splicing regulatory protein 1 0.0507468
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0501893
FNIP1 folliculin interacting protein 1 0.0476275
KMT2C lysine (K)-specific methyltransferase 2C 0.0460662
SETD5 SET domain containing 5 0.0444712
KMT2E lysine (K)-specific methyltransferase 2E 0.0440404
BCLAF1 BCL2-associated transcription factor 1 0.0439598
ZCCHC7 zinc finger, CCHC domain containing 7 0.0433579
ENO1 enolase 1, (alpha) 0.0416777
HKDC1 hexokinase domain containing 1 0.0409969
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0406669
DDIT4 DNA-damage-inducible transcript 4 0.0400474
CDK19 cyclin-dependent kinase 19 0.039193
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0389105
ANLN anillin, actin binding protein 0.0385518
ATXN1 ataxin 1 0.0376893
KDM3A lysine (K)-specific demethylase 3A 0.0374626
TES testin LIM domain protein 0.0372984
TCEA1 transcription elongation factor A (SII), 1 0.0368642
KDM6A lysine (K)-specific demethylase 6A 0.0366387
AREG amphiregulin 0.0366274
PAPOLA poly(A) polymerase alpha 0.0355592
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0355388
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0350577
EIF2A eukaryotic translation initiation factor 2A, 65kDa 0.034971
RPL37A ribosomal protein L37a 0.0342832
ZFAND3 zinc finger, AN1-type domain 3 0.0339378
FNDC3B fibronectin type III domain containing 3B 0.0338632
SRP54 signal recognition particle 54kDa 0.0338027
MXI1 MAX interactor 1, dimerization protein 0.033768
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.033612
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0331346
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0330956
FTL ferritin, light polypeptide 0.0329473
MBNL2 muscleblind-like splicing regulator 2 0.0321339
SEC31A SEC31 homolog A (S. cerevisiae) 0.0316347
PDIA6 protein disulfide isomerase family A, member 6 0.031408
NCKAP1 NCK-associated protein 1 0.0300868
CTTN cortactin 0.029967
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0298053
ANKRD10 ankyrin repeat domain 10 0.0297994
ESYT2 extended synaptotagmin-like protein 2 0.0294015
PCBP2 poly(rC) binding protein 2 0.028769
ZMYM2 zinc finger, MYM-type 2 0.028574
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0283607
OGA O-GlcNAcase 0.0280121
BRD2 bromodomain containing 2 0.027912
DSPP dentin sialophosphoprotein 0.0278452
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0276852
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.0276834
PUM2 pumilio RNA-binding family member 2 0.0276529
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0275509
TM9SF3 transmembrane 9 superfamily member 3 0.0273953
UBA6 ubiquitin-like modifier activating enzyme 6 0.0273946
TRIM2 tripartite motif containing 2 0.0271272
ZNF706 zinc finger protein 706 0.0269527
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0269017
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0262482
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0256827
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0255827
WSB1 WD repeat and SOCS box containing 1 0.0255515
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0254031
RPS2 ribosomal protein S2 0.0253594
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0253266
RPS12 ribosomal protein S12 0.0252217
DSCAM Down syndrome cell adhesion molecule 0.0249401
ZNF292 zinc finger protein 292 0.0247904
ANXA1 annexin A1 0.0247854
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0246647
PICALM phosphatidylinositol binding clathrin assembly protein 0.0244731
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0244062
KLHL29 kelch-like family member 29 0.0240358
HYOU1 hypoxia up-regulated 1 0.0238932
EPB41 erythrocyte membrane protein band 4.1 0.0237265
RPS17 ribosomal protein S17 0.0236607
TM9SF2 transmembrane 9 superfamily member 2 0.0235909
NPSR1 neuropeptide S receptor 1 0.0235002
MAML2 mastermind-like 2 (Drosophila) 0.0234992
SRSF11 serine/arginine-rich splicing factor 11 0.0234937
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0233109
COG5 component of oligomeric golgi complex 5 0.0232696
PPARG peroxisome proliferator-activated receptor gamma 0.0232589
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0231606
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0228909
ELP2 elongator acetyltransferase complex subunit 2 0.022886
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.022859
SKIC3 SKI3 subunit of superkiller complex 0.0224473
PREPL prolyl endopeptidase-like 0.0224365
CREBRF CREB3 regulatory factor 0.0221592
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0217985

decreased expression

Symbol Name Standardized Value
LOC112694756 uncharaterized LOC112694756 -0.132665
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.125404
CEMIP cell migration inducing protein, hyaluronan binding -0.108118
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105143
LMO7 LIM domain 7 -0.098109
GMDS GDP-mannose 4,6-dehydratase -0.0942599
RPL35A ribosomal protein L35a -0.0918232
KRT8 keratin 8, type II -0.0878545
TPT1 tumor protein, translationally-controlled 1 -0.0784705
TMSB10 thymosin beta 10 -0.0772392
TMC5 transmembrane channel-like 5 -0.0680764
FAT1 FAT atypical cadherin 1 -0.0668175
RNF213 ring finger protein 213 -0.066044
RRBP1 ribosome binding protein 1 -0.0615751
AGR2 anterior gradient 2 -0.0612533
TXNRD1 thioredoxin reductase 1 -0.05961
RPL23 ribosomal protein L23 -0.0585504
PLSCR1 phospholipid scramblase 1 -0.057336
RPS21 ribosomal protein S21 -0.0537518
GPX2 glutathione peroxidase 2 -0.0521815
KRT18 keratin 18, type I -0.0520228
CALR calreticulin -0.0513824
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0505208
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0498775
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0484786
RPLP1 ribosomal protein, large, P1 -0.0469843
LOC102724023 ES1 protein homolog, mitochondrial -0.0462066
ACTN4 actinin, alpha 4 -0.0459152
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0452489
S100A6 S100 calcium binding protein A6 -0.0451492
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0447929
CDK6 cyclin-dependent kinase 6 -0.0438588
TM4SF1 transmembrane 4 L six family member 1 -0.0437433
PRSS3 protease, serine, 3 -0.0437322
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.043079
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.042118
TMEM45B transmembrane protein 45B -0.0408106
RPL38 ribosomal protein L38 -0.0401099
RPS24 ribosomal protein S24 -0.0398329
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0396269
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0394976
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0392004
ADAM9 ADAM metallopeptidase domain 9 -0.0388343
RPS16 ribosomal protein S16 -0.0379859
SP100 SP100 nuclear antigen -0.0374255
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0374173
RPL39 ribosomal protein L39 -0.0373832
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0368312
HLA-C major histocompatibility complex, class I, C -0.0364677
IFI27 interferon, alpha-inducible protein 27 -0.0363178
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.03555
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.035009
MSI2 musashi RNA-binding protein 2 -0.0343248
PLEC plectin -0.0342758
S100A9 S100 calcium binding protein A9 -0.0340852
KRT19 keratin 19, type I -0.0337473
COBL cordon-bleu WH2 repeat protein -0.0335574
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0332891
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0332172
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0332007
TMEM123 transmembrane protein 123 -0.0330771
ATF5 activating transcription factor 5 -0.0329502
WWC1 WW and C2 domain containing 1 -0.0328111
YBX1 Y box binding protein 1 -0.032264
RPS20 ribosomal protein S20 -0.0322589
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0318735
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0313534
MX1 MX dynamin-like GTPase 1 -0.0312993
TAPBP TAP binding protein (tapasin) -0.031248
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0312206
CBX3 chromobox homolog 3 -0.0308809
ZBTB44 zinc finger and BTB domain containing 44 -0.030423
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0301499
ASPH aspartate beta-hydroxylase -0.0299397
BPTF bromodomain PHD finger transcription factor -0.029909
TMSB4X thymosin beta 4, X-linked -0.0295768
EPCAM epithelial cell adhesion molecule -0.0295658
PKM pyruvate kinase, muscle -0.0294277
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0292195
RNF43 ring finger protein 43 -0.0291457
MYO1E myosin IE -0.0289658
MUC1 mucin 1, cell surface associated -0.0288058
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0286004
SMAD3 SMAD family member 3 -0.0285075
EXT1 exostosin glycosyltransferase 1 -0.0284155
NCOA7 nuclear receptor coactivator 7 -0.0283556
RASEF RAS and EF-hand domain containing -0.0278717
S100A10 S100 calcium binding protein A10 -0.0278662
INSIG1 insulin induced gene 1 -0.0278401
RPLP0 ribosomal protein, large, P0 -0.0276771
FASN fatty acid synthase -0.0274932
POTEF POTE ankyrin domain family, member F -0.0274884
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0272834
EGR1 early growth response 1 -0.0272664
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0271216
SHB Src homology 2 domain containing adaptor protein B -0.0270022
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0269368
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0268772
UBASH3B ubiquitin associated and SH3 domain containing B -0.0268406
EXOC4 exocyst complex component 4 -0.0266771