Verapamil_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.322031
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.254259
RPS3 ribosomal protein S3 0.129069
RPS12 ribosomal protein S12 0.123529
TMSB10 thymosin beta 10 0.111769
RPL12 ribosomal protein L12 0.108686
RPL37A ribosomal protein L37a 0.0912906
RPS19 ribosomal protein S19 0.0895857
RPS6 ribosomal protein S6 0.0891987
S100P S100 calcium binding protein P 0.0868832
RPL26 ribosomal protein L26 0.0861762
RPS2 ribosomal protein S2 0.0737307
RPL18 ribosomal protein L18 0.0736754
RPL36 ribosomal protein L36 0.0733585
PIGR polymeric immunoglobulin receptor 0.070997
RPS8 ribosomal protein S8 0.0697016
RPL23 ribosomal protein L23 0.0696939
EREG epiregulin 0.0696775
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0679092
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0671117
ENO1 enolase 1, (alpha) 0.0653697
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0651787
RPLP2 ribosomal protein, large, P2 0.0627998
RPL11 ribosomal protein L11 0.0624469
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0614993
RPS29 ribosomal protein S29 0.0600808
RPL32 ribosomal protein L32 0.0590959
RNF43 ring finger protein 43 0.0589799
DDIT4 DNA-damage-inducible transcript 4 0.0585101
H1-0 H1.0 linker histone 0.0583386
AREG amphiregulin 0.0582641
RPLP1 ribosomal protein, large, P1 0.0582424
RPL5 ribosomal protein L5 0.0548375
RPL34 ribosomal protein L34 0.0545181
RPS17 ribosomal protein S17 0.0538942
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0536665
RPL19 ribosomal protein L19 0.0533423
RACK1 receptor for activated C kinase 1 0.0525726
TNS4 tensin 4 0.0508536
EIF1 eukaryotic translation initiation factor 1 0.04998
ANXA2 annexin A2 0.0487195
RPL9 ribosomal protein L9 0.0471742
VCL vinculin 0.0471593
RPL13A ribosomal protein L13a 0.0460373
PGK1 phosphoglycerate kinase 1 0.0460342
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0459681
RPS23 ribosomal protein S23 0.0434706
RPL4 ribosomal protein L4 0.0416487
CEMIP cell migration inducing protein, hyaluronan binding 0.0413542
RPS27 ribosomal protein S27 0.0411645
PRELID2 PRELI domain containing 2 0.0406672
PUM2 pumilio RNA-binding family member 2 0.039215
FAM13A family with sequence similarity 13, member A 0.0387787
RPS27A ribosomal protein S27a 0.038232
RPL31 ribosomal protein L31 0.0382317
RPL10A ribosomal protein L10a 0.0365833
ARHGAP32 Rho GTPase activating protein 32 0.036344
FTH1 ferritin, heavy polypeptide 1 0.0362777
RPL37 ribosomal protein L37 0.0361778
RPL7 ribosomal protein L7 0.0358884
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0352538
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0352409
FTL ferritin, light polypeptide 0.0351902
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0347229
RPS25 ribosomal protein S25 0.0346984
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0339982
RPS14 ribosomal protein S14 0.033742
TXNIP thioredoxin interacting protein 0.0333356
RPL27 ribosomal protein L27 0.0331301
RPL3 ribosomal protein L3 0.0330098
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0319796
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.0311525
ISG15 ISG15 ubiquitin-like modifier 0.0308117
RPL7A ribosomal protein L7a 0.0303996
RPL6 ribosomal protein L6 0.03016
PLAUR plasminogen activator, urokinase receptor 0.0300219
NAP1L1 nucleosome assembly protein 1-like 1 0.0298806
MBD5 methyl-CpG binding domain protein 5 0.0298262
RPL35 ribosomal protein L35 0.0295866
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0295731
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0289907
GSTP1 glutathione S-transferase pi 1 0.0288991
EPCAM epithelial cell adhesion molecule 0.0287996
PNISR PNN-interacting serine/arginine-rich protein 0.0286461
B2M beta-2-microglobulin 0.0281575
CADPS Ca++-dependent secretion activator 0.0281476
ATF4 activating transcription factor 4 0.0271539
ACTN4 actinin, alpha 4 0.0269803
RPL8 ribosomal protein L8 0.0268031
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0265779
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0265539
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0264908
PCBP2 poly(rC) binding protein 2 0.026355
MED13L mediator complex subunit 13-like 0.026261
ONECUT3 one cut homeobox 3 0.0260338
INSIG1 insulin induced gene 1 0.0257787
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0257766
RPS11 ribosomal protein S11 0.0256667
COX6C cytochrome c oxidase subunit VIc 0.0256582
SOX9 SRY (sex determining region Y)-box 9 0.025605

decreased expression

Symbol Name Standardized Value
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.119263
LMO7 LIM domain 7 -0.0777587
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0759896
ITGA6 integrin, alpha 6 -0.0708364
MYO1E myosin IE -0.0653252
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0647544
VEGFA vascular endothelial growth factor A -0.0617056
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0576641
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0556139
EZR ezrin -0.0502936
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0451132
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0438765
TTC3 tetratricopeptide repeat domain 3 -0.0424947
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0423362
MED13 mediator complex subunit 13 -0.0420013
SOX4 SRY (sex determining region Y)-box 4 -0.0405412
PTPRK protein tyrosine phosphatase, receptor type, K -0.0398106
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.038428
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0381698
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.037865
TFF1 trefoil factor 1 -0.0368875
GREB1L growth regulation by estrogen in breast cancer-like -0.0367875
TPM4 tropomyosin 4 -0.0358885
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0354312
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0351434
SVIL supervillin -0.0346834
FAT1 FAT atypical cadherin 1 -0.0337004
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0333956
MUC17 mucin 17, cell surface associated -0.0330085
ESYT2 extended synaptotagmin-like protein 2 -0.0323436
GRB10 growth factor receptor-bound protein 10 -0.0320655
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.031971
JMJD1C jumonji domain containing 1C -0.0316732
MARCHF3 membrane associated ring-CH-type finger 3 -0.03144
PSD3 pleckstrin and Sec7 domain containing 3 -0.0308087
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0305978
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0305485
BTBD9 BTB (POZ) domain containing 9 -0.030473
EXT1 exostosin glycosyltransferase 1 -0.0302812
ALCAM activated leukocyte cell adhesion molecule -0.0302445
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.029628
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0295759
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0290268
AKAP9 A kinase (PRKA) anchor protein 9 -0.0287129
LOC112694756 uncharaterized LOC112694756 -0.0283405
GMDS GDP-mannose 4,6-dehydratase -0.0283251
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0280673
NPSR1 neuropeptide S receptor 1 -0.0279515
GCC2 GRIP and coiled-coil domain containing 2 -0.027499
PDE4D phosphodiesterase 4D, cAMP-specific -0.0274319
NEBL nebulette -0.0272851
UBC ubiquitin C -0.027257
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0271811
CRACD capping protein inhibiting regulator of actin dynamics -0.0271253
FBXO11 F-box protein 11 -0.0266175
SNX9 sorting nexin 9 -0.0263781
AGR2 anterior gradient 2 -0.0258932
PER2 period circadian clock 2 -0.0254456
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0252547
SAMD5 sterile alpha motif domain containing 5 -0.0250475
KDM7A lysine (K)-specific demethylase 7A -0.0250069
CALB1 calbindin 1, 28kDa -0.0248191
TJP1 tight junction protein 1 -0.024752
EGFR epidermal growth factor receptor -0.0245834
TPT1 tumor protein, translationally-controlled 1 -0.0241663
SRRM2 serine/arginine repetitive matrix 2 -0.0239093
AFF1 AF4/FMR2 family, member 1 -0.0237839
SH3D19 SH3 domain containing 19 -0.0237758
LAMA4 laminin, alpha 4 -0.0235683
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0231419
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0230817
F3 coagulation factor III (thromboplastin, tissue factor) -0.0229144
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0226024
GOLGB1 golgin B1 -0.0224426
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0222079
RNF217 ring finger protein 217 -0.0221924
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0219914
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0219678
LMNA lamin A/C -0.0219472
UNC13B unc-13 homolog B (C. elegans) -0.0219183
PPARG peroxisome proliferator-activated receptor gamma -0.0218208
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0217672
HM13 histocompatibility (minor) 13 -0.0212123
BTG1 B-cell translocation gene 1, anti-proliferative -0.0211406
DIAPH1 diaphanous-related formin 1 -0.0211398
POTEF POTE ankyrin domain family, member F -0.0211074
KTN1 kinectin 1 (kinesin receptor) -0.0210682
RIGI RNA sensor RIG-I -0.021033
BACE2 beta-site APP-cleaving enzyme 2 -0.0209505
DIAPH2 diaphanous-related formin 2 -0.0207823
MLF1 myeloid leukemia factor 1 -0.0207817
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0207646
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0207525
VCAN versican -0.0207256
SLC35F3 solute carrier family 35, member F3 -0.0206362
RREB1 ras responsive element binding protein 1 -0.0205196
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0203675
CRY1 cryptochrome circadian clock 1 -0.0202471
HILPDA hypoxia inducible lipid droplet-associated -0.0200685
FNDC3B fibronectin type III domain containing 3B -0.0199903