Verapamil_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.149098
PDE4D phosphodiesterase 4D, cAMP-specific 0.143274
FAM13A family with sequence similarity 13, member A 0.102528
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0806105
SDK1 sidekick cell adhesion molecule 1 0.0740889
DLG1 discs, large homolog 1 (Drosophila) 0.0654915
RAD51B RAD51 paralog B 0.063849
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0626725
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0623523
GPC6 glypican 6 0.0590878
PRELID2 PRELI domain containing 2 0.0528686
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0524062
NAV2 neuron navigator 2 0.0517847
KMT2C lysine (K)-specific methyltransferase 2C 0.0508854
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0492077
PTPRR protein tyrosine phosphatase, receptor type, R 0.0453748
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0429616
ESYT2 extended synaptotagmin-like protein 2 0.0422831
ELL2 elongation factor, RNA polymerase II, 2 0.0410372
GRB10 growth factor receptor-bound protein 10 0.0372977
RARB retinoic acid receptor, beta 0.0371293
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.036437
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.036159
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0361448
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0346556
NPC1 Niemann-Pick disease, type C1 0.0344837
PLAUR plasminogen activator, urokinase receptor 0.0340265
RUNX2 runt-related transcription factor 2 0.0337735
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0335169
ZEB2 zinc finger E-box binding homeobox 2 0.0326905
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0321041
NGLY1 N-glycanase 1 0.0318963
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0317648
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0306234
ZMYND8 zinc finger, MYND-type containing 8 0.0305377
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0301037
PELI1 pellino E3 ubiquitin protein ligase 1 0.0294993
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0294957
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.028303
KDM3A lysine (K)-specific demethylase 3A 0.0282291
MEF2A myocyte enhancer factor 2A 0.0279983
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0278592
IL6ST interleukin 6 signal transducer 0.0278267
SETD5 SET domain containing 5 0.0271077
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0268252
TSPAN5 tetraspanin 5 0.0262472
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0261229
KCTD16 potassium channel tetramerization domain containing 16 0.0259962
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0258693
LRRC8C leucine rich repeat containing 8 family, member C 0.0256091
CDK17 cyclin-dependent kinase 17 0.0255354
AGFG1 ArfGAP with FG repeats 1 0.024958
PFKP phosphofructokinase, platelet 0.0248973
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0247332
FNDC3B fibronectin type III domain containing 3B 0.0246801
ANKRD36 ankyrin repeat domain 36 0.0246516
KLF6 Kruppel-like factor 6 0.0245671
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0237269
RTN4 reticulon 4 0.0234653
JARID2 jumonji, AT rich interactive domain 2 0.0233524
RAB8B RAB8B, member RAS oncogene family 0.023201
LIMCH1 LIM and calponin homology domains 1 0.023174
ARHGAP5 Rho GTPase activating protein 5 0.0230715
PPARG peroxisome proliferator-activated receptor gamma 0.0230506
FAM20C family with sequence similarity 20, member C 0.022922
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0228055
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0227429
DOCK5 dedicator of cytokinesis 5 0.0223294
FMNL2 formin-like 2 0.0221198
YEATS2 YEATS domain containing 2 0.0219364
BRWD3 bromodomain and WD repeat domain containing 3 0.0218878
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0218546
AHR aryl hydrocarbon receptor 0.0218378
MXI1 MAX interactor 1, dimerization protein 0.0217596
LRMDA leucine rich melanocyte differentiation associated 0.0216281
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0215847
MECOM MDS1 and EVI1 complex locus 0.0215368
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0214017
BCLAF1 BCL2-associated transcription factor 1 0.0213653
AKAP12 A kinase (PRKA) anchor protein 12 0.0213087
WDPCP WD repeat containing planar cell polarity effector 0.0212838
ARHGAP42 Rho GTPase activating protein 42 0.0212091
SPRED2 sprouty-related, EVH1 domain containing 2 0.0209042
ARHGAP32 Rho GTPase activating protein 32 0.0207988
WDR26 WD repeat domain 26 0.0207166
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0206433
POM121 POM121 transmembrane nucleoporin 0.0206259
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0203722
CD109 CD109 molecule 0.0203116
FBXL13 F-box and leucine-rich repeat protein 13 0.0202514
TPST1 tyrosylprotein sulfotransferase 1 0.0202183
ZFP36L1 ZFP36 ring finger protein-like 1 0.0201098
MAML2 mastermind-like 2 (Drosophila) 0.020088
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0200249
MAML3 mastermind-like 3 (Drosophila) 0.0200069
TMEM263 transmembrane protein 263 0.0199895
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0199657
RICTOR RPTOR independent companion of MTOR, complex 2 0.0199142
CHD1L chromodomain helicase DNA binding protein 1-like 0.0198643
TCF12 transcription factor 12 0.0198531

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.240522
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.239081
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.221359
LOX lysyl oxidase -0.106779
FN1 fibronectin 1 -0.085442
TMSB10 thymosin beta 10 -0.0844411
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0843161
UBC ubiquitin C -0.0766761
P4HB prolyl 4-hydroxylase, beta polypeptide -0.074802
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0687855
EEF2 eukaryotic translation elongation factor 2 -0.0642629
SOD2 superoxide dismutase 2, mitochondrial -0.0639753
LMAN1 lectin, mannose-binding, 1 -0.0630329
CANX calnexin -0.059751
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0595688
PKM pyruvate kinase, muscle -0.0592544
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0574662
RPLP1 ribosomal protein, large, P1 -0.0574659
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0564384
FTL ferritin, light polypeptide -0.0563712
LDHA lactate dehydrogenase A -0.054444
LOC112694756 uncharaterized LOC112694756 -0.0544246
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0539192
KDM2A lysine (K)-specific demethylase 2A -0.0526761
YBX1 Y box binding protein 1 -0.0523921
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0522496
CALR calreticulin -0.0516754
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0511384
POTEF POTE ankyrin domain family, member F -0.0475328
EGR1 early growth response 1 -0.0463816
NDRG1 N-myc downstream regulated 1 -0.04565
PDIA3 protein disulfide isomerase family A, member 3 -0.0452593
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0451076
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.043796
ANKRD28 ankyrin repeat domain 28 -0.0436627
VEGFA vascular endothelial growth factor A -0.0434717
HMGA1 high mobility group AT-hook 1 -0.0427063
IGFBP3 insulin-like growth factor binding protein 3 -0.0424487
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0408707
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0405822
RPL35A ribosomal protein L35a -0.0404583
FTH1 ferritin, heavy polypeptide 1 -0.0401084
RPL28 ribosomal protein L28 -0.0397165
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0391102
COPA coatomer protein complex, subunit alpha -0.037139
HDLBP high density lipoprotein binding protein -0.0353341
RPLP0 ribosomal protein, large, P0 -0.0346902
EIF1 eukaryotic translation initiation factor 1 -0.0344325
S100A10 S100 calcium binding protein A10 -0.0339627
OXSR1 oxidative stress responsive 1 -0.0335643
TMSB4X thymosin beta 4, X-linked -0.033348
BPTF bromodomain PHD finger transcription factor -0.0328232
AHNAK AHNAK nucleoprotein -0.0322578
WDR45B WD repeat domain 45B -0.0320185
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0317819
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0311586
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0308315
TGFB1 transforming growth factor, beta 1 -0.0308116
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.030542
RPS8 ribosomal protein S8 -0.0298711
S100A6 S100 calcium binding protein A6 -0.0290485
PDIA4 protein disulfide isomerase family A, member 4 -0.0288974
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0287943
RPS21 ribosomal protein S21 -0.0287783
GDI2 GDP dissociation inhibitor 2 -0.0286795
ZNF207 zinc finger protein 207 -0.0284316
MYADM myeloid-associated differentiation marker -0.0281505
PFN1 profilin 1 -0.0281333
VDAC1 voltage-dependent anion channel 1 -0.0280923
AKAP9 A kinase (PRKA) anchor protein 9 -0.0280707
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0279521
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0274774
RPL23 ribosomal protein L23 -0.0274315
RPL38 ribosomal protein L38 -0.0273364
EEF1G eukaryotic translation elongation factor 1 gamma -0.0271829
MRPS6 mitochondrial ribosomal protein S6 -0.0271169
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0269659
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0269258
SEC31A SEC31 homolog A (S. cerevisiae) -0.0269143
GLCCI1 glucocorticoid induced 1 -0.0267215
KYNU kynureninase -0.0266617
AADAC arylacetamide deacetylase -0.0265593
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0264767
TUT7 terminal uridylyl transferase 7 -0.0260321
NTN4 netrin 4 -0.0254645
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0254207
MAP1B microtubule-associated protein 1B -0.0251548
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0249559
PRRC2C proline-rich coiled-coil 2C -0.0248335
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0245753
IER3 immediate early response 3 -0.0245009
KTN1 kinectin 1 (kinesin receptor) -0.0244171
LOC102724023 ES1 protein homolog, mitochondrial -0.0243426
VRK2 vaccinia related kinase 2 -0.0243285
EXT1 exostosin glycosyltransferase 1 -0.0241091
RPL5 ribosomal protein L5 -0.0237955
CD44 CD44 molecule (Indian blood group) -0.0237808
SPDYA speedy/RINGO cell cycle regulator family member A -0.0237557
PSEN1 presenilin 1 -0.02371
OSMR oncostatin M receptor -0.0233146