Verapamil_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.086807
PM20D1 peptidase M20 domain containing 1 0.069971
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0698676
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.044641
PARD3 par-3 family cell polarity regulator 0.0440366
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0420063
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0413891
UBASH3B ubiquitin associated and SH3 domain containing B 0.041075
TRIO trio Rho guanine nucleotide exchange factor 0.0405049
WDR43 WD repeat domain 43 0.0382459
RBM25 RNA binding motif protein 25 0.0373757
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0369985
CCNL1 cyclin L1 0.0369726
ECT2 epithelial cell transforming 2 0.0367306
JMJD1C jumonji domain containing 1C 0.0351664
P4HB prolyl 4-hydroxylase, beta polypeptide 0.034894
PAWR PRKC, apoptosis, WT1, regulator 0.0343619
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0338998
AKAP13 A kinase (PRKA) anchor protein 13 0.0337058
PUM2 pumilio RNA-binding family member 2 0.032599
CHN1 chimerin 1 0.0325265
CDC73 cell division cycle 73 0.0323451
TPD52 tumor protein D52 0.032064
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0318332
BCLAF1 BCL2-associated transcription factor 1 0.0315519
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0312695
USP3 ubiquitin specific peptidase 3 0.0307506
MBNL1 muscleblind-like splicing regulator 1 0.0298219
FMNL2 formin-like 2 0.0291147
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0290071
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0289808
ZNF292 zinc finger protein 292 0.0289199
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0280018
APP amyloid beta (A4) precursor protein 0.0279677
EWSR1 EWS RNA-binding protein 1 0.0279363
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0278766
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0269607
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.026284
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0261989
YME1L1 YME1-like 1 ATPase 0.0261501
NEGR1 neuronal growth regulator 1 0.0261005
RBM39 RNA binding motif protein 39 0.0257282
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0254642
NUP153 nucleoporin 153kDa 0.0253357
NCKAP1 NCK-associated protein 1 0.0253321
COG5 component of oligomeric golgi complex 5 0.0252254
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0247935
INO80 INO80 complex subunit 0.0246858
BMPR1B bone morphogenetic protein receptor, type IB 0.0246674
TNPO1 transportin 1 0.0245303
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0244599
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0244158
NEK7 NIMA-related kinase 7 0.0242956
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0241907
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0240585
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0239986
ERRFI1 ERBB receptor feedback inhibitor 1 0.0235308
NCEH1 neutral cholesterol ester hydrolase 1 0.0231182
PCBP2 poly(rC) binding protein 2 0.0231084
RANBP9 RAN binding protein 9 0.0230307
SRSF11 serine/arginine-rich splicing factor 11 0.0230277
PRR16 proline rich 16 0.0229093
ANKRD28 ankyrin repeat domain 28 0.0228397
PLS3 plastin 3 0.0228115
RASAL2 RAS protein activator like 2 0.0226139
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0225664
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.022333
SRPK2 SRSF protein kinase 2 0.0223252
CFDP1 craniofacial development protein 1 0.0223162
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0219121
PDE4D phosphodiesterase 4D, cAMP-specific 0.0215612
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0215354
ADAM9 ADAM metallopeptidase domain 9 0.0214513
TPM3 tropomyosin 3 0.0213156
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0209977
SLC38A2 solute carrier family 38, member 2 0.0208882
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0207488
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0206635
ERBIN erbb2 interacting protein 0.0206404
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0205635
PDLIM5 PDZ and LIM domain 5 0.0205161
MAML3 mastermind-like 3 (Drosophila) 0.020222
KMT2C lysine (K)-specific methyltransferase 2C 0.0202049
EIF4B eukaryotic translation initiation factor 4B 0.0200034
ABI1 abl-interactor 1 0.0198036
SPOPL speckle-type POZ protein-like 0.0196309
MITF microphthalmia-associated transcription factor 0.01962
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0195684
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0194927
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0191909
CSDE1 cold shock domain containing E1, RNA-binding 0.019109
CHD9 chromodomain helicase DNA binding protein 9 0.019078
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0186767
NUP58 nucleoporin 58 0.0186346
ADGRG6 adhesion G protein-coupled receptor G6 0.0184958
CSNK1A1 casein kinase 1, alpha 1 0.0184712
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.0181653
RAI1 retinoic acid induced 1 0.0178506
RAD51B RAD51 paralog B 0.0176135
RNF145 ring finger protein 145 0.0172501

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195211
VIM vimentin -0.192044
MT2A metallothionein 2A -0.148544
FTL ferritin, light polypeptide -0.0880691
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0816151
IER3 immediate early response 3 -0.0776821
RPLP1 ribosomal protein, large, P1 -0.0719492
RPL23 ribosomal protein L23 -0.0699208
GRAMD1B GRAM domain containing 1B -0.0694408
S100A6 S100 calcium binding protein A6 -0.065734
RPL35A ribosomal protein L35a -0.0597366
ACTG1 actin gamma 1 -0.0591266
TPT1 tumor protein, translationally-controlled 1 -0.0589858
EIF1 eukaryotic translation initiation factor 1 -0.0577017
POTEF POTE ankyrin domain family, member F -0.0570046
RPS8 ribosomal protein S8 -0.0553836
TMSB10 thymosin beta 10 -0.0473178
HLA-B major histocompatibility complex, class I, B -0.0464821
RPL31 ribosomal protein L31 -0.0454453
RPS21 ribosomal protein S21 -0.0452054
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0443462
RPS27A ribosomal protein S27a -0.0437906
TM4SF1 transmembrane 4 L six family member 1 -0.0431945
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0380296
IGFBP3 insulin-like growth factor binding protein 3 -0.0360026
UBC ubiquitin C -0.0355895
STC1 stanniocalcin 1 -0.0355772
RPS6 ribosomal protein S6 -0.0347734
MCL1 myeloid cell leukemia 1 -0.0342642
RPS20 ribosomal protein S20 -0.0339235
RPS29 ribosomal protein S29 -0.0335751
PYGL phosphorylase, glycogen, liver -0.0335599
IGF2 insulin-like growth factor 2 -0.0335376
LDHA lactate dehydrogenase A -0.0334793
S100A9 S100 calcium binding protein A9 -0.0329361
CALR calreticulin -0.0325187
RPL38 ribosomal protein L38 -0.0324936
RPS13 ribosomal protein S13 -0.0321139
RPL37 ribosomal protein L37 -0.0316778
RPL19 ribosomal protein L19 -0.031255
AKAP12 A kinase (PRKA) anchor protein 12 -0.0301371
LOC112694756 uncharaterized LOC112694756 -0.0299184
S100A10 S100 calcium binding protein A10 -0.0295989
RPL28 ribosomal protein L28 -0.0295036
HLA-A major histocompatibility complex, class I, A -0.0292309
HLA-E major histocompatibility complex, class I, E -0.0291872
C15ORF48 chromosome 15 open reading frame 48 -0.028969
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0287996
RPS16 ribosomal protein S16 -0.0286482
RPS15 ribosomal protein S15 -0.0279948
RPLP2 ribosomal protein, large, P2 -0.0274187
RPL9 ribosomal protein L9 -0.0273384
SLC38A1 solute carrier family 38, member 1 -0.0261247
RPS24 ribosomal protein S24 -0.0256907
DOCK5 dedicator of cytokinesis 5 -0.0256006
EGFR epidermal growth factor receptor -0.0254048
RPL34 ribosomal protein L34 -0.025134
RPL7 ribosomal protein L7 -0.0251275
RPL11 ribosomal protein L11 -0.0251154
ASPH aspartate beta-hydroxylase -0.0249832
RPL37A ribosomal protein L37a -0.0247029
TPM1 tropomyosin 1 (alpha) -0.0245477
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0240132
RPS25 ribosomal protein S25 -0.0237267
IL6 interleukin 6 -0.0237066
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0234437
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0231433
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0228864
PKM pyruvate kinase, muscle -0.022783
RPS23 ribosomal protein S23 -0.0227631
RPL27A ribosomal protein L27a -0.0224588
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.022449
RPL26 ribosomal protein L26 -0.0223964
LMNA lamin A/C -0.0223429
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0219101
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0215398
RPL30 ribosomal protein L30 -0.0214654
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0214113
RPL39 ribosomal protein L39 -0.0213634
RPS11 ribosomal protein S11 -0.0212163
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0211436
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0211066
RPL8 ribosomal protein L8 -0.0209969
RPL36A ribosomal protein L36a -0.0208953
RCC1 regulator of chromosome condensation 1 -0.0200201
MT1X metallothionein 1X -0.0199453
RPLP0 ribosomal protein, large, P0 -0.0196964
ASTN2 astrotactin 2 -0.0196643
THBS1 thrombospondin 1 -0.0195128
RPS5 ribosomal protein S5 -0.019497
TBCA tubulin folding cofactor A -0.0194942
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0194581
LOC102724023 ES1 protein homolog, mitochondrial -0.0194206
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0190127
RPS17 ribosomal protein S17 -0.0187871
NAV3 neuron navigator 3 -0.0187524
GDI2 GDP dissociation inhibitor 2 -0.0186483
RPL12 ribosomal protein L12 -0.0184816
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0184613
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0182397