Verapamil_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.118364
PM20D1 peptidase M20 domain containing 1 0.11802
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.117852
ESYT2 extended synaptotagmin-like protein 2 0.0566061
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0518828
ELL2 elongation factor, RNA polymerase II, 2 0.0470543
IGFBP3 insulin-like growth factor binding protein 3 0.0455956
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0444446
ERRFI1 ERBB receptor feedback inhibitor 1 0.0416151
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0377455
PDE4D phosphodiesterase 4D, cAMP-specific 0.0337889
FAM13A family with sequence similarity 13, member A 0.032589
SDK1 sidekick cell adhesion molecule 1 0.0318383
FNDC3B fibronectin type III domain containing 3B 0.030649
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0302937
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0296092
AGFG1 ArfGAP with FG repeats 1 0.0290521
MSN moesin 0.0289778
BDNF brain-derived neurotrophic factor 0.027654
NEK7 NIMA-related kinase 7 0.0268226
KMT2C lysine (K)-specific methyltransferase 2C 0.0257583
NBEAL1 neurobeachin-like 1 0.0252027
NHSL1 NHS-like 1 0.0251006
NRCAM neuronal cell adhesion molecule 0.0246492
PLAUR plasminogen activator, urokinase receptor 0.0242823
PSD3 pleckstrin and Sec7 domain containing 3 0.023176
KYNU kynureninase 0.0228774
ZNF292 zinc finger protein 292 0.0225523
USP34 ubiquitin specific peptidase 34 0.0215649
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0214798
STC1 stanniocalcin 1 0.0213692
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.021081
CSNK1A1 casein kinase 1, alpha 1 0.0206851
SUCO SUN domain containing ossification factor 0.0204119
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.020199
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0200507
CTBP2 C-terminal binding protein 2 0.0200291
BRWD3 bromodomain and WD repeat domain containing 3 0.0199046
ITPRID2 ITPR interacting domain containing 2 0.019843
RTN4 reticulon 4 0.0197128
BIRC6 baculoviral IAP repeat containing 6 0.0196174
FAM219A family with sequence similarity 219, member A 0.0195454
FLNB filamin B, beta 0.0193531
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0192512
PTEN phosphatase and tensin homolog 0.0189922
ZMIZ1 zinc finger, MIZ-type containing 1 0.0189731
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0187818
NBAS neuroblastoma amplified sequence 0.0187695
CTIF CBP80/20-dependent translation initiation factor 0.0186395
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0185663
HELZ helicase with zinc finger 0.018453
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0181479
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0180869
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0180093
BASP1 brain abundant, membrane attached signal protein 1 0.0178228
MALT1 MALT1 paracaspase 0.0178086
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0174643
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0174488
IL1RAP interleukin 1 receptor accessory protein 0.0173576
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0173564
SEC24D SEC24 family member D 0.0172916
LIMCH1 LIM and calponin homology domains 1 0.0170487
ARRDC3 arrestin domain containing 3 0.0169974
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0169486
GPC6 glypican 6 0.016921
COL4A6 collagen, type IV, alpha 6 0.0168938
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0168098
CTSC cathepsin C 0.0167918
SPRED2 sprouty-related, EVH1 domain containing 2 0.016543
DIAPH3 diaphanous-related formin 3 0.0163164
FNIP1 folliculin interacting protein 1 0.0162662
SLF1 SMC5-SMC6 complex localization factor 1 0.0161494
NCAM1 neural cell adhesion molecule 1 0.0160623
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0158603
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0157348
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0155624
SPAG9 sperm associated antigen 9 0.0153607
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0153032
TMEM263 transmembrane protein 263 0.0152539
BCAR3 breast cancer anti-estrogen resistance 3 0.0152197
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0151359
MBD5 methyl-CpG binding domain protein 5 0.015008
WDR26 WD repeat domain 26 0.0149867
PDGFA platelet-derived growth factor alpha polypeptide 0.0148535
AVL9 AVL9 homolog (S. cerevisiase) 0.0147181
KIAA1958 KIAA1958 0.0147093
RCOR1 REST corepressor 1 0.0146989
KMT2E lysine (K)-specific methyltransferase 2E 0.0146316
CEP170 centrosomal protein 170kDa 0.0145485
ANKRD36 ankyrin repeat domain 36 0.0145338
SEC24A SEC24 family member A 0.0144858
SEC31A SEC31 homolog A (S. cerevisiae) 0.0144643
RGS2 regulator of G-protein signaling 2 0.014406
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0141266
CARD16 caspase recruitment domain family, member 16 0.0139293
H1-4 H1.4 linker histone, cluster member 0.0139093
RAB1A RAB1A, member RAS oncogene family 0.0138136
AKAP13 A kinase (PRKA) anchor protein 13 0.0137831
SNX14 sorting nexin 14 0.0136415
LRP12 low density lipoprotein receptor-related protein 12 0.013624

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.187033
VIM vimentin -0.186133
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.142888
TPT1 tumor protein, translationally-controlled 1 -0.132267
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.125424
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.1149
TMSB10 thymosin beta 10 -0.108356
FN1 fibronectin 1 -0.104425
RPLP1 ribosomal protein, large, P1 -0.0994469
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0974695
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0895253
PTMA prothymosin, alpha -0.0886845
CDH13 cadherin 13 -0.0885162
RPS24 ribosomal protein S24 -0.0868586
PDE10A phosphodiesterase 10A -0.0864156
RPS6 ribosomal protein S6 -0.0855325
RPL35A ribosomal protein L35a -0.0734912
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0690567
RPS8 ribosomal protein S8 -0.0678552
RPL26 ribosomal protein L26 -0.0654805
RPL31 ribosomal protein L31 -0.0608744
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0606102
S100A6 S100 calcium binding protein A6 -0.0604117
NALF1 NALCN channel auxiliary factor 1 -0.0597956
RPLP0 ribosomal protein, large, P0 -0.0595289
RPL12 ribosomal protein L12 -0.0594639
NAP1L1 nucleosome assembly protein 1-like 1 -0.0580419
RPS23 ribosomal protein S23 -0.0580248
FTL ferritin, light polypeptide -0.0579403
RPL23 ribosomal protein L23 -0.0563263
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0562394
RPS27A ribosomal protein S27a -0.0561745
COL5A2 collagen, type V, alpha 2 -0.0561305
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0545331
RPL34 ribosomal protein L34 -0.0541015
CANX calnexin -0.0537867
RPL36A ribosomal protein L36a -0.0534635
EEF2 eukaryotic translation elongation factor 2 -0.0527763
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.052676
RPS21 ribosomal protein S21 -0.0516288
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0514971
S100A10 S100 calcium binding protein A10 -0.0507881
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0505454
HLA-B major histocompatibility complex, class I, B -0.0490887
SOX4 SRY (sex determining region Y)-box 4 -0.0479549
TM4SF1 transmembrane 4 L six family member 1 -0.0476028
UBC ubiquitin C -0.0468738
RPL38 ribosomal protein L38 -0.0465004
RPL7A ribosomal protein L7a -0.0463464
RPS4X ribosomal protein S4, X-linked -0.0460123
RPL19 ribosomal protein L19 -0.0457274
RPS14 ribosomal protein S14 -0.0455515
RPS13 ribosomal protein S13 -0.0445961
RPS19 ribosomal protein S19 -0.0442591
ADGRD1 adhesion G protein-coupled receptor D1 -0.0440105
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0439259
RPLP2 ribosomal protein, large, P2 -0.0435655
RPL9 ribosomal protein L9 -0.0431843
CTSL cathepsin L -0.0430696
TTC28 tetratricopeptide repeat domain 28 -0.0422889
RPL37A ribosomal protein L37a -0.0413699
RPS16 ribosomal protein S16 -0.0406922
AHNAK AHNAK nucleoprotein -0.0402509
TFPI2 tissue factor pathway inhibitor 2 -0.0399693
RPS25 ribosomal protein S25 -0.0398683
RPL37 ribosomal protein L37 -0.036746
SMYD3 SET and MYND domain containing 3 -0.0366668
RPL11 ribosomal protein L11 -0.0365845
PRRC2C proline-rich coiled-coil 2C -0.0359762
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0355859
TXNRD1 thioredoxin reductase 1 -0.0354382
ACTG1 actin gamma 1 -0.0349956
LOC112694756 uncharaterized LOC112694756 -0.0349914
SOD2 superoxide dismutase 2, mitochondrial -0.0349087
RPL35 ribosomal protein L35 -0.034673
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0344705
EIF1 eukaryotic translation initiation factor 1 -0.0342204
RPS27 ribosomal protein S27 -0.0340827
TMSB4X thymosin beta 4, X-linked -0.0338292
RPL5 ribosomal protein L5 -0.0335748
LDHA lactate dehydrogenase A -0.0330662
RPL39 ribosomal protein L39 -0.032707
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0324471
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0322569
YBX1 Y box binding protein 1 -0.0320952
RPS12 ribosomal protein S12 -0.0318274
EIF4A1 eukaryotic translation initiation factor 4A1 -0.031804
RAB31 RAB31, member RAS oncogene family -0.0313924
ANTXR1 anthrax toxin receptor 1 -0.0313089
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0309222
MATR3 matrin 3 -0.0305391
ASTN2 astrotactin 2 -0.0303084
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0301043
FMNL2 formin-like 2 -0.0299355
RPS28 ribosomal protein S28 -0.0299199
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0298359
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.02965
PALLD palladin, cytoskeletal associated protein -0.0289355
PKM pyruvate kinase, muscle -0.0288657
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0288412