Verapamil_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in NCI-H596 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Verapamil_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.291264
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.135358
UBA6 ubiquitin-like modifier activating enzyme 6 0.126778
FTL ferritin, light polypeptide 0.123719
NAP1L1 nucleosome assembly protein 1-like 1 0.115723
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.11556
GOLGA4 golgin A4 0.10309
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0977519
UBC ubiquitin C 0.088697
S100A10 S100 calcium binding protein A10 0.0855257
FOSL1 FOS-like antigen 1 0.0850817
ZFP36L1 ZFP36 ring finger protein-like 1 0.0844811
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0843991
TPR translocated promoter region, nuclear basket protein 0.0838222
MYOF myoferlin 0.0832943
MXI1 MAX interactor 1, dimerization protein 0.0830432
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0822406
EFNA5 ephrin-A5 0.0814551
MT2A metallothionein 2A 0.0792908
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0779564
NAMPT nicotinamide phosphoribosyltransferase 0.0758262
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0754458
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0750548
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0714761
PRRC2C proline-rich coiled-coil 2C 0.069819
SPAG9 sperm associated antigen 9 0.0697334
MAP1B microtubule-associated protein 1B 0.0696309
ALCAM activated leukocyte cell adhesion molecule 0.068322
TOP1 topoisomerase (DNA) I 0.0655356
FLNB filamin B, beta 0.0635155
YAP1 Yes-associated protein 1 0.0629452
FTH1 ferritin, heavy polypeptide 1 0.0613221
RPL12 ribosomal protein L12 0.0612365
USP34 ubiquitin specific peptidase 34 0.0599954
RBM39 RNA binding motif protein 39 0.0597936
RASA2 RAS p21 protein activator 2 0.0595768
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.058932
DLC1 DLC1 Rho GTPase activating protein 0.0571683
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0543271
FUS FUS RNA binding protein 0.0536779
ENO1 enolase 1, (alpha) 0.0502782
STK24 serine/threonine kinase 24 0.0482311
RLF rearranged L-myc fusion 0.0468831
CALU calumenin 0.0463042
RPS12 ribosomal protein S12 0.0449262
CANX calnexin 0.0444802
RPL9 ribosomal protein L9 0.0442557
NDRG1 N-myc downstream regulated 1 0.0429394
GNAS GNAS complex locus 0.042108
ERRFI1 ERBB receptor feedback inhibitor 1 0.041724
PTMA prothymosin, alpha 0.0412172
ZFAND3 zinc finger, AN1-type domain 3 0.041074
OGA O-GlcNAcase 0.0406166
KTN1 kinectin 1 (kinesin receptor) 0.0400858
RICTOR RPTOR independent companion of MTOR, complex 2 0.0392754
RPL4 ribosomal protein L4 0.0387487
KMT2E lysine (K)-specific methyltransferase 2E 0.0381073
ELL2 elongation factor, RNA polymerase II, 2 0.0379399
PCBP2 poly(rC) binding protein 2 0.0376161
COPA coatomer protein complex, subunit alpha 0.0373107
LCOR ligand dependent nuclear receptor corepressor 0.0367628
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0347462
HOOK2 hook microtubule-tethering protein 2 0.0335548
LMO7 LIM domain 7 0.0334658
TMSB10 thymosin beta 10 0.0334404
MATR3 matrin 3 0.032389
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.032067
JARID2 jumonji, AT rich interactive domain 2 0.0318933
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0314224
SAMD4A sterile alpha motif domain containing 4A 0.0302928
PUM1 pumilio RNA-binding family member 1 0.0301836
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0300793
ZMYM2 zinc finger, MYM-type 2 0.029944
RPLP2 ribosomal protein, large, P2 0.0297701
BHLHE40 basic helix-loop-helix family, member e40 0.0296384
PGK1 phosphoglycerate kinase 1 0.029537
TRIO trio Rho guanine nucleotide exchange factor 0.0282365
RBM25 RNA binding motif protein 25 0.028182
TENT2 terminal nucleotidyltransferase 2 0.0280577
ADNP activity-dependent neuroprotector homeobox 0.0268296
LOC112694756 uncharaterized LOC112694756 0.0265175
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0265128
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0261026
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0257011
ANXA1 annexin A1 0.0256625
N4BP2L2 NEDD4 binding protein 2-like 2 0.0249216
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0248867
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.02457
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0245153
RSF1 remodeling and spacing factor 1 0.0242999
VMP1 vacuole membrane protein 1 0.0242352
VIM vimentin 0.024038
CTNND1 catenin (cadherin-associated protein), delta 1 0.0240087
RAI14 retinoic acid induced 14 0.0238811
CLTC clathrin, heavy chain (Hc) 0.0232659
SLC38A1 solute carrier family 38, member 1 0.0232143
ZNF292 zinc finger protein 292 0.0231287
PCM1 pericentriolar material 1 0.0227037
SYT1 synaptotagmin I 0.0223398
USP9X ubiquitin specific peptidase 9, X-linked 0.0222932

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.199372
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.145927
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.101607
EGFR epidermal growth factor receptor -0.0988526
MYO1E myosin IE -0.0984013
ASPH aspartate beta-hydroxylase -0.0891677
NALF1 NALCN channel auxiliary factor 1 -0.0849826
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0744973
RNF213 ring finger protein 213 -0.0741954
ATXN1 ataxin 1 -0.0720325
INHBA inhibin, beta A -0.06705
TPT1 tumor protein, translationally-controlled 1 -0.0666528
ZBTB20 zinc finger and BTB domain containing 20 -0.0633517
SMYD3 SET and MYND domain containing 3 -0.063195
FMNL2 formin-like 2 -0.0629746
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.060702
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0588837
GPC6 glypican 6 -0.0577537
NF1 neurofibromin 1 -0.0574181
PSD3 pleckstrin and Sec7 domain containing 3 -0.0533615
LAMB3 laminin, beta 3 -0.0531079
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.053076
PALM2AKAP2 PALM2 and AKAP2 fusion -0.052394
FNDC3B fibronectin type III domain containing 3B -0.0511233
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0503068
MAML3 mastermind-like 3 (Drosophila) -0.049728
SEPTIN9 septin 9 -0.0486569
KDM2A lysine (K)-specific demethylase 2A -0.0479341
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0476064
EXT1 exostosin glycosyltransferase 1 -0.047373
WASF2 WAS protein family, member 2 -0.046532
FMN1 formin 1 -0.0465272
HMGA2 high mobility group AT-hook 2 -0.0464532
BBX bobby sox homolog (Drosophila) -0.0460642
RPL35A ribosomal protein L35a -0.0458132
MMP1 matrix metallopeptidase 1 -0.0449286
TENM3 teneurin transmembrane protein 3 -0.0448198
MED13 mediator complex subunit 13 -0.0445308
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0445091
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0439083
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0436491
AKAP9 A kinase (PRKA) anchor protein 9 -0.0435148
KMT2C lysine (K)-specific methyltransferase 2C -0.0434391
AKAP12 A kinase (PRKA) anchor protein 12 -0.0424207
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0422589
COL1A1 collagen, type I, alpha 1 -0.0412305
RAB1A RAB1A, member RAS oncogene family -0.0410477
FAM13A family with sequence similarity 13, member A -0.0407289
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0406283
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0405263
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0403742
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0403363
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0396756
UBE2K ubiquitin-conjugating enzyme E2K -0.0395868
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0389337
RAB10 RAB10, member RAS oncogene family -0.0386451
PDE10A phosphodiesterase 10A -0.0380368
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0372833
RPLP0 ribosomal protein, large, P0 -0.0361526
BPTF bromodomain PHD finger transcription factor -0.0361511
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0359853
LAMA4 laminin, alpha 4 -0.0359274
IGF1R insulin-like growth factor 1 receptor -0.0359021
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0349169
MAML2 mastermind-like 2 (Drosophila) -0.034629
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0344731
DSCAM Down syndrome cell adhesion molecule -0.0337502
RPL34 ribosomal protein L34 -0.0335893
MBD5 methyl-CpG binding domain protein 5 -0.0333746
RPLP1 ribosomal protein, large, P1 -0.0326892
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0320457
PRKCA protein kinase C, alpha -0.0319645
PTPRM protein tyrosine phosphatase, receptor type, M -0.0319043
WNK1 WNK lysine deficient protein kinase 1 -0.0316623
TFG TRK-fused gene -0.0312352
RAD51B RAD51 paralog B -0.0310977
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0304118
RUNX1 runt-related transcription factor 1 -0.0302774
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0300993
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0296717
PARD3 par-3 family cell polarity regulator -0.0293794
PIBF1 progesterone immunomodulatory binding factor 1 -0.0284872
MCL1 myeloid cell leukemia 1 -0.0283605
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0283562
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0283515
DOCK5 dedicator of cytokinesis 5 -0.0281381
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0279703
BIRC6 baculoviral IAP repeat containing 6 -0.0277655
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0276218
BASP1 brain abundant, membrane attached signal protein 1 -0.0274355
PDE8A phosphodiesterase 8A -0.0271096
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0270206
FN1 fibronectin 1 -0.0268141
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0267329
PKM pyruvate kinase, muscle -0.0264359
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0262718
ATP13A3 ATPase type 13A3 -0.0262659
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0258992
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0258766
MACF1 microtubule-actin crosslinking factor 1 -0.0257963