Verapamil_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.149369
NAP1L1 nucleosome assembly protein 1-like 1 0.0906099
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0676834
ZNF292 zinc finger protein 292 0.066956
NUP58 nucleoporin 58 0.0635645
WAC WW domain containing adaptor with coiled-coil 0.0618528
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0597243
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0590099
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0582522
PUM2 pumilio RNA-binding family member 2 0.0554096
ANKRD28 ankyrin repeat domain 28 0.0546728
ENO1 enolase 1, (alpha) 0.0511935
DERA deoxyribose-phosphate aldolase (putative) 0.0497511
RPS3 ribosomal protein S3 0.0473132
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0461353
NAMPT nicotinamide phosphoribosyltransferase 0.0450819
CENPF centromere protein F, 350/400kDa 0.0442949
GOLGA4 golgin A4 0.0441735
TRIO trio Rho guanine nucleotide exchange factor 0.0439547
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0435689
BIRC2 baculoviral IAP repeat containing 2 0.0419982
ANLN anillin, actin binding protein 0.0416016
RNF145 ring finger protein 145 0.0415101
SETD5 SET domain containing 5 0.040938
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0407919
BIRC3 baculoviral IAP repeat containing 3 0.0407166
PDE4D phosphodiesterase 4D, cAMP-specific 0.038059
FAM13A family with sequence similarity 13, member A 0.0376622
QKI QKI, KH domain containing, RNA binding 0.0371761
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0368357
DIAPH3 diaphanous-related formin 3 0.0365696
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.035463
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0354475
ATP13A3 ATPase type 13A3 0.0353908
PCBP2 poly(rC) binding protein 2 0.0352526
SUCO SUN domain containing ossification factor 0.0352181
CKAP5 cytoskeleton associated protein 5 0.0340896
CDCP1 CUB domain containing protein 1 0.0336538
PTMA prothymosin, alpha 0.0336535
LCORL ligand dependent nuclear receptor corepressor-like 0.0336022
STRN3 striatin, calmodulin binding protein 3 0.0333604
HELZ helicase with zinc finger 0.0331169
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0330559
AHCTF1 AT hook containing transcription factor 1 0.0330412
MMP1 matrix metallopeptidase 1 0.0328519
RUNX1 runt-related transcription factor 1 0.032658
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0326456
CHD1 chromodomain helicase DNA binding protein 1 0.0322861
HJURP Holliday junction recognition protein 0.0321595
OLA1 Obg-like ATPase 1 0.0321279
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0321057
YBX3 Y box binding protein 3 0.0317491
AXL AXL receptor tyrosine kinase 0.0313939
TMEM263 transmembrane protein 263 0.0312086
BHLHE40 basic helix-loop-helix family, member e40 0.0311357
SLMAP sarcolemma associated protein 0.0307291
ECT2 epithelial cell transforming 2 0.0303426
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0302737
TXNRD1 thioredoxin reductase 1 0.0302593
WDFY2 WD repeat and FYVE domain containing 2 0.0301982
SNX14 sorting nexin 14 0.030119
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0301022
SET SET nuclear proto-oncogene 0.0300457
EEF2 eukaryotic translation elongation factor 2 0.0299244
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0289846
BIRC6 baculoviral IAP repeat containing 6 0.028844
NCKAP1 NCK-associated protein 1 0.0286403
RPLP2 ribosomal protein, large, P2 0.0283497
TPX2 TPX2, microtubule-associated 0.0282249
KMT2A lysine (K)-specific methyltransferase 2A 0.0280439
NCOA6 nuclear receptor coactivator 6 0.028011
SMYD3 SET and MYND domain containing 3 0.0278191
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0275251
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0274396
WBP11 WW domain binding protein 11 0.0273576
UBE2O ubiquitin-conjugating enzyme E2O 0.0273464
SGO2 shugoshin 2 0.0270548
TPR translocated promoter region, nuclear basket protein 0.0269445
RB1CC1 RB1-inducible coiled-coil 1 0.0269187
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0268519
H1-0 H1.0 linker histone 0.0268457
USP3 ubiquitin specific peptidase 3 0.0267552
RPS2 ribosomal protein S2 0.0266687
PRR11 proline rich 11 0.0263677
ARRDC3 arrestin domain containing 3 0.0263336
RPL35 ribosomal protein L35 0.0262296
RACK1 receptor for activated C kinase 1 0.0261987
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0261632
KLHL24 kelch-like family member 24 0.0260974
ZFR zinc finger RNA binding protein 0.0260737
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0259145
GPHN gephyrin 0.0258016
RLF rearranged L-myc fusion 0.0257042
AVL9 AVL9 homolog (S. cerevisiase) 0.0256782
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0255681
RNF111 ring finger protein 111 0.0255339
CAPN7 calpain 7 0.0254203
TMEM123 transmembrane protein 123 0.0253812
PRC1 protein regulator of cytokinesis 1 0.0253117
WDR45B WD repeat domain 45B 0.0252941

decreased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.108849
HMGA2 high mobility group AT-hook 2 -0.101569
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0893214
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0881382
TMSB10 thymosin beta 10 -0.0862812
TPT1 tumor protein, translationally-controlled 1 -0.0824396
MT2A metallothionein 2A -0.0753633
GOLGB1 golgin B1 -0.0628492
RPL35A ribosomal protein L35a -0.0618381
POTEF POTE ankyrin domain family, member F -0.0612166
SLC38A2 solute carrier family 38, member 2 -0.0597606
PRSS23 protease, serine, 23 -0.0588486
FNDC3A fibronectin type III domain containing 3A -0.0583629
RIGI RNA sensor RIG-I -0.0575516
INTS6 integrator complex subunit 6 -0.0556291
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0527927
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0521916
IGF2 insulin-like growth factor 2 -0.0471365
WSB1 WD repeat and SOCS box containing 1 -0.0466119
PODXL podocalyxin-like -0.0454298
FTL ferritin, light polypeptide -0.0453172
LOC112694756 uncharaterized LOC112694756 -0.043618
B2M beta-2-microglobulin -0.0431631
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0428595
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0426238
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0422478
RPL38 ribosomal protein L38 -0.0416775
CD44 CD44 molecule (Indian blood group) -0.041282
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0408914
VCL vinculin -0.0408586
HLA-B major histocompatibility complex, class I, B -0.0407735
EGR1 early growth response 1 -0.0405174
CCND1 cyclin D1 -0.0403428
TAOK3 TAO kinase 3 -0.0395836
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0394783
ANGPTL4 angiopoietin-like 4 -0.0394471
TTC17 tetratricopeptide repeat domain 17 -0.039284
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0388989
FBXO11 F-box protein 11 -0.0387879
LMO7 LIM domain 7 -0.0369727
DNER delta/notch-like EGF repeat containing -0.0369667
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0361923
HM13 histocompatibility (minor) 13 -0.0359591
BICD1 bicaudal D homolog 1 (Drosophila) -0.0358881
RAD51B RAD51 paralog B -0.0356567
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0350752
ISG15 ISG15 ubiquitin-like modifier -0.0344053
LDHA lactate dehydrogenase A -0.0338632
CDK13 cyclin-dependent kinase 13 -0.0337878
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -0.0336406
HLA-C major histocompatibility complex, class I, C -0.0334568
RPS29 ribosomal protein S29 -0.0333641
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0332193
PCED1B PC-esterase domain containing 1B -0.0326376
MACF1 microtubule-actin crosslinking factor 1 -0.0326055
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0323573
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0320579
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0320274
MYO9B myosin IXB -0.0318811
MTDH metadherin -0.0317602
EHBP1 EH domain binding protein 1 -0.0316878
PURA purine-rich element binding protein A -0.0315227
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0315224
PCNX2 pecanex 2 -0.0314077
VDAC1 voltage-dependent anion channel 1 -0.0312683
OSMR oncostatin M receptor -0.031217
PRR16 proline rich 16 -0.0310377
FNDC3B fibronectin type III domain containing 3B -0.031005
SOD2 superoxide dismutase 2, mitochondrial -0.0309974
RAI14 retinoic acid induced 14 -0.0305699
BBX bobby sox homolog (Drosophila) -0.0305535
SIK3 SIK family kinase 3 -0.030385
RPS27A ribosomal protein S27a -0.030287
ZBTB20 zinc finger and BTB domain containing 20 -0.0302646
EGFR epidermal growth factor receptor -0.0302477
KLF3 Kruppel-like factor 3 (basic) -0.0302149
HDAC9 histone deacetylase 9 -0.0301321
RNF213 ring finger protein 213 -0.0300892
LPP LIM domain containing preferred translocation partner in lipoma -0.0299516
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0298456
LAMA5 laminin, alpha 5 -0.029828
RAB1A RAB1A, member RAS oncogene family -0.0296529
GSK3B glycogen synthase kinase 3 beta -0.0296493
CCDC88A coiled-coil domain containing 88A -0.0296171
PRKCA protein kinase C, alpha -0.0293902
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0293826
NCEH1 neutral cholesterol ester hydrolase 1 -0.0293105
TBCA tubulin folding cofactor A -0.0290979
CCNH cyclin H -0.0288695
ARHGAP26 Rho GTPase activating protein 26 -0.0287745
CCNY cyclin Y -0.0286417
RPS11 ribosomal protein S11 -0.0286286
GPATCH2L G patch domain containing 2-like -0.0284421
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0279425
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0279039
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0274642
FRYL FRY-like -0.0273693
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0271655
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0270839
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0269939