Verapamil_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verapamil perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verapamil_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.130346
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.100856
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0932755
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0759139
CD109 CD109 molecule 0.0750621
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0722235
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0679592
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0623736
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0616117
GOLGA4 golgin A4 0.0605186
FAM13A family with sequence similarity 13, member A 0.0595871
KMT2C lysine (K)-specific methyltransferase 2C 0.0571082
NDRG1 N-myc downstream regulated 1 0.055775
BIRC6 baculoviral IAP repeat containing 6 0.0543104
WAC WW domain containing adaptor with coiled-coil 0.0528593
YME1L1 YME1-like 1 ATPase 0.0479212
RNF145 ring finger protein 145 0.0477928
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0475211
CCNL1 cyclin L1 0.0465661
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.046383
SUCO SUN domain containing ossification factor 0.0456346
COG5 component of oligomeric golgi complex 5 0.0455471
ELL2 elongation factor, RNA polymerase II, 2 0.0443344
ZNF292 zinc finger protein 292 0.0443211
HELZ helicase with zinc finger 0.0441091
WDR26 WD repeat domain 26 0.0435553
ACBD3 acyl-CoA binding domain containing 3 0.043293
NEK7 NIMA-related kinase 7 0.0428651
TXNIP thioredoxin interacting protein 0.0428026
ADAM17 ADAM metallopeptidase domain 17 0.0422743
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0418025
FNDC3B fibronectin type III domain containing 3B 0.0416441
KDM3A lysine (K)-specific demethylase 3A 0.0412067
BCLAF1 BCL2-associated transcription factor 1 0.0407745
RTN4 reticulon 4 0.0399946
TFG TRK-fused gene 0.0397062
TM9SF3 transmembrane 9 superfamily member 3 0.0395955
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0395462
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0395193
AKAP9 A kinase (PRKA) anchor protein 9 0.0388343
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0383108
RAB1A RAB1A, member RAS oncogene family 0.0379631
CALU calumenin 0.0374083
NUP58 nucleoporin 58 0.0370461
SPRED2 sprouty-related, EVH1 domain containing 2 0.036272
KMT2E lysine (K)-specific methyltransferase 2E 0.0361647
SEC23A Sec23 homolog A (S. cerevisiae) 0.0360978
DLG1 discs, large homolog 1 (Drosophila) 0.0350899
SRP54 signal recognition particle 54kDa 0.0350085
YAP1 Yes-associated protein 1 0.0346647
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0346297
ZC3H11A zinc finger CCCH-type containing 11A 0.034518
UBE2K ubiquitin-conjugating enzyme E2K 0.033974
OGA O-GlcNAcase 0.0337895
CORO1C coronin, actin binding protein, 1C 0.0334148
RAB6A RAB6A, member RAS oncogene family 0.0333088
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0332035
PTK2 protein tyrosine kinase 2 0.0331983
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0328764
UBE2H ubiquitin-conjugating enzyme E2H 0.0327498
SNX13 sorting nexin 13 0.032288
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0322396
ANKRD28 ankyrin repeat domain 28 0.032133
MXI1 MAX interactor 1, dimerization protein 0.0320876
PELO pelota homolog (Drosophila) 0.0320497
IL6ST interleukin 6 signal transducer 0.031967
TENT2 terminal nucleotidyltransferase 2 0.0318382
CDC73 cell division cycle 73 0.0318352
MCTP2 multiple C2 domains, transmembrane 2 0.0316631
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0316298
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0315933
SEC31A SEC31 homolog A (S. cerevisiae) 0.0311543
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0307383
TXNRD1 thioredoxin reductase 1 0.0305708
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0305524
ERRFI1 ERBB receptor feedback inhibitor 1 0.0302949
RB1CC1 RB1-inducible coiled-coil 1 0.0298107
NBAS neuroblastoma amplified sequence 0.02973
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0294572
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0292657
KDM6A lysine (K)-specific demethylase 6A 0.0290623
LCORL ligand dependent nuclear receptor corepressor-like 0.0287119
XPO1 exportin 1 0.0286374
CLINT1 clathrin interactor 1 0.0285768
CHD1 chromodomain helicase DNA binding protein 1 0.0285212
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0283262
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0282462
PCBP2 poly(rC) binding protein 2 0.0281875
RAB5A RAB5A, member RAS oncogene family 0.0280747
SQSTM1 sequestosome 1 0.0280124
TPR translocated promoter region, nuclear basket protein 0.0280123
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0279336
AFDN afadin, adherens junction formation factor 0.0276566
TBK1 TANK-binding kinase 1 0.0275815
EWSR1 EWS RNA-binding protein 1 0.0275497
RAB8B RAB8B, member RAS oncogene family 0.0273961
SMYD3 SET and MYND domain containing 3 0.0273681
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0273457
RUNX1 runt-related transcription factor 1 0.0271785
ZFAND3 zinc finger, AN1-type domain 3 0.0271225

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.252738
FN1 fibronectin 1 -0.185618
HMGA2 high mobility group AT-hook 2 -0.132375
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.118757
GLIS3 GLIS family zinc finger 3 -0.0736032
TMSB4X thymosin beta 4, X-linked -0.0677626
HLA-B major histocompatibility complex, class I, B -0.0671014
ITGA1 integrin, alpha 1 -0.0661233
TMSB10 thymosin beta 10 -0.055522
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0544992
IFI27 interferon, alpha-inducible protein 27 -0.050557
TPT1 tumor protein, translationally-controlled 1 -0.0449544
S100A6 S100 calcium binding protein A6 -0.0442646
DNAH5 dynein, axonemal, heavy chain 5 -0.0440381
INTS6 integrator complex subunit 6 -0.0424952
VIM vimentin -0.040369
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0375839
TNS3 tensin 3 -0.0364419
SOX4 SRY (sex determining region Y)-box 4 -0.0349702
STC2 stanniocalcin 2 -0.0300859
SYT1 synaptotagmin I -0.0300029
B2M beta-2-microglobulin -0.0293267
PALLD palladin, cytoskeletal associated protein -0.0291363
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.028532
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0282448
RPL35A ribosomal protein L35a -0.0267321
MT2A metallothionein 2A -0.0266145
MRPS6 mitochondrial ribosomal protein S6 -0.0265401
ABR active BCR-related -0.0261763
OXR1 oxidation resistance 1 -0.0257537
LMNA lamin A/C -0.0257508
EFNA5 ephrin-A5 -0.024786
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0246215
ACTG1 actin gamma 1 -0.0243789
SAMD4A sterile alpha motif domain containing 4A -0.0243324
RPL34 ribosomal protein L34 -0.0239794
TENM4 teneurin transmembrane protein 4 -0.0235137
SLC35F3 solute carrier family 35, member F3 -0.0232112
AEBP2 AE binding protein 2 -0.0230766
RPL38 ribosomal protein L38 -0.0221204
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0220251
SMAD3 SMAD family member 3 -0.0220087
CADM1 cell adhesion molecule 1 -0.0219582
LOXL2 lysyl oxidase-like 2 -0.0219401
AKAP12 A kinase (PRKA) anchor protein 12 -0.0218099
MAML2 mastermind-like 2 (Drosophila) -0.0217221
FBN1 fibrillin 1 -0.0215211
IER3 immediate early response 3 -0.021505
CALR calreticulin -0.0214808
AHNAK AHNAK nucleoprotein -0.0213276
LOX lysyl oxidase -0.0212406
RPS8 ribosomal protein S8 -0.0212243
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0212115
TBC1D22A TBC1 domain family, member 22A -0.0206577
SFRP1 secreted frizzled-related protein 1 -0.0206334
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0203744
MKI67 marker of proliferation Ki-67 -0.0202098
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0201781
FAM20C family with sequence similarity 20, member C -0.0201431
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.020083
TAGLN2 transgelin 2 -0.019798
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0196813
TSHZ2 teashirt zinc finger homeobox 2 -0.0196239
RPS24 ribosomal protein S24 -0.0196225
ARF1 ADP-ribosylation factor 1 -0.0196192
ADAM8 ADAM metallopeptidase domain 8 -0.0193016
CTSD cathepsin D -0.0192831
AOPEP aminopeptidase O (putative) -0.0192093
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0190323
TM4SF1 transmembrane 4 L six family member 1 -0.0189629
AHRR aryl-hydrocarbon receptor repressor -0.0189215
RPS21 ribosomal protein S21 -0.0189072
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0187062
TFPI2 tissue factor pathway inhibitor 2 -0.0186368
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0186085
IL6 interleukin 6 -0.0185498
TGFB1 transforming growth factor, beta 1 -0.0184068
MCL1 myeloid cell leukemia 1 -0.0178699
GNAS GNAS complex locus -0.017849
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0178047
S100A10 S100 calcium binding protein A10 -0.0177718
IFI44L interferon-induced protein 44-like -0.0177244
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0176688
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0174372
LIMCH1 LIM and calponin homology domains 1 -0.017424
IGFBP3 insulin-like growth factor binding protein 3 -0.0172934
LOC102724023 ES1 protein homolog, mitochondrial -0.0171408
SOX5 SRY (sex determining region Y)-box 5 -0.0169555
RPL26 ribosomal protein L26 -0.016941
RIN2 Ras and Rab interactor 2 -0.0169119
VAC14 Vac14 homolog (S. cerevisiae) -0.0166253
PRH1 proline-rich protein HaeIII subfamily 1 -0.0165502
PTMA prothymosin, alpha -0.0165341
NSD2 nuclear receptor binding SET domain protein 2 -0.0163422
PLEC plectin -0.0162311
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0161253
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0159949
NTN4 netrin 4 -0.0159509
FAM107B family with sequence similarity 107, member B -0.0158827
RNF213 ring finger protein 213 -0.015851