Verteporfin_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verteporfin perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verteporfin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.206906
MT2A metallothionein 2A 0.12293
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.113202
FN1 fibronectin 1 0.110307
P4HB prolyl 4-hydroxylase, beta polypeptide 0.097325
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0804363
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0794686
STC1 stanniocalcin 1 0.0696316
VIM vimentin 0.0635589
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0633441
CXCL8 chemokine (C-X-C motif) ligand 8 0.0553842
CALR calreticulin 0.0485753
PTMA prothymosin, alpha 0.047277
ICAM1 intercellular adhesion molecule 1 0.0414803
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0392253
CANX calnexin 0.0358577
INHBA inhibin, beta A 0.0329273
EEF2 eukaryotic translation elongation factor 2 0.0328918
RPS8 ribosomal protein S8 0.032876
YBX1 Y box binding protein 1 0.031363
RPS6 ribosomal protein S6 0.0305843
RPL26 ribosomal protein L26 0.0296088
RPL11 ribosomal protein L11 0.0291816
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0291686
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0291453
B2M beta-2-microglobulin 0.0288807
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0271663
RPS12 ribosomal protein S12 0.0271017
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0268396
RACK1 receptor for activated C kinase 1 0.0265898
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0263784
TMSB10 thymosin beta 10 0.0263652
RPS3 ribosomal protein S3 0.0262721
HMGA1 high mobility group AT-hook 1 0.0261837
LGALS1 lectin, galactoside-binding, soluble, 1 0.0261577
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.025427
POSTN periostin, osteoblast specific factor 0.0251592
HAS2 hyaluronan synthase 2 0.0248781
LDHA lactate dehydrogenase A 0.0237618
LMAN1 lectin, mannose-binding, 1 0.0230095
RPS2 ribosomal protein S2 0.0228457
PFN1 profilin 1 0.0227254
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0219088
ELL2 elongation factor, RNA polymerase II, 2 0.0213518
RPL18 ribosomal protein L18 0.0206862
RPL7 ribosomal protein L7 0.0206465
KLF6 Kruppel-like factor 6 0.0204434
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0203517
RPL23 ribosomal protein L23 0.0203269
RPS19 ribosomal protein S19 0.0202961
PRRC2C proline-rich coiled-coil 2C 0.0199633
ANXA5 annexin A5 0.0198953
PLAUR plasminogen activator, urokinase receptor 0.0193025
IGFBP3 insulin-like growth factor binding protein 3 0.0192888
TMSB4X thymosin beta 4, X-linked 0.0192294
GOLGA4 golgin A4 0.0190657
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0189529
ECE1 endothelin converting enzyme 1 0.0187312
MYH9 myosin, heavy chain 9, non-muscle 0.0182639
TLN1 talin 1 0.0180808
HMGB2 high mobility group box 2 0.0178665
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.017758
RPL36 ribosomal protein L36 0.0176945
COL4A1 collagen, type IV, alpha 1 0.0176204
DDIT4 DNA-damage-inducible transcript 4 0.0174382
EIF1 eukaryotic translation initiation factor 1 0.0171144
RPL30 ribosomal protein L30 0.0168334
RPL12 ribosomal protein L12 0.0167583
TPI1 triosephosphate isomerase 1 0.0167021
RRBP1 ribosome binding protein 1 0.0164629
RAB7A RAB7A, member RAS oncogene family 0.0162627
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0161863
RPLP2 ribosomal protein, large, P2 0.015936
RPL34 ribosomal protein L34 0.0159172
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0159155
ARRDC3 arrestin domain containing 3 0.0159051
RPL13A ribosomal protein L13a 0.0157938
RPLP1 ribosomal protein, large, P1 0.0156144
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0153959
KTN1 kinectin 1 (kinesin receptor) 0.0153007
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.015289
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0152699
SERBP1 SERPINE1 mRNA binding protein 1 0.0152699
PTN pleiotrophin 0.0152163
GANAB glucosidase, alpha; neutral AB 0.015099
STC2 stanniocalcin 2 0.0150862
IGFBP7 insulin-like growth factor binding protein 7 0.0150625
NFE2L1 nuclear factor, erythroid 2-like 1 0.0150597
HLA-B major histocompatibility complex, class I, B 0.0150571
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0148536
TNIP1 TNFAIP3 interacting protein 1 0.0147635
TPM3 tropomyosin 3 0.0147446
ACBD3 acyl-CoA binding domain containing 3 0.014738
MT1X metallothionein 1X 0.0146823
EEF1G eukaryotic translation elongation factor 1 gamma 0.0146632
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0146294
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0145003
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.01447
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0140417
CD44 CD44 molecule (Indian blood group) 0.0139291

decreased expression

Symbol Name Standardized Value
CDH13 cadherin 13 -0.122761
EXT1 exostosin glycosyltransferase 1 -0.116454
FNDC3B fibronectin type III domain containing 3B -0.0841855
COL1A1 collagen, type I, alpha 1 -0.0824811
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0752087
PSD3 pleckstrin and Sec7 domain containing 3 -0.0721903
ZBTB20 zinc finger and BTB domain containing 20 -0.0711002
DPYD dihydropyrimidine dehydrogenase -0.060522
CADM1 cell adhesion molecule 1 -0.0580609
HMGA2 high mobility group AT-hook 2 -0.050711
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0499402
FBN1 fibrillin 1 -0.0485605
PDE10A phosphodiesterase 10A -0.0471675
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0458826
LPP LIM domain containing preferred translocation partner in lipoma -0.0451217
TRPS1 trichorhinophalangeal syndrome I -0.0450691
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0441767
TRIO trio Rho guanine nucleotide exchange factor -0.0441311
GLIS3 GLIS family zinc finger 3 -0.0434063
PTK2 protein tyrosine kinase 2 -0.0367056
AHNAK AHNAK nucleoprotein -0.0366073
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.036006
MBNL1 muscleblind-like splicing regulator 1 -0.0336358
ATXN1 ataxin 1 -0.0335474
JARID2 jumonji, AT rich interactive domain 2 -0.0333008
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0326936
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0321112
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0318697
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0317508
CNTN5 contactin 5 -0.0312113
PDE4D phosphodiesterase 4D, cAMP-specific -0.0302226
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0291859
PICALM phosphatidylinositol binding clathrin assembly protein -0.0289444
SMYD3 SET and MYND domain containing 3 -0.0283075
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.02813
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0276267
NALF1 NALCN channel auxiliary factor 1 -0.0274736
GSK3B glycogen synthase kinase 3 beta -0.0274049
MAML2 mastermind-like 2 (Drosophila) -0.027279
PTPRG protein tyrosine phosphatase, receptor type, G -0.0272293
COL6A3 collagen, type VI, alpha 3 -0.0271194
ZFAND3 zinc finger, AN1-type domain 3 -0.0270262
COL1A2 collagen, type I, alpha 2 -0.0269667
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0265424
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0264945
ZFPM2 zinc finger protein, FOG family member 2 -0.0261155
USP34 ubiquitin specific peptidase 34 -0.0253603
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0252817
NAV2 neuron navigator 2 -0.025233
BBS9 Bardet-Biedl syndrome 9 -0.0252048
EGFR epidermal growth factor receptor -0.0250478
ZSWIM6 zinc finger, SWIM-type containing 6 -0.024711
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0244781
DLG1 discs, large homolog 1 (Drosophila) -0.0237797
SBF2 SET binding factor 2 -0.0236959
FNIP1 folliculin interacting protein 1 -0.0222744
FER fer (fps/fes related) tyrosine kinase -0.0222206
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0221427
FMNL2 formin-like 2 -0.022043
UBC ubiquitin C -0.0218671
IARS1 isoleucyl-tRNA synthetase 1 -0.0218346
EBF1 early B-cell factor 1 -0.0215496
ANKRD28 ankyrin repeat domain 28 -0.0215196
KMT2C lysine (K)-specific methyltransferase 2C -0.0214762
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0214373
PALLD palladin, cytoskeletal associated protein -0.0207837
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0204996
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0204813
PRELID2 PRELI domain containing 2 -0.0204564
COL5A1 collagen, type V, alpha 1 -0.0202857
GPC6 glypican 6 -0.0202631
PDLIM5 PDZ and LIM domain 5 -0.0201419
DOCK5 dedicator of cytokinesis 5 -0.0197732
FOXP1 forkhead box P1 -0.0193872
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0191422
WWTR1 WW domain containing transcription regulator 1 -0.0189854
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0189124
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0188648
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0188303
BNC2 basonuclin 2 -0.018684
KDM4C lysine (K)-specific demethylase 4C -0.0186524
TTC28 tetratricopeptide repeat domain 28 -0.0183229
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.018224
CLMP CXADR-like membrane protein -0.0181717
CUX1 cut-like homeobox 1 -0.0179214
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0175967
FTH1 ferritin, heavy polypeptide 1 -0.0174539
RUNX1 runt-related transcription factor 1 -0.0173579
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0172255
F3 coagulation factor III (thromboplastin, tissue factor) -0.0172117
EVI5 ecotropic viral integration site 5 -0.0171097
NRP1 neuropilin 1 -0.0168715
VEGFC vascular endothelial growth factor C -0.0168042
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.016765
FTO fat mass and obesity associated -0.0164787
CPQ carboxypeptidase Q -0.0162459
ERBIN erbb2 interacting protein -0.0162401
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0160997
RASAL2 RAS protein activator like 2 -0.015893
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.015834