Verteporfin_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verteporfin perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verteporfin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.258601
IGF2 insulin-like growth factor 2 0.249556
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.126464
SDC4 syndecan 4 0.0694603
RPS12 ribosomal protein S12 0.0512905
DDIT4 DNA-damage-inducible transcript 4 0.0506467
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0499953
CCL20 chemokine (C-C motif) ligand 20 0.0468862
CFB complement factor B 0.046697
ERRFI1 ERBB receptor feedback inhibitor 1 0.0461983
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0437671
EGR1 early growth response 1 0.0428427
DSPP dentin sialophosphoprotein 0.0426725
RPS6 ribosomal protein S6 0.042202
RPL11 ribosomal protein L11 0.0374404
VMP1 vacuole membrane protein 1 0.0365938
RBM39 RNA binding motif protein 39 0.0349879
EIF3A eukaryotic translation initiation factor 3, subunit A 0.033293
JUN jun proto-oncogene 0.0331394
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0316443
IGFBP1 insulin-like growth factor binding protein 1 0.0314537
TOP1 topoisomerase (DNA) I 0.03073
KLF6 Kruppel-like factor 6 0.0299683
RPS8 ribosomal protein S8 0.0297367
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0295758
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0275691
KIF5B kinesin family member 5B 0.0262423
ANXA5 annexin A5 0.0253359
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0249578
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0247891
RPL26 ribosomal protein L26 0.0246262
PCBP1 poly(rC) binding protein 1 0.0222708
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0222049
RRBP1 ribosome binding protein 1 0.021821
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.021803
SKIL SKI-like proto-oncogene 0.0217831
RSRC2 arginine/serine-rich coiled-coil 2 0.0217301
CCNL1 cyclin L1 0.0215296
TPM4 tropomyosin 4 0.0213273
RPLP1 ribosomal protein, large, P1 0.0208682
PDGFB platelet-derived growth factor beta polypeptide 0.0206051
RBM25 RNA binding motif protein 25 0.0203611
MCL1 myeloid cell leukemia 1 0.0201104
FILIP1L filamin A interacting protein 1-like 0.0200902
GOLGA4 golgin A4 0.0197367
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0196017
TXNIP thioredoxin interacting protein 0.0195901
NACA nascent polypeptide-associated complex alpha subunit 0.0192993
TM9SF3 transmembrane 9 superfamily member 3 0.0192812
RPS2 ribosomal protein S2 0.01918
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0189749
TCIM transcriptional and immune response regulator 0.0188557
EEF2 eukaryotic translation elongation factor 2 0.0187976
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0186242
APOB apolipoprotein B 0.0185724
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.018062
TRIM26 tripartite motif containing 26 0.0178096
RPL35A ribosomal protein L35a 0.0177232
RPS13 ribosomal protein S13 0.0173897
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0172983
EIF5B eukaryotic translation initiation factor 5B 0.016996
ATF3 activating transcription factor 3 0.0167261
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0166573
A2M alpha-2-macroglobulin 0.0166222
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0166156
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0163725
RTN4 reticulon 4 0.0160595
RELL1 RELT-like 1 0.0159707
RPS23 ribosomal protein S23 0.0156773
USP47 ubiquitin specific peptidase 47 0.0156721
GDF15 growth differentiation factor 15 0.0153929
PLAC8 placenta-specific 8 0.0153836
ZFP36L1 ZFP36 ring finger protein-like 1 0.0153192
JMJD1C jumonji domain containing 1C 0.0152286
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0152199
ARHGAP9 Rho GTPase activating protein 9 0.0151247
KIF1B kinesin family member 1B 0.0150446
RPS17 ribosomal protein S17 0.0150249
GPC3 glypican 3 0.0148441
EEA1 early endosome antigen 1 0.014829
YBX1 Y box binding protein 1 0.0147434
SEC62 SEC62 homolog (S. cerevisiae) 0.0146866
ABAT 4-aminobutyrate aminotransferase 0.0145766
SRRM1 serine/arginine repetitive matrix 1 0.0145332
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0143445
SFSWAP splicing factor, suppressor of white-apricot family 0.0142298
PNN pinin, desmosome associated protein 0.0141614
BHLHE40 basic helix-loop-helix family, member e40 0.0141541
EEF1G eukaryotic translation elongation factor 1 gamma 0.0140972
MT2A metallothionein 2A 0.01409
DSCAM Down syndrome cell adhesion molecule 0.0140577
HMGA1 high mobility group AT-hook 1 0.0138767
RACK1 receptor for activated C kinase 1 0.013602
RSL1D1 ribosomal L1 domain containing 1 0.0135066
RPL12 ribosomal protein L12 0.0134427
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0134362
CEMIP2 cell migration inducing hyaluronidase 2 0.0133328
MYH9 myosin, heavy chain 9, non-muscle 0.01333
EIF1 eukaryotic translation initiation factor 1 0.0132659
OSBPL9 oxysterol binding protein-like 9 0.0132586

decreased expression

Symbol Name Standardized Value
RERE arginine-glutamic acid dipeptide (RE) repeats -0.100535
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0859827
EHBP1 EH domain binding protein 1 -0.0818739
LRMDA leucine rich melanocyte differentiation associated -0.0811616
FN1 fibronectin 1 -0.079696
FNDC3B fibronectin type III domain containing 3B -0.0660684
MAML2 mastermind-like 2 (Drosophila) -0.061453
GMDS GDP-mannose 4,6-dehydratase -0.0612724
SAMD4A sterile alpha motif domain containing 4A -0.0561576
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0556816
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0552898
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0538348
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0458934
DOCK4 dedicator of cytokinesis 4 -0.0441282
NDRG1 N-myc downstream regulated 1 -0.0426348
ZFAND3 zinc finger, AN1-type domain 3 -0.0419521
DLC1 DLC1 Rho GTPase activating protein -0.0407688
USP34 ubiquitin specific peptidase 34 -0.0380524
SOS1 son of sevenless homolog 1 (Drosophila) -0.0379643
SOX5 SRY (sex determining region Y)-box 5 -0.0367713
ZBTB20 zinc finger and BTB domain containing 20 -0.0364096
ATXN1 ataxin 1 -0.0360936
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0348588
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0341307
KIAA1217 KIAA1217 -0.033565
GK glycerol kinase -0.0328566
MSI2 musashi RNA-binding protein 2 -0.0326647
FMNL2 formin-like 2 -0.0326195
TRIO trio Rho guanine nucleotide exchange factor -0.0325851
TBC1D22A TBC1 domain family, member 22A -0.0323429
FLNB filamin B, beta -0.0318246
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0313165
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0310314
NHSL1 NHS-like 1 -0.0307697
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0302893
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0299475
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0298719
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0291129
GPC6 glypican 6 -0.0288431
WDFY2 WD repeat and FYVE domain containing 2 -0.0285888
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0284599
AKAP12 A kinase (PRKA) anchor protein 12 -0.028393
AFDN afadin, adherens junction formation factor -0.0281799
ASPH aspartate beta-hydroxylase -0.028029
EML4 echinoderm microtubule associated protein like 4 -0.0279892
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0278418
ZNF638 zinc finger protein 638 -0.0274493
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0274031
ZHX2 zinc fingers and homeoboxes 2 -0.0273991
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.027379
SESTD1 SEC14 and spectrin domains 1 -0.0273519
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0269155
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0265397
KDM3A lysine (K)-specific demethylase 3A -0.0261713
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0259982
KDM4C lysine (K)-specific demethylase 4C -0.0259694
PARD3 par-3 family cell polarity regulator -0.0255036
PTCHD4 patched domain containing 4 -0.0254852
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0247598
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0245547
APOA2 apolipoprotein A-II -0.0244559
NPAS2 neuronal PAS domain protein 2 -0.0239478
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.023754
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0235491
TAS2R14 taste receptor, type 2, member 14 -0.0234442
PTPRK protein tyrosine phosphatase, receptor type, K -0.0234343
FAM13A family with sequence similarity 13, member A -0.0232976
PTPRM protein tyrosine phosphatase, receptor type, M -0.0229157
PICALM phosphatidylinositol binding clathrin assembly protein -0.0226243
ZMYND8 zinc finger, MYND-type containing 8 -0.022319
TMEM181 transmembrane protein 181 -0.0222967
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0222631
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0222439
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0221197
MALT1 MALT1 paracaspase -0.0220229
KDM7A lysine (K)-specific demethylase 7A -0.0219595
TNRC6B trinucleotide repeat containing 6B -0.0218107
ATP10A ATPase, class V, type 10A -0.0216716
CCNY cyclin Y -0.0216178
FOXP1 forkhead box P1 -0.0212987
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0209726
CNKSR3 CNKSR family member 3 -0.0208394
GPHN gephyrin -0.0207473
DTNA dystrobrevin, alpha -0.0207349
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -0.0205613
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0204987
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0204238
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0199086
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0199066
OSBPL10 oxysterol binding protein-like 10 -0.0195472
BIRC6 baculoviral IAP repeat containing 6 -0.0194308
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0193645
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0193505
AMBP alpha-1-microglobulin/bikunin precursor -0.0193479
ZNF292 zinc finger protein 292 -0.0191226
RAD51B RAD51 paralog B -0.0190762
TMEM123 transmembrane protein 123 -0.0190082
WSB1 WD repeat and SOCS box containing 1 -0.0188812
DENND1A DENN/MADD domain containing 1A -0.018869
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0188361