Verteporfin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verteporfin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verteporfin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0780728
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0547744
TNS4 tensin 4 0.053596
GOLGA4 golgin A4 0.0382991
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0338782
TXNIP thioredoxin interacting protein 0.0300262
FAT1 FAT atypical cadherin 1 0.0293061
FAM13A family with sequence similarity 13, member A 0.0286075
DSPP dentin sialophosphoprotein 0.0236457
TMF1 TATA element modulatory factor 1 0.0215975
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.02085
UBA6 ubiquitin-like modifier activating enzyme 6 0.0202009
KIF5B kinesin family member 5B 0.0201337
NDRG1 N-myc downstream regulated 1 0.0195896
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0187104
EHF ets homologous factor 0.0186448
CENPF centromere protein F, 350/400kDa 0.0182591
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0179934
DSCAM Down syndrome cell adhesion molecule 0.0178541
DDIT4 DNA-damage-inducible transcript 4 0.0175261
TPM3 tropomyosin 3 0.0171945
ESYT2 extended synaptotagmin-like protein 2 0.0165137
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.016
SRP54 signal recognition particle 54kDa 0.0157998
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0157266
RPS2 ribosomal protein S2 0.0154623
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0150568
ZNF292 zinc finger protein 292 0.015003
SRRM1 serine/arginine repetitive matrix 1 0.0147109
BMP4 bone morphogenetic protein 4 0.0146766
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0146649
ACBD3 acyl-CoA binding domain containing 3 0.0146356
PNN pinin, desmosome associated protein 0.0142347
DERA deoxyribose-phosphate aldolase (putative) 0.0140587
YBX1 Y box binding protein 1 0.0138717
GPA33 glycoprotein A33 (transmembrane) 0.0137908
RBM39 RNA binding motif protein 39 0.0133115
MLEC malectin 0.0131886
FOSL1 FOS-like antigen 1 0.0131873
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0129779
DSG2 desmoglein 2 0.0121801
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0119345
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0119147
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0118539
RSRC2 arginine/serine-rich coiled-coil 2 0.0118389
EZR ezrin 0.0118358
NBAS neuroblastoma amplified sequence 0.0115119
HMGB2 high mobility group box 2 0.0115011
HMGA1 high mobility group AT-hook 1 0.0114386
GOLGA2 golgin A2 0.0113919
SCFD1 sec1 family domain containing 1 0.0113875
EXOC1 exocyst complex component 1 0.0113782
LMAN1 lectin, mannose-binding, 1 0.0112611
BIRC6 baculoviral IAP repeat containing 6 0.0112432
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0111384
DGKD diacylglycerol kinase, delta 130kDa 0.0111143
MBNL2 muscleblind-like splicing regulator 2 0.0110842
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0110669
AKAP9 A kinase (PRKA) anchor protein 9 0.0109782
LRRC1 leucine rich repeat containing 1 0.0108869
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.010864
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0104618
CSNK1A1 casein kinase 1, alpha 1 0.0103759
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.010309
PRPF4B pre-mRNA processing factor 4B 0.0102221
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0102151
SUCO SUN domain containing ossification factor 0.0101915
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0101184
TLN1 talin 1 0.0101078
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.010098
SLK STE20-like kinase 0.0100718
NCOR1 nuclear receptor corepressor 1 0.010052
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0100067
ABHD17C abhydrolase domain containing 17C 0.00999106
MON2 MON2 homolog (S. cerevisiae) 0.00993692
PLEK2 pleckstrin 2 0.00975585
PRRC2C proline-rich coiled-coil 2C 0.00974649
ABHD2 abhydrolase domain containing 2 0.00968759
EIF4B eukaryotic translation initiation factor 4B 0.0096449
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.00962756
KLF3 Kruppel-like factor 3 (basic) 0.00957225
DUSP4 dual specificity phosphatase 4 0.00945115
SNX13 sorting nexin 13 0.00944189
RNMT RNA (guanine-7-) methyltransferase 0.0093426
AFF4 AF4/FMR2 family, member 4 0.00930968
GIGYF2 GRB10 interacting GYF protein 2 0.00926437
YTHDC1 YTH domain containing 1 0.00925646
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.00925576
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.00917978
KDM2A lysine (K)-specific demethylase 2A 0.00902033
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.00899213
KIAA0040 KIAA0040 0.00890046
ITPRID2 ITPR interacting domain containing 2 0.00888104
FERMT1 fermitin family member 1 0.00885661
XPC xeroderma pigmentosum, complementation group C 0.00884358
EMP1 epithelial membrane protein 1 0.00884137
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00878962
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.00861959
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.00851766
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.008496

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.276648
TPT1 tumor protein, translationally-controlled 1 -0.18981
PTMA prothymosin, alpha -0.137313
TMSB10 thymosin beta 10 -0.127565
RPL35A ribosomal protein L35a -0.0805152
ACTG1 actin gamma 1 -0.075245
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0722865
GMDS GDP-mannose 4,6-dehydratase -0.0713314
RPS8 ribosomal protein S8 -0.0692935
RPS6 ribosomal protein S6 -0.0684208
RPLP1 ribosomal protein, large, P1 -0.0673386
VCL vinculin -0.0624252
RPL34 ribosomal protein L34 -0.0578573
RPS24 ribosomal protein S24 -0.0548447
RPS23 ribosomal protein S23 -0.0545494
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.053106
ONECUT3 one cut homeobox 3 -0.0519398
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0510132
RPL31 ribosomal protein L31 -0.0504545
FTL ferritin, light polypeptide -0.0495982
RPLP2 ribosomal protein, large, P2 -0.0491961
RPS29 ribosomal protein S29 -0.0485994
RPS27A ribosomal protein S27a -0.0485529
RPS25 ribosomal protein S25 -0.047497
RPS13 ribosomal protein S13 -0.0469609
S100A10 S100 calcium binding protein A10 -0.0425106
AHNAK AHNAK nucleoprotein -0.0422294
PKM pyruvate kinase, muscle -0.0409849
EXT1 exostosin glycosyltransferase 1 -0.0409336
MT2A metallothionein 2A -0.0400926
RPS11 ribosomal protein S11 -0.0400158
NPSR1 neuropeptide S receptor 1 -0.0399455
RPS19 ribosomal protein S19 -0.0392291
RPL8 ribosomal protein L8 -0.0387987
RPL9 ribosomal protein L9 -0.038387
RPL7A ribosomal protein L7a -0.0383778
MYO1E myosin IE -0.0383223
RPL19 ribosomal protein L19 -0.0374578
IER3 immediate early response 3 -0.0371559
GPHN gephyrin -0.037084
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0368785
FHIT fragile histidine triad -0.0366687
RPS21 ribosomal protein S21 -0.0351353
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0342305
RPL23 ribosomal protein L23 -0.0338979
RPLP0 ribosomal protein, large, P0 -0.0337585
RPL37A ribosomal protein L37a -0.0334889
ALCAM activated leukocyte cell adhesion molecule -0.0333326
NALF1 NALCN channel auxiliary factor 1 -0.0325143
RPL28 ribosomal protein L28 -0.03233
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0315562
RPL12 ribosomal protein L12 -0.0314816
RPL27A ribosomal protein L27a -0.0310256
RPL38 ribosomal protein L38 -0.0303992
PTPRK protein tyrosine phosphatase, receptor type, K -0.0303978
RPL32 ribosomal protein L32 -0.0299272
S100A9 S100 calcium binding protein A9 -0.0292076
SMYD3 SET and MYND domain containing 3 -0.0286345
RPS15 ribosomal protein S15 -0.0282751
RPS14 ribosomal protein S14 -0.0282454
PGK1 phosphoglycerate kinase 1 -0.0278836
PDE4D phosphodiesterase 4D, cAMP-specific -0.0275784
FBXO11 F-box protein 11 -0.0275505
B2M beta-2-microglobulin -0.0268053
RPL36 ribosomal protein L36 -0.0266773
RPL5 ribosomal protein L5 -0.0265982
RPS5 ribosomal protein S5 -0.0263057
AGR2 anterior gradient 2 -0.0262899
RPL36A ribosomal protein L36a -0.0261826
RPL11 ribosomal protein L11 -0.0257892
TPM4 tropomyosin 4 -0.0257738
S100A6 S100 calcium binding protein A6 -0.0256772
CEMIP cell migration inducing protein, hyaluronan binding -0.0254226
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0253928
RPL15 ribosomal protein L15 -0.0250434
DEK DEK proto-oncogene -0.0249254
UBC ubiquitin C -0.0248273
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0244849
TFF1 trefoil factor 1 -0.0244483
MAML3 mastermind-like 3 (Drosophila) -0.0241408
RPS10 ribosomal protein S10 -0.0239865
RPS16 ribosomal protein S16 -0.0233999
CCSER1 coiled-coil serine-rich protein 1 -0.022845
ACTN4 actinin, alpha 4 -0.0227487
DIAPH2 diaphanous-related formin 2 -0.0225024
KPNB1 karyopherin (importin) beta 1 -0.0223696
RPS12 ribosomal protein S12 -0.0222929
POTEF POTE ankyrin domain family, member F -0.0222738
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0218782
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0217931
ZBTB20 zinc finger and BTB domain containing 20 -0.0217928
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0215949
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0213024
KRT8 keratin 8, type II -0.0209517
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.020934
RPS17 ribosomal protein S17 -0.0208131
MYH14 myosin, heavy chain 14, non-muscle -0.0207136
EIF1 eukaryotic translation initiation factor 1 -0.0206777
RPS27 ribosomal protein S27 -0.0205879
MYO1D myosin ID -0.0205565