Verteporfin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verteporfin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verteporfin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.095423
ERRFI1 ERBB receptor feedback inhibitor 1 0.0823317
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0769904
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0615962
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0572719
EZR ezrin 0.0520599
RAI1 retinoic acid induced 1 0.0484128
EREG epiregulin 0.0481497
TM4SF1 transmembrane 4 L six family member 1 0.0453802
BCAR3 breast cancer anti-estrogen resistance 3 0.0418635
EGR1 early growth response 1 0.0397072
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0386203
CXCL8 chemokine (C-X-C motif) ligand 8 0.0317197
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0290252
KLF6 Kruppel-like factor 6 0.0285272
ANXA1 annexin A1 0.0279261
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0273383
CENPF centromere protein F, 350/400kDa 0.0272095
KTN1 kinectin 1 (kinesin receptor) 0.0270331
SET SET nuclear proto-oncogene 0.0238066
ANGPTL4 angiopoietin-like 4 0.0237447
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0224401
EIF3A eukaryotic translation initiation factor 3, subunit A 0.02188
SYAP1 synapse associated protein 1 0.0217211
SRRM2 serine/arginine repetitive matrix 2 0.0206812
MKI67 marker of proliferation Ki-67 0.0202896
RTN4 reticulon 4 0.0197256
TPM4 tropomyosin 4 0.0196823
JUN jun proto-oncogene 0.0196142
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0191771
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0189302
BIRC2 baculoviral IAP repeat containing 2 0.0186458
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0179679
PRRC2C proline-rich coiled-coil 2C 0.0178051
GOLGA4 golgin A4 0.0175127
CAPRIN2 caprin family member 2 0.0173426
CSNK1A1 casein kinase 1, alpha 1 0.017226
TMEM41B transmembrane protein 41B 0.0171943
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0165615
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0164764
RBM25 RNA binding motif protein 25 0.0163284
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0160172
KMT2E lysine (K)-specific methyltransferase 2E 0.0155621
FOSL1 FOS-like antigen 1 0.0150871
ANTXR2 anthrax toxin receptor 2 0.0149263
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0145245
MYH9 myosin, heavy chain 9, non-muscle 0.0144819
PNN pinin, desmosome associated protein 0.0144396
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0144016
SGK1 serum/glucocorticoid regulated kinase 1 0.0141563
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0138288
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0136226
SRGN serglycin 0.0127479
JMJD1C jumonji domain containing 1C 0.0125917
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0123964
NAMPT nicotinamide phosphoribosyltransferase 0.0123451
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0120186
CAPN2 calpain 2, (m/II) large subunit 0.0119708
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0119511
CALR calreticulin 0.011829
EIF5B eukaryotic translation initiation factor 5B 0.0118285
IER2 immediate early response 2 0.0117499
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0116886
SRSF4 serine/arginine-rich splicing factor 4 0.0116691
CDCP1 CUB domain containing protein 1 0.0115945
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0114297
WDR43 WD repeat domain 43 0.011408
RAB27B RAB27B, member RAS oncogene family 0.0113513
RGS4 regulator of G-protein signaling 4 0.0113315
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0110423
MSN moesin 0.0109771
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 0.010928
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0109268
HLA-B major histocompatibility complex, class I, B 0.0105529
APLP2 amyloid beta (A4) precursor-like protein 2 0.0105433
BMERB1 bMERB domain containing 1 0.010507
TMF1 TATA element modulatory factor 1 0.0104532
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0103779
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0103591
LMAN1 lectin, mannose-binding, 1 0.0103108
ARHGAP5 Rho GTPase activating protein 5 0.0101931
MYADM myeloid-associated differentiation marker 0.0100877
SDC4 syndecan 4 0.0100665
BCLAF1 BCL2-associated transcription factor 1 0.0100179
ZBTB38 zinc finger and BTB domain containing 38 0.00998209
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00993408
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.00990925
FHL2 four and a half LIM domains 2 0.00972533
RSRC2 arginine/serine-rich coiled-coil 2 0.00967576
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00964209
VMP1 vacuole membrane protein 1 0.00964189
PCBP1 poly(rC) binding protein 1 0.0095624
MAT2A methionine adenosyltransferase II, alpha 0.00954309
GPATCH2L G patch domain containing 2-like 0.00946542
TOP1 topoisomerase (DNA) I 0.00943896
CCDC47 coiled-coil domain containing 47 0.00941625
MACF1 microtubule-actin crosslinking factor 1 0.00940678
DYNC2I1 dynein 2 intermediate chain 1 0.00939056
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0093768
HJURP Holliday junction recognition protein 0.00936591

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.277609
MT2A metallothionein 2A -0.111968
TMSB10 thymosin beta 10 -0.104285
PTMA prothymosin, alpha -0.0853319
VIM vimentin -0.0830566
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0525386
CADM2 cell adhesion molecule 2 -0.0507363
WSB1 WD repeat and SOCS box containing 1 -0.0464549
TMSB4X thymosin beta 4, X-linked -0.0461141
FTL ferritin, light polypeptide -0.0459008
TP63 tumor protein p63 -0.0445176
PGK1 phosphoglycerate kinase 1 -0.0429527
FMNL2 formin-like 2 -0.0420447
DST dystonin -0.0410789
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0409222
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0404154
RPL35A ribosomal protein L35a -0.0378688
AHNAK AHNAK nucleoprotein -0.0370581
TPT1 tumor protein, translationally-controlled 1 -0.0354858
MT1E metallothionein 1E -0.0325507
DLG1 discs, large homolog 1 (Drosophila) -0.0315365
TSC22D1 TSC22 domain family, member 1 -0.0310079
RPS19 ribosomal protein S19 -0.0306972
TNS3 tensin 3 -0.0306765
POTEF POTE ankyrin domain family, member F -0.0298581
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0278859
RPS24 ribosomal protein S24 -0.0272124
GARS1 glycyl-tRNA synthetase 1 -0.0271548
TRIO trio Rho guanine nucleotide exchange factor -0.0268278
DPYD dihydropyrimidine dehydrogenase -0.0266499
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.026559
RPL19 ribosomal protein L19 -0.0264824
RPS3 ribosomal protein S3 -0.0262865
RPL12 ribosomal protein L12 -0.0258175
RPL31 ribosomal protein L31 -0.0249558
PIAS2 protein inhibitor of activated STAT, 2 -0.024899
EFNA5 ephrin-A5 -0.0243514
ENO1 enolase 1, (alpha) -0.0242086
RPL36 ribosomal protein L36 -0.0240985
RPLP1 ribosomal protein, large, P1 -0.0230735
LPP LIM domain containing preferred translocation partner in lipoma -0.0229829
IFITM1 interferon induced transmembrane protein 1 -0.0224687
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0222958
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0221726
APP amyloid beta (A4) precursor protein -0.0219721
EPHA4 EPH receptor A4 -0.0219014
ENO2 enolase 2 (gamma, neuronal) -0.0217514
ANKRD11 ankyrin repeat domain 11 -0.0217116
PTK2 protein tyrosine kinase 2 -0.021462
RPL28 ribosomal protein L28 -0.0210347
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0208679
EXOC4 exocyst complex component 4 -0.0205177
ZFAND3 zinc finger, AN1-type domain 3 -0.020361
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0202837
RPS23 ribosomal protein S23 -0.0196051
RPS8 ribosomal protein S8 -0.0195632
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0195041
RNF213 ring finger protein 213 -0.0194791
TPI1 triosephosphate isomerase 1 -0.0192811
RAD51B RAD51 paralog B -0.0190824
RPLP2 ribosomal protein, large, P2 -0.0189163
ACTG1 actin gamma 1 -0.0188815
UBC ubiquitin C -0.0184206
CSMD3 CUB and Sushi multiple domains 3 -0.0183298
MT1X metallothionein 1X -0.0181706
GNAS GNAS complex locus -0.0181128
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0180753
RPL26 ribosomal protein L26 -0.0180498
KMT2C lysine (K)-specific methyltransferase 2C -0.0180323
RPL5 ribosomal protein L5 -0.01801
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0179065
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0178665
EIF4A1 eukaryotic translation initiation factor 4A1 -0.017814
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0176247
RAB7A RAB7A, member RAS oncogene family -0.017485
RPS14 ribosomal protein S14 -0.0173522
KDM3A lysine (K)-specific demethylase 3A -0.0173409
QKI QKI, KH domain containing, RNA binding -0.0172703
RPS27A ribosomal protein S27a -0.0170886
RPS13 ribosomal protein S13 -0.0169682
FUS FUS RNA binding protein -0.0168435
PKM pyruvate kinase, muscle -0.0168274
STRN3 striatin, calmodulin binding protein 3 -0.0168106
OLA1 Obg-like ATPase 1 -0.0167913
PRELID2 PRELI domain containing 2 -0.0167154
KDM4C lysine (K)-specific demethylase 4C -0.0167055
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0167046
ADGRG6 adhesion G protein-coupled receptor G6 -0.0166988
RPL34 ribosomal protein L34 -0.0166203
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0164263
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.016407
FAM162A family with sequence similarity 162, member A -0.0162972
ZNF217 zinc finger protein 217 -0.0161719
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0161348
FNDC3B fibronectin type III domain containing 3B -0.0161086
MARCHF6 membrane associated ring-CH-type finger 6 -0.0161046
RPS15 ribosomal protein S15 -0.0160437
SMYD3 SET and MYND domain containing 3 -0.0159805
NAP1L1 nucleosome assembly protein 1-like 1 -0.0159567
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0159308