Verteporfin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verteporfin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verteporfin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0815772
NDRG1 N-myc downstream regulated 1 0.0648284
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0625427
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0477264
EGR1 early growth response 1 0.0405459
UBA6 ubiquitin-like modifier activating enzyme 6 0.0369693
FAM13A family with sequence similarity 13, member A 0.0336132
KMT2E lysine (K)-specific methyltransferase 2E 0.0329293
ARRDC3 arrestin domain containing 3 0.0328367
HILPDA hypoxia inducible lipid droplet-associated 0.0282972
MSN moesin 0.0282206
SRRM2 serine/arginine repetitive matrix 2 0.0264539
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.025275
PCBP2 poly(rC) binding protein 2 0.0241953
STC1 stanniocalcin 1 0.0230815
GOLGA4 golgin A4 0.022375
HYOU1 hypoxia up-regulated 1 0.0215994
MYH9 myosin, heavy chain 9, non-muscle 0.0209583
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0204559
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0202679
ANKRD37 ankyrin repeat domain 37 0.0202029
MCL1 myeloid cell leukemia 1 0.0197173
LAMC2 laminin, gamma 2 0.019692
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0192337
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0188184
DDIT4 DNA-damage-inducible transcript 4 0.0187291
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0186611
TSC22D2 TSC22 domain family, member 2 0.0183852
RPS6 ribosomal protein S6 0.0178238
MKI67 marker of proliferation Ki-67 0.0175234
ATP13A3 ATPase type 13A3 0.017189
WASF2 WAS protein family, member 2 0.0168502
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0157926
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0157714
RSRC2 arginine/serine-rich coiled-coil 2 0.0156498
BRD2 bromodomain containing 2 0.0155965
PNN pinin, desmosome associated protein 0.0155399
SRP54 signal recognition particle 54kDa 0.0152684
SPAG9 sperm associated antigen 9 0.0151467
MIDEAS mitotic deacetylase associated SANT domain protein 0.0148905
GIGYF2 GRB10 interacting GYF protein 2 0.0148293
APLP2 amyloid beta (A4) precursor-like protein 2 0.0147267
CSNK1E casein kinase 1, epsilon 0.0143765
NUP58 nucleoporin 58 0.0142841
ADAM17 ADAM metallopeptidase domain 17 0.0142256
FOSL1 FOS-like antigen 1 0.0141426
RAB7A RAB7A, member RAS oncogene family 0.0139319
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0136187
TPM3 tropomyosin 3 0.0134528
HDGF hepatoma-derived growth factor 0.013335
CCNL1 cyclin L1 0.0133316
PDIA3 protein disulfide isomerase family A, member 3 0.0132584
RNASEH2A ribonuclease H2, subunit A 0.013151
RPS12 ribosomal protein S12 0.0131097
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0129376
SNX9 sorting nexin 9 0.0128708
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0127243
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0126685
HMGA1 high mobility group AT-hook 1 0.0126292
BCL9L B-cell CLL/lymphoma 9-like 0.0126262
PTMA prothymosin, alpha 0.0126044
NGLY1 N-glycanase 1 0.0125383
RBM25 RNA binding motif protein 25 0.0125257
AKAP12 A kinase (PRKA) anchor protein 12 0.0124891
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0123918
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0123606
VEZT vezatin, adherens junctions transmembrane protein 0.0123575
RNMT RNA (guanine-7-) methyltransferase 0.0122624
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0122112
KTN1 kinectin 1 (kinesin receptor) 0.0121978
ATF4 activating transcription factor 4 0.0118209
PCBP1 poly(rC) binding protein 1 0.0117608
TM9SF3 transmembrane 9 superfamily member 3 0.01173
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0116866
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0116772
SETD5 SET domain containing 5 0.0116747
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.011626
SOS2 son of sevenless homolog 2 (Drosophila) 0.011399
ANXA5 annexin A5 0.0113627
PDIA6 protein disulfide isomerase family A, member 6 0.0113552
VIM vimentin 0.0113551
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0111985
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0111902
TOM1 target of myb1 (chicken) 0.011069
CAMTA1 calmodulin binding transcription activator 1 0.010981
RAB6A RAB6A, member RAS oncogene family 0.0108761
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0108732
CYLD cylindromatosis (turban tumor syndrome) 0.0107787
INSIG2 insulin induced gene 2 0.010653
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0105878
TNIP1 TNFAIP3 interacting protein 1 0.0105567
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.0104975
SMAD4 SMAD family member 4 0.0104725
RNF149 ring finger protein 149 0.0104073
ZFC3H1 zinc finger, C3H1-type containing 0.010353
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0101365
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0101242
ACBD3 acyl-CoA binding domain containing 3 0.0101203
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0101063
DUSP5 dual specificity phosphatase 5 0.0100439

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148713
EGFR epidermal growth factor receptor -0.147781
ASPH aspartate beta-hydroxylase -0.0917733
LMO7 LIM domain 7 -0.0792422
TPT1 tumor protein, translationally-controlled 1 -0.072461
TXNRD1 thioredoxin reductase 1 -0.0708341
AHNAK AHNAK nucleoprotein -0.0605795
LRP1B low density lipoprotein receptor-related protein 1B -0.0543037
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0539545
OSMR oncostatin M receptor -0.0538905
PTPRM protein tyrosine phosphatase, receptor type, M -0.0533761
EFNA5 ephrin-A5 -0.0504893
H1-0 H1.0 linker histone -0.0491863
PATJ PATJ crumbs cell polarity complex component -0.0490821
ANXA2 annexin A2 -0.0488675
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0474109
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0471199
CAV1 caveolin 1, caveolae protein, 22kDa -0.0469579
THSD4 thrombospondin, type I, domain containing 4 -0.0456165
ANKRD10 ankyrin repeat domain 10 -0.0453031
PGK1 phosphoglycerate kinase 1 -0.0448685
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0445737
TMSB10 thymosin beta 10 -0.0426578
PDE4D phosphodiesterase 4D, cAMP-specific -0.0421712
ZBTB20 zinc finger and BTB domain containing 20 -0.0407098
SLTM SAFB-like, transcription modulator -0.03832
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0379608
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0377765
HDLBP high density lipoprotein binding protein -0.0375232
MYOF myoferlin -0.0375109
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0355358
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0354963
CANX calnexin -0.0351348
AKR1C1 aldo-keto reductase family 1, member C1 -0.034995
ARHGAP32 Rho GTPase activating protein 32 -0.0346727
SMYD3 SET and MYND domain containing 3 -0.0344851
DSCAM Down syndrome cell adhesion molecule -0.0344781
DOCK5 dedicator of cytokinesis 5 -0.034316
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0335397
TBC1D22A TBC1 domain family, member 22A -0.0335323
UGDH UDP-glucose 6-dehydrogenase -0.0334021
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.033386
USP34 ubiquitin specific peptidase 34 -0.0326179
LPP LIM domain containing preferred translocation partner in lipoma -0.032436
PKM pyruvate kinase, muscle -0.0324224
EXT1 exostosin glycosyltransferase 1 -0.0322769
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.031768
RNF213 ring finger protein 213 -0.0315624
INTS6 integrator complex subunit 6 -0.0314742
ELL2 elongation factor, RNA polymerase II, 2 -0.0311176
NABP1 nucleic acid binding protein 1 -0.0310694
TRAPPC9 trafficking protein particle complex 9 -0.0309012
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0308044
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0304148
ABLIM1 actin binding LIM protein 1 -0.0303606
GM2A GM2 ganglioside activator -0.029865
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0296097
RAB10 RAB10, member RAS oncogene family -0.0293424
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0291961
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0284221
TES testin LIM domain protein -0.0281218
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0279063
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.027556
SLC38A1 solute carrier family 38, member 1 -0.0271028
RPS24 ribosomal protein S24 -0.0269395
HBP1 HMG-box transcription factor 1 -0.0268239
DOCK1 dedicator of cytokinesis 1 -0.0265819
KDM3A lysine (K)-specific demethylase 3A -0.0265628
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0265044
MCTP1 multiple C2 domains, transmembrane 1 -0.0265031
MAML3 mastermind-like 3 (Drosophila) -0.0260492
SLC38A2 solute carrier family 38, member 2 -0.0258033
RAB1A RAB1A, member RAS oncogene family -0.0257893
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0253312
FOXP1 forkhead box P1 -0.0250786
AGO2 argonaute RISC catalytic component 2 -0.024925
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0247867
RPL35A ribosomal protein L35a -0.0246481
NCOA3 nuclear receptor coactivator 3 -0.0246104
RIMS2 regulating synaptic membrane exocytosis 2 -0.0244285
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0243384
IGF1R insulin-like growth factor 1 receptor -0.0242703
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0239275
UBC ubiquitin C -0.0237905
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0237869
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0235815
VCL vinculin -0.0235617
NAMPT nicotinamide phosphoribosyltransferase -0.0234764
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.02329
TMCO3 transmembrane and coiled-coil domains 3 -0.0232403
MGST1 microsomal glutathione S-transferase 1 -0.02319
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0231174
SUMF1 sulfatase modifying factor 1 -0.0230742
LRP12 low density lipoprotein receptor-related protein 12 -0.0229016
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0228708
SOD2 superoxide dismutase 2, mitochondrial -0.0226093
GRAMD1B GRAM domain containing 1B -0.0223741
ACTG1 actin gamma 1 -0.0223382
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0222144
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0221896