Verteporfin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verteporfin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verteporfin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) 0.0835767
AKAP12 A kinase (PRKA) anchor protein 12 0.0701301
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0614401
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0553678
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0516173
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0351176
NAMPT nicotinamide phosphoribosyltransferase 0.0319221
TGM2 transglutaminase 2 0.031096
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0301324
NPC1 Niemann-Pick disease, type C1 0.0297879
NAV2 neuron navigator 2 0.0275106
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0257429
HAS2 hyaluronan synthase 2 0.0255446
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0244822
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0236351
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0231748
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0230288
CDCP1 CUB domain containing protein 1 0.022816
ANTXR2 anthrax toxin receptor 2 0.0216235
RAB27B RAB27B, member RAS oncogene family 0.0210468
ARHGAP5 Rho GTPase activating protein 5 0.0208685
CENPF centromere protein F, 350/400kDa 0.0206292
BIRC3 baculoviral IAP repeat containing 3 0.0206183
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0205537
STK38L serine/threonine kinase 38 like 0.0203501
EGFR epidermal growth factor receptor 0.0198156
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0191136
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0189395
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0187989
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0182434
NRP1 neuropilin 1 0.0178538
ZEB2 zinc finger E-box binding homeobox 2 0.0170667
FNDC3B fibronectin type III domain containing 3B 0.01665
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0162975
CEP95 centrosomal protein 95kDa 0.0159895
DOCK5 dedicator of cytokinesis 5 0.0158424
PNN pinin, desmosome associated protein 0.0157406
ANKRD36 ankyrin repeat domain 36 0.0154242
MKI67 marker of proliferation Ki-67 0.015249
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0151179
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0150459
SRP54 signal recognition particle 54kDa 0.0149734
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0147983
SAMD4A sterile alpha motif domain containing 4A 0.01475
OSMR oncostatin M receptor 0.0145406
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0144418
KTN1 kinectin 1 (kinesin receptor) 0.0143594
LUZP1 leucine zipper protein 1 0.0142836
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0141377
VMP1 vacuole membrane protein 1 0.014129
IFI44 interferon-induced protein 44 0.0137374
MSN moesin 0.0132403
HMGA1 high mobility group AT-hook 1 0.0132388
DST dystonin 0.0131114
STAT1 signal transducer and activator of transcription 1, 91kDa 0.012835
RBM25 RNA binding motif protein 25 0.0124166
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0123458
SLFN5 schlafen family member 5 0.012303
DUSP5 dual specificity phosphatase 5 0.0122375
PELI1 pellino E3 ubiquitin protein ligase 1 0.0120097
BMAL2 basic helix-loop-helix ARNT like 2 0.0119142
RUNX1 runt-related transcription factor 1 0.0117011
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0114411
SDK1 sidekick cell adhesion molecule 1 0.0113768
MYO1E myosin IE 0.0112596
KLF6 Kruppel-like factor 6 0.0112411
ADD3 adducin 3 (gamma) 0.0111427
CENPE centromere protein E, 312kDa 0.0110791
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0109771
PLSCR1 phospholipid scramblase 1 0.0108488
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0108127
GIGYF2 GRB10 interacting GYF protein 2 0.0106569
GPAT3 glycerol-3-phosphate acyltransferase 3 0.010579
IL6ST interleukin 6 signal transducer 0.0105214
GPATCH2L G patch domain containing 2-like 0.0104895
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0104658
ARRDC3 arrestin domain containing 3 0.0104448
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0102844
ERRFI1 ERBB receptor feedback inhibitor 1 0.010274
NRG4 neuregulin 4 0.0101834
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0101688
MYH9 myosin, heavy chain 9, non-muscle 0.0101685
WWTR1 WW domain containing transcription regulator 1 0.0101499
ANGPTL4 angiopoietin-like 4 0.010122
HIPK3 homeodomain interacting protein kinase 3 0.0100928
TMF1 TATA element modulatory factor 1 0.00990159
APLP2 amyloid beta (A4) precursor-like protein 2 0.00988232
MAP1B microtubule-associated protein 1B 0.00988122
ITGAV integrin, alpha V 0.00982754
TBC1D15 TBC1 domain family, member 15 0.00979868
CKAP2L cytoskeleton associated protein 2-like 0.00969781
YEATS2 YEATS domain containing 2 0.00960304
CAPN2 calpain 2, (m/II) large subunit 0.00957112
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.00953131
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.00942827
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.00935018
SCAF11 SR-related CTD-associated factor 11 0.00926991
RNF19B ring finger protein 19B 0.00920055
SRRM2 serine/arginine repetitive matrix 2 0.0088738
NUCB2 nucleobindin 2 0.00885942

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188306
TMSB10 thymosin beta 10 -0.110622
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.102012
PDE4D phosphodiesterase 4D, cAMP-specific -0.0808585
FTL ferritin, light polypeptide -0.0760008
VIM vimentin -0.0705789
KDM3A lysine (K)-specific demethylase 3A -0.0621958
RAB1A RAB1A, member RAS oncogene family -0.0583981
RPLP1 ribosomal protein, large, P1 -0.0517063
PTMA prothymosin, alpha -0.0481934
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0476278
IER3 immediate early response 3 -0.0451545
NAP1L1 nucleosome assembly protein 1-like 1 -0.0446918
TPT1 tumor protein, translationally-controlled 1 -0.0445496
PARD3 par-3 family cell polarity regulator -0.0360568
RPS19 ribosomal protein S19 -0.0360064
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0342335
RPL32 ribosomal protein L32 -0.0340838
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0333406
WAC WW domain containing adaptor with coiled-coil -0.0322288
RPL35A ribosomal protein L35a -0.032225
RPLP0 ribosomal protein, large, P0 -0.0313022
PGK1 phosphoglycerate kinase 1 -0.030912
EIF1 eukaryotic translation initiation factor 1 -0.0309053
USP3 ubiquitin specific peptidase 3 -0.0308472
BASP1 brain abundant, membrane attached signal protein 1 -0.0308184
FTH1 ferritin, heavy polypeptide 1 -0.030604
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0305162
GNAS GNAS complex locus -0.0303155
RPS24 ribosomal protein S24 -0.0301386
RPS29 ribosomal protein S29 -0.0301094
WDR45B WD repeat domain 45B -0.0288361
RPL34 ribosomal protein L34 -0.0285799
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0281961
RPS8 ribosomal protein S8 -0.0278847
RIOK3 RIO kinase 3 -0.0275708
LOX lysyl oxidase -0.0275131
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0271486
RPL23 ribosomal protein L23 -0.0271335
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0271225
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0270933
USP34 ubiquitin specific peptidase 34 -0.026828
RPL19 ribosomal protein L19 -0.0267461
S100A10 S100 calcium binding protein A10 -0.026633
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0263703
S100A6 S100 calcium binding protein A6 -0.0262487
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0262185
PKM pyruvate kinase, muscle -0.026021
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0260196
DDIT3 DNA-damage-inducible transcript 3 -0.0258963
TMEM263 transmembrane protein 263 -0.0256903
ENO1 enolase 1, (alpha) -0.0256155
WSB1 WD repeat and SOCS box containing 1 -0.0255197
RPS13 ribosomal protein S13 -0.0254765
RLF rearranged L-myc fusion -0.0248445
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0248421
RPS3 ribosomal protein S3 -0.0244834
RPL36 ribosomal protein L36 -0.0243738
GARS1 glycyl-tRNA synthetase 1 -0.0243558
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0238882
RPL11 ribosomal protein L11 -0.0233798
UBC ubiquitin C -0.0232943
RPL37 ribosomal protein L37 -0.022854
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0228236
RPL31 ribosomal protein L31 -0.0226565
TFPI2 tissue factor pathway inhibitor 2 -0.0221503
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0221204
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0221012
C15ORF48 chromosome 15 open reading frame 48 -0.0220705
RPL37A ribosomal protein L37a -0.0219651
RPS16 ribosomal protein S16 -0.0217346
RPLP2 ribosomal protein, large, P2 -0.021559
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0214512
RPS23 ribosomal protein S23 -0.0212129
RPS21 ribosomal protein S21 -0.0208131
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.020687
MARCHF6 membrane associated ring-CH-type finger 6 -0.0204804
FN1 fibronectin 1 -0.02039
CCNY cyclin Y -0.0203213
RPS25 ribosomal protein S25 -0.0202543
FOXO3 forkhead box O3 -0.0202349
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0202176
RPS5 ribosomal protein S5 -0.0201864
RPL27A ribosomal protein L27a -0.0201056
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0200599
ANKRD11 ankyrin repeat domain 11 -0.0199626
RPL12 ribosomal protein L12 -0.0199451
LDHA lactate dehydrogenase A -0.0198526
PSD3 pleckstrin and Sec7 domain containing 3 -0.0197885
ZFAND3 zinc finger, AN1-type domain 3 -0.0197376
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0197103
RPL28 ribosomal protein L28 -0.0196912
QKI QKI, KH domain containing, RNA binding -0.0191408
AHNAK AHNAK nucleoprotein -0.0189257
VDAC1 voltage-dependent anion channel 1 -0.0186935
GLCCI1 glucocorticoid induced 1 -0.0186727
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0185568
S100A9 S100 calcium binding protein A9 -0.0185062
LOC112694756 uncharaterized LOC112694756 -0.0184777
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0184707