Verteporfin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verteporfin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verteporfin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.107207
PDE4B phosphodiesterase 4B, cAMP-specific 0.0932632
CPED1 cadherin-like and PC-esterase domain containing 1 0.0743966
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0724672
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0721584
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0657998
EGFR epidermal growth factor receptor 0.0517407
TJP1 tight junction protein 1 0.0426112
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0414255
ANXA1 annexin A1 0.040273
SOX6 SRY (sex determining region Y)-box 6 0.0399143
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0393166
LPP LIM domain containing preferred translocation partner in lipoma 0.0381792
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0376942
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.037498
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0359154
PDGFC platelet derived growth factor C 0.0338461
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0325508
RRBP1 ribosome binding protein 1 0.0314282
TAS2R14 taste receptor, type 2, member 14 0.0307082
BMP2K BMP2 inducible kinase 0.0304698
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0303956
HDAC9 histone deacetylase 9 0.0300098
ZEB1 zinc finger E-box binding homeobox 1 0.0297641
NCEH1 neutral cholesterol ester hydrolase 1 0.0290747
FLNB filamin B, beta 0.0280945
RSRC2 arginine/serine-rich coiled-coil 2 0.0279519
KIF5B kinesin family member 5B 0.0276684
NPAS2 neuronal PAS domain protein 2 0.0269814
RBM39 RNA binding motif protein 39 0.0269238
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0268207
CEP95 centrosomal protein 95kDa 0.0262308
TMEM65 transmembrane protein 65 0.0256819
MYOF myoferlin 0.0253828
EVI5 ecotropic viral integration site 5 0.0253054
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0247362
GOLGA4 golgin A4 0.0243807
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0243446
SMNDC1 survival motor neuron domain containing 1 0.0243128
PYGB phosphorylase, glycogen; brain 0.0242641
NBEA neurobeachin 0.0235393
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0235006
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0228055
CANX calnexin 0.0225262
MKI67 marker of proliferation Ki-67 0.0221221
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0219747
ANKRD17 ankyrin repeat domain 17 0.0212644
FOXP1 forkhead box P1 0.0209216
OGA O-GlcNAcase 0.0206522
PHF3 PHD finger protein 3 0.0204441
TMF1 TATA element modulatory factor 1 0.0201332
NEBL nebulette 0.0200501
SLC38A2 solute carrier family 38, member 2 0.0199025
SAMD4A sterile alpha motif domain containing 4A 0.0194084
NT5C2 5'-nucleotidase, cytosolic II 0.0192563
NARS1 asparaginyl-tRNA synthetase 1 0.0191003
PUM3 pumilio RNA binding family member 3 0.0191
TGFBR3 transforming growth factor, beta receptor III 0.0190333
FNBP4 formin binding protein 4 0.0189394
TM9SF3 transmembrane 9 superfamily member 3 0.0188051
MYO5A myosin VA (heavy chain 12, myoxin) 0.0186612
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.018094
CAMKMT calmodulin-lysine N-methyltransferase 0.017411
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0174012
IQGAP1 IQ motif containing GTPase activating protein 1 0.0171354
ZNF608 zinc finger protein 608 0.0171246
TMEM39A transmembrane protein 39A 0.0170552
GOLGB1 golgin B1 0.0169774
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0169588
EZR ezrin 0.0168714
GLI2 GLI family zinc finger 2 0.0167545
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0167406
HMGB2 high mobility group box 2 0.0164677
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0163812
KLF6 Kruppel-like factor 6 0.0163078
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0162673
LMCD1 LIM and cysteine-rich domains 1 0.0162427
CALR calreticulin 0.0156409
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0153379
FAM114A1 family with sequence similarity 114, member A1 0.015221
CDK13 cyclin-dependent kinase 13 0.0151638
SET SET nuclear proto-oncogene 0.0149339
RPS2 ribosomal protein S2 0.0149157
PLXNA1 plexin A1 0.0149077
ZC3H11A zinc finger CCCH-type containing 11A 0.0147323
EFNA5 ephrin-A5 0.0146307
NDE1 nudE neurodevelopment protein 1 0.0145615
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.0145306
CHD1 chromodomain helicase DNA binding protein 1 0.0143715
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.014322
ZFC3H1 zinc finger, C3H1-type containing 0.0142507
HEG1 heart development protein with EGF-like domains 1 0.0142054
SEPTIN11 septin 11 0.0142045
PRPF38B pre-mRNA processing factor 38B 0.0141958
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0141829
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0141514
FBXO34 F-box protein 34 0.0141039
UNC13A unc-13 homolog A (C. elegans) 0.0140098
ANLN anillin, actin binding protein 0.0140051
IRX2 iroquois homeobox 2 0.0138948

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.379016
PKM pyruvate kinase, muscle -0.0721012
TPT1 tumor protein, translationally-controlled 1 -0.0635926
ACTG1 actin gamma 1 -0.0501176
RPS23 ribosomal protein S23 -0.0490987
POTEF POTE ankyrin domain family, member F -0.0483803
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0482086
RPS8 ribosomal protein S8 -0.0456048
TMSB10 thymosin beta 10 -0.0440234
RPL31 ribosomal protein L31 -0.0419994
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0414882
PFN1 profilin 1 -0.040964
B2M beta-2-microglobulin -0.0384758
RPS13 ribosomal protein S13 -0.0375528
RPL32 ribosomal protein L32 -0.0366077
RPL19 ribosomal protein L19 -0.0364928
RPL35A ribosomal protein L35a -0.0363368
RPLP1 ribosomal protein, large, P1 -0.0349448
RPL8 ribosomal protein L8 -0.0343433
RPL11 ribosomal protein L11 -0.0339947
S100A9 S100 calcium binding protein A9 -0.0334675
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0319326
IFI16 interferon, gamma-inducible protein 16 -0.0309711
RPS11 ribosomal protein S11 -0.0309455
GARS1 glycyl-tRNA synthetase 1 -0.0306724
ENO2 enolase 2 (gamma, neuronal) -0.0306177
MT2A metallothionein 2A -0.0305736
RPL5 ribosomal protein L5 -0.0305005
RPL28 ribosomal protein L28 -0.0300117
RPS25 ribosomal protein S25 -0.0290937
RPS19 ribosomal protein S19 -0.0289358
PTMA prothymosin, alpha -0.0286732
RPS15 ribosomal protein S15 -0.0285283
RPS6 ribosomal protein S6 -0.0282349
PRDX2 peroxiredoxin 2 -0.0280049
RPLP2 ribosomal protein, large, P2 -0.027673
UBC ubiquitin C -0.0276556
RPS29 ribosomal protein S29 -0.0274978
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0265673
ZNF292 zinc finger protein 292 -0.0265565
HSPB1 heat shock 27kDa protein 1 -0.026389
RPL37A ribosomal protein L37a -0.0262659
S100A6 S100 calcium binding protein A6 -0.0259554
CCNL1 cyclin L1 -0.0253412
FTL ferritin, light polypeptide -0.0248918
PCBP2 poly(rC) binding protein 2 -0.0247066
RPS5 ribosomal protein S5 -0.0246679
RPLP0 ribosomal protein, large, P0 -0.0244764
ECT2 epithelial cell transforming 2 -0.0240776
EIF1 eukaryotic translation initiation factor 1 -0.0240254
RPL12 ribosomal protein L12 -0.0239412
RTN4 reticulon 4 -0.0238983
RPS21 ribosomal protein S21 -0.0238006
PGK1 phosphoglycerate kinase 1 -0.0236927
S100A10 S100 calcium binding protein A10 -0.023532
ENO1 enolase 1, (alpha) -0.0234991
NAMPT nicotinamide phosphoribosyltransferase -0.0233376
PHIP pleckstrin homology domain interacting protein -0.0231584
ZNF609 zinc finger protein 609 -0.0223584
DLG1 discs, large homolog 1 (Drosophila) -0.0223349
AKAP9 A kinase (PRKA) anchor protein 9 -0.0221044
OLA1 Obg-like ATPase 1 -0.0219648
ATP5F1E ATP synthase F1 subunit epsilon -0.0214121
LOC112694756 uncharaterized LOC112694756 -0.0212537
USP3 ubiquitin specific peptidase 3 -0.0212451
KMT2E lysine (K)-specific methyltransferase 2E -0.0211573
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0210254
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0209433
S100A4 S100 calcium binding protein A4 -0.0207699
SEPTIN7 septin 7 -0.0207584
RPL36 ribosomal protein L36 -0.0202795
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0201479
WSB1 WD repeat and SOCS box containing 1 -0.0201212
ZNF638 zinc finger protein 638 -0.019613
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0194638
RABGAP1L RAB GTPase activating protein 1-like -0.0194086
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0194066
RPS12 ribosomal protein S12 -0.019128
ZMYM2 zinc finger, MYM-type 2 -0.0190553
KDM3A lysine (K)-specific demethylase 3A -0.0189247
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0189118
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0186713
DIAPH2 diaphanous-related formin 2 -0.0186472
BCAS3 breast carcinoma amplified sequence 3 -0.0186388
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0184527
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0182769
RPL9 ribosomal protein L9 -0.0182341
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0180738
TBK1 TANK-binding kinase 1 -0.0178746
FAM13A family with sequence similarity 13, member A -0.0174459
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0173905
RPL38 ribosomal protein L38 -0.0172814
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.017213
S100A11 S100 calcium binding protein A11 -0.0169543
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0165723
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0165438
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0164543
SSBP2 single-stranded DNA binding protein 2 -0.0163929
FAM162A family with sequence similarity 162, member A -0.0163339
DSTN destrin (actin depolymerizing factor) -0.0163085