Verteporfin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Verteporfin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Verteporfin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.133736
NAMPT nicotinamide phosphoribosyltransferase 0.123267
MYH9 myosin, heavy chain 9, non-muscle 0.119256
FN1 fibronectin 1 0.0942488
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0901253
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0839603
VIM vimentin 0.0828073
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0778044
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0644743
MSN moesin 0.0641239
RPS6 ribosomal protein S6 0.0612392
EGR1 early growth response 1 0.0594572
MKI67 marker of proliferation Ki-67 0.0576581
CD44 CD44 molecule (Indian blood group) 0.0557268
EEF2 eukaryotic translation elongation factor 2 0.0544414
CENPF centromere protein F, 350/400kDa 0.0525755
TOP2A topoisomerase (DNA) II alpha 170kDa 0.052269
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0521634
UGCG UDP-glucose ceramide glucosyltransferase 0.0512689
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0498166
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0494627
PTMA prothymosin, alpha 0.0449423
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.043913
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0420568
KLF6 Kruppel-like factor 6 0.0398553
TPM4 tropomyosin 4 0.0398458
VMP1 vacuole membrane protein 1 0.0396243
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0387868
AKAP12 A kinase (PRKA) anchor protein 12 0.0385065
JUN jun proto-oncogene 0.0380167
ELL2 elongation factor, RNA polymerase II, 2 0.0379982
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0365008
RPS12 ribosomal protein S12 0.0341558
RTN4 reticulon 4 0.0340657
SOD2 superoxide dismutase 2, mitochondrial 0.0338621
FTH1 ferritin, heavy polypeptide 1 0.0337957
YBX1 Y box binding protein 1 0.0334661
ICAM1 intercellular adhesion molecule 1 0.0333854
IER2 immediate early response 2 0.0321937
LDHA lactate dehydrogenase A 0.0318532
TPM3 tropomyosin 3 0.0318085
HLA-E major histocompatibility complex, class I, E 0.0316315
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0316113
DSTN destrin (actin depolymerizing factor) 0.0315049
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0307068
HLA-B major histocompatibility complex, class I, B 0.0303692
CCNL1 cyclin L1 0.0290539
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0287385
ARRDC3 arrestin domain containing 3 0.0286956
ANLN anillin, actin binding protein 0.0285853
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0280678
SRRM2 serine/arginine repetitive matrix 2 0.0279341
STC1 stanniocalcin 1 0.0270822
PCBP2 poly(rC) binding protein 2 0.0269953
TM9SF3 transmembrane 9 superfamily member 3 0.0261177
EZR ezrin 0.0256687
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0255628
GOLGA4 golgin A4 0.025525
LAMP2 lysosomal-associated membrane protein 2 0.0254127
TNIP1 TNFAIP3 interacting protein 1 0.0252816
NONO non-POU domain containing, octamer-binding 0.0250988
TNNC1 troponin C type 1 (slow) 0.0245177
LIMA1 LIM domain and actin binding 1 0.0243227
SNX3 sorting nexin 3 0.023836
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0237794
EEF1G eukaryotic translation elongation factor 1 gamma 0.0236865
SDC4 syndecan 4 0.0233621
CKAP5 cytoskeleton associated protein 5 0.0232326
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0228101
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0226344
HMGA1 high mobility group AT-hook 1 0.0225116
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0224946
IPO7 importin 7 0.022368
RB1CC1 RB1-inducible coiled-coil 1 0.0220171
KTN1 kinectin 1 (kinesin receptor) 0.0220026
TXNRD1 thioredoxin reductase 1 0.021951
SET SET nuclear proto-oncogene 0.0218993
RPL26 ribosomal protein L26 0.0218551
BCLAF1 BCL2-associated transcription factor 1 0.0218217
RSRC2 arginine/serine-rich coiled-coil 2 0.0217931
RPS2 ribosomal protein S2 0.0217453
WEE1 WEE1 G2 checkpoint kinase 0.0216492
ACTN1 actinin, alpha 1 0.0215882
CALD1 caldesmon 1 0.0214824
RPL23 ribosomal protein L23 0.0214505
TMF1 TATA element modulatory factor 1 0.0212486
OPTN optineurin 0.0210137
DUSP5 dual specificity phosphatase 5 0.0209244
TPX2 TPX2, microtubule-associated 0.0207064
ERRFI1 ERBB receptor feedback inhibitor 1 0.020422
EIF1 eukaryotic translation initiation factor 1 0.0203597
LCORL ligand dependent nuclear receptor corepressor-like 0.0202933
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0202156
SFTPA2 surfactant protein A2 0.0201887
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0199818
MATR3 matrin 3 0.0196212
SPAG9 sperm associated antigen 9 0.0194873
ARF4 ADP-ribosylation factor 4 0.0193999
FLNA filamin A, alpha 0.019379
CENPE centromere protein E, 312kDa 0.0192509

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.0967651
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0943312
GLIS3 GLIS family zinc finger 3 -0.0845872
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0802035
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0798968
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0759072
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0712546
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0629634
TRIO trio Rho guanine nucleotide exchange factor -0.0617823
SDK1 sidekick cell adhesion molecule 1 -0.0598315
DIAPH2 diaphanous-related formin 2 -0.058908
CADM1 cell adhesion molecule 1 -0.0586595
FNDC3B fibronectin type III domain containing 3B -0.0577699
HMGA2 high mobility group AT-hook 2 -0.0574376
EXT1 exostosin glycosyltransferase 1 -0.055603
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0555487
CDH13 cadherin 13 -0.0541588
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0519593
ATXN1 ataxin 1 -0.0456914
SMYD3 SET and MYND domain containing 3 -0.0455567
IER3 immediate early response 3 -0.0447418
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0414998
ZFAND3 zinc finger, AN1-type domain 3 -0.0402662
TNS3 tensin 3 -0.0389862
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0380036
RAD51B RAD51 paralog B -0.0378008
INTS6 integrator complex subunit 6 -0.0371115
FRMD4A FERM domain containing 4A -0.0368427
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0361781
COL5A1 collagen, type V, alpha 1 -0.0360303
PGK1 phosphoglycerate kinase 1 -0.035953
PTPRK protein tyrosine phosphatase, receptor type, K -0.0355795
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0345026
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0324972
EFNA5 ephrin-A5 -0.0315458
TPT1 tumor protein, translationally-controlled 1 -0.0314468
KYNU kynureninase -0.0311808
ZMYND8 zinc finger, MYND-type containing 8 -0.0309425
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0305767
TMSB10 thymosin beta 10 -0.0300318
PHF21A PHD finger protein 21A -0.0298821
TMEM132D transmembrane protein 132D -0.0297846
PRELID2 PRELI domain containing 2 -0.0297662
BNC2 basonuclin 2 -0.0294713
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0293905
RAI14 retinoic acid induced 14 -0.0288466
RUNX1 runt-related transcription factor 1 -0.0269226
BICC1 BicC family RNA binding protein 1 -0.0268324
PRKCA protein kinase C, alpha -0.02662
SLC35F3 solute carrier family 35, member F3 -0.0266152
DLG1 discs, large homolog 1 (Drosophila) -0.026404
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0260525
MBD5 methyl-CpG binding domain protein 5 -0.0260074
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0257393
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0251635
FMNL2 formin-like 2 -0.0250823
TBC1D22A TBC1 domain family, member 22A -0.0250059
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0248972
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0247409
NCKAP5 NCK-associated protein 5 -0.0243524
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0242518
COL6A3 collagen, type VI, alpha 3 -0.0241544
FBXL7 F-box and leucine-rich repeat protein 7 -0.024016
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0233978
AFF3 AF4/FMR2 family, member 3 -0.0233485
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0232014
EGFR epidermal growth factor receptor -0.0230551
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0230437
WSB1 WD repeat and SOCS box containing 1 -0.0228774
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0228205
RNF213 ring finger protein 213 -0.0225509
ADAM12 ADAM metallopeptidase domain 12 -0.0223256
DENND1A DENN/MADD domain containing 1A -0.0220581
ZNF638 zinc finger protein 638 -0.0217655
MAML2 mastermind-like 2 (Drosophila) -0.021761
AUTS2 autism susceptibility candidate 2 -0.0216462
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0216192
ZHX2 zinc fingers and homeoboxes 2 -0.0214961
AHNAK AHNAK nucleoprotein -0.0214164
EPAS1 endothelial PAS domain protein 1 -0.0213795
KDM4C lysine (K)-specific demethylase 4C -0.0213409
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0212981
PRR16 proline rich 16 -0.0211604
PSD3 pleckstrin and Sec7 domain containing 3 -0.0211527
BACE2 beta-site APP-cleaving enzyme 2 -0.0211284
SOX5 SRY (sex determining region Y)-box 5 -0.0207916
IGFBP3 insulin-like growth factor binding protein 3 -0.0204584
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0202499
ARFGEF3 ARFGEF family member 3 -0.0200975
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0200632
LPP LIM domain containing preferred translocation partner in lipoma -0.0200367
KMT2C lysine (K)-specific methyltransferase 2C -0.0196467
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0195926
SMAD3 SMAD family member 3 -0.0194268
FRMPD4 FERM and PDZ domain containing 4 -0.0194044
RAB7A RAB7A, member RAS oncogene family -0.0193864
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.019307
JARID2 jumonji, AT rich interactive domain 2 -0.0189334
CUX1 cut-like homeobox 1 -0.0188023
MMP12 matrix metallopeptidase 12 -0.0187967