Vibrio cholerae infection Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Cholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-chain (CTXB) binds to ganglioside GM1 on the surface of the host's cells. After binding takes place, the entire CTX complex is carried from plasma membrane (PM) to endoplasmic reticulum (ER). In the ER, the A-chain (CTXA) is recognized by protein disulfide isomerase (PDI), unfolded, and delivered to the membrane where the membrane-associated ER-oxidase, Ero1, oxidizes PDI to release the CTXA into the protein-conducting channel, Sec61. CTXA is then retro-translocated to the cytosol and induces water and electrolyte secretion by increasing cAMP levels via adenylate cyclase (AC) to exert toxicity. Other than CTX, Vibrio cholerae generates several toxins that are perilous to eukaryotic cells. Zonula occludens toxin (ZOT) causes tight junction disruption through protein kinase C-dependent actin polymerization. RTX toxin (RtxA) causes actin depolymerization by covalently cross-linking actin monomers into dimers, trimers, and higher multimers. Vibrio cholerae cytolysin (VCC) is an important pore-forming toxin. The assembly of VCC anion channels in cells cause vacuolization and lysis. (Kyoto Encyclopedia of Genes and Genomes, hsa05110)
External Link https://www.kegg.jp/entry/hsa05110
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Genes

49 proteins participating in the Vibrio cholerae infection pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACTG1 actin gamma 1
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ARF1 ADP-ribosylation factor 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
ERO1A endoplasmic reticulum oxidoreductase 1 alpha
GNAS GNAS complex locus
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
PDIA4 protein disulfide isomerase family A, member 4
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POTEF POTE ankyrin domain family, member F
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SEC61B Sec61 beta subunit
SEC61G Sec61 gamma subunit
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TJP1 tight junction protein 1
TJP2 tight junction protein 2