Vilanterol_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vilanterol perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vilanterol_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.147786
TLE4 transducin-like enhancer of split 4 0.106716
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.104894
ZSWIM6 zinc finger, SWIM-type containing 6 0.0970388
TPST1 tyrosylprotein sulfotransferase 1 0.0827549
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0786314
FMN1 formin 1 0.0683196
RPL23 ribosomal protein L23 0.062817
FNDC3A fibronectin type III domain containing 3A 0.0577513
MEIS2 Meis homeobox 2 0.0553016
GLCCI1 glucocorticoid induced 1 0.0532448
RPS6 ribosomal protein S6 0.0511315
ACTG1 actin gamma 1 0.0467741
KLHL13 kelch-like family member 13 0.0442417
PLPP1 phospholipid phosphatase 1 0.0434793
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0429493
EXT1 exostosin glycosyltransferase 1 0.0409371
MED13 mediator complex subunit 13 0.0407615
PDE10A phosphodiesterase 10A 0.0393398
TPT1 tumor protein, translationally-controlled 1 0.0378251
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0372993
SIK2 salt-inducible kinase 2 0.0371674
EIF1 eukaryotic translation initiation factor 1 0.0360523
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0359562
STK38L serine/threonine kinase 38 like 0.0357817
RIGI RNA sensor RIG-I 0.0346439
EEF2 eukaryotic translation elongation factor 2 0.0342671
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0337826
STAT1 signal transducer and activator of transcription 1, 91kDa 0.033246
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0327014
THBS1 thrombospondin 1 0.0315382
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0314996
FERMT2 fermitin family member 2 0.0312586
TBX2 T-box 2 0.0302086
VMP1 vacuole membrane protein 1 0.0293474
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0289344
RPS12 ribosomal protein S12 0.0289035
FAM107B family with sequence similarity 107, member B 0.0281529
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0280434
TRIO trio Rho guanine nucleotide exchange factor 0.0278275
PDLIM5 PDZ and LIM domain 5 0.0273472
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0273418
RAP1B RAP1B, member of RAS oncogene family 0.026497
MRTFA myocardin related transcription factor A 0.0256894
RPL26 ribosomal protein L26 0.0253757
TPM1 tropomyosin 1 (alpha) 0.0253754
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0250488
DSCAM Down syndrome cell adhesion molecule 0.0250365
SYT1 synaptotagmin I 0.0250166
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0245419
BPTF bromodomain PHD finger transcription factor 0.0242475
CTNND1 catenin (cadherin-associated protein), delta 1 0.0238546
GAB2 GRB2-associated binding protein 2 0.0237224
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0237146
SET SET nuclear proto-oncogene 0.0236353
MYO1E myosin IE 0.0225462
RPS29 ribosomal protein S29 0.021841
SP100 SP100 nuclear antigen 0.0217597
RPS8 ribosomal protein S8 0.0217194
AMOTL1 angiomotin like 1 0.0217076
PTPRK protein tyrosine phosphatase, receptor type, K 0.0215749
SYNPO2 synaptopodin 2 0.0214607
MYO6 myosin VI 0.0214401
KLF6 Kruppel-like factor 6 0.0210464
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0210174
NPAS2 neuronal PAS domain protein 2 0.0207699
RPS2 ribosomal protein S2 0.0206843
CUL3 cullin 3 0.0205343
RBM39 RNA binding motif protein 39 0.0201895
LPIN1 lipin 1 0.0199161
FOXO3 forkhead box O3 0.0196645
RPL11 ribosomal protein L11 0.0195862
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0194718
RACK1 receptor for activated C kinase 1 0.0191765
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0190415
WNK1 WNK lysine deficient protein kinase 1 0.0190176
IL6ST interleukin 6 signal transducer 0.0187349
ANKRD17 ankyrin repeat domain 17 0.0183968
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0183552
FHL2 four and a half LIM domains 2 0.0183499
MBNL1 muscleblind-like splicing regulator 1 0.0182297
RPS27A ribosomal protein S27a 0.0180547
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.017984
ADGRB3 adhesion G protein-coupled receptor B3 0.0179599
RAB10 RAB10, member RAS oncogene family 0.0179092
RPLP0 ribosomal protein, large, P0 0.0177896
RPS27 ribosomal protein S27 0.0177821
INTS6 integrator complex subunit 6 0.017768
SENP6 SUMO1/sentrin specific peptidase 6 0.0177022
IRS1 insulin receptor substrate 1 0.0173852
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0172638
GATA3 GATA binding protein 3 0.0171909
GRK5 G protein-coupled receptor kinase 5 0.0169317
ITGAV integrin, alpha V 0.0168999
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.016883
RORA RAR-related orphan receptor A 0.0168353
RPL34 ribosomal protein L34 0.0167015
RPL35A ribosomal protein L35a 0.0166316
MED13L mediator complex subunit 13-like 0.0165745
PNISR PNN-interacting serine/arginine-rich protein 0.016565

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.179476
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.153458
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0619199
AKAP12 A kinase (PRKA) anchor protein 12 -0.0573553
NDRG1 N-myc downstream regulated 1 -0.0533067
LIMCH1 LIM and calponin homology domains 1 -0.0488042
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0468577
MEF2A myocyte enhancer factor 2A -0.045739
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0454844
GDF15 growth differentiation factor 15 -0.0449459
MAML2 mastermind-like 2 (Drosophila) -0.0422567
GPC5 glypican 5 -0.0422122
IGF2 insulin-like growth factor 2 -0.036659
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0362132
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0361069
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.035716
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0356102
MAP1B microtubule-associated protein 1B -0.0327586
ZBTB20 zinc finger and BTB domain containing 20 -0.0322181
FAM13A family with sequence similarity 13, member A -0.0319578
COPA coatomer protein complex, subunit alpha -0.0315271
STC1 stanniocalcin 1 -0.0313677
GOLGA4 golgin A4 -0.0300133
WDR45B WD repeat domain 45B -0.0287514
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.027083
MTSS2 MTSS I-BAR domain containing 2 -0.0265857
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0248723
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.024489
CDH13 cadherin 13 -0.02439
COL4A5 collagen, type IV, alpha 5 -0.0241998
SOS1 son of sevenless homolog 1 (Drosophila) -0.0238539
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0232891
SETD5 SET domain containing 5 -0.0227297
HMGA2 high mobility group AT-hook 2 -0.0227181
CENPF centromere protein F, 350/400kDa -0.0226147
COL6A1 collagen, type VI, alpha 1 -0.022592
PKM pyruvate kinase, muscle -0.0223859
PTMA prothymosin, alpha -0.0219746
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0218489
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0214631
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0207643
CLINT1 clathrin interactor 1 -0.0206531
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0206338
USP34 ubiquitin specific peptidase 34 -0.0204344
FKBP1A FK506 binding protein 1A, 12kDa -0.020424
CEMIP cell migration inducing protein, hyaluronan binding -0.0203483
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0202812
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0202776
KPNB1 karyopherin (importin) beta 1 -0.0201832
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0193076
RPTOR regulatory associated protein of MTOR, complex 1 -0.0193068
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0192825
CADM2 cell adhesion molecule 2 -0.0191039
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0189218
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0184057
MSI2 musashi RNA-binding protein 2 -0.0183445
ZNF292 zinc finger protein 292 -0.0181534
ACBD3 acyl-CoA binding domain containing 3 -0.0180786
RTN4 reticulon 4 -0.0179933
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0178896
DLC1 DLC1 Rho GTPase activating protein -0.0177941
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0176114
FTH1 ferritin, heavy polypeptide 1 -0.0173683
NUP58 nucleoporin 58 -0.0172841
PCDH9 protocadherin 9 -0.0172559
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0170156
ANGPT1 angiopoietin 1 -0.0169207
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0167647
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0166453
DLG1 discs, large homolog 1 (Drosophila) -0.0166116
HIP1 huntingtin interacting protein 1 -0.0165551
KDM5B lysine (K)-specific demethylase 5B -0.0164198
VIM vimentin -0.0164131
IARS1 isoleucyl-tRNA synthetase 1 -0.0162954
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0162188
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0161288
EPAS1 endothelial PAS domain protein 1 -0.0160177
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0158722
UBA6 ubiquitin-like modifier activating enzyme 6 -0.015794
RHOA ras homolog family member A -0.0157567
CADM1 cell adhesion molecule 1 -0.0157298
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0157062
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0156976
GCC2 GRIP and coiled-coil domain containing 2 -0.0156841
ADGRG6 adhesion G protein-coupled receptor G6 -0.0156505
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0155892
PLIN2 perilipin 2 -0.0155241
CRABP2 cellular retinoic acid binding protein 2 -0.0155214
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0154766
SEC63 SEC63 homolog (S. cerevisiae) -0.0154583
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0154112
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.015356
IGFBP3 insulin-like growth factor binding protein 3 -0.0153551
NBAS neuroblastoma amplified sequence -0.0153476
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0152902
AFF3 AF4/FMR2 family, member 3 -0.0151556
VEGFA vascular endothelial growth factor A -0.0151251
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0149243
C1ORF21 chromosome 1 open reading frame 21 -0.0148492
HELZ helicase with zinc finger -0.0147659