Vilanterol_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vilanterol perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vilanterol_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.12503
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.103038
B2M beta-2-microglobulin 0.102248
SPTBN1 spectrin, beta, non-erythrocytic 1 0.102243
LCN2 lipocalin 2 0.0837735
MACC1 metastasis associated in colon cancer 1 0.0823969
PTBP3 polypyrimidine tract binding protein 3 0.0751818
ERBIN erbb2 interacting protein 0.0716528
MYO1E myosin IE 0.0713463
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.062472
TMC5 transmembrane channel-like 5 0.0623963
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0549411
TXNIP thioredoxin interacting protein 0.0514951
EPS8 epidermal growth factor receptor pathway substrate 8 0.0504242
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0488064
EFNB2 ephrin-B2 0.0486174
AKAP13 A kinase (PRKA) anchor protein 13 0.0481618
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0459515
ITGA6 integrin, alpha 6 0.045524
ARGLU1 arginine and glutamate rich 1 0.0448315
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0442391
ZNF292 zinc finger protein 292 0.0434268
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0425492
IFI6 interferon, alpha-inducible protein 6 0.0412316
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0408755
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.04067
ENO1 enolase 1, (alpha) 0.0399128
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0396704
TRIM2 tripartite motif containing 2 0.0393979
RPS6 ribosomal protein S6 0.0392595
KLF5 Kruppel-like factor 5 (intestinal) 0.038816
SMAD3 SMAD family member 3 0.0382657
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0378932
UBC ubiquitin C 0.0357716
MAP7 microtubule-associated protein 7 0.0356645
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0349252
N4BP2L2 NEDD4 binding protein 2-like 2 0.0342909
MED13 mediator complex subunit 13 0.0340264
SOX9 SRY (sex determining region Y)-box 9 0.033718
FNDC3B fibronectin type III domain containing 3B 0.0332717
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0329267
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0325587
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0325127
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0319211
RUNX1 runt-related transcription factor 1 0.0318317
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0312745
LIMA1 LIM domain and actin binding 1 0.0312524
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0308011
AREG amphiregulin 0.0305671
ETV6 ets variant 6 0.0301688
SON SON DNA binding protein 0.0300699
BCL2L1 BCL2-like 1 0.0297489
TM9SF2 transmembrane 9 superfamily member 2 0.0296019
RBM47 RNA binding motif protein 47 0.0295854
TJP1 tight junction protein 1 0.029264
IFNGR1 interferon gamma receptor 1 0.0292371
CTNND1 catenin (cadherin-associated protein), delta 1 0.0286869
PDZD8 PDZ domain containing 8 0.0286839
PKM pyruvate kinase, muscle 0.0285284
KLF6 Kruppel-like factor 6 0.0283014
ZMYM2 zinc finger, MYM-type 2 0.0280704
FMN1 formin 1 0.0279402
YAP1 Yes-associated protein 1 0.0279358
EIF1 eukaryotic translation initiation factor 1 0.0275564
STK24 serine/threonine kinase 24 0.0271352
BAIAP2L1 BAI1-associated protein 2-like 1 0.0269824
PRSS3 protease, serine, 3 0.0268998
EHF ets homologous factor 0.0268346
ADAM10 ADAM metallopeptidase domain 10 0.0264589
IFI27 interferon, alpha-inducible protein 27 0.0264276
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0263954
ABHD2 abhydrolase domain containing 2 0.0257336
ARHGAP5 Rho GTPase activating protein 5 0.0254225
PDIA3 protein disulfide isomerase family A, member 3 0.0253556
DSCAM Down syndrome cell adhesion molecule 0.0253288
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0250765
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0250251
KYNU kynureninase 0.0249341
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.024738
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0245076
NPEPPS aminopeptidase puromycin sensitive 0.0237775
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0234682
RPS8 ribosomal protein S8 0.0227613
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0226669
DIAPH1 diaphanous-related formin 1 0.022416
EML4 echinoderm microtubule associated protein like 4 0.0223616
JAK1 Janus kinase 1 0.0223341
MCU mitochondrial calcium uniporter 0.0223151
SPATA13 spermatogenesis associated 13 0.0221531
MEIS2 Meis homeobox 2 0.0219731
TSC22D1 TSC22 domain family, member 1 0.0218702
IL20RA interleukin 20 receptor, alpha 0.0217296
ZFP36L1 ZFP36 ring finger protein-like 1 0.021696
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0216621
GPX2 glutathione peroxidase 2 0.0216446
HKDC1 hexokinase domain containing 1 0.0215732
RNF149 ring finger protein 149 0.0214101
AHI1 Abelson helper integration site 1 0.0213567
IRS2 insulin receptor substrate 2 0.0213091
RPL18 ribosomal protein L18 0.0208486

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0907078
LYZ lysozyme -0.0650733
SP100 SP100 nuclear antigen -0.053928
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0526962
INTS6 integrator complex subunit 6 -0.0514508
RNF213 ring finger protein 213 -0.0504112
MUC20 mucin 20, cell surface associated -0.0491125
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0470445
RIGI RNA sensor RIG-I -0.0448235
GMDS GDP-mannose 4,6-dehydratase -0.0405677
NPSR1 neuropeptide S receptor 1 -0.0381033
PLSCR2 phospholipid scramblase 2 -0.0376769
XAF1 XIAP associated factor 1 -0.0352938
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0327182
TRIO trio Rho guanine nucleotide exchange factor -0.0322436
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0308791
IGFBP3 insulin-like growth factor binding protein 3 -0.0288482
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0269545
EGR1 early growth response 1 -0.0269043
RAD51B RAD51 paralog B -0.0254683
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0249758
RAB7A RAB7A, member RAS oncogene family -0.0248371
HLA-E major histocompatibility complex, class I, E -0.0245131
RPS24 ribosomal protein S24 -0.0233921
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0227965
CANX calnexin -0.0222742
TM4SF1 transmembrane 4 L six family member 1 -0.0222427
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0221873
TBC1D22A TBC1 domain family, member 22A -0.0221559
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0221103
EPSTI1 epithelial stromal interaction 1 (breast) -0.0216238
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0210832
RPL31 ribosomal protein L31 -0.0199616
MMP7 matrix metallopeptidase 7 -0.0197742
POU2F2 POU class 2 homeobox 2 -0.0194211
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0193918
HM13 histocompatibility (minor) 13 -0.0185218
VIM vimentin -0.0176834
MX1 MX dynamin-like GTPase 1 -0.0175775
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0173192
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0172669
TNS4 tensin 4 -0.0164806
HMGB1 high mobility group box 1 -0.0163582
ANKRD10 ankyrin repeat domain 10 -0.0162932
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0161459
KPNB1 karyopherin (importin) beta 1 -0.015911
NDRG1 N-myc downstream regulated 1 -0.015336
PMP22 peripheral myelin protein 22 -0.0151618
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0150952
TAS2R14 taste receptor, type 2, member 14 -0.0150003
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0149228
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0147514
FUS FUS RNA binding protein -0.014409
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0142786
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.014244
FOSL1 FOS-like antigen 1 -0.0141399
S100A6 S100 calcium binding protein A6 -0.014082
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0140224
R3HDM2 R3H domain containing 2 -0.0139488
DENND1A DENN/MADD domain containing 1A -0.0138645
ACTG1 actin gamma 1 -0.0138375
CUX1 cut-like homeobox 1 -0.0138083
SAMD4A sterile alpha motif domain containing 4A -0.0136868
IER3 immediate early response 3 -0.0135548
FRMD5 FERM domain containing 5 -0.0134229
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0133685
SELENOS selenoprotein S -0.0133258
CCDC32 coiled-coil domain containing 32 -0.0132687
LRRC23 leucine rich repeat containing 23 -0.0132627
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0130677
AGR2 anterior gradient 2 -0.0129135
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0128775
IGF2 insulin-like growth factor 2 -0.0123886
FTH1 ferritin, heavy polypeptide 1 -0.0122038
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0121683
APOL6 apolipoprotein L, 6 -0.0121465
IARS1 isoleucyl-tRNA synthetase 1 -0.0119991
ADGRG1 adhesion G protein-coupled receptor G1 -0.0119334
HDLBP high density lipoprotein binding protein -0.0118886
BRI3BP BRI3 binding protein -0.0118715
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0117244
RPLP1 ribosomal protein, large, P1 -0.0115501
TPM4 tropomyosin 4 -0.0115444
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0115087
RPL38 ribosomal protein L38 -0.0114688
RPL7A ribosomal protein L7a -0.0114269
PATJ PATJ crumbs cell polarity complex component -0.0114219
TRIM25 tripartite motif containing 25 -0.0114122
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0113019
MAML2 mastermind-like 2 (Drosophila) -0.0112928
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0112146
VDAC1 voltage-dependent anion channel 1 -0.0112102
ZNFX1 zinc finger, NFX1-type containing 1 -0.0111469
USP18 ubiquitin specific peptidase 18 -0.0111068
MYO1D myosin ID -0.0110091
TUFT1 tuftelin 1 -0.0109027
FBXO39 F-box protein 39 -0.0108764
TRIM56 tripartite motif containing 56 -0.0108355
RPL5 ribosomal protein L5 -0.0108112
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0108033