Vilanterol_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vilanterol perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vilanterol_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.148717
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.102579
LMO7 LIM domain 7 0.101224
ENO1 enolase 1, (alpha) 0.0885055
ERRFI1 ERBB receptor feedback inhibitor 1 0.0823888
FAM13A family with sequence similarity 13, member A 0.0760566
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0739036
GRAMD1B GRAM domain containing 1B 0.0684677
TOP1 topoisomerase (DNA) I 0.0667398
PM20D1 peptidase M20 domain containing 1 0.0658966
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.065196
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0613954
JMJD1C jumonji domain containing 1C 0.0594784
CSNK1A1 casein kinase 1, alpha 1 0.0555604
BIRC3 baculoviral IAP repeat containing 3 0.055298
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0551673
GCLC glutamate-cysteine ligase, catalytic subunit 0.0551583
ELL2 elongation factor, RNA polymerase II, 2 0.0533909
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0532197
AKAP12 A kinase (PRKA) anchor protein 12 0.0529928
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.050041
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0498636
ARGLU1 arginine and glutamate rich 1 0.0490948
AREG amphiregulin 0.0476957
CXCL8 chemokine (C-X-C motif) ligand 8 0.0470886
DSPP dentin sialophosphoprotein 0.0464275
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0445878
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0434959
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0420162
NAMPT nicotinamide phosphoribosyltransferase 0.0419129
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0387648
MCL1 myeloid cell leukemia 1 0.0387363
IRS2 insulin receptor substrate 2 0.0383705
CAV1 caveolin 1, caveolae protein, 22kDa 0.0353108
FNDC3A fibronectin type III domain containing 3A 0.0344043
CEMIP cell migration inducing protein, hyaluronan binding 0.0331696
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0328453
TTC3 tetratricopeptide repeat domain 3 0.0325565
SPAG9 sperm associated antigen 9 0.0321919
BAIAP2L1 BAI1-associated protein 2-like 1 0.0318874
BCAR3 breast cancer anti-estrogen resistance 3 0.0318838
PDIA3 protein disulfide isomerase family A, member 3 0.0316899
RNF145 ring finger protein 145 0.0316097
ZNF638 zinc finger protein 638 0.0315621
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0308907
AKAP9 A kinase (PRKA) anchor protein 9 0.0308825
DSCAM Down syndrome cell adhesion molecule 0.0306814
SEC31A SEC31 homolog A (S. cerevisiae) 0.030596
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0302366
PDIA6 protein disulfide isomerase family A, member 6 0.0301976
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0300845
RPS12 ribosomal protein S12 0.0298724
STC1 stanniocalcin 1 0.0296386
ESYT2 extended synaptotagmin-like protein 2 0.0294083
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0294018
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0291631
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0291213
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0289349
MACF1 microtubule-actin crosslinking factor 1 0.0288246
NIPBL Nipped-B homolog (Drosophila) 0.0285074
BMP6 bone morphogenetic protein 6 0.0285054
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0282931
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0280091
IFI6 interferon, alpha-inducible protein 6 0.0276807
NSUN6 NOP2/Sun domain family, member 6 0.0275285
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0265639
TM9SF2 transmembrane 9 superfamily member 2 0.0264922
XRN2 5'-3' exoribonuclease 2 0.0264663
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0264262
SLC38A2 solute carrier family 38, member 2 0.0258201
SYAP1 synapse associated protein 1 0.0258098
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0257082
SLK STE20-like kinase 0.0251275
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0247786
ARRDC3 arrestin domain containing 3 0.0247518
YTHDC1 YTH domain containing 1 0.0241504
KMT2E lysine (K)-specific methyltransferase 2E 0.0241306
FBXO11 F-box protein 11 0.0238204
ANKRD12 ankyrin repeat domain 12 0.0237077
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0235726
FNDC3B fibronectin type III domain containing 3B 0.0235585
BZW1 basic leucine zipper and W2 domains 1 0.023376
DYNC2I1 dynein 2 intermediate chain 1 0.0233497
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0233272
CANX calnexin 0.023302
OGA O-GlcNAcase 0.0231314
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.02277
RPS2 ribosomal protein S2 0.0227152
GIGYF2 GRB10 interacting GYF protein 2 0.022586
GOLGA4 golgin A4 0.0225809
MYOF myoferlin 0.0224714
RAB1A RAB1A, member RAS oncogene family 0.022438
GOLGB1 golgin B1 0.0222674
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0220317
CD163L1 CD163 molecule-like 1 0.0220265
TPR translocated promoter region, nuclear basket protein 0.021263
DOCK5 dedicator of cytokinesis 5 0.0212204
KTN1 kinectin 1 (kinesin receptor) 0.0210171
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0210049
FNIP1 folliculin interacting protein 1 0.0209895

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.329025
ASPH aspartate beta-hydroxylase -0.171716
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.150202
PTPRM protein tyrosine phosphatase, receptor type, M -0.121258
FTH1 ferritin, heavy polypeptide 1 -0.0936598
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.087409
PKM pyruvate kinase, muscle -0.0826429
TMSB10 thymosin beta 10 -0.0783114
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0757423
THSD4 thrombospondin, type I, domain containing 4 -0.0739706
MT2A metallothionein 2A -0.0643166
NDRG1 N-myc downstream regulated 1 -0.0589325
PDLIM5 PDZ and LIM domain 5 -0.0543635
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.053472
LOC112694756 uncharaterized LOC112694756 -0.0511014
EGR1 early growth response 1 -0.0492694
RNF213 ring finger protein 213 -0.0452914
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0443828
NABP1 nucleic acid binding protein 1 -0.0429046
TNS3 tensin 3 -0.0427219
RPLP1 ribosomal protein, large, P1 -0.0416262
RPS24 ribosomal protein S24 -0.0404377
PATJ PATJ crumbs cell polarity complex component -0.0401112
MYO1D myosin ID -0.035648
LRP1B low density lipoprotein receptor-related protein 1B -0.0344106
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0343709
RPL35A ribosomal protein L35a -0.0335969
TRAF3 TNF receptor-associated factor 3 -0.0335528
CES1 carboxylesterase 1 -0.0331486
PTMA prothymosin, alpha -0.0317229
VCL vinculin -0.0311863
MCU mitochondrial calcium uniporter -0.0309388
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0301572
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0299433
SP100 SP100 nuclear antigen -0.0297207
SRRM2 serine/arginine repetitive matrix 2 -0.0291177
ADAM32 ADAM metallopeptidase domain 32 -0.0288113
GSK3B glycogen synthase kinase 3 beta -0.0283435
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0275161
ATG7 autophagy related 7 -0.0275033
SOD2 superoxide dismutase 2, mitochondrial -0.0273226
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0271382
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0270415
TAPBP TAP binding protein (tapasin) -0.0269794
CMIP c-Maf inducing protein -0.0267507
HMGA1 high mobility group AT-hook 1 -0.0266663
ZBTB20 zinc finger and BTB domain containing 20 -0.0261504
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0261419
MAML3 mastermind-like 3 (Drosophila) -0.0259324
MYH9 myosin, heavy chain 9, non-muscle -0.0255824
FOSL1 FOS-like antigen 1 -0.0254992
RPL30 ribosomal protein L30 -0.0248801
MAML2 mastermind-like 2 (Drosophila) -0.024779
FTL ferritin, light polypeptide -0.0242839
ADAR adenosine deaminase, RNA-specific -0.0241226
MGAT4C MGAT4 family, member C -0.0238201
TBC1D22A TBC1 domain family, member 22A -0.0236874
ABLIM1 actin binding LIM protein 1 -0.0235422
KRT8 keratin 8, type II -0.0230767
ANKRD10 ankyrin repeat domain 10 -0.022852
WASF2 WAS protein family, member 2 -0.0225699
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0224138
KCMF1 potassium channel modulatory factor 1 -0.0222187
PRKCA protein kinase C, alpha -0.0221587
HLA-B major histocompatibility complex, class I, B -0.0219164
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0219101
RPS25 ribosomal protein S25 -0.0218309
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0218264
LAMA5 laminin, alpha 5 -0.0212205
GM2A GM2 ganglioside activator -0.0210277
TXNRD1 thioredoxin reductase 1 -0.0207174
PTK2 protein tyrosine kinase 2 -0.0207005
RAB27B RAB27B, member RAS oncogene family -0.0206204
IGFBP3 insulin-like growth factor binding protein 3 -0.0203416
OSMR oncostatin M receptor -0.0202993
JUP junction plakoglobin -0.0202527
NDE1 nudE neurodevelopment protein 1 -0.0202215
SHB Src homology 2 domain containing adaptor protein B -0.020111
TRAPPC9 trafficking protein particle complex 9 -0.0200729
RPLP0 ribosomal protein, large, P0 -0.0200574
LGALS12 lectin, galactoside-binding, soluble, 12 -0.01994
TRIO trio Rho guanine nucleotide exchange factor -0.0197854
NPTN neuroplastin -0.0196457
NRIP1 nuclear receptor interacting protein 1 -0.019621
AGRN agrin -0.0195984
CDCP1 CUB domain containing protein 1 -0.0194035
EFNA5 ephrin-A5 -0.0193226
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -0.0193059
RPL31 ribosomal protein L31 -0.0191756
ADAM9 ADAM metallopeptidase domain 9 -0.0191317
WDR1 WD repeat domain 1 -0.0191132
LDHA lactate dehydrogenase A -0.0188328
GPC6 glypican 6 -0.0187577
SDC4 syndecan 4 -0.0187089
TJP1 tight junction protein 1 -0.0186612
MT1X metallothionein 1X -0.0186355
NF1 neurofibromin 1 -0.01857
F11R F11 receptor -0.0185359
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0180449
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0179262