Vilanterol_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vilanterol perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vilanterol_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.143662
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0820382
ZBTB38 zinc finger and BTB domain containing 38 0.0711528
STC1 stanniocalcin 1 0.069977
MT2A metallothionein 2A 0.0680468
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0622729
TPT1 tumor protein, translationally-controlled 1 0.0563298
KYNU kynureninase 0.0520115
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0482804
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0467953
HDAC9 histone deacetylase 9 0.0455697
RPS12 ribosomal protein S12 0.044533
ENO1 enolase 1, (alpha) 0.0421012
SQSTM1 sequestosome 1 0.0390257
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.035483
RPS6 ribosomal protein S6 0.0336079
HMGA2 high mobility group AT-hook 2 0.0335312
RND3 Rho family GTPase 3 0.0321634
IFI16 interferon, gamma-inducible protein 16 0.0320752
BPTF bromodomain PHD finger transcription factor 0.0310037
CTSB cathepsin B 0.0307533
HLA-B major histocompatibility complex, class I, B 0.0293068
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.029172
BICC1 BicC family RNA binding protein 1 0.0290458
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.029037
RPL37A ribosomal protein L37a 0.0289301
EIF1 eukaryotic translation initiation factor 1 0.0275852
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.026899
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0266099
MT1X metallothionein 1X 0.0258091
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0256892
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0256123
INHBA inhibin, beta A 0.0255688
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0255109
ARFGEF3 ARFGEF family member 3 0.0246788
RPS8 ribosomal protein S8 0.0241672
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0229598
SLC38A2 solute carrier family 38, member 2 0.0227838
DUSP5 dual specificity phosphatase 5 0.0223766
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0219623
ZSWIM6 zinc finger, SWIM-type containing 6 0.021938
TUT7 terminal uridylyl transferase 7 0.0216904
DOCK5 dedicator of cytokinesis 5 0.0215665
BACE2 beta-site APP-cleaving enzyme 2 0.0215106
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0214235
RPL23 ribosomal protein L23 0.0206009
RPL26 ribosomal protein L26 0.0205808
CRYBG3 beta-gamma crystallin domain containing 3 0.0203897
RPS3 ribosomal protein S3 0.0203599
ANKRD12 ankyrin repeat domain 12 0.0201627
INTS6 integrator complex subunit 6 0.0199517
ASPH aspartate beta-hydroxylase 0.0199478
NT5E 5'-nucleotidase, ecto (CD73) 0.0198917
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0191402
RPS17 ribosomal protein S17 0.0191267
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0187232
GPC6 glypican 6 0.0183956
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0181782
NAMPT nicotinamide phosphoribosyltransferase 0.0181021
VCAN versican 0.0179263
EPAS1 endothelial PAS domain protein 1 0.0177435
EFNA5 ephrin-A5 0.017728
ARHGAP5 Rho GTPase activating protein 5 0.0176319
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0176111
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0171371
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0169632
JMJD1C jumonji domain containing 1C 0.0168536
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0165803
PMP22 peripheral myelin protein 22 0.0164092
IFI6 interferon, alpha-inducible protein 6 0.0162685
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0161903
FBXL7 F-box and leucine-rich repeat protein 7 0.016108
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0158265
SYAP1 synapse associated protein 1 0.0157105
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0156616
NDRG1 N-myc downstream regulated 1 0.015649
PHF3 PHD finger protein 3 0.0153571
MYO9A myosin IXA 0.0152644
NRIP1 nuclear receptor interacting protein 1 0.015223
MBNL2 muscleblind-like splicing regulator 2 0.0151959
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.015156
GOLGB1 golgin B1 0.0150134
NFE2L1 nuclear factor, erythroid 2-like 1 0.0150071
RPL37 ribosomal protein L37 0.0149033
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0148702
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0147584
SOX9 SRY (sex determining region Y)-box 9 0.0146178
TGM2 transglutaminase 2 0.0145724
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0144758
INSR insulin receptor 0.0144651
PCBP3 poly(rC) binding protein 3 0.0143037
ZHX2 zinc fingers and homeoboxes 2 0.0142504
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0140021
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0136644
TGFBI transforming growth factor, beta-induced, 68kDa 0.0135724
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0133556
IRAK2 interleukin-1 receptor-associated kinase 2 0.0133157
SON SON DNA binding protein 0.0130461
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0128498
OSBPL8 oxysterol binding protein-like 8 0.0128023

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.15067
FRMD4A FERM domain containing 4A -0.140586
SOD2 superoxide dismutase 2, mitochondrial -0.126696
CADM1 cell adhesion molecule 1 -0.115907
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.109622
MYH9 myosin, heavy chain 9, non-muscle -0.0855142
FTH1 ferritin, heavy polypeptide 1 -0.0683244
TSC22D2 TSC22 domain family, member 2 -0.0576161
QKI QKI, KH domain containing, RNA binding -0.0574242
TRIO trio Rho guanine nucleotide exchange factor -0.0560138
PDE10A phosphodiesterase 10A -0.0558102
ATP13A3 ATPase type 13A3 -0.0514016
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0455106
UGCG UDP-glucose ceramide glucosyltransferase -0.0442828
ZFAND3 zinc finger, AN1-type domain 3 -0.0438877
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.040551
TAPBP TAP binding protein (tapasin) -0.0397257
RBM39 RNA binding motif protein 39 -0.0369491
FRMPD4 FERM and PDZ domain containing 4 -0.0363434
YBX1 Y box binding protein 1 -0.0356714
DST dystonin -0.0356216
FNDC3B fibronectin type III domain containing 3B -0.035358
VEGFA vascular endothelial growth factor A -0.0351567
PCBP2 poly(rC) binding protein 2 -0.0350063
ZNF292 zinc finger protein 292 -0.0337538
THBS1 thrombospondin 1 -0.0335379
SPAG9 sperm associated antigen 9 -0.0334473
GOLGA4 golgin A4 -0.032929
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0325209
HELZ helicase with zinc finger -0.0324166
CDH13 cadherin 13 -0.0310412
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0309658
PTMA prothymosin, alpha -0.0305904
TENM2 teneurin transmembrane protein 2 -0.0304445
DLG1 discs, large homolog 1 (Drosophila) -0.0299584
COL6A3 collagen, type VI, alpha 3 -0.029545
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0294505
TNS3 tensin 3 -0.0291205
AFF4 AF4/FMR2 family, member 4 -0.0288959
EGR1 early growth response 1 -0.0286892
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0283359
WTAP Wilms tumor 1 associated protein -0.0280293
CCNL1 cyclin L1 -0.0276727
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0274977
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0274164
COL1A2 collagen, type I, alpha 2 -0.0273174
DIAPH2 diaphanous-related formin 2 -0.0269703
POTEF POTE ankyrin domain family, member F -0.0268658
ICAM1 intercellular adhesion molecule 1 -0.0267674
EXT1 exostosin glycosyltransferase 1 -0.0266545
IGFBP3 insulin-like growth factor binding protein 3 -0.026086
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0260008
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0257337
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0256242
SBF2 SET binding factor 2 -0.025336
TMEM123 transmembrane protein 123 -0.0252756
TPM4 tropomyosin 4 -0.0248102
TPM1 tropomyosin 1 (alpha) -0.024548
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0245361
EEF1G eukaryotic translation elongation factor 1 gamma -0.0245186
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0241379
ELL2 elongation factor, RNA polymerase II, 2 -0.0240674
MAML2 mastermind-like 2 (Drosophila) -0.0234247
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0234048
UBE2H ubiquitin-conjugating enzyme E2H -0.0232298
WAC WW domain containing adaptor with coiled-coil -0.0231425
CSDE1 cold shock domain containing E1, RNA-binding -0.023027
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.022912
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0228755
MATR3 matrin 3 -0.0228524
CTSD cathepsin D -0.0227815
TFG TRK-fused gene -0.0226999
PGK1 phosphoglycerate kinase 1 -0.0226926
RLF rearranged L-myc fusion -0.0226523
TMSB10 thymosin beta 10 -0.0225178
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0224034
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0222728
ANLN anillin, actin binding protein -0.022038
FLNA filamin A, alpha -0.0219719
SDK1 sidekick cell adhesion molecule 1 -0.021783
ARF4 ADP-ribosylation factor 4 -0.0215727
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0214513
NT5C2 5'-nucleotidase, cytosolic II -0.021296
RTN4 reticulon 4 -0.0212701
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0212115
ANXA2 annexin A2 -0.0212037
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0211984
MARCHF6 membrane associated ring-CH-type finger 6 -0.0211484
LCORL ligand dependent nuclear receptor corepressor-like -0.0210971
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0209811
AFDN afadin, adherens junction formation factor -0.0209434
PTPRK protein tyrosine phosphatase, receptor type, K -0.0206073
LOC112694756 uncharaterized LOC112694756 -0.0205265
NPEPPS aminopeptidase puromycin sensitive -0.0203425
BNC2 basonuclin 2 -0.0201886
WSB1 WD repeat and SOCS box containing 1 -0.0201315
COL1A1 collagen, type I, alpha 1 -0.0199176
CCBE1 collagen and calcium binding EGF domains 1 -0.0199021
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0197776
SFRP1 secreted frizzled-related protein 1 -0.0194585