Vilanterol_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vilanterol perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vilanterol_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
STC1 stanniocalcin 1 0.0908751
KYNU kynureninase 0.0745326
TPT1 tumor protein, translationally-controlled 1 0.0718096
HIP1 huntingtin interacting protein 1 0.0715052
TTC3 tetratricopeptide repeat domain 3 0.058986
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0557583
PRELID2 PRELI domain containing 2 0.0551226
ZBTB20 zinc finger and BTB domain containing 20 0.0534626
IGF2 insulin-like growth factor 2 0.0517797
ZSWIM6 zinc finger, SWIM-type containing 6 0.0485708
WSB1 WD repeat and SOCS box containing 1 0.0444857
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0438323
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.040362
CEMIP cell migration inducing protein, hyaluronan binding 0.0380783
PDE4D phosphodiesterase 4D, cAMP-specific 0.0373258
AKAP9 A kinase (PRKA) anchor protein 9 0.0367867
FAM13A family with sequence similarity 13, member A 0.036407
INTS6 integrator complex subunit 6 0.0358344
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0351308
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.034424
CSNK1A1 casein kinase 1, alpha 1 0.0343905
EFNA5 ephrin-A5 0.0343103
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.034289
CANX calnexin 0.0334701
TGFBI transforming growth factor, beta-induced, 68kDa 0.0333613
NCOA7 nuclear receptor coactivator 7 0.0332203
PDLIM5 PDZ and LIM domain 5 0.0325938
FNDC3A fibronectin type III domain containing 3A 0.032409
ARHGAP22 Rho GTPase activating protein 22 0.0323621
POLK polymerase (DNA directed) kappa 0.0323452
CDK13 cyclin-dependent kinase 13 0.0323346
SEC31A SEC31 homolog A (S. cerevisiae) 0.0322051
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0310885
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0299933
MCL1 myeloid cell leukemia 1 0.0290648
MORF4L2 mortality factor 4 like 2 0.0288311
FBXL7 F-box and leucine-rich repeat protein 7 0.0288059
BBS9 Bardet-Biedl syndrome 9 0.0286803
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0286692
ITGAV integrin, alpha V 0.0279905
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0279416
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0276837
RICTOR RPTOR independent companion of MTOR, complex 2 0.0273562
RPS12 ribosomal protein S12 0.02659
BMERB1 bMERB domain containing 1 0.0262652
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0262471
WNK1 WNK lysine deficient protein kinase 1 0.0261153
NABP1 nucleic acid binding protein 1 0.0260069
RPS2 ribosomal protein S2 0.02549
FNIP1 folliculin interacting protein 1 0.0254772
RPL28 ribosomal protein L28 0.0252896
USP53 ubiquitin specific peptidase 53 0.0252174
QKI QKI, KH domain containing, RNA binding 0.0250969
DSCAM Down syndrome cell adhesion molecule 0.0249925
ZCCHC7 zinc finger, CCHC domain containing 7 0.0249861
METTL15 methyltransferase like 15 0.0248126
PDIA5 protein disulfide isomerase family A, member 5 0.024503
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0241898
NCOR1 nuclear receptor corepressor 1 0.024145
ATXN1 ataxin 1 0.0240004
FAM20C family with sequence similarity 20, member C 0.0239676
CCNI cyclin I 0.0239493
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0238284
SPOP speckle-type POZ protein 0.023761
EEF2 eukaryotic translation elongation factor 2 0.0236034
AHNAK AHNAK nucleoprotein 0.0235414
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0235014
TM4SF1 transmembrane 4 L six family member 1 0.0233107
RND3 Rho family GTPase 3 0.0228532
RPS17 ribosomal protein S17 0.0228282
ACTN1 actinin, alpha 1 0.0227653
IFI44 interferon-induced protein 44 0.0226289
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0224823
IVNS1ABP influenza virus NS1A binding protein 0.0224617
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0224473
RPS8 ribosomal protein S8 0.0224457
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0223592
RPLP2 ribosomal protein, large, P2 0.0222211
HIPK2 homeodomain interacting protein kinase 2 0.0221704
AKAP10 A kinase (PRKA) anchor protein 10 0.0221327
OXSR1 oxidative stress responsive 1 0.022069
PDGFC platelet derived growth factor C 0.0219418
GOLGB1 golgin B1 0.0219401
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0217912
ITGA1 integrin, alpha 1 0.0217713
NFX1 nuclear transcription factor, X-box binding 1 0.0217412
ANO6 anoctamin 6 0.0216235
EFCAB13 EF-hand calcium binding domain 13 0.0215109
PALLD palladin, cytoskeletal associated protein 0.0213129
PDE8A phosphodiesterase 8A 0.0211315
GATAD1 GATA zinc finger domain containing 1 0.0209987
RPS29 ribosomal protein S29 0.0208571
SEC24A SEC24 family member A 0.0208463
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.020682
AEBP2 AE binding protein 2 0.0206717
KLF6 Kruppel-like factor 6 0.0204055
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0203811
FYCO1 FYVE and coiled-coil domain containing 1 0.0203136
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0203019
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0201783

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.18134
TMSB10 thymosin beta 10 -0.150796
VIM vimentin -0.145428
IGFBP3 insulin-like growth factor binding protein 3 -0.138845
FTH1 ferritin, heavy polypeptide 1 -0.131147
FN1 fibronectin 1 -0.109029
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.106731
COL1A2 collagen, type I, alpha 2 -0.0880508
COL1A1 collagen, type I, alpha 1 -0.0778837
RTN4 reticulon 4 -0.0777472
MYH9 myosin, heavy chain 9, non-muscle -0.0734325
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0724338
NDRG1 N-myc downstream regulated 1 -0.0670882
PTMA prothymosin, alpha -0.0663255
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0649322
POTEF POTE ankyrin domain family, member F -0.0645651
PKM pyruvate kinase, muscle -0.0642666
MAP1B microtubule-associated protein 1B -0.0630713
CDH13 cadherin 13 -0.0574557
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.057353
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0554566
LDHA lactate dehydrogenase A -0.0527496
CDK6 cyclin-dependent kinase 6 -0.0497263
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0480678
FTL ferritin, light polypeptide -0.0476138
TPM1 tropomyosin 1 (alpha) -0.0470894
CD44 CD44 molecule (Indian blood group) -0.0460134
SETD5 SET domain containing 5 -0.0460029
F3 coagulation factor III (thromboplastin, tissue factor) -0.0451628
CALU calumenin -0.0450904
HLA-B major histocompatibility complex, class I, B -0.0439742
DST dystonin -0.0435566
HOOK2 hook microtubule-tethering protein 2 -0.0433618
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0424603
HLA-C major histocompatibility complex, class I, C -0.042116
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0419541
LOC112694756 uncharaterized LOC112694756 -0.0407697
ELL2 elongation factor, RNA polymerase II, 2 -0.0399279
TPM4 tropomyosin 4 -0.0398298
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0393846
ANXA5 annexin A5 -0.0386889
COL5A2 collagen, type V, alpha 2 -0.038518
NAV1 neuron navigator 1 -0.0380883
COL5A1 collagen, type V, alpha 1 -0.0374705
ITCH itchy E3 ubiquitin protein ligase -0.0356497
CALD1 caldesmon 1 -0.0355204
KMT2C lysine (K)-specific methyltransferase 2C -0.0352656
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0352446
LAMB1 laminin, beta 1 -0.0351391
SBF2 SET binding factor 2 -0.0350299
CAV1 caveolin 1, caveolae protein, 22kDa -0.0348705
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0346366
ANXA2 annexin A2 -0.0346023
MEF2A myocyte enhancer factor 2A -0.0343126
NAMPT nicotinamide phosphoribosyltransferase -0.0337446
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.033433
TNPO1 transportin 1 -0.0329687
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0325997
ANKRD11 ankyrin repeat domain 11 -0.0322004
PICALM phosphatidylinositol binding clathrin assembly protein -0.0321609
DPYD dihydropyrimidine dehydrogenase -0.0316463
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0312358
PFN1 profilin 1 -0.0311225
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0310119
CLTC clathrin, heavy chain (Hc) -0.0307229
PTN pleiotrophin -0.0306911
HLA-A major histocompatibility complex, class I, A -0.0305729
FRMD6 FERM domain containing 6 -0.0294916
AFF4 AF4/FMR2 family, member 4 -0.0292218
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.028932
CCNY cyclin Y -0.0289224
SMAD3 SMAD family member 3 -0.0287064
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0286808
SPAG9 sperm associated antigen 9 -0.0285506
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0285129
MYOF myoferlin -0.0284478
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0283849
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0281292
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0278837
TENT2 terminal nucleotidyltransferase 2 -0.0278066
ENO1 enolase 1, (alpha) -0.0276357
EGR1 early growth response 1 -0.027308
ARRDC3 arrestin domain containing 3 -0.0269491
UGCG UDP-glucose ceramide glucosyltransferase -0.0267044
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0266107
ZMYM2 zinc finger, MYM-type 2 -0.0264243
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0263959
RNF145 ring finger protein 145 -0.0260489
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0259746
NBAS neuroblastoma amplified sequence -0.0259642
PGK1 phosphoglycerate kinase 1 -0.025867
MARCHF6 membrane associated ring-CH-type finger 6 -0.0258433
RAP1B RAP1B, member of RAS oncogene family -0.0256345
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0252141
IL6 interleukin 6 -0.0250422
RAB1A RAB1A, member RAS oncogene family -0.0249567
ARF4 ADP-ribosylation factor 4 -0.0246555
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0246035
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0244718
ALCAM activated leukocyte cell adhesion molecule -0.0244536