Vilanterol_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vilanterol perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vilanterol_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0931431
TPT1 tumor protein, translationally-controlled 1 0.0870799
FNDC3B fibronectin type III domain containing 3B 0.0793556
AHNAK AHNAK nucleoprotein 0.0752662
HMGA2 high mobility group AT-hook 2 0.0749217
INTS6 integrator complex subunit 6 0.0742795
MACF1 microtubule-actin crosslinking factor 1 0.070103
N4BP2L2 NEDD4 binding protein 2-like 2 0.0602752
SQSTM1 sequestosome 1 0.0528047
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0525687
ZSWIM6 zinc finger, SWIM-type containing 6 0.0512385
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0502526
ANGPTL4 angiopoietin-like 4 0.0484672
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0480877
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0480475
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0478238
FMNL2 formin-like 2 0.04782
SH3KBP1 SH3-domain kinase binding protein 1 0.0474588
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0472429
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0467306
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0463578
SLC38A2 solute carrier family 38, member 2 0.046023
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0448924
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.043781
DST dystonin 0.0431479
GPC5 glypican 5 0.0425487
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0419055
SSH2 slingshot protein phosphatase 2 0.0417578
ATXN1 ataxin 1 0.040207
AKAP12 A kinase (PRKA) anchor protein 12 0.0397609
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0391042
MYOF myoferlin 0.0388759
IGFBP3 insulin-like growth factor binding protein 3 0.0382035
CDK13 cyclin-dependent kinase 13 0.0362944
PTK2 protein tyrosine kinase 2 0.0359197
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0355064
ANXA1 annexin A1 0.035135
SYNJ2 synaptojanin 2 0.035052
JAK1 Janus kinase 1 0.0347178
NPAS2 neuronal PAS domain protein 2 0.0343828
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0340339
AHI1 Abelson helper integration site 1 0.0335309
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0335059
NDRG1 N-myc downstream regulated 1 0.0330796
LDHA lactate dehydrogenase A 0.0330757
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0327047
AEBP2 AE binding protein 2 0.0325911
CANX calnexin 0.0323521
DTNA dystrobrevin, alpha 0.0323359
FOXO3 forkhead box O3 0.0322665
ANKRD11 ankyrin repeat domain 11 0.0321909
PODXL podocalyxin-like 0.031933
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0318594
NT5E 5'-nucleotidase, ecto (CD73) 0.0317939
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0311249
CAMK4 calcium/calmodulin-dependent protein kinase IV 0.0310772
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0309183
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0307542
ANO6 anoctamin 6 0.0305216
DNAAF9 dynein axonemal assembly factor 9 0.0303554
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0302918
WSB1 WD repeat and SOCS box containing 1 0.0297265
ARRDC3 arrestin domain containing 3 0.0295834
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0293507
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0291521
S100A10 S100 calcium binding protein A10 0.0287919
TPD52 tumor protein D52 0.028724
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0285828
ATM ATM serine/threonine kinase 0.0283998
CAPRIN2 caprin family member 2 0.02814
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0278069
FAM114A1 family with sequence similarity 114, member A1 0.027663
EGFR epidermal growth factor receptor 0.0271256
ASXL1 additional sex combs like transcriptional regulator 1 0.0269899
AHNAK2 AHNAK nucleoprotein 2 0.0268024
CLTC clathrin, heavy chain (Hc) 0.0267556
SAMD4A sterile alpha motif domain containing 4A 0.0265675
MYO9B myosin IXB 0.026341
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0263079
IGF2 insulin-like growth factor 2 0.0259022
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0258297
ACTG1 actin gamma 1 0.0257469
OGA O-GlcNAcase 0.0254981
DENND5B DENN/MADD domain containing 5B 0.025389
RAI14 retinoic acid induced 14 0.0253732
KMT5B lysine methyltransferase 5B 0.0253282
SATB2 SATB homeobox 2 0.025256
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0251257
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0250965
SKIL SKI-like proto-oncogene 0.025027
SVIL supervillin 0.0249616
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0246675
JMJD1C jumonji domain containing 1C 0.0246263
KLF3 Kruppel-like factor 3 (basic) 0.0243695
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0241061
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0240213
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.023823
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0237832
ENO1 enolase 1, (alpha) 0.0236541
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0235148

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148059
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0945353
TMSB10 thymosin beta 10 -0.0848588
PTMA prothymosin, alpha -0.083182
VIM vimentin -0.0703379
DIAPH3 diaphanous-related formin 3 -0.063685
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.059806
ZNF292 zinc finger protein 292 -0.0560165
AKAP9 A kinase (PRKA) anchor protein 9 -0.0554969
BSG basigin (Ok blood group) -0.0547473
LOC112694756 uncharaterized LOC112694756 -0.0531939
DNER delta/notch-like EGF repeat containing -0.0519013
HJURP Holliday junction recognition protein -0.0502554
SGO2 shugoshin 2 -0.0485342
TPX2 TPX2, microtubule-associated -0.0483683
ANKRD28 ankyrin repeat domain 28 -0.0473599
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.046683
NCEH1 neutral cholesterol ester hydrolase 1 -0.0460613
VMP1 vacuole membrane protein 1 -0.0449965
CENPF centromere protein F, 350/400kDa -0.0444059
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0441963
KIAA1328 KIAA1328 -0.0441634
ECT2 epithelial cell transforming 2 -0.0437823
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0434574
CKAP2 cytoskeleton associated protein 2 -0.0433821
CALU calumenin -0.0430741
SPAG9 sperm associated antigen 9 -0.0428058
THSD4 thrombospondin, type I, domain containing 4 -0.0421064
R3HDM1 R3H domain containing 1 -0.0415482
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0410869
MKI67 marker of proliferation Ki-67 -0.0403874
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0382697
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0381274
KIAA1958 KIAA1958 -0.0371511
MORF4L1 mortality factor 4 like 1 -0.0371391
KIF5B kinesin family member 5B -0.0367935
STRN3 striatin, calmodulin binding protein 3 -0.0366782
GNAS GNAS complex locus -0.0365503
PCBP2 poly(rC) binding protein 2 -0.0358778
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0356516
SS18 synovial sarcoma translocation, chromosome 18 -0.0356201
LCORL ligand dependent nuclear receptor corepressor-like -0.0356105
RSRC2 arginine/serine-rich coiled-coil 2 -0.0351069
RFC3 replication factor C (activator 1) 3, 38kDa -0.0351007
FTH1 ferritin, heavy polypeptide 1 -0.0346514
MIS18BP1 MIS18 binding protein 1 -0.0342226
TPM4 tropomyosin 4 -0.0338886
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0333174
TXNRD1 thioredoxin reductase 1 -0.0322636
CCDC88A coiled-coil domain containing 88A -0.03211
KIF23 kinesin family member 23 -0.0312948
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0306383
SMC4 structural maintenance of chromosomes 4 -0.0302121
OSMR oncostatin M receptor -0.0300905
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0297116
RPS28 ribosomal protein S28 -0.0296784
CKAP2L cytoskeleton associated protein 2-like -0.0295829
RPL11 ribosomal protein L11 -0.0294297
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.029204
RPL15 ribosomal protein L15 -0.0291999
PDE4D phosphodiesterase 4D, cAMP-specific -0.0291021
PKM pyruvate kinase, muscle -0.0290651
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0289074
ETV6 ets variant 6 -0.0286654
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0285906
HMGB1 high mobility group box 1 -0.028576
TTK TTK protein kinase -0.0283032
PIAS1 protein inhibitor of activated STAT, 1 -0.0277771
PRR11 proline rich 11 -0.0277596
DEK DEK proto-oncogene -0.0276701
CLASP1 cytoplasmic linker associated protein 1 -0.027655
MCTP1 multiple C2 domains, transmembrane 1 -0.0275612
RPL27A ribosomal protein L27a -0.0274738
PAPOLA poly(A) polymerase alpha -0.0273578
CELF1 CUGBP, Elav-like family member 1 -0.0272478
ANLN anillin, actin binding protein -0.0271251
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0270342
TRA2A transformer 2 alpha homolog (Drosophila) -0.0267859
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0267718
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0266443
TMPO thymopoietin -0.0265295
RPLP1 ribosomal protein, large, P1 -0.0265081
RPL32 ribosomal protein L32 -0.0264784
GPR107 G protein-coupled receptor 107 -0.0264031
RB1CC1 RB1-inducible coiled-coil 1 -0.0263042
WDFY2 WD repeat and FYVE domain containing 2 -0.0262525
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0261352
GLG1 golgi glycoprotein 1 -0.0261311
SMAD2 SMAD family member 2 -0.0260321
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0259163
NBEAL1 neurobeachin-like 1 -0.0258237
RPL19 ribosomal protein L19 -0.0257065
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0256814
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.025664
RSF1 remodeling and spacing factor 1 -0.025647
RPL12 ribosomal protein L12 -0.0254772
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0253558
GRB2 growth factor receptor-bound protein 2 -0.0253048
TOP1 topoisomerase (DNA) I -0.0251754
RPL30 ribosomal protein L30 -0.0251443