| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/6918314 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Vilazodone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 2.29 |
| PAH | phenylalanine hydroxylase | 1.79 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.74 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.55 |
| TMEM59 | transmembrane protein 59 | 1.54 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.44 |
| TSPAN3 | tetraspanin 3 | 1.34 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 1.34 |
| SQLE | squalene epoxidase | 1.28 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.22 |
| NDFIP1 | Nedd4 family interacting protein 1 | 1.16 |
| PTPDC1 | protein tyrosine phosphatase domain containing 1 | 1.16 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.15 |
| NDFIP2 | Nedd4 family interacting protein 2 | 1.15 |
| ALPK3 | alpha-kinase 3 | 1.11 |
| NCOA4 | nuclear receptor coactivator 4 | 1.09 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 1.06 |
| NBR1 | neighbor of BRCA1 gene 1 | 1.04 |
| GJC1 | gap junction protein, gamma 1, 45kDa | 1.01 |
| MSMO1 | methylsterol monooxygenase 1 | 1.0 |
| LDLR | low density lipoprotein receptor | 0.96 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.94 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.93 |
| ABHD2 | abhydrolase domain containing 2 | 0.9 |
| MVK | mevalonate kinase | 0.87 |
| CD63 | CD63 molecule | 0.85 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.84 |
| DUOX1 | dual oxidase 1 | 0.83 |
| RNF130 | ring finger protein 130 | 0.8 |
| RPL35 | ribosomal protein L35 | 0.76 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.75 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 0.74 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.73 |
| RPL32 | ribosomal protein L32 | 0.73 |
| MT1X | metallothionein 1X | 0.73 |
| RNF149 | ring finger protein 149 | 0.72 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.72 |
| ITM2B | integral membrane protein 2B | 0.72 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 0.71 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.7 |
| SC5D | sterol-C5-desaturase | 0.7 |
| RPL27 | ribosomal protein L27 | 0.7 |
| RPL22L1 | ribosomal protein L22-like 1 | 0.7 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.69 |
| GM2A | GM2 ganglioside activator | 0.68 |
| MPZL2 | myelin protein zero-like 2 | 0.68 |
| TTYH2 | tweety family member 2 | 0.67 |
| CLDN3 | claudin 3 | 0.67 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.66 |
| GINM1 | glycoprotein integral membrane 1 | 0.64 |
| SAYSD1 | SAYSVFN motif domain containing 1 | 0.64 |
| PRELID1 | PRELI domain containing 1 | 0.61 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.59 |
| ITM2C | integral membrane protein 2C | 0.58 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.58 |
| JAG1 | jagged 1 | 0.57 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.57 |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | 0.57 |
| RPS28 | ribosomal protein S28 | 0.57 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.57 |
| TEN1 | TEN1 CST complex subunit | 0.57 |
| RGN | regucalcin | 0.56 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.56 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.56 |
| RPL7 | ribosomal protein L7 | 0.55 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.55 |
| H1-2 | H1.2 linker histone, cluster member | 0.55 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.55 |
| TSPAN5 | tetraspanin 5 | 0.54 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | 0.54 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.54 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | 0.54 |
| FADS1 | fatty acid desaturase 1 | 0.53 |
| PLPP2 | phospholipid phosphatase 2 | 0.53 |
| NMNAT3 | nicotinamide nucleotide adenylyltransferase 3 | 0.53 |
| BMERB1 | bMERB domain containing 1 | 0.52 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | 0.52 |
| CCDC150 | coiled-coil domain containing 150 | 0.51 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.51 |
| RPL3L | ribosomal protein L3-like | 0.5 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.5 |
| APOE | apolipoprotein E | 0.5 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.49 |
| CCNE2 | cyclin E2 | 0.48 |
| MFSD14B | major facilitator superfamily domain containing 14B | 0.48 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | 0.47 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.47 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.47 |
| PEX7 | peroxisomal biogenesis factor 7 | 0.46 |
| SLC49A4 | solute carrier family 49 member 4 | 0.46 |
| RTN3 | reticulon 3 | 0.46 |
| ACTN1 | actinin, alpha 1 | 0.45 |
| ZNF616 | zinc finger protein 616 | 0.45 |
| SDCBP | syndecan binding protein (syntenin) | 0.45 |
| TUBB1 | tubulin, beta 1 class VI | 0.45 |
| RPL3 | ribosomal protein L3 | 0.44 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.44 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.44 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.43 |
| EEF1A1P5 | eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 | 0.43 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYB561 | cytochrome b561 | -0.85 |
| STX1A | syntaxin 1A (brain) | -0.78 |
| ZNF408 | zinc finger protein 408 | -0.76 |
| ANKRD39 | ankyrin repeat domain 39 | -0.73 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | -0.72 |
| NSUN5 | NOP2/Sun domain family, member 5 | -0.7 |
| ZBTB49 | zinc finger and BTB domain containing 49 | -0.7 |
| TAF4B | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa | -0.68 |
| GBA | glucosidase, beta, acid | -0.64 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.61 |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | -0.6 |
| KRT222 | keratin 222, type II | -0.59 |
| CCNI | cyclin I | -0.59 |
| SULF2 | sulfatase 2 | -0.57 |
| KIAA1191 | KIAA1191 | -0.56 |
| RNASEH2C | ribonuclease H2, subunit C | -0.54 |
| C2ORF42 | chromosome 2 open reading frame 42 | -0.53 |
| CERS4 | ceramide synthase 4 | -0.53 |
| CCN3 | cellular communication network factor 3 | -0.5 |
| CES3 | carboxylesterase 3 | -0.5 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.5 |
| ZDHHC8 | zinc finger, DHHC-type containing 8 | -0.5 |
| SEMG2 | semenogelin II | -0.49 |
| LGMN | legumain | -0.48 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.47 |
| NKX2-8 | NK2 homeobox 8 | -0.46 |
| FZD2 | frizzled class receptor 2 | -0.45 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -0.45 |
| ZNF28 | zinc finger protein 28 | -0.45 |
| PROS1 | protein S (alpha) | -0.45 |
| ZNRD1 | zinc ribbon domain containing 1 | -0.44 |
| GGACT | gamma-glutamylamine cyclotransferase | -0.44 |
| TRIM36 | tripartite motif containing 36 | -0.44 |
| TPST2 | tyrosylprotein sulfotransferase 2 | -0.43 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.43 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 | -0.43 |
| HLA-F | major histocompatibility complex, class I, F | -0.43 |
| MRPL32 | mitochondrial ribosomal protein L32 | -0.42 |
| MOCS2 | molybdenum cofactor synthesis 2 | -0.42 |
| GRTP1 | growth hormone regulated TBC protein 1 | -0.42 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.4 |
| CENPJ | centromere protein J | -0.4 |
| SIVA1 | SIVA1, apoptosis-inducing factor | -0.4 |
| TRAIP | TRAF interacting protein | -0.4 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -0.4 |
| GPRIN1 | G protein regulated inducer of neurite outgrowth 1 | -0.39 |
| PRMT2IP | PRMT2 interacting protein | -0.39 |
| TOX2 | TOX high mobility group box family member 2 | -0.39 |
| CDC37 | cell division cycle 37 | -0.39 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.38 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.38 |
| PRRX2 | paired related homeobox 2 | -0.38 |
| CDCA7 | cell division cycle associated 7 | -0.38 |
| SH3BP4 | SH3-domain binding protein 4 | -0.38 |
| PEX19 | peroxisomal biogenesis factor 19 | -0.38 |
| WSB2 | WD repeat and SOCS box containing 2 | -0.38 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.38 |
| ODC1 | ornithine decarboxylase 1 | -0.38 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | -0.38 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.37 |
| LIG1 | ligase I, DNA, ATP-dependent | -0.37 |
| USP30 | ubiquitin specific peptidase 30 | -0.37 |
| TPM2 | tropomyosin 2 (beta) | -0.37 |
| TCEA3 | transcription elongation factor A (SII), 3 | -0.37 |
| SLC4A11 | solute carrier family 4, sodium borate transporter, member 11 | -0.36 |
| NOP16 | NOP16 nucleolar protein | -0.36 |
| RILPL2 | Rab interacting lysosomal protein-like 2 | -0.36 |
| CDCA7L | cell division cycle associated 7-like | -0.36 |
| WDR54 | WD repeat domain 54 | -0.36 |
| EMP3 | epithelial membrane protein 3 | -0.35 |
| NUCB1 | nucleobindin 1 | -0.35 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.35 |
| ZNF121 | zinc finger protein 121 | -0.35 |
| GGCX | gamma-glutamyl carboxylase | -0.35 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.35 |
| SUPT4H1 | suppressor of Ty 4 homolog 1 (S. cerevisiae) | -0.35 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.35 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.35 |
| ALDOA | aldolase A, fructose-bisphosphate | -0.35 |
| TRIM16 | tripartite motif containing 16 | -0.35 |
| TMEM223 | transmembrane protein 223 | -0.35 |
| COMMD5 | COMM domain containing 5 | -0.34 |
| TTC30B | tetratricopeptide repeat domain 30B | -0.34 |
| ZNF707 | zinc finger protein 707 | -0.34 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | -0.34 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | -0.34 |
| VAMP3 | vesicle-associated membrane protein 3 | -0.34 |
| ZNF205 | zinc finger protein 205 | -0.34 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.34 |
| SLC4A3 | solute carrier family 4 (anion exchanger), member 3 | -0.34 |
| PTTG1 | pituitary tumor-transforming 1 | -0.34 |
| PLEKHN1 | pleckstrin homology domain containing, family N member 1 | -0.34 |
| OSGIN2 | oxidative stress induced growth inhibitor family member 2 | -0.34 |
| CDK14 | cyclin-dependent kinase 14 | -0.34 |
| KIAA0513 | KIAA0513 | -0.33 |
| MCM9 | minichromosome maintenance complex component 9 | -0.33 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -0.33 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.33 |
| RGL2 | ral guanine nucleotide dissociation stimulator-like 2 | -0.33 |
| TBC1D13 | TBC1 domain family, member 13 | -0.33 |
