Vinblastine (sulfate)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.139792
EGFR epidermal growth factor receptor 0.0952303
IGFBP3 insulin-like growth factor binding protein 3 0.0865212
PDE4D phosphodiesterase 4D, cAMP-specific 0.0831614
DOCK5 dedicator of cytokinesis 5 0.0751772
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0688956
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.061509
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0573644
ZSWIM6 zinc finger, SWIM-type containing 6 0.0543303
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0542064
ALCAM activated leukocyte cell adhesion molecule 0.0538228
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0529245
HMGA2 high mobility group AT-hook 2 0.0524186
PRKCA protein kinase C, alpha 0.0501024
MAML3 mastermind-like 3 (Drosophila) 0.0496551
LIMCH1 LIM and calponin homology domains 1 0.0466991
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0460672
PDLIM5 PDZ and LIM domain 5 0.0451228
FBXO11 F-box protein 11 0.0447338
ZCCHC7 zinc finger, CCHC domain containing 7 0.0443939
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0439441
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0436594
FMNL2 formin-like 2 0.0416149
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0406559
EXT1 exostosin glycosyltransferase 1 0.0395221
GOLGB1 golgin B1 0.0376104
SAMD4A sterile alpha motif domain containing 4A 0.0359367
INTS6 integrator complex subunit 6 0.0355207
FAM13A family with sequence similarity 13, member A 0.0355201
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0352942
NDRG1 N-myc downstream regulated 1 0.0348679
ERRFI1 ERBB receptor feedback inhibitor 1 0.0347715
EHBP1 EH domain binding protein 1 0.0344486
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0344407
SP100 SP100 nuclear antigen 0.0344119
COPA coatomer protein complex, subunit alpha 0.0334915
CCDC88A coiled-coil domain containing 88A 0.0333057
VMP1 vacuole membrane protein 1 0.0310014
MYO1E myosin IE 0.0304555
FNIP1 folliculin interacting protein 1 0.0304177
IGF1R insulin-like growth factor 1 receptor 0.0303366
BACE2 beta-site APP-cleaving enzyme 2 0.0301914
SEC31A SEC31 homolog A (S. cerevisiae) 0.0300604
RND3 Rho family GTPase 3 0.0299065
AUTS2 autism susceptibility candidate 2 0.0295428
VCL vinculin 0.0294671
AKAP13 A kinase (PRKA) anchor protein 13 0.0292861
RAD51B RAD51 paralog B 0.0291536
DUSP16 dual specificity phosphatase 16 0.0290399
GRB10 growth factor receptor-bound protein 10 0.0288443
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0280326
CUX1 cut-like homeobox 1 0.0276145
ZBTB20 zinc finger and BTB domain containing 20 0.0270548
CCNY cyclin Y 0.0268635
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.026636
IQGAP1 IQ motif containing GTPase activating protein 1 0.0266304
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.026596
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0263522
PTK2 protein tyrosine kinase 2 0.026205
AKAP9 A kinase (PRKA) anchor protein 9 0.0259079
LMO7 LIM domain 7 0.0258377
SHB Src homology 2 domain containing adaptor protein B 0.0255914
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.025564
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0254585
RCOR1 REST corepressor 1 0.0254384
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0251413
MED13 mediator complex subunit 13 0.0250549
FRMD6 FERM domain containing 6 0.0248281
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0247837
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0247077
EPAS1 endothelial PAS domain protein 1 0.0246635
ANKRD11 ankyrin repeat domain 11 0.0245457
ZFHX3 zinc finger homeobox 3 0.0242692
AFF1 AF4/FMR2 family, member 1 0.024161
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0240302
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0239313
PTPRM protein tyrosine phosphatase, receptor type, M 0.0236349
MED13L mediator complex subunit 13-like 0.0234738
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.023178
MON2 MON2 homolog (S. cerevisiae) 0.0229854
ITSN2 intersectin 2 0.0227729
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0226303
CDK13 cyclin-dependent kinase 13 0.0224252
CTBP2 C-terminal binding protein 2 0.0222951
MCL1 myeloid cell leukemia 1 0.0222057
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0220832
SETX senataxin 0.0218511
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0214855
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0213904
SOS1 son of sevenless homolog 1 (Drosophila) 0.0212998
ZNF638 zinc finger protein 638 0.0212558
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0212298
USP34 ubiquitin specific peptidase 34 0.0208331
GOLGA4 golgin A4 0.0205162
AADAC arylacetamide deacetylase 0.0204356
ZFC3H1 zinc finger, C3H1-type containing 0.0203467
MACF1 microtubule-actin crosslinking factor 1 0.020262
ANKHD1 ankyrin repeat and KH domain containing 1 0.0201422
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0201315
KMT2E lysine (K)-specific methyltransferase 2E 0.0200369

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1879
TMSB10 thymosin beta 10 -0.165961
FTL ferritin, light polypeptide -0.113547
ACTG1 actin gamma 1 -0.111254
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.110586
VIM vimentin -0.106355
MT2A metallothionein 2A -0.104622
RPS19 ribosomal protein S19 -0.102109
FTH1 ferritin, heavy polypeptide 1 -0.0939461
RPLP1 ribosomal protein, large, P1 -0.0902382
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0892688
ARHGAP26 Rho GTPase activating protein 26 -0.0802803
RPL23 ribosomal protein L23 -0.0704149
RPS6 ribosomal protein S6 -0.0694234
RPL12 ribosomal protein L12 -0.0660819
RPL26 ribosomal protein L26 -0.0628868
IGFBP4 insulin-like growth factor binding protein 4 -0.062556
RPS16 ribosomal protein S16 -0.0613474
NAMPT nicotinamide phosphoribosyltransferase -0.056771
TM4SF1 transmembrane 4 L six family member 1 -0.0522907
TXNRD1 thioredoxin reductase 1 -0.0514005
PDE10A phosphodiesterase 10A -0.0512797
RPL19 ribosomal protein L19 -0.0494621
NAP1L1 nucleosome assembly protein 1-like 1 -0.0480901
RPS24 ribosomal protein S24 -0.0479901
AKAP12 A kinase (PRKA) anchor protein 12 -0.0470775
C15ORF48 chromosome 15 open reading frame 48 -0.0435641
TPT1 tumor protein, translationally-controlled 1 -0.0435253
EIF1 eukaryotic translation initiation factor 1 -0.0434846
ANXA2 annexin A2 -0.0420849
OSMR oncostatin M receptor -0.0418615
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0415284
MT1X metallothionein 1X -0.040875
RPL4 ribosomal protein L4 -0.040654
RPLP0 ribosomal protein, large, P0 -0.0404638
RACK1 receptor for activated C kinase 1 -0.0404138
RPLP2 ribosomal protein, large, P2 -0.0396176
RPL35A ribosomal protein L35a -0.0389155
RPL28 ribosomal protein L28 -0.0381272
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0380911
RPL8 ribosomal protein L8 -0.0380648
RPL13A ribosomal protein L13a -0.0379067
STC1 stanniocalcin 1 -0.0374135
KRT81 keratin 81, type II -0.0372566
LOC112694756 uncharaterized LOC112694756 -0.0364921
BHLHE40 basic helix-loop-helix family, member e40 -0.0363905
TKT transketolase -0.0350917
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0350521
DGKD diacylglycerol kinase, delta 130kDa -0.0348576
RPS5 ribosomal protein S5 -0.0348561
RPS17 ribosomal protein S17 -0.0346962
RPS8 ribosomal protein S8 -0.0346282
KLF6 Kruppel-like factor 6 -0.0342636
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0342361
RPS23 ribosomal protein S23 -0.0340767
AGFG1 ArfGAP with FG repeats 1 -0.0339807
KRT7 keratin 7, type II -0.0337799
NCOA7 nuclear receptor coactivator 7 -0.0332841
RPS21 ribosomal protein S21 -0.0331516
RPS14 ribosomal protein S14 -0.0326364
RPL37A ribosomal protein L37a -0.0325479
RRBP1 ribosome binding protein 1 -0.032518
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0322598
RPS11 ribosomal protein S11 -0.0317351
RPS27A ribosomal protein S27a -0.0315483
CMIP c-Maf inducing protein -0.031469
RPL32 ribosomal protein L32 -0.0313675
S100A10 S100 calcium binding protein A10 -0.0304768
RPS3 ribosomal protein S3 -0.0303504
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0299982
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0296024
RPL31 ribosomal protein L31 -0.0288994
GPRIN3 GPRIN family member 3 -0.0281027
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0280482
TGFBI transforming growth factor, beta-induced, 68kDa -0.0279206
PFN1 profilin 1 -0.0278418
RPL11 ribosomal protein L11 -0.0277352
TMSB4X thymosin beta 4, X-linked -0.0276962
RPL7 ribosomal protein L7 -0.0275927
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0274445
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0274314
RPS13 ribosomal protein S13 -0.0273601
RPS4X ribosomal protein S4, X-linked -0.0272648
S100A6 S100 calcium binding protein A6 -0.0269279
RTN4 reticulon 4 -0.0268552
RPL37 ribosomal protein L37 -0.0265016
BMAL2 basic helix-loop-helix ARNT like 2 -0.0264637
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0264224
EEF2 eukaryotic translation elongation factor 2 -0.0262506
RPL18 ribosomal protein L18 -0.0259979
PDCD5 programmed cell death 5 -0.025846
RPL38 ribosomal protein L38 -0.0258202
CD44 CD44 molecule (Indian blood group) -0.0253753
BASP1 brain abundant, membrane attached signal protein 1 -0.0253749
RPS12 ribosomal protein S12 -0.0252987
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0251071
ARL5B ADP-ribosylation factor-like 5B -0.02487
VEZT vezatin, adherens junctions transmembrane protein -0.0248518
PGK1 phosphoglycerate kinase 1 -0.0248095
RPS27 ribosomal protein S27 -0.0247072