Vinblastine (sulfate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I 0.0817885
MEST mesoderm specific transcript 0.059494
SPAG9 sperm associated antigen 9 0.0315579
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0302651
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0275274
CADM2 cell adhesion molecule 2 0.0263751
PICALM phosphatidylinositol binding clathrin assembly protein 0.0251488
SSBP2 single-stranded DNA binding protein 2 0.0250138
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0244461
TRA2A transformer 2 alpha homolog (Drosophila) 0.0240644
USP9X ubiquitin specific peptidase 9, X-linked 0.0236518
FAM13A family with sequence similarity 13, member A 0.0230555
MYOF myoferlin 0.0225481
SAMD4A sterile alpha motif domain containing 4A 0.0224362
NDRG1 N-myc downstream regulated 1 0.0221718
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0220498
MON2 MON2 homolog (S. cerevisiae) 0.021483
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0210113
KDM6A lysine (K)-specific demethylase 6A 0.0203972
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.020296
RNF145 ring finger protein 145 0.0201555
FN1 fibronectin 1 0.0197945
KMT2E lysine (K)-specific methyltransferase 2E 0.0197929
OSBPL10 oxysterol binding protein-like 10 0.0194359
WDFY3 WD repeat and FYVE domain containing 3 0.0192451
ANO6 anoctamin 6 0.0191591
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0189912
TSC22D2 TSC22 domain family, member 2 0.0186232
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0185132
HBP1 HMG-box transcription factor 1 0.018326
ZNF292 zinc finger protein 292 0.0182609
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0181833
VEGFA vascular endothelial growth factor A 0.0181323
DOP1A DOP1 leucine zipper like protein A 0.017989
MCU mitochondrial calcium uniporter 0.0178303
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0177968
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0176505
FNDC3B fibronectin type III domain containing 3B 0.0175549
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0173786
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0173723
SNX25 sorting nexin 25 0.0173358
MTUS1 microtubule associated tumor suppressor 1 0.017255
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0169918
TTC3 tetratricopeptide repeat domain 3 0.0167179
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0166633
ZNF148 zinc finger protein 148 0.0166584
TOP1 topoisomerase (DNA) I 0.0164495
PDS5B PDS5 cohesin associated factor B 0.0163291
SIK3 SIK family kinase 3 0.0162899
LOXL2 lysyl oxidase-like 2 0.0162795
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0161898
ELL2 elongation factor, RNA polymerase II, 2 0.0161616
LYPD6 LY6/PLAUR domain containing 6 0.0161519
ADIPOR2 adiponectin receptor 2 0.0161334
NEK7 NIMA-related kinase 7 0.0158474
YAP1 Yes-associated protein 1 0.0157805
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0157255
UBA6 ubiquitin-like modifier activating enzyme 6 0.0155947
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.015445
KAT6A K(lysine) acetyltransferase 6A 0.0153695
FMNL2 formin-like 2 0.0152174
RBM26 RNA binding motif protein 26 0.0150917
AKAP13 A kinase (PRKA) anchor protein 13 0.014969
CDK8 cyclin-dependent kinase 8 0.0147648
EGFR epidermal growth factor receptor 0.0147282
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0146755
HOXC10 homeobox C10 0.0146102
JARID2 jumonji, AT rich interactive domain 2 0.014483
MXI1 MAX interactor 1, dimerization protein 0.0144789
GLS2 glutaminase 2 (liver, mitochondrial) 0.0144062
SMYD3 SET and MYND domain containing 3 0.0142391
STRN striatin, calmodulin binding protein 0.014218
SH3RF1 SH3 domain containing ring finger 1 0.0140572
LCORL ligand dependent nuclear receptor corepressor-like 0.0140155
QKI QKI, KH domain containing, RNA binding 0.0140002
NFIB nuclear factor I/B 0.0138964
BMP2K BMP2 inducible kinase 0.0138584
SOX6 SRY (sex determining region Y)-box 6 0.0137771
SMC5 structural maintenance of chromosomes 5 0.0137102
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0137088
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0137065
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0136425
PDE8A phosphodiesterase 8A 0.0134583
SRP54 signal recognition particle 54kDa 0.0133376
CDC73 cell division cycle 73 0.0133179
RSBN1L round spermatid basic protein 1-like 0.0133118
OGA O-GlcNAcase 0.0132773
MAML3 mastermind-like 3 (Drosophila) 0.0132325
SPPL3 signal peptide peptidase like 3 0.0132296
SHROOM3 shroom family member 3 0.01319
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.013159
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0130879
GYS1 glycogen synthase 1 (muscle) 0.0130711
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0130496
TET2 tet methylcytosine dioxygenase 2 0.0129353
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0129028
TJP1 tight junction protein 1 0.0128831
SEC31A SEC31 homolog A (S. cerevisiae) 0.0128335
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0128282
DCAF5 DDB1 and CUL4 associated factor 5 0.012807

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.320077
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137127
PTMA prothymosin, alpha -0.114763
RPLP1 ribosomal protein, large, P1 -0.101814
RPL35A ribosomal protein L35a -0.0892005
RPS8 ribosomal protein S8 -0.0879837
RPS6 ribosomal protein S6 -0.0877655
RPLP2 ribosomal protein, large, P2 -0.084
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0834961
TMSB10 thymosin beta 10 -0.072905
TMSB4X thymosin beta 4, X-linked -0.0721989
RPL23 ribosomal protein L23 -0.0703046
RPL34 ribosomal protein L34 -0.0691717
CENPF centromere protein F, 350/400kDa -0.0673536
MT2A metallothionein 2A -0.0658863
RPS23 ribosomal protein S23 -0.0646376
RPL19 ribosomal protein L19 -0.0644445
RPS24 ribosomal protein S24 -0.0642163
RACK1 receptor for activated C kinase 1 -0.0627387
SLC38A2 solute carrier family 38, member 2 -0.062493
ACTG1 actin gamma 1 -0.0611941
TPT1 tumor protein, translationally-controlled 1 -0.0603331
RPL12 ribosomal protein L12 -0.0596727
TUBB tubulin, beta class I -0.0577548
RPS19 ribosomal protein S19 -0.0565643
IER3 immediate early response 3 -0.0560072
MKI67 marker of proliferation Ki-67 -0.0555968
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0545982
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0545767
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.054206
RPL37 ribosomal protein L37 -0.0534621
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0529466
RPL37A ribosomal protein L37a -0.0527382
RPS27A ribosomal protein S27a -0.0496031
ENO1 enolase 1, (alpha) -0.049271
RPL7 ribosomal protein L7 -0.0474938
RPL26 ribosomal protein L26 -0.0467106
RPL36 ribosomal protein L36 -0.0462814
SOX4 SRY (sex determining region Y)-box 4 -0.045976
RPL5 ribosomal protein L5 -0.0458553
RPL32 ribosomal protein L32 -0.0456084
EEF2 eukaryotic translation elongation factor 2 -0.0455917
RPL31 ribosomal protein L31 -0.0454471
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0452991
RPS25 ribosomal protein S25 -0.0442468
RPS14 ribosomal protein S14 -0.0440125
RPS12 ribosomal protein S12 -0.0436251
DEK DEK proto-oncogene -0.0405169
RPLP0 ribosomal protein, large, P0 -0.0404794
RPS29 ribosomal protein S29 -0.0389732
TSHZ2 teashirt zinc finger homeobox 2 -0.0388709
ATP5F1B ATP synthase F1 subunit beta -0.0387634
RPS11 ribosomal protein S11 -0.0386864
RPL38 ribosomal protein L38 -0.0381383
RPS16 ribosomal protein S16 -0.0379896
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0366759
MGP matrix Gla protein -0.0363912
RPS13 ribosomal protein S13 -0.0362879
FTL ferritin, light polypeptide -0.036279
KPNB1 karyopherin (importin) beta 1 -0.0360035
HMGB1 high mobility group box 1 -0.034699
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0341535
RPS3 ribosomal protein S3 -0.034032
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.033222
RPS17 ribosomal protein S17 -0.0327981
HMGA1 high mobility group AT-hook 1 -0.0316315
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0314673
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.031279
RPL11 ribosomal protein L11 -0.0311233
PEG10 paternally expressed 10 -0.0310045
RPS21 ribosomal protein S21 -0.0309649
TUBA1B tubulin, alpha 1b -0.0309494
LOC112694756 uncharaterized LOC112694756 -0.0308239
RPL3 ribosomal protein L3 -0.0305687
EIF1 eukaryotic translation initiation factor 1 -0.0302521
RPL28 ribosomal protein L28 -0.0296915
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0294685
HSPA8 heat shock 70kDa protein 8 -0.0293148
VCL vinculin -0.0291822
RPS4X ribosomal protein S4, X-linked -0.0290151
RPS20 ribosomal protein S20 -0.0289746
RPS27 ribosomal protein S27 -0.0289123
RPL27A ribosomal protein L27a -0.0286904
RPL13A ribosomal protein L13a -0.0286639
RPL35 ribosomal protein L35 -0.0286331
DLG1 discs, large homolog 1 (Drosophila) -0.0284883
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0283048
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0282009
S100A9 S100 calcium binding protein A9 -0.0272915
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0265054
YBX1 Y box binding protein 1 -0.0263547
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.026344
FOXC1 forkhead box C1 -0.026123
MATR3 matrin 3 -0.0256912
RPL30 ribosomal protein L30 -0.0254091
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0253244
SMC4 structural maintenance of chromosomes 4 -0.0250943
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0250549
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0250345
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0248443