Vinblastine (sulfate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.106044
IGFBP3 insulin-like growth factor binding protein 3 0.0942311
ITGA6 integrin, alpha 6 0.069871
EGFR epidermal growth factor receptor 0.0648695
ESYT2 extended synaptotagmin-like protein 2 0.0584712
PSD3 pleckstrin and Sec7 domain containing 3 0.0564386
BAIAP2L1 BAI1-associated protein 2-like 1 0.0523035
FNDC3B fibronectin type III domain containing 3B 0.0511115
MYOF myoferlin 0.0485822
ARHGAP42 Rho GTPase activating protein 42 0.0427687
RICTOR RPTOR independent companion of MTOR, complex 2 0.0415781
EPS8 epidermal growth factor receptor pathway substrate 8 0.0403147
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0401952
ITPRID2 ITPR interacting domain containing 2 0.0387202
UBA6 ubiquitin-like modifier activating enzyme 6 0.0367861
EFNA5 ephrin-A5 0.0360831
OGA O-GlcNAcase 0.0346708
LAMA4 laminin, alpha 4 0.0346402
ERBIN erbb2 interacting protein 0.0338389
RBM39 RNA binding motif protein 39 0.0332386
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0319353
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0310139
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0306093
PPARG peroxisome proliferator-activated receptor gamma 0.0304939
KMT2E lysine (K)-specific methyltransferase 2E 0.030357
ASPH aspartate beta-hydroxylase 0.0298528
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0296962
ITCH itchy E3 ubiquitin protein ligase 0.0295932
TRIO trio Rho guanine nucleotide exchange factor 0.0295209
DSPP dentin sialophosphoprotein 0.0289352
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0286763
TSC22D2 TSC22 domain family, member 2 0.0279752
EMP1 epithelial membrane protein 1 0.0277321
ITGB4 integrin, beta 4 0.027082
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0268893
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0260832
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0260722
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.025769
KCMF1 potassium channel modulatory factor 1 0.0256996
ANLN anillin, actin binding protein 0.0256211
STK39 serine threonine kinase 39 0.0256071
XPO1 exportin 1 0.0255498
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0253206
SMAD3 SMAD family member 3 0.0251468
ARHGAP29 Rho GTPase activating protein 29 0.0250267
CAPRIN2 caprin family member 2 0.0247521
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0246447
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0243688
PTPRR protein tyrosine phosphatase, receptor type, R 0.0240289
ADAM9 ADAM metallopeptidase domain 9 0.0236702
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0233387
FLNB filamin B, beta 0.0230067
ZEB1 zinc finger E-box binding homeobox 1 0.0229838
JMJD1C jumonji domain containing 1C 0.0229657
AHNAK AHNAK nucleoprotein 0.0229022
HMGA2 high mobility group AT-hook 2 0.0227175
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0225515
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0222263
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0221167
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0220359
TRRAP transformation/transcription domain-associated protein 0.0219283
VCAN versican 0.0218569
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0217153
FAM13A family with sequence similarity 13, member A 0.0213499
ERRFI1 ERBB receptor feedback inhibitor 1 0.0211981
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0207283
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0206803
PRELID2 PRELI domain containing 2 0.0205064
GRB10 growth factor receptor-bound protein 10 0.0204265
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0203543
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0200863
MBNL2 muscleblind-like splicing regulator 2 0.0199771
OPTN optineurin 0.0196342
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0195583
PCBP2 poly(rC) binding protein 2 0.0195131
PTK2 protein tyrosine kinase 2 0.0192555
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0191245
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0190611
SLMAP sarcolemma associated protein 0.0188632
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0188444
SKAP2 src kinase associated phosphoprotein 2 0.0187495
MBNL1 muscleblind-like splicing regulator 1 0.0186818
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0186547
DCAF6 DDB1 and CUL4 associated factor 6 0.0185587
YAP1 Yes-associated protein 1 0.0185151
NCKAP1 NCK-associated protein 1 0.0185078
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0185014
NCOA3 nuclear receptor coactivator 3 0.0183057
NEK7 NIMA-related kinase 7 0.018021
ADD3 adducin 3 (gamma) 0.0180129
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0179088
ZNF292 zinc finger protein 292 0.0179054
FAT1 FAT atypical cadherin 1 0.0178674
MED13L mediator complex subunit 13-like 0.0177104
GDA guanine deaminase 0.017549
WDFY3 WD repeat and FYVE domain containing 3 0.0175055
CHD1 chromodomain helicase DNA binding protein 1 0.017253
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0172393
CCDC88A coiled-coil domain containing 88A 0.0172328
CLIP2 CAP-GLY domain containing linker protein 2 0.0171715

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.259257
LAMB3 laminin, beta 3 -0.241034
TPT1 tumor protein, translationally-controlled 1 -0.204725
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.193516
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.172017
KLK10 kallikrein-related peptidase 10 -0.126697
FTL ferritin, light polypeptide -0.124175
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.113706
SACK1A scaffolding CK1 anchoring protein A -0.108043
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.093028
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0871112
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0862562
B2M beta-2-microglobulin -0.0828887
RPL37A ribosomal protein L37a -0.0823429
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0770683
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0696532
RPL35A ribosomal protein L35a -0.0690271
RPLP2 ribosomal protein, large, P2 -0.0690181
TXNRD1 thioredoxin reductase 1 -0.0689143
RPS8 ribosomal protein S8 -0.0682039
RPL12 ribosomal protein L12 -0.0642303
TM4SF1 transmembrane 4 L six family member 1 -0.0636259
MXD1 MAX dimerization protein 1 -0.0601285
RPS3 ribosomal protein S3 -0.0599295
F3 coagulation factor III (thromboplastin, tissue factor) -0.0599093
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0596913
RPL23 ribosomal protein L23 -0.0572624
RPL37 ribosomal protein L37 -0.057115
RPS13 ribosomal protein S13 -0.0567041
ZSWIM6 zinc finger, SWIM-type containing 6 -0.055973
CD59 CD59 molecule, complement regulatory protein -0.0558434
RPL26 ribosomal protein L26 -0.05504
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.054854
RPL31 ribosomal protein L31 -0.0544797
VIM vimentin -0.0532705
RPS12 ribosomal protein S12 -0.0524071
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0501357
HMGA1 high mobility group AT-hook 1 -0.0477141
RPS24 ribosomal protein S24 -0.0476421
RPL30 ribosomal protein L30 -0.0472004
RPS19 ribosomal protein S19 -0.0470846
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0468975
FTH1 ferritin, heavy polypeptide 1 -0.0467814
CLMP CXADR-like membrane protein -0.0450057
RPL36A ribosomal protein L36a -0.0444588
PGK1 phosphoglycerate kinase 1 -0.0444371
RPS14 ribosomal protein S14 -0.0438685
TPM4 tropomyosin 4 -0.0437772
RPS27 ribosomal protein S27 -0.0437715
RPL9 ribosomal protein L9 -0.0434314
RAB7A RAB7A, member RAS oncogene family -0.0428508
RPS21 ribosomal protein S21 -0.0427427
EGR1 early growth response 1 -0.0424471
RPL34 ribosomal protein L34 -0.0415199
RPS25 ribosomal protein S25 -0.0409964
RPL11 ribosomal protein L11 -0.0408231
RPLP1 ribosomal protein, large, P1 -0.0404036
S100A6 S100 calcium binding protein A6 -0.0403954
SP100 SP100 nuclear antigen -0.0402113
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0384256
RPS27A ribosomal protein S27a -0.0370336
S100A11 S100 calcium binding protein A11 -0.0361832
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0361243
KLF6 Kruppel-like factor 6 -0.0353018
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0348931
RPL27A ribosomal protein L27a -0.034716
EIF5B eukaryotic translation initiation factor 5B -0.0345151
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0340558
BLZF1 basic leucine zipper nuclear factor 1 -0.0339708
RACK1 receptor for activated C kinase 1 -0.0335667
RPS16 ribosomal protein S16 -0.0335031
IFI6 interferon, alpha-inducible protein 6 -0.0331055
RPL8 ribosomal protein L8 -0.0327666
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0324164
EIF1 eukaryotic translation initiation factor 1 -0.0323925
LAMC2 laminin, gamma 2 -0.0317888
RPS23 ribosomal protein S23 -0.0313284
RPS20 ribosomal protein S20 -0.0312198
UBC ubiquitin C -0.0308448
HM13 histocompatibility (minor) 13 -0.0307273
MIDN midnolin -0.0304116
RPL36 ribosomal protein L36 -0.0299094
OSMR oncostatin M receptor -0.0296726
RPS29 ribosomal protein S29 -0.0293645
RPL28 ribosomal protein L28 -0.0291577
CD63 CD63 molecule -0.0283041
WSB1 WD repeat and SOCS box containing 1 -0.0280414
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0277839
GNAS GNAS complex locus -0.0275649
THBD thrombomodulin -0.0269945
RPS17 ribosomal protein S17 -0.0266934
RPS15 ribosomal protein S15 -0.0265953
HLA-A major histocompatibility complex, class I, A -0.0264977
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0261656
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0261554
MCL1 myeloid cell leukemia 1 -0.0260927
TXNIP thioredoxin interacting protein -0.0258537
DSC3 desmocollin 3 -0.0256828
CALU calumenin -0.0253398
PRRC2C proline-rich coiled-coil 2C -0.0253083