Vinblastine (sulfate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.0728645
RCC1 regulator of chromosome condensation 1 0.0724868
DSCAM Down syndrome cell adhesion molecule 0.0691884
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.067558
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.066875
NEBL nebulette 0.0566165
ZCCHC7 zinc finger, CCHC domain containing 7 0.055901
ARHGAP32 Rho GTPase activating protein 32 0.0555012
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0487111
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0439127
INTS6 integrator complex subunit 6 0.0434915
WLS wntless Wnt ligand secretion mediator 0.0432431
ZNF638 zinc finger protein 638 0.0430709
DENND1A DENN/MADD domain containing 1A 0.0423585
UBAP2 ubiquitin associated protein 2 0.0419756
MSH4 mutS homolog 4 0.0381669
USP34 ubiquitin specific peptidase 34 0.0374549
ZNF407 zinc finger protein 407 0.0355147
FMNL2 formin-like 2 0.0351098
AEBP2 AE binding protein 2 0.0340166
SNX14 sorting nexin 14 0.0337866
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0332983
RYK receptor-like tyrosine kinase 0.0332485
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0331664
UBE3C ubiquitin protein ligase E3C 0.0321079
SLIT2 slit homolog 2 (Drosophila) 0.0311536
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0308232
SFPQ splicing factor proline/glutamine-rich 0.0306156
KMT2C lysine (K)-specific methyltransferase 2C 0.0302009
SCFD1 sec1 family domain containing 1 0.0301557
TBC1D22A TBC1 domain family, member 22A 0.0301019
CPNE1 copine I 0.0289608
JARID2 jumonji, AT rich interactive domain 2 0.0284936
KDM4B lysine (K)-specific demethylase 4B 0.0280176
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0277545
CTBP2 C-terminal binding protein 2 0.0276245
HMGA2 high mobility group AT-hook 2 0.0275653
FAM193A family with sequence similarity 193, member A 0.0274596
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0271939
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0269743
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0261931
AKAP9 A kinase (PRKA) anchor protein 9 0.0261054
SCARB1 scavenger receptor class B, member 1 0.0255753
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0255363
ADAM32 ADAM metallopeptidase domain 32 0.0255284
TTC17 tetratricopeptide repeat domain 17 0.0255043
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0253977
ZFHX4 zinc finger homeobox 4 0.0247057
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0245776
GSK3B glycogen synthase kinase 3 beta 0.0242822
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 0.024236
MED13 mediator complex subunit 13 0.0241334
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0240757
PUM1 pumilio RNA-binding family member 1 0.0238825
AGO3 argonaute RISC catalytic component 3 0.0237228
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.023667
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0236476
GPBP1 GC-rich promoter binding protein 1 0.0236212
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0234532
PDE7A phosphodiesterase 7A 0.0230136
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0227416
SPDYA speedy/RINGO cell cycle regulator family member A 0.0227212
NF1 neurofibromin 1 0.0225034
WDR27 WD repeat domain 27 0.0224814
FNDC3B fibronectin type III domain containing 3B 0.0222804
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0222129
BMPR1A bone morphogenetic protein receptor, type IA 0.0213792
MMS22L MMS22-like, DNA repair protein 0.0213231
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) 0.0212215
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0211166
ARMH4 armadillo like helical domain containing 4 0.0211008
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0210469
CDK13 cyclin-dependent kinase 13 0.0210428
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0210407
KDM2A lysine (K)-specific demethylase 2A 0.0208742
GPATCH2L G patch domain containing 2-like 0.020757
TBL1X transducin (beta)-like 1X-linked 0.0207049
HELZ helicase with zinc finger 0.0205701
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 0.0204778
SHISA5 shisa family member 5 0.0202864
USP37 ubiquitin specific peptidase 37 0.0202848
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.020125
ICE2 interactor of little elongation complex ELL subunit 2 0.0200946
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0200907
IFRD1 interferon-related developmental regulator 1 0.020041
ADARB1 adenosine deaminase, RNA-specific, B1 0.0200043
PSEN1 presenilin 1 0.0197478
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0196552
NBEAL1 neurobeachin-like 1 0.0195257
PSPC1 paraspeckle component 1 0.0194962
RFC3 replication factor C (activator 1) 3, 38kDa 0.0194738
SLMAP sarcolemma associated protein 0.0194424
POU2F1 POU class 2 homeobox 1 0.0194324
CREBBP CREB binding protein 0.0194021
HP1BP3 heterochromatin protein 1, binding protein 3 0.0193159
ZNF451 zinc finger protein 451 0.0192433
KMT2E lysine (K)-specific methyltransferase 2E 0.0191581
RPTOR regulatory associated protein of MTOR, complex 1 0.0190998
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0190137
SP3 Sp3 transcription factor 0.0189733

decreased expression

Symbol Name Standardized Value
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.158214
RAD51B RAD51 paralog B -0.138662
STAT1 signal transducer and activator of transcription 1, 91kDa -0.130668
ADGRG6 adhesion G protein-coupled receptor G6 -0.107946
RPS6 ribosomal protein S6 -0.107857
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.104916
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.103717
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.100479
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0974453
SHROOM3 shroom family member 3 -0.0894394
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0885949
CADM2 cell adhesion molecule 2 -0.083829
RPLP1 ribosomal protein, large, P1 -0.080195
TOX thymocyte selection-associated high mobility group box -0.0800135
NPAS3 neuronal PAS domain protein 3 -0.0730296
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0703892
GRID2 glutamate receptor, ionotropic, delta 2 -0.0674058
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0669567
PDE4D phosphodiesterase 4D, cAMP-specific -0.0644795
TMEM41B transmembrane protein 41B -0.0639009
PTMA prothymosin, alpha -0.0621988
B2M beta-2-microglobulin -0.06162
RIGI RNA sensor RIG-I -0.0597589
TENM3 teneurin transmembrane protein 3 -0.0572166
IFI6 interferon, alpha-inducible protein 6 -0.0558287
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0549252
ACTG1 actin gamma 1 -0.0527257
GJA1 gap junction protein, alpha 1, 43kDa -0.0524228
LOC112694756 uncharaterized LOC112694756 -0.0519803
DST dystonin -0.0510988
SOX2 SRY (sex determining region Y)-box 2 -0.0510549
SLF1 SMC5-SMC6 complex localization factor 1 -0.0505064
EGR1 early growth response 1 -0.0500474
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0495335
LDHA lactate dehydrogenase A -0.0484895
RPL4 ribosomal protein L4 -0.0480941
RPS8 ribosomal protein S8 -0.047612
PGK1 phosphoglycerate kinase 1 -0.0474198
RAP1B RAP1B, member of RAS oncogene family -0.0471063
SOX4 SRY (sex determining region Y)-box 4 -0.0467361
RPL23 ribosomal protein L23 -0.0448641
EEF2 eukaryotic translation elongation factor 2 -0.0441002
ARB2A ARB2 cotranscriptional regulator A -0.0434813
ENO1 enolase 1, (alpha) -0.0433653
TPD52 tumor protein D52 -0.0433208
RPL12 ribosomal protein L12 -0.0425897
RPS5 ribosomal protein S5 -0.0423678
MIMS1 mitochondrial inner membrane scaffold 1 -0.0421503
KTN1 kinectin 1 (kinesin receptor) -0.0419137
RPL26 ribosomal protein L26 -0.0419076
SOX5 SRY (sex determining region Y)-box 5 -0.0415945
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0411896
RPL34 ribosomal protein L34 -0.0410237
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0405982
OSBPL10 oxysterol binding protein-like 10 -0.0405513
TMSB10 thymosin beta 10 -0.0400471
CELF2 CUGBP, Elav-like family member 2 -0.0393015
RPL19 ribosomal protein L19 -0.0384992
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0384516
EFNA5 ephrin-A5 -0.0378398
ZFP64 ZFP64 zinc finger protein -0.0377443
RPS21 ribosomal protein S21 -0.0376351
RACK1 receptor for activated C kinase 1 -0.0376039
YBX1 Y box binding protein 1 -0.0372387
RPS27 ribosomal protein S27 -0.0368693
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0366436
MYL12B myosin, light chain 12B, regulatory -0.0366242
TXNRD1 thioredoxin reductase 1 -0.035656
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0356416
RPS4X ribosomal protein S4, X-linked -0.0354256
H1-0 H1.0 linker histone -0.0353727
PRICKLE1 prickle homolog 1 (Drosophila) -0.0345444
VMP1 vacuole membrane protein 1 -0.0344704
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.034419
TUBB tubulin, beta class I -0.0343875
RPS19 ribosomal protein S19 -0.0340219
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0336852
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0336401
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0335894
RPL11 ribosomal protein L11 -0.0334106
RPS24 ribosomal protein S24 -0.0332263
ZNFX1 zinc finger, NFX1-type containing 1 -0.0328944
RPL35A ribosomal protein L35a -0.0328546
RPLP0 ribosomal protein, large, P0 -0.0327122
RPL36 ribosomal protein L36 -0.0322497
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0321874
RPS28 ribosomal protein S28 -0.0320908
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0317559
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0317423
HMGB1 high mobility group box 1 -0.0311118
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0309144
FAM162A family with sequence similarity 162, member A -0.0307894
MCTP1 multiple C2 domains, transmembrane 1 -0.0307887
RPL31 ribosomal protein L31 -0.0307726
CALD1 caldesmon 1 -0.0305776
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0304538
TPI1 triosephosphate isomerase 1 -0.0301184
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0299853
RPL13A ribosomal protein L13a -0.02996
RPS3 ribosomal protein S3 -0.0299595