Vinblastine (sulfate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.12503
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0965951
GPC6 glypican 6 0.0935187
NLGN1 neuroligin 1 0.0837442
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0716407
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0676645
FMN1 formin 1 0.0623605
LEF1 lymphoid enhancer-binding factor 1 0.05674
ASPH aspartate beta-hydroxylase 0.0528692
FRMD4A FERM domain containing 4A 0.0510838
MACROD2 MACRO domain containing 2 0.0507354
IGFBP5 insulin-like growth factor binding protein 5 0.0490084
PCDH7 protocadherin 7 0.0476808
PRELID2 PRELI domain containing 2 0.0436192
SETBP1 SET binding protein 1 0.035619
CTTNBP2 cortactin binding protein 2 0.0349051
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0347046
EXOC4 exocyst complex component 4 0.0344916
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0341241
WWTR1 WW domain containing transcription regulator 1 0.0332367
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0315897
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0306619
TMEM178B transmembrane protein 178B 0.0306034
LRMDA leucine rich melanocyte differentiation associated 0.0304368
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0303819
NAV3 neuron navigator 3 0.0290808
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0288592
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0287209
PDIA4 protein disulfide isomerase family A, member 4 0.0278217
HMCN1 hemicentin 1 0.0277469
UTRN utrophin 0.0259377
OSBPL10 oxysterol binding protein-like 10 0.0252268
DOCK4 dedicator of cytokinesis 4 0.0245008
A2M alpha-2-macroglobulin 0.0244872
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.023932
PDE10A phosphodiesterase 10A 0.023755
AHR aryl hydrocarbon receptor 0.0231665
TNIK TRAF2 and NCK interacting kinase 0.0230606
CDK14 cyclin-dependent kinase 14 0.0229882
COL19A1 collagen, type XIX, alpha 1 0.0228389
SOX5 SRY (sex determining region Y)-box 5 0.0225797
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0224136
SCFD2 sec1 family domain containing 2 0.0215335
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0209932
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0209762
OXR1 oxidation resistance 1 0.0209134
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0207962
ETV6 ets variant 6 0.0207216
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0206622
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0204833
FBXL17 F-box and leucine-rich repeat protein 17 0.0202385
SMYD3 SET and MYND domain containing 3 0.0200099
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0197023
MITF microphthalmia-associated transcription factor 0.0195802
NPC1 Niemann-Pick disease, type C1 0.0194433
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0191848
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0190779
NEGR1 neuronal growth regulator 1 0.0189878
EFCAB13 EF-hand calcium binding domain 13 0.0187954
NHSL1 NHS-like 1 0.0186258
TRIM9 tripartite motif containing 9 0.0180959
EHBP1 EH domain binding protein 1 0.0178965
AHCYL2 adenosylhomocysteinase-like 2 0.0177694
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0175253
SDCCAG8 serologically defined colon cancer antigen 8 0.0173604
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0172417
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0171213
ATXN1 ataxin 1 0.0169293
MBD5 methyl-CpG binding domain protein 5 0.0166839
NBEA neurobeachin 0.0166536
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.016365
NRCAM neuronal cell adhesion molecule 0.0163159
MEF2C myocyte enhancer factor 2C 0.0160924
LINGO2 leucine rich repeat and Ig domain containing 2 0.0159789
CDH19 cadherin 19, type 2 0.0159594
SDC2 syndecan 2 0.0158637
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0157277
PARD3B par-3 family cell polarity regulator beta 0.0156442
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0156421
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0155152
IL6ST interleukin 6 signal transducer 0.0154728
SHROOM4 shroom family member 4 0.0154615
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0152385
IFI16 interferon, gamma-inducible protein 16 0.0152195
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.01511
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.0145778
PI15 peptidase inhibitor 15 0.0144959
TCF12 transcription factor 12 0.0144001
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0142902
MAML3 mastermind-like 3 (Drosophila) 0.0142882
ARL15 ADP-ribosylation factor-like 15 0.0141196
DPYD dihydropyrimidine dehydrogenase 0.013962
AFAP1 actin filament associated protein 1 0.0138038
RAD51B RAD51 paralog B 0.0137795
ATM ATM serine/threonine kinase 0.0136303
SVIL supervillin 0.0135992
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 0.0131666
RHOJ ras homolog family member J 0.0131603
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0130838
AOPEP aminopeptidase O (putative) 0.0129563

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.387477
VIM vimentin -0.183341
NDRG1 N-myc downstream regulated 1 -0.135766
TMSB10 thymosin beta 10 -0.100456
MT2A metallothionein 2A -0.0944904
HLA-B major histocompatibility complex, class I, B -0.0888539
PTMA prothymosin, alpha -0.0828617
GDF15 growth differentiation factor 15 -0.0766968
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0738679
FTL ferritin, light polypeptide -0.0731569
FN1 fibronectin 1 -0.0689774
VGF VGF nerve growth factor inducible -0.0660791
HILPDA hypoxia inducible lipid droplet-associated -0.0628593
RPL35A ribosomal protein L35a -0.0604044
ENO1 enolase 1, (alpha) -0.059786
RPLP1 ribosomal protein, large, P1 -0.0574075
RPL37A ribosomal protein L37a -0.0571715
AKAP12 A kinase (PRKA) anchor protein 12 -0.0564207
RPS8 ribosomal protein S8 -0.0559453
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0525482
S100A6 S100 calcium binding protein A6 -0.052363
RPS6 ribosomal protein S6 -0.0463644
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0458324
ACTG1 actin gamma 1 -0.0429995
RPS19 ribosomal protein S19 -0.0426692
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0415031
ADM adrenomedullin -0.0407414
RPLP2 ribosomal protein, large, P2 -0.0407048
PKM pyruvate kinase, muscle -0.0396507
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0392583
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0370221
TPT1 tumor protein, translationally-controlled 1 -0.0369853
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.036607
RPS13 ribosomal protein S13 -0.0364333
RPS12 ribosomal protein S12 -0.0347942
VDAC1 voltage-dependent anion channel 1 -0.0346008
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0337672
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0336169
WSB1 WD repeat and SOCS box containing 1 -0.0334163
CALD1 caldesmon 1 -0.033114
RPS23 ribosomal protein S23 -0.0327835
SFTPA2 surfactant protein A2 -0.032188
CD44 CD44 molecule (Indian blood group) -0.0314914
RPL9 ribosomal protein L9 -0.0313629
EIF1 eukaryotic translation initiation factor 1 -0.0312688
WDR45B WD repeat domain 45B -0.03114
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0305446
EGR1 early growth response 1 -0.0304729
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0303855
RPL31 ribosomal protein L31 -0.0301324
ENO2 enolase 2 (gamma, neuronal) -0.0296547
RPL11 ribosomal protein L11 -0.0288228
RPL36 ribosomal protein L36 -0.0286972
RPL19 ribosomal protein L19 -0.0281593
RPL23 ribosomal protein L23 -0.0276762
S100A10 S100 calcium binding protein A10 -0.0271102
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0270594
ESYT2 extended synaptotagmin-like protein 2 -0.0268372
KMT2C lysine (K)-specific methyltransferase 2C -0.0267853
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0266637
KTN1 kinectin 1 (kinesin receptor) -0.0264638
RPS27A ribosomal protein S27a -0.0263629
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0258542
KDM5B lysine (K)-specific demethylase 5B -0.0257763
LMNA lamin A/C -0.0256729
TAC4 tachykinin 4 (hemokinin) -0.0253724
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0248818
RPS29 ribosomal protein S29 -0.0248062
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0247501
RPL5 ribosomal protein L5 -0.0246495
GNAS GNAS complex locus -0.0243117
IGF2 insulin-like growth factor 2 -0.0241918
GOLGA4 golgin A4 -0.0239916
MYH9 myosin, heavy chain 9, non-muscle -0.0238534
RPL34 ribosomal protein L34 -0.023626
RAB7A RAB7A, member RAS oncogene family -0.0235209
CALR calreticulin -0.0232907
LOC112694756 uncharaterized LOC112694756 -0.0232631
RPS3 ribosomal protein S3 -0.0232304
IFITM3 interferon induced transmembrane protein 3 -0.0231497
UBE2H ubiquitin-conjugating enzyme E2H -0.0230982
RPL28 ribosomal protein L28 -0.0230069
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0228358
RPL8 ribosomal protein L8 -0.0224695
EEF2 eukaryotic translation elongation factor 2 -0.0220818
UBC ubiquitin C -0.0219778
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0218519
PTPRF protein tyrosine phosphatase, receptor type, F -0.0215967
RPL37 ribosomal protein L37 -0.0215181
COPA coatomer protein complex, subunit alpha -0.0214738
CD109 CD109 molecule -0.0212845
GARS1 glycyl-tRNA synthetase 1 -0.0210566
FOSL1 FOS-like antigen 1 -0.0208903
ATF4 activating transcription factor 4 -0.0208301
IER3 immediate early response 3 -0.0206616
RPS16 ribosomal protein S16 -0.0206486
HLA-A major histocompatibility complex, class I, A -0.0206281
RPS17 ribosomal protein S17 -0.0205356
HSPB1 heat shock 27kDa protein 1 -0.0205074
POTEF POTE ankyrin domain family, member F -0.0204801