Vinblastine (sulfate)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0730115
SAMD4A sterile alpha motif domain containing 4A 0.0717313
DTNA dystrobrevin, alpha 0.0692404
TRIO trio Rho guanine nucleotide exchange factor 0.0674846
LAMC2 laminin, gamma 2 0.0578727
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0557798
LAMB3 laminin, beta 3 0.0532197
AKAP12 A kinase (PRKA) anchor protein 12 0.0471865
LMO7 LIM domain 7 0.0440146
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0418714
BCAR3 breast cancer anti-estrogen resistance 3 0.0398741
BZW1 basic leucine zipper and W2 domains 1 0.0393329
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0379684
THSD4 thrombospondin, type I, domain containing 4 0.0360181
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0359465
EXT1 exostosin glycosyltransferase 1 0.0354882
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0343994
GRB10 growth factor receptor-bound protein 10 0.0343259
SVIL supervillin 0.0341587
MACF1 microtubule-actin crosslinking factor 1 0.0313936
F3 coagulation factor III (thromboplastin, tissue factor) 0.0302295
ELL2 elongation factor, RNA polymerase II, 2 0.0281855
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0280772
ERRFI1 ERBB receptor feedback inhibitor 1 0.0275781
ZFAND3 zinc finger, AN1-type domain 3 0.0271196
ANKRD11 ankyrin repeat domain 11 0.0258673
LPP LIM domain containing preferred translocation partner in lipoma 0.0257865
MYO5B myosin VB 0.025629
RASAL2 RAS protein activator like 2 0.0255223
MMP7 matrix metallopeptidase 7 0.0252494
PICALM phosphatidylinositol binding clathrin assembly protein 0.0241574
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0238591
TJP1 tight junction protein 1 0.0230015
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0224375
ITGA6 integrin, alpha 6 0.0219705
RUNX1 runt-related transcription factor 1 0.0218602
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0214743
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0214377
TSC22D2 TSC22 domain family, member 2 0.0211738
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0210496
MAP1B microtubule-associated protein 1B 0.0208254
AFF4 AF4/FMR2 family, member 4 0.0207683
PARD3 par-3 family cell polarity regulator 0.0205644
IGFBP3 insulin-like growth factor binding protein 3 0.0202097
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0199009
HMGA2 high mobility group AT-hook 2 0.0196833
ALCAM activated leukocyte cell adhesion molecule 0.0193522
ARHGAP5 Rho GTPase activating protein 5 0.0193317
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0192439
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0191443
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0190178
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0188577
NPEPPS aminopeptidase puromycin sensitive 0.0188345
DSG2 desmoglein 2 0.0188283
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0187306
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0187245
CAPN2 calpain 2, (m/II) large subunit 0.0184374
MAST4 microtubule associated serine/threonine kinase family member 4 0.0182542
SMYD3 SET and MYND domain containing 3 0.0181914
RAD51B RAD51 paralog B 0.0181574
FMNL2 formin-like 2 0.0180756
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0180662
LAMA4 laminin, alpha 4 0.0175918
RASA2 RAS p21 protein activator 2 0.0174788
BMAL2 basic helix-loop-helix ARNT like 2 0.0173138
AHNAK2 AHNAK nucleoprotein 2 0.017281
FAM13A family with sequence similarity 13, member A 0.0172524
HDAC9 histone deacetylase 9 0.0172467
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0167863
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0167842
ITCH itchy E3 ubiquitin protein ligase 0.0167019
SAMD9 sterile alpha motif domain containing 9 0.0164612
AK1 adenylate kinase 1 0.0164559
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0162406
ATXN1 ataxin 1 0.0162112
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0161582
MYO1B myosin IB 0.0160274
MACC1 metastasis associated in colon cancer 1 0.0158858
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0156735
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0156563
RAB10 RAB10, member RAS oncogene family 0.0156441
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0153975
FRMD6 FERM domain containing 6 0.0153402
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.015163
ARHGAP21 Rho GTPase activating protein 21 0.0150919
BIRC6 baculoviral IAP repeat containing 6 0.0150086
FGD6 FYVE, RhoGEF and PH domain containing 6 0.01476
ZEB1 zinc finger E-box binding homeobox 1 0.0146329
DSPP dentin sialophosphoprotein 0.0145387
BACE2 beta-site APP-cleaving enzyme 2 0.014422
KMT2C lysine (K)-specific methyltransferase 2C 0.014325
PLS3 plastin 3 0.0143116
NRG3 neuregulin 3 0.0141639
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0141262
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0140971
TMCC3 transmembrane and coiled-coil domain family 3 0.0140376
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0140353
MYO1E myosin IE 0.0140177
IGF1R insulin-like growth factor 1 receptor 0.0138891
CDK17 cyclin-dependent kinase 17 0.0138089

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.304034
TMSB10 thymosin beta 10 -0.236385
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.225125
UBC ubiquitin C -0.184091
PTMA prothymosin, alpha -0.159879
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.110892
RPL23 ribosomal protein L23 -0.0952091
EIF1 eukaryotic translation initiation factor 1 -0.0867873
FTL ferritin, light polypeptide -0.0853654
MT1X metallothionein 1X -0.0838065
B2M beta-2-microglobulin -0.0798784
HLA-B major histocompatibility complex, class I, B -0.0796827
LOC112694756 uncharaterized LOC112694756 -0.0772243
POTEF POTE ankyrin domain family, member F -0.0746481
NDRG1 N-myc downstream regulated 1 -0.0721036
RPL19 ribosomal protein L19 -0.0703997
RPS8 ribosomal protein S8 -0.0681743
ISG15 ISG15 ubiquitin-like modifier -0.0676653
RPS27A ribosomal protein S27a -0.0666441
ENO1 enolase 1, (alpha) -0.0665063
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0616569
TPT1 tumor protein, translationally-controlled 1 -0.060799
ACTG1 actin gamma 1 -0.059793
RPS3 ribosomal protein S3 -0.059147
S100A6 S100 calcium binding protein A6 -0.057167
HLA-A major histocompatibility complex, class I, A -0.0561714
VIM vimentin -0.0518282
RPS19 ribosomal protein S19 -0.0514519
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0514117
RPLP1 ribosomal protein, large, P1 -0.0513412
RPL9 ribosomal protein L9 -0.0494715
PKM pyruvate kinase, muscle -0.0493683
HMGA1 high mobility group AT-hook 1 -0.0488979
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0457619
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0455475
RPS29 ribosomal protein S29 -0.0448007
PCBP2 poly(rC) binding protein 2 -0.0427458
RPL37A ribosomal protein L37a -0.0426218
PLAU plasminogen activator, urokinase -0.0415619
RACK1 receptor for activated C kinase 1 -0.0410927
RPS12 ribosomal protein S12 -0.0405666
JUN jun proto-oncogene -0.0382719
LDHA lactate dehydrogenase A -0.0382424
BRD2 bromodomain containing 2 -0.0382058
RPL34 ribosomal protein L34 -0.0377143
RPL31 ribosomal protein L31 -0.0374339
RPL5 ribosomal protein L5 -0.0370757
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0369828
RPS23 ribosomal protein S23 -0.0367381
RPS17 ribosomal protein S17 -0.0366908
RPS21 ribosomal protein S21 -0.0366139
MT1E metallothionein 1E -0.0363147
EEF2 eukaryotic translation elongation factor 2 -0.0358176
RPL35A ribosomal protein L35a -0.0356941
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0344104
C15ORF48 chromosome 15 open reading frame 48 -0.0343929
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0342915
SLC38A1 solute carrier family 38, member 1 -0.0340904
TGM2 transglutaminase 2 -0.033237
RPL11 ribosomal protein L11 -0.0331605
RPS25 ribosomal protein S25 -0.0312125
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0311538
RPLP0 ribosomal protein, large, P0 -0.0309425
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0308953
KRT8 keratin 8, type II -0.0303907
TMSB4X thymosin beta 4, X-linked -0.0298183
RPS16 ribosomal protein S16 -0.0295416
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0292383
CLDN4 claudin 4 -0.0290394
RPS14 ribosomal protein S14 -0.028796
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0283092
RPL12 ribosomal protein L12 -0.0276777
CALR calreticulin -0.0276614
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0276154
HLA-E major histocompatibility complex, class I, E -0.0272162
YBX1 Y box binding protein 1 -0.0269862
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0268245
RPL28 ribosomal protein L28 -0.0263135
DDIT4 DNA-damage-inducible transcript 4 -0.0262537
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0259314
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.025851
RPS24 ribosomal protein S24 -0.025727
TAGLN2 transgelin 2 -0.0251421
RPS5 ribosomal protein S5 -0.0250555
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0249451
CIB1 calcium and integrin binding 1 (calmyrin) -0.0248781
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0248233
S100A10 S100 calcium binding protein A10 -0.0248099
RPLP2 ribosomal protein, large, P2 -0.0247442
CCNL1 cyclin L1 -0.0239698
RPS6 ribosomal protein S6 -0.0238737
RPL37 ribosomal protein L37 -0.0238035
TXNIP thioredoxin interacting protein -0.0237996
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0236954
RPL8 ribosomal protein L8 -0.023536
KLF6 Kruppel-like factor 6 -0.0229037
RPL36AL ribosomal protein L36a-like -0.0228728
IFITM1 interferon induced transmembrane protein 1 -0.0228331
MCL1 myeloid cell leukemia 1 -0.022709
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0224955