Vinblastine (sulfate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0951564
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0737578
KDM4C lysine (K)-specific demethylase 4C 0.0471332
PDIA3 protein disulfide isomerase family A, member 3 0.0440026
PRELID2 PRELI domain containing 2 0.0413108
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0338706
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0324619
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0317107
ZNF292 zinc finger protein 292 0.027412
PCBP2 poly(rC) binding protein 2 0.024938
ZNF638 zinc finger protein 638 0.0224582
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0215624
COPA coatomer protein complex, subunit alpha 0.0215432
SEC31A SEC31 homolog A (S. cerevisiae) 0.0214999
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0212991
COG6 component of oligomeric golgi complex 6 0.0211566
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0206562
RAD51B RAD51 paralog B 0.0205609
MED13L mediator complex subunit 13-like 0.0205132
YAP1 Yes-associated protein 1 0.0193547
YEATS2 YEATS domain containing 2 0.0193256
NEBL nebulette 0.0191859
PCM1 pericentriolar material 1 0.0190439
HELZ helicase with zinc finger 0.0182303
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0178111
TTC3 tetratricopeptide repeat domain 3 0.0172509
BBX bobby sox homolog (Drosophila) 0.0171725
WWOX WW domain containing oxidoreductase 0.0171268
PCNT pericentrin 0.0168354
AKAP9 A kinase (PRKA) anchor protein 9 0.0164101
MBD5 methyl-CpG binding domain protein 5 0.016085
TMF1 TATA element modulatory factor 1 0.0157486
METTL15 methyltransferase like 15 0.0153651
SEC24D SEC24 family member D 0.0150562
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0149302
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0147485
SUMF1 sulfatase modifying factor 1 0.0146223
LCOR ligand dependent nuclear receptor corepressor 0.0142156
RBM5 RNA binding motif protein 5 0.0138447
RBM39 RNA binding motif protein 39 0.0137837
N4BP2L2 NEDD4 binding protein 2-like 2 0.0136259
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0135989
FAM117B family with sequence similarity 117, member B 0.0135483
MYH9 myosin, heavy chain 9, non-muscle 0.0134789
KMT2E lysine (K)-specific methyltransferase 2E 0.0134594
CTNND1 catenin (cadherin-associated protein), delta 1 0.0133444
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0130026
OGA O-GlcNAcase 0.0129697
KAT6A K(lysine) acetyltransferase 6A 0.0129561
CEP350 centrosomal protein 350kDa 0.0128881
UTRN utrophin 0.0128498
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0127403
ZC3H11A zinc finger CCCH-type containing 11A 0.0127099
GPHN gephyrin 0.012529
NCOR1 nuclear receptor corepressor 1 0.0124753
DENND4C DENN/MADD domain containing 4C 0.0123013
TNRC6A trinucleotide repeat containing 6A 0.012221
TUT7 terminal uridylyl transferase 7 0.0122088
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0121055
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.012066
NBAS neuroblastoma amplified sequence 0.0119835
DSCAM Down syndrome cell adhesion molecule 0.0119648
NT5DC3 5'-nucleotidase domain containing 3 0.0118798
USP53 ubiquitin specific peptidase 53 0.0118225
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0118223
TAS2R14 taste receptor, type 2, member 14 0.0117732
LSR lipolysis stimulated lipoprotein receptor 0.0117023
BCAS3 breast carcinoma amplified sequence 3 0.0116969
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.011692
KIF13A kinesin family member 13A 0.0116146
FOCAD focadhesin 0.0116103
ARHGAP5 Rho GTPase activating protein 5 0.0114961
AFF4 AF4/FMR2 family, member 4 0.0114537
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0114074
SEC23A Sec23 homolog A (S. cerevisiae) 0.0113668
ARFIP1 ADP-ribosylation factor interacting protein 1 0.0113578
SPRED2 sprouty-related, EVH1 domain containing 2 0.0113569
MON2 MON2 homolog (S. cerevisiae) 0.0113077
CTBP2 C-terminal binding protein 2 0.0112909
KDM6A lysine (K)-specific demethylase 6A 0.0112892
RPL3 ribosomal protein L3 0.0112138
GPR75-ASB3 GPR75-ASB3 readthrough 0.0112021
MTMR3 myotubularin related protein 3 0.0111359
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0111254
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0110587
FHIT fragile histidine triad 0.0110157
UBE4A ubiquitination factor E4A 0.0109701
KSR2 kinase suppressor of ras 2 0.0109077
NCKAP1 NCK-associated protein 1 0.0108861
CDK19 cyclin-dependent kinase 19 0.0108509
SEC24A SEC24 family member A 0.0108486
WWC2 WW and C2 domain containing 2 0.0107853
FNDC3B fibronectin type III domain containing 3B 0.0107726
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0107462
ZSWIM5 zinc finger, SWIM-type containing 5 0.0106503
SPICE1 spindle and centriole associated protein 1 0.0106389
SDCCAG8 serologically defined colon cancer antigen 8 0.0105501
DYNC2I1 dynein 2 intermediate chain 1 0.0104365
AGTPBP1 ATP/GTP binding protein 1 0.0103452
WDPCP WD repeat containing planar cell polarity effector 0.0103399

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.210647
TPT1 tumor protein, translationally-controlled 1 -0.191385
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.172916
PTMA prothymosin, alpha -0.15504
MT2A metallothionein 2A -0.116053
RPS6 ribosomal protein S6 -0.0946163
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0900208
FTL ferritin, light polypeptide -0.0719715
RPS8 ribosomal protein S8 -0.0717343
RPL35A ribosomal protein L35a -0.0716045
NDRG1 N-myc downstream regulated 1 -0.0684924
KRT18 keratin 18, type I -0.0637394
HMGA1 high mobility group AT-hook 1 -0.0615686
RPS24 ribosomal protein S24 -0.0604718
RPL23 ribosomal protein L23 -0.0593048
RPS19 ribosomal protein S19 -0.0573902
RPL26 ribosomal protein L26 -0.0561367
RPL37A ribosomal protein L37a -0.0553459
AHNAK AHNAK nucleoprotein -0.0552372
RPS3 ribosomal protein S3 -0.055071
RPL34 ribosomal protein L34 -0.0542414
KRT19 keratin 19, type I -0.0510967
RPL19 ribosomal protein L19 -0.0509695
RPL31 ribosomal protein L31 -0.049367
POTEF POTE ankyrin domain family, member F -0.0484698
EIF1 eukaryotic translation initiation factor 1 -0.0484025
RPS27A ribosomal protein S27a -0.0479418
AKAP12 A kinase (PRKA) anchor protein 12 -0.0477673
RPL12 ribosomal protein L12 -0.0464705
RPLP0 ribosomal protein, large, P0 -0.046388
ENO1 enolase 1, (alpha) -0.0462417
S100A9 S100 calcium binding protein A9 -0.0460582
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0452106
RPS25 ribosomal protein S25 -0.0449089
RPL36 ribosomal protein L36 -0.0439316
RPL30 ribosomal protein L30 -0.0431775
ACTG1 actin gamma 1 -0.0430087
S100A10 S100 calcium binding protein A10 -0.042519
RPLP2 ribosomal protein, large, P2 -0.0420261
RACK1 receptor for activated C kinase 1 -0.0416288
RPS12 ribosomal protein S12 -0.0413494
S100A6 S100 calcium binding protein A6 -0.0408404
RPS14 ribosomal protein S14 -0.0408156
TPM4 tropomyosin 4 -0.0404998
RPS17 ribosomal protein S17 -0.040452
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0392929
RPL32 ribosomal protein L32 -0.0390224
RPS16 ribosomal protein S16 -0.0382226
RPL11 ribosomal protein L11 -0.037894
RPLP1 ribosomal protein, large, P1 -0.0377043
RPS13 ribosomal protein S13 -0.0371767
MYL12B myosin, light chain 12B, regulatory -0.0367272
RPL8 ribosomal protein L8 -0.0365037
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0364583
RPL18 ribosomal protein L18 -0.0360594
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0354498
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0350158
RPL9 ribosomal protein L9 -0.0346009
RPL7A ribosomal protein L7a -0.0344409
LOC112694756 uncharaterized LOC112694756 -0.0335728
NAP1L1 nucleosome assembly protein 1-like 1 -0.0333071
RPL5 ribosomal protein L5 -0.0331737
TPI1 triosephosphate isomerase 1 -0.0322609
RPS11 ribosomal protein S11 -0.0315621
RPL35 ribosomal protein L35 -0.0313112
MIDN midnolin -0.0311471
RPS21 ribosomal protein S21 -0.0311279
RPL7 ribosomal protein L7 -0.0303595
RPL37 ribosomal protein L37 -0.0301898
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0297488
PFN1 profilin 1 -0.0294845
HLA-A major histocompatibility complex, class I, A -0.0294733
RPS10 ribosomal protein S10 -0.029315
EPCAM epithelial cell adhesion molecule -0.0288635
CCND1 cyclin D1 -0.0279734
KRT8 keratin 8, type II -0.0277221
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.027239
IFITM3 interferon induced transmembrane protein 3 -0.0268814
ANXA2 annexin A2 -0.0266557
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.026522
RPL27A ribosomal protein L27a -0.0256556
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0254046
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0253556
EIF5B eukaryotic translation initiation factor 5B -0.0253335
OAZ1 ornithine decarboxylase antizyme 1 -0.0252771
RPS15 ribosomal protein S15 -0.024873
RPL36A ribosomal protein L36a -0.0248396
NACA nascent polypeptide-associated complex alpha subunit -0.024792
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0247177
KPNB1 karyopherin (importin) beta 1 -0.0242571
YBX3 Y box binding protein 3 -0.0241073
RPL28 ribosomal protein L28 -0.023864
RPS5 ribosomal protein S5 -0.0235866
VIM vimentin -0.023563
RAN RAN, member RAS oncogene family -0.0234985
PKM pyruvate kinase, muscle -0.0234355
SLC38A2 solute carrier family 38, member 2 -0.0231899
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.022335
RPS29 ribosomal protein S29 -0.0223303
RPS23 ribosomal protein S23 -0.0220981