Vinblastine (sulfate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.216263
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.133329
CANX calnexin 0.0774694
PDIA3 protein disulfide isomerase family A, member 3 0.0683666
ASPH aspartate beta-hydroxylase 0.0646211
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0588089
CALR calreticulin 0.052065
VCL vinculin 0.0515061
GOLGA4 golgin A4 0.0468631
TPM4 tropomyosin 4 0.0457608
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0456018
TTC3 tetratricopeptide repeat domain 3 0.0453601
ALCAM activated leukocyte cell adhesion molecule 0.0425782
HMGA2 high mobility group AT-hook 2 0.0379701
CDK13 cyclin-dependent kinase 13 0.0379357
PRELID2 PRELI domain containing 2 0.037458
WWOX WW domain containing oxidoreductase 0.0353935
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0352833
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0341673
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0335693
ECT2 epithelial cell transforming 2 0.0335182
BZW1 basic leucine zipper and W2 domains 1 0.0304549
EXOC4 exocyst complex component 4 0.0290806
LARP1B La ribonucleoprotein domain family, member 1B 0.0286067
FNDC3B fibronectin type III domain containing 3B 0.0282118
ENO1 enolase 1, (alpha) 0.0278309
PDIA5 protein disulfide isomerase family A, member 5 0.0273937
MKI67 marker of proliferation Ki-67 0.0273285
BBS9 Bardet-Biedl syndrome 9 0.0273037
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0270074
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0269951
SEC31A SEC31 homolog A (S. cerevisiae) 0.026964
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0268299
PDIA6 protein disulfide isomerase family A, member 6 0.0267419
IGFBP3 insulin-like growth factor binding protein 3 0.026732
LMAN1 lectin, mannose-binding, 1 0.0265213
CSNK1A1 casein kinase 1, alpha 1 0.0259486
IQGAP1 IQ motif containing GTPase activating protein 1 0.0256984
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0256664
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0254924
SEC24D SEC24 family member D 0.0253704
FLNA filamin A, alpha 0.0250553
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.024971
TMF1 TATA element modulatory factor 1 0.0248065
OSBPL10 oxysterol binding protein-like 10 0.02474
MANF mesencephalic astrocyte-derived neurotrophic factor 0.0243299
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0240845
ANXA2 annexin A2 0.0239096
BICD1 bicaudal D homolog 1 (Drosophila) 0.0235965
PGM3 phosphoglucomutase 3 0.023558
SCFD1 sec1 family domain containing 1 0.0234841
RAD51B RAD51 paralog B 0.0231953
TES testin LIM domain protein 0.0228241
LDHA lactate dehydrogenase A 0.0227321
PDIA4 protein disulfide isomerase family A, member 4 0.0223092
EHBP1 EH domain binding protein 1 0.0222707
SET SET nuclear proto-oncogene 0.0221786
LAMA4 laminin, alpha 4 0.0220432
SEC63 SEC63 homolog (S. cerevisiae) 0.0218989
ANXA3 annexin A3 0.0218796
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0216433
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0212694
IARS1 isoleucyl-tRNA synthetase 1 0.0206637
HP1BP3 heterochromatin protein 1, binding protein 3 0.0206298
TFG TRK-fused gene 0.020627
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0204633
HMGB1 high mobility group box 1 0.0203637
NFX1 nuclear transcription factor, X-box binding 1 0.020282
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0202383
SPATA13 spermatogenesis associated 13 0.0199167
CENPE centromere protein E, 312kDa 0.0198647
SMC4 structural maintenance of chromosomes 4 0.0196202
HYOU1 hypoxia up-regulated 1 0.0194215
RAD50 RAD50 homolog (S. cerevisiae) 0.0192331
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0192173
TPX2 TPX2, microtubule-associated 0.0191329
PLS3 plastin 3 0.01906
ANKRD36 ankyrin repeat domain 36 0.0187473
PRR11 proline rich 11 0.0187004
ESRP1 epithelial splicing regulatory protein 1 0.0182816
ATM ATM serine/threonine kinase 0.018198
MACC1 metastasis associated in colon cancer 1 0.0181679
CENPP centromere protein P 0.018075
SIL1 SIL1 nucleotide exchange factor 0.0179944
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.01792
GARS1 glycyl-tRNA synthetase 1 0.0178372
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0175662
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0175576
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0173915
DEPDC1 DEP domain containing 1 0.0172844
COPB1 coatomer protein complex, subunit beta 1 0.0172814
PICALM phosphatidylinositol binding clathrin assembly protein 0.0172614
HMGB2 high mobility group box 2 0.0172496
APOLD1 apolipoprotein L domain containing 1 0.0169726
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.0168585
KIF4A kinesin family member 4A 0.0167881
XPOT exportin, tRNA 0.0167615
FNIP1 folliculin interacting protein 1 0.016529
FBXO16 F-box protein 16 0.0163517
RSL1D1 ribosomal L1 domain containing 1 0.0163284

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.150989
MT2A metallothionein 2A -0.140758
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120931
RPS19 ribosomal protein S19 -0.108903
RPL23 ribosomal protein L23 -0.106202
RPL35A ribosomal protein L35a -0.0863128
TUBB4B tubulin, beta 4B class IVb -0.0779523
FTL ferritin, light polypeptide -0.0730056
RPL32 ribosomal protein L32 -0.0700798
RPS6 ribosomal protein S6 -0.0695156
B2M beta-2-microglobulin -0.062223
MYH9 myosin, heavy chain 9, non-muscle -0.0607081
TUBA1B tubulin, alpha 1b -0.0603593
TUBB tubulin, beta class I -0.0569181
KRT7 keratin 7, type II -0.0552389
RPL34 ribosomal protein L34 -0.0549018
RPL12 ribosomal protein L12 -0.0546864
TXNRD1 thioredoxin reductase 1 -0.0529386
RPLP1 ribosomal protein, large, P1 -0.0527069
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0526351
RPLP2 ribosomal protein, large, P2 -0.0520585
RPL28 ribosomal protein L28 -0.0519601
RPS11 ribosomal protein S11 -0.0498441
RPS14 ribosomal protein S14 -0.0490244
S100A9 S100 calcium binding protein A9 -0.0488409
RPL19 ribosomal protein L19 -0.0480875
EGR1 early growth response 1 -0.0469945
PLEC plectin -0.0458724
ACTG1 actin gamma 1 -0.0455358
MT1X metallothionein 1X -0.0443084
RPL35 ribosomal protein L35 -0.0441462
SMAD3 SMAD family member 3 -0.0430345
APP amyloid beta (A4) precursor protein -0.0404608
RPL31 ribosomal protein L31 -0.0404025
RPL18 ribosomal protein L18 -0.0397914
NRIP1 nuclear receptor interacting protein 1 -0.039032
UGCG UDP-glucose ceramide glucosyltransferase -0.0380457
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0371285
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.036845
PFN1 profilin 1 -0.0358884
RPS21 ribosomal protein S21 -0.0358551
POTEF POTE ankyrin domain family, member F -0.035041
RPL13A ribosomal protein L13a -0.0349302
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0345886
ITGB8 integrin, beta 8 -0.0331722
RPL11 ribosomal protein L11 -0.0329232
RPS5 ribosomal protein S5 -0.032538
TUBA1C tubulin, alpha 1c -0.0320879
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0318898
RPL26 ribosomal protein L26 -0.0317619
RPS23 ribosomal protein S23 -0.0314381
MATR3 matrin 3 -0.0313635
EEF2 eukaryotic translation elongation factor 2 -0.0303589
LOC112694756 uncharaterized LOC112694756 -0.0302274
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0301517
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0301228
RPL36 ribosomal protein L36 -0.0300335
RPL5 ribosomal protein L5 -0.0300326
RPS4X ribosomal protein S4, X-linked -0.0295634
RPS16 ribosomal protein S16 -0.0293554
CCNL1 cyclin L1 -0.0293187
RPL8 ribosomal protein L8 -0.0291495
TPT1 tumor protein, translationally-controlled 1 -0.0289852
FOSL1 FOS-like antigen 1 -0.0285705
H1-0 H1.0 linker histone -0.0279274
RPS8 ribosomal protein S8 -0.027782
RPS17 ribosomal protein S17 -0.0274718
RPS24 ribosomal protein S24 -0.0273579
RPS29 ribosomal protein S29 -0.0270774
LAMB3 laminin, beta 3 -0.0268313
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0263428
PNISR PNN-interacting serine/arginine-rich protein -0.0257311
ICAM1 intercellular adhesion molecule 1 -0.025611
AHNAK AHNAK nucleoprotein -0.0255635
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0254005
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0252706
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0248128
CLDN4 claudin 4 -0.0246938
GPX4 glutathione peroxidase 4 -0.0246355
GNAS GNAS complex locus -0.0245797
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.02448
AKAP12 A kinase (PRKA) anchor protein 12 -0.0243176
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0241967
ARHGAP26 Rho GTPase activating protein 26 -0.0238431
SNX9 sorting nexin 9 -0.0237636
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0237551
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0237311
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0234616
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0234512
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0231633
TKT transketolase -0.0224746
RNF213 ring finger protein 213 -0.0224253
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0223876
CYBA cytochrome b-245, alpha polypeptide -0.0221751
RPS27 ribosomal protein S27 -0.022151
RPS13 ribosomal protein S13 -0.0220247
RPL3 ribosomal protein L3 -0.0219748
RPS10 ribosomal protein S10 -0.0218934
LMNA lamin A/C -0.0218495
RPS15 ribosomal protein S15 -0.0214855