Vinblastine (sulfate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0594646
PDLIM5 PDZ and LIM domain 5 0.0462206
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0413284
DTNA dystrobrevin, alpha 0.0377409
FMNL2 formin-like 2 0.0350663
INTS6 integrator complex subunit 6 0.0314527
PCBP2 poly(rC) binding protein 2 0.0278521
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0277284
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0262792
SAMD4A sterile alpha motif domain containing 4A 0.0260369
TNS1 tensin 1 0.0258219
VEGFA vascular endothelial growth factor A 0.0236942
FAM107B family with sequence similarity 107, member B 0.0232693
PTPRM protein tyrosine phosphatase, receptor type, M 0.0225476
KMT2E lysine (K)-specific methyltransferase 2E 0.0222877
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0218687
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0218548
CLIC4 chloride intracellular channel 4 0.0208906
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0206632
TRA2A transformer 2 alpha homolog (Drosophila) 0.0205128
HSPH1 heat shock 105kDa/110kDa protein 1 0.0204734
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0198359
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0190592
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.018925
QKI QKI, KH domain containing, RNA binding 0.0188633
MBNL2 muscleblind-like splicing regulator 2 0.0180272
MYO6 myosin VI 0.0172665
GMDS GDP-mannose 4,6-dehydratase 0.0170372
FAM13A family with sequence similarity 13, member A 0.0165198
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0162694
MYO1B myosin IB 0.016267
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0157415
CCNY cyclin Y 0.0157289
SRRM1 serine/arginine repetitive matrix 1 0.0156089
RYBP RING1 and YY1 binding protein 0.0154155
GLS2 glutaminase 2 (liver, mitochondrial) 0.0153854
CCNL1 cyclin L1 0.0153436
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0150366
KIF1B kinesin family member 1B 0.0150196
FKTN fukutin 0.0148658
EPS8 epidermal growth factor receptor pathway substrate 8 0.014521
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0141218
NABP1 nucleic acid binding protein 1 0.0139511
P4HB prolyl 4-hydroxylase, beta polypeptide 0.013654
ZEB1 zinc finger E-box binding homeobox 1 0.0136458
HELZ helicase with zinc finger 0.013197
CAMTA1 calmodulin binding transcription activator 1 0.013113
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0130404
ASXL2 additional sex combs like transcriptional regulator 2 0.0129282
COLEC11 collectin sub-family member 11 0.0128631
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0128563
UBA6 ubiquitin-like modifier activating enzyme 6 0.012852
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0127624
PICALM phosphatidylinositol binding clathrin assembly protein 0.0126929
SERTAD2 SERTA domain containing 2 0.0124408
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0124033
KYNU kynureninase 0.0123723
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0123541
ZNF451 zinc finger protein 451 0.0123369
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0123253
HOMER1 homer scaffolding protein 1 0.0122191
DDIT4 DNA-damage-inducible transcript 4 0.0122013
RNF145 ring finger protein 145 0.0121738
GRK3 G protein-coupled receptor kinase 3 0.012086
NUP58 nucleoporin 58 0.0120292
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0119901
KDM6A lysine (K)-specific demethylase 6A 0.0119859
OSBPL8 oxysterol binding protein-like 8 0.011926
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.0113923
MIMS1 mitochondrial inner membrane scaffold 1 0.0113285
BIRC3 baculoviral IAP repeat containing 3 0.0113254
ZFC3H1 zinc finger, C3H1-type containing 0.0113182
KDM4C lysine (K)-specific demethylase 4C 0.0112902
ADGRG6 adhesion G protein-coupled receptor G6 0.0111998
SPAG9 sperm associated antigen 9 0.0111431
USP37 ubiquitin specific peptidase 37 0.0111166
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 0.0111052
FBXO42 F-box protein 42 0.0110807
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0110702
SORBS1 sorbin and SH3 domain containing 1 0.0110214
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0109967
RPL3 ribosomal protein L3 0.0108812
TLE4 transducin-like enhancer of split 4 0.0108595
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0106503
ADAM32 ADAM metallopeptidase domain 32 0.0105018
ZNF638 zinc finger protein 638 0.0104432
RSRP1 arginine/serine-rich protein 1 0.0104026
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0104025
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.010315
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0103008
PLIN2 perilipin 2 0.0102737
USP34 ubiquitin specific peptidase 34 0.0102442
SHISA5 shisa family member 5 0.010206
AKAP13 A kinase (PRKA) anchor protein 13 0.00998522
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.00987479
ADARB1 adenosine deaminase, RNA-specific, B1 0.00973446
ERN1 endoplasmic reticulum to nucleus signaling 1 0.00972158
COPA coatomer protein complex, subunit alpha 0.00959928
MCU mitochondrial calcium uniporter 0.00956859
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00945207

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.267161
IGF2 insulin-like growth factor 2 -0.177074
APOB apolipoprotein B -0.157329
TPT1 tumor protein, translationally-controlled 1 -0.147076
FN1 fibronectin 1 -0.145048
MT2A metallothionein 2A -0.131774
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.127365
GPC3 glypican 3 -0.117921
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.10945
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.101732
TMSB10 thymosin beta 10 -0.0936413
ENO1 enolase 1, (alpha) -0.0932422
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0792203
TM4SF1 transmembrane 4 L six family member 1 -0.0780992
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0741566
RPLP1 ribosomal protein, large, P1 -0.0739011
SLC38A2 solute carrier family 38, member 2 -0.0708036
NKD1 naked cuticle homolog 1 (Drosophila) -0.0695928
IGFBP1 insulin-like growth factor binding protein 1 -0.0691533
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0666515
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0662036
RPS6 ribosomal protein S6 -0.0640218
RPS24 ribosomal protein S24 -0.0637964
RPL37A ribosomal protein L37a -0.0608982
ZMYND8 zinc finger, MYND-type containing 8 -0.060477
RPL35A ribosomal protein L35a -0.0600064
RPS8 ribosomal protein S8 -0.0580443
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.057958
RPL34 ribosomal protein L34 -0.0575683
GPC6 glypican 6 -0.057519
RPL11 ribosomal protein L11 -0.0574386
RPS19 ribosomal protein S19 -0.0569073
APOA2 apolipoprotein A-II -0.054822
RPS27A ribosomal protein S27a -0.053618
LOC112694756 uncharaterized LOC112694756 -0.0526702
FTL ferritin, light polypeptide -0.052252
RPS12 ribosomal protein S12 -0.0516665
ELL2 elongation factor, RNA polymerase II, 2 -0.0516396
EHBP1 EH domain binding protein 1 -0.0482876
RPL23 ribosomal protein L23 -0.0477058
ITGAV integrin, alpha V -0.0473867
RPL31 ribosomal protein L31 -0.0471972
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0468922
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0468354
NPAS2 neuronal PAS domain protein 2 -0.0458942
PEG3 paternally expressed 3 -0.0454734
FRMD5 FERM domain containing 5 -0.0451892
RPLP0 ribosomal protein, large, P0 -0.0438179
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0426595
RPS21 ribosomal protein S21 -0.0426383
MAML2 mastermind-like 2 (Drosophila) -0.0423535
OSMR oncostatin M receptor -0.0414914
DSPP dentin sialophosphoprotein -0.0412104
DLC1 DLC1 Rho GTPase activating protein -0.0411244
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0410895
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0410839
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0410376
RACK1 receptor for activated C kinase 1 -0.0408342
RRBP1 ribosome binding protein 1 -0.0407864
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0403686
RPL12 ribosomal protein L12 -0.0387291
RPLP2 ribosomal protein, large, P2 -0.0386594
TPM4 tropomyosin 4 -0.0385676
RPL37 ribosomal protein L37 -0.0382338
TRIM26 tripartite motif containing 26 -0.0382072
CP ceruloplasmin (ferroxidase) -0.0376298
SDC4 syndecan 4 -0.0364366
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0360132
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0357352
C3 complement component 3 -0.035616
MRTFA myocardin related transcription factor A -0.0348171
KLF6 Kruppel-like factor 6 -0.0347725
RPL26 ribosomal protein L26 -0.0346409
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0339899
AMBP alpha-1-microglobulin/bikunin precursor -0.0338086
ARHGAP5 Rho GTPase activating protein 5 -0.0337608
VCL vinculin -0.0333745
RPL5 ribosomal protein L5 -0.0331806
RPL38 ribosomal protein L38 -0.0329205
EGR1 early growth response 1 -0.0325257
B2M beta-2-microglobulin -0.032458
CTSB cathepsin B -0.0317922
RPS29 ribosomal protein S29 -0.0317225
ACTN4 actinin, alpha 4 -0.0316739
RPS3 ribosomal protein S3 -0.031649
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0314019
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0312781
PTPRF protein tyrosine phosphatase, receptor type, F -0.0311089
ACTG1 actin gamma 1 -0.0310933
BCL2L1 BCL2-like 1 -0.0310064
GNAS GNAS complex locus -0.0309681
DNAH17 dynein, axonemal, heavy chain 17 -0.0307484
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0305993
PTMA prothymosin, alpha -0.0305394
ABTB3 ankyrin repeat and BTB domain containing 3 -0.030026
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0298941
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.0293109
RPS14 ribosomal protein S14 -0.0290384
IFI6 interferon, alpha-inducible protein 6 -0.0289754
FERMT1 fermitin family member 1 -0.0285792