Vinblastine (sulfate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.0794255
INTS6 integrator complex subunit 6 0.0716995
EXT1 exostosin glycosyltransferase 1 0.0573379
PDE4D phosphodiesterase 4D, cAMP-specific 0.0523935
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0464175
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0447498
JMJD1C jumonji domain containing 1C 0.0421578
MBNL2 muscleblind-like splicing regulator 2 0.0403205
HMGA2 high mobility group AT-hook 2 0.0393122
PTK2 protein tyrosine kinase 2 0.0392441
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.038861
MYOF myoferlin 0.0387419
EFNA5 ephrin-A5 0.0371463
TRIO trio Rho guanine nucleotide exchange factor 0.0351477
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0327731
DSCAM Down syndrome cell adhesion molecule 0.032244
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0321126
PICALM phosphatidylinositol binding clathrin assembly protein 0.0319356
ASPH aspartate beta-hydroxylase 0.0311694
RBM39 RNA binding motif protein 39 0.0302287
RAI14 retinoic acid induced 14 0.0299225
NAV2 neuron navigator 2 0.0295164
ZSWIM6 zinc finger, SWIM-type containing 6 0.0291969
AOPEP aminopeptidase O (putative) 0.0281028
FNIP1 folliculin interacting protein 1 0.0278872
VCL vinculin 0.0277124
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0272857
ESYT2 extended synaptotagmin-like protein 2 0.0271646
IFI44L interferon-induced protein 44-like 0.0266083
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0264789
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.026209
RIGI RNA sensor RIG-I 0.0259832
MACF1 microtubule-actin crosslinking factor 1 0.0259268
RASAL2 RAS protein activator like 2 0.0256286
BCAR3 breast cancer anti-estrogen resistance 3 0.0252202
NRIP1 nuclear receptor interacting protein 1 0.0251895
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0245977
ANKHD1 ankyrin repeat and KH domain containing 1 0.0244594
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0242516
DST dystonin 0.024016
PDLIM5 PDZ and LIM domain 5 0.0238046
ATXN1 ataxin 1 0.0237087
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0232195
CSNK1A1 casein kinase 1, alpha 1 0.0229751
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0227545
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0226089
SQSTM1 sequestosome 1 0.0225556
UTRN utrophin 0.0215565
TTC3 tetratricopeptide repeat domain 3 0.021496
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0212119
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0211754
KLF5 Kruppel-like factor 5 (intestinal) 0.0209814
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0207567
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0205105
ANO6 anoctamin 6 0.0201155
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0201124
ZFAND3 zinc finger, AN1-type domain 3 0.0199918
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0198078
RNF220 ring finger protein 220 0.0194307
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0191021
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0187116
ZCCHC7 zinc finger, CCHC domain containing 7 0.0185819
IFI16 interferon, gamma-inducible protein 16 0.0185705
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0184257
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0183707
PLS3 plastin 3 0.0182307
UBAP2 ubiquitin associated protein 2 0.0182194
SMC5 structural maintenance of chromosomes 5 0.0180867
TOP1 topoisomerase (DNA) I 0.0180601
TSC22D1 TSC22 domain family, member 1 0.0180495
PRKCA protein kinase C, alpha 0.0175603
MTSS1 metastasis suppressor 1 0.0174913
ASXL1 additional sex combs like transcriptional regulator 1 0.0169268
SMAD3 SMAD family member 3 0.0168966
SVIL supervillin 0.0168927
SP100 SP100 nuclear antigen 0.0167539
DGKH diacylglycerol kinase, eta 0.0164075
HDAC9 histone deacetylase 9 0.0162038
IPO7 importin 7 0.016157
AGO2 argonaute RISC catalytic component 2 0.0161481
ERRFI1 ERBB receptor feedback inhibitor 1 0.0160943
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0160148
IARS1 isoleucyl-tRNA synthetase 1 0.0159707
PSD3 pleckstrin and Sec7 domain containing 3 0.0157947
FMNL2 formin-like 2 0.0157927
FNDC3B fibronectin type III domain containing 3B 0.0157109
GPHN gephyrin 0.0155912
AKAP13 A kinase (PRKA) anchor protein 13 0.015431
CD44 CD44 molecule (Indian blood group) 0.0153451
GRB10 growth factor receptor-bound protein 10 0.0152946
MTAP methylthioadenosine phosphorylase 0.0152102
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0151804
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0150675
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 0.0148736
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0148064
SIK3 SIK family kinase 3 0.0147715
STAU1 staufen double-stranded RNA binding protein 1 0.0146959
LCORL ligand dependent nuclear receptor corepressor-like 0.0146879
ECPAS Ecm29 proteasome adaptor and scaffold 0.0144277
FOXO1 forkhead box O1 0.014368

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.172851
NDRG1 N-myc downstream regulated 1 -0.127095
TIMP3 TIMP metallopeptidase inhibitor 3 -0.120176
CLU clusterin -0.0870978
LDHA lactate dehydrogenase A -0.0564877
POTEF POTE ankyrin domain family, member F -0.0502874
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0496866
B2M beta-2-microglobulin -0.0492613
STC1 stanniocalcin 1 -0.0487747
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0486846
MT2A metallothionein 2A -0.0459907
PGK1 phosphoglycerate kinase 1 -0.0443511
TMSB10 thymosin beta 10 -0.0441129
ENO1 enolase 1, (alpha) -0.0403921
HSPG2 heparan sulfate proteoglycan 2 -0.040127
BCL2L1 BCL2-like 1 -0.0397197
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0376217
MEF2A myocyte enhancer factor 2A -0.0365142
SQLE squalene epoxidase -0.0344833
RPS3 ribosomal protein S3 -0.0330951
KRT17 keratin 17, type I -0.0330846
LOC112694756 uncharaterized LOC112694756 -0.0316083
EPHA2 EPH receptor A2 -0.030757
FTH1 ferritin, heavy polypeptide 1 -0.030388
FOSL1 FOS-like antigen 1 -0.0299369
RPS6 ribosomal protein S6 -0.0297681
RPS8 ribosomal protein S8 -0.0295346
NRG1 neuregulin 1 -0.0290611
ITGA6 integrin, alpha 6 -0.0285621
RPL37 ribosomal protein L37 -0.0283565
CYB5R3 cytochrome b5 reductase 3 -0.0282736
EFHD2 EF-hand domain family, member D2 -0.0280025
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0272341
IGF2 insulin-like growth factor 2 -0.0267726
TGM2 transglutaminase 2 -0.0266137
RPS17 ribosomal protein S17 -0.0266049
PLEC plectin -0.0265626
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0264691
CEMIP cell migration inducing protein, hyaluronan binding -0.0264619
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0258955
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0254255
RPS12 ribosomal protein S12 -0.0253991
SULF1 sulfatase 1 -0.0247506
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0245031
KISS1 KiSS-1 metastasis-suppressor -0.0242265
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0241267
IGFBP4 insulin-like growth factor binding protein 4 -0.0240216
LIMA1 LIM domain and actin binding 1 -0.0239976
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0238006
CSNK1E casein kinase 1, epsilon -0.0237022
IGFBP6 insulin-like growth factor binding protein 6 -0.0235299
KRT6A keratin 6A, type II -0.0235055
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.023329
OSMR oncostatin M receptor -0.0232977
PODXL podocalyxin-like -0.0231968
HLA-A major histocompatibility complex, class I, A -0.0231581
CSDE1 cold shock domain containing E1, RNA-binding -0.023018
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0227563
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0216438
PFN1 profilin 1 -0.0214714
TPM3 tropomyosin 3 -0.0213068
TAGLN2 transgelin 2 -0.0211579
RPL21 ribosomal protein L21 -0.0210979
CAPN2 calpain 2, (m/II) large subunit -0.0209253
SYNJ2 synaptojanin 2 -0.020861
LAMA5 laminin, alpha 5 -0.0207076
RPL9 ribosomal protein L9 -0.0206569
IFITM1 interferon induced transmembrane protein 1 -0.0206506
RPL31 ribosomal protein L31 -0.0205755
DSG2 desmoglein 2 -0.0205705
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0204169
S100A11 S100 calcium binding protein A11 -0.0202488
ANXA11 annexin A11 -0.0201727
RPS14 ribosomal protein S14 -0.0201218
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0200942
WASF2 WAS protein family, member 2 -0.0200458
S100A2 S100 calcium binding protein A2 -0.0198706
S100A10 S100 calcium binding protein A10 -0.0197336
RPS5 ribosomal protein S5 -0.0195391
ACBD3 acyl-CoA binding domain containing 3 -0.019389
PLAT plasminogen activator, tissue -0.0192365
HMGA1 high mobility group AT-hook 1 -0.0187307
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0187244
SOX7 SRY (sex determining region Y)-box 7 -0.0186152
RPS2 ribosomal protein S2 -0.0185961
KTN1 kinectin 1 (kinesin receptor) -0.0185119
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0184934
TMSB4X thymosin beta 4, X-linked -0.018341
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0181538
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0180415
THOC2 THO complex 2 -0.0180128
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0176686
FSCN1 fascin actin-bundling protein 1 -0.0175436
CD59 CD59 molecule, complement regulatory protein -0.017523
RACK1 receptor for activated C kinase 1 -0.0174147
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.017217
KRT14 keratin 14, type I -0.0172056
ENO2 enolase 2 (gamma, neuronal) -0.0164203
RPS27 ribosomal protein S27 -0.0163096
YBX1 Y box binding protein 1 -0.0162162