Vinblastine (sulfate)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.164502
NALF1 NALCN channel auxiliary factor 1 0.141314
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.128564
NAV2 neuron navigator 2 0.123441
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.108981
IGFBP3 insulin-like growth factor binding protein 3 0.102532
ASPH aspartate beta-hydroxylase 0.102356
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0867139
TRIO trio Rho guanine nucleotide exchange factor 0.0863088
INTS6 integrator complex subunit 6 0.0859686
TLE4 transducin-like enhancer of split 4 0.0831361
PHACTR1 phosphatase and actin regulator 1 0.0771216
ZSWIM6 zinc finger, SWIM-type containing 6 0.0681525
ENO1 enolase 1, (alpha) 0.0674814
SET SET nuclear proto-oncogene 0.0649969
FNDC3B fibronectin type III domain containing 3B 0.0624082
PDIA3 protein disulfide isomerase family A, member 3 0.0615565
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.061518
UBC ubiquitin C 0.0612623
SMAD3 SMAD family member 3 0.0604691
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0572602
PKM pyruvate kinase, muscle 0.0560834
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0557741
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0556822
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0553349
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0548878
SLIT2 slit homolog 2 (Drosophila) 0.0548393
MBNL1 muscleblind-like splicing regulator 1 0.0545519
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0536699
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0523222
CANX calnexin 0.0503833
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0488529
ABI3BP ABI family, member 3 (NESH) binding protein 0.0488416
SQSTM1 sequestosome 1 0.0478019
RIGI RNA sensor RIG-I 0.0471382
PRELID2 PRELI domain containing 2 0.0470064
PCBP2 poly(rC) binding protein 2 0.0458544
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0456766
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0454859
MYOF myoferlin 0.0454817
PLSCR1 phospholipid scramblase 1 0.0449885
ERBIN erbb2 interacting protein 0.0447404
BBX bobby sox homolog (Drosophila) 0.0443147
FLNA filamin A, alpha 0.0431145
FN1 fibronectin 1 0.0430386
VCL vinculin 0.0421291
PDLIM5 PDZ and LIM domain 5 0.0418483
RAD51B RAD51 paralog B 0.0416418
ATXN1 ataxin 1 0.0413595
FNIP1 folliculin interacting protein 1 0.0411209
POTEF POTE ankyrin domain family, member F 0.0406656
KTN1 kinectin 1 (kinesin receptor) 0.0402419
RND3 Rho family GTPase 3 0.0400944
LIMCH1 LIM and calponin homology domains 1 0.0400696
LPP LIM domain containing preferred translocation partner in lipoma 0.0399422
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0397808
GLS2 glutaminase 2 (liver, mitochondrial) 0.0393652
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0390579
SEPTIN9 septin 9 0.0389794
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0386824
DST dystonin 0.0386363
WWOX WW domain containing oxidoreductase 0.0386347
HSPH1 heat shock 105kDa/110kDa protein 1 0.0382817
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0382559
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0380437
SDK1 sidekick cell adhesion molecule 1 0.0377351
PBX3 pre-B-cell leukemia homeobox 3 0.0374745
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0374521
DLG1 discs, large homolog 1 (Drosophila) 0.0374383
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0373736
KMT2C lysine (K)-specific methyltransferase 2C 0.0367844
CLIC4 chloride intracellular channel 4 0.0365424
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0363241
RNF213 ring finger protein 213 0.0362302
LDHA lactate dehydrogenase A 0.0362259
NAP1L1 nucleosome assembly protein 1-like 1 0.0360262
LRMDA leucine rich melanocyte differentiation associated 0.0358324
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0356167
MED13L mediator complex subunit 13-like 0.0355274
DTNA dystrobrevin, alpha 0.0355161
MYO10 myosin X 0.0353289
RUNX1 runt-related transcription factor 1 0.0343904
MSN moesin 0.0343364
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0340615
PTPRG protein tyrosine phosphatase, receptor type, G 0.0340344
TPM3 tropomyosin 3 0.0339735
ANKRD33B ankyrin repeat domain 33B 0.0338699
FHIT fragile histidine triad 0.0338616
SMYD3 SET and MYND domain containing 3 0.0336953
UTRN utrophin 0.0336557
EFNA5 ephrin-A5 0.0335755
ZFP36L1 ZFP36 ring finger protein-like 1 0.0334398
UBAP2 ubiquitin associated protein 2 0.0333197
CEMIP2 cell migration inducing hyaluronidase 2 0.0331619
PRKCA protein kinase C, alpha 0.0330716
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0329931
JARID2 jumonji, AT rich interactive domain 2 0.0328766
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0322955
DIPK2A divergent protein kinase domain 2A 0.0321846
TUFT1 tuftelin 1 0.0317741

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.164169
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.159721
HLA-B major histocompatibility complex, class I, B -0.108344
PALM2AKAP2 PALM2 and AKAP2 fusion -0.101661
AKAP12 A kinase (PRKA) anchor protein 12 -0.0994897
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.080832
NAMPT nicotinamide phosphoribosyltransferase -0.0794311
GLIS3 GLIS family zinc finger 3 -0.0756782
OSMR oncostatin M receptor -0.0747446
FTH1 ferritin, heavy polypeptide 1 -0.0675138
TXNRD1 thioredoxin reductase 1 -0.0649814
EXT1 exostosin glycosyltransferase 1 -0.0595418
ATP13A3 ATPase type 13A3 -0.05911
HLA-C major histocompatibility complex, class I, C -0.0538017
TUBB tubulin, beta class I -0.052074
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.05184
MT1X metallothionein 1X -0.0509434
MT2A metallothionein 2A -0.0492683
POSTN periostin, osteoblast specific factor -0.0492156
FTL ferritin, light polypeptide -0.0492034
HEG1 heart development protein with EGF-like domains 1 -0.0476858
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0458812
CD44 CD44 molecule (Indian blood group) -0.0442675
TGFB2 transforming growth factor, beta 2 -0.0439806
TMSB10 thymosin beta 10 -0.0434918
MAP1B microtubule-associated protein 1B -0.042696
F3 coagulation factor III (thromboplastin, tissue factor) -0.041125
RPS6 ribosomal protein S6 -0.0404693
RPL35A ribosomal protein L35a -0.0392256
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0386161
SLC12A8 solute carrier family 12, member 8 -0.0380658
ACTG1 actin gamma 1 -0.0374618
ELL2 elongation factor, RNA polymerase II, 2 -0.0356336
MKI67 marker of proliferation Ki-67 -0.0342857
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0337204
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0324553
GOLGA3 golgin A3 -0.0314445
LOC112694756 uncharaterized LOC112694756 -0.0301077
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0295884
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0291855
PGK1 phosphoglycerate kinase 1 -0.0288909
SCFD2 sec1 family domain containing 2 -0.0288489
RPL12 ribosomal protein L12 -0.0286952
ARF4 ADP-ribosylation factor 4 -0.0284539
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0278937
TRIM56 tripartite motif containing 56 -0.0275224
LOX lysyl oxidase -0.0266556
RPS19 ribosomal protein S19 -0.0264928
TMEM41B transmembrane protein 41B -0.0264824
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.026348
GPR107 G protein-coupled receptor 107 -0.0262936
FOXP1 forkhead box P1 -0.0260869
ARF1 ADP-ribosylation factor 1 -0.025038
MYH9 myosin, heavy chain 9, non-muscle -0.024908
GOLGA2 golgin A2 -0.0246796
EIF1 eukaryotic translation initiation factor 1 -0.0239624
PLCB4 phospholipase C, beta 4 -0.02384
UFM1 ubiquitin-fold modifier 1 -0.023804
PRRC2B proline-rich coiled-coil 2B -0.0235568
GRAMD2B GRAM domain containing 2B -0.0231642
PTPRF protein tyrosine phosphatase, receptor type, F -0.022838
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0226472
RPLP2 ribosomal protein, large, P2 -0.0225205
TUBB4B tubulin, beta 4B class IVb -0.0224094
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0223988
TMSB4X thymosin beta 4, X-linked -0.0221726
CREB5 cAMP responsive element binding protein 5 -0.0219126
MAP4 microtubule-associated protein 4 -0.0219019
BLZF1 basic leucine zipper nuclear factor 1 -0.0218824
ANKRD10 ankyrin repeat domain 10 -0.0217219
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0216692
NPPB natriuretic peptide B -0.0214878
RHOBTB3 Rho-related BTB domain containing 3 -0.0213397
KLF6 Kruppel-like factor 6 -0.0212612
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0211531
GOLT1B golgi transport 1B -0.0209943
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0208282
PTX3 pentraxin 3, long -0.0206244
IARS1 isoleucyl-tRNA synthetase 1 -0.0204543
ZXDC ZXD family zinc finger C -0.020391
CTSD cathepsin D -0.0202559
NUP214 nucleoporin 214kDa -0.0202139
RAB2A RAB2A, member RAS oncogene family -0.020026
MGLL monoglyceride lipase -0.0199827
COPB1 coatomer protein complex, subunit beta 1 -0.0199155
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0197245
SENP5 SUMO1/sentrin specific peptidase 5 -0.0195231
HM13 histocompatibility (minor) 13 -0.0192905
MON2 MON2 homolog (S. cerevisiae) -0.0192524
PRUNE2 prune homolog 2 (Drosophila) -0.0191044
RPLP1 ribosomal protein, large, P1 -0.0188436
RPL35 ribosomal protein L35 -0.0187345
NT5E 5'-nucleotidase, ecto (CD73) -0.0186572
FSTL1 follistatin-like 1 -0.0185234
RPL26 ribosomal protein L26 -0.0184664
SERF2 small EDRK-rich factor 2 -0.0184071
MYL12B myosin, light chain 12B, regulatory -0.018121
HLA-A major histocompatibility complex, class I, A -0.0180905
BSG basigin (Ok blood group) -0.0180034
ZEB2 zinc finger E-box binding homeobox 2 -0.0177734