Vinblastine (sulfate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.202605
AKAP12 A kinase (PRKA) anchor protein 12 0.175171
PABPC1 poly(A) binding protein, cytoplasmic 1 0.103196
DTNA dystrobrevin, alpha 0.0923049
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0784974
DST dystonin 0.0726423
VIM vimentin 0.0709112
RUNX1 runt-related transcription factor 1 0.0596353
MMP12 matrix metallopeptidase 12 0.059139
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0541356
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0529482
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0527076
TRIO trio Rho guanine nucleotide exchange factor 0.0517639
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0486934
FNDC3B fibronectin type III domain containing 3B 0.0463553
SPAG9 sperm associated antigen 9 0.0463039
CD109 CD109 molecule 0.0459676
ERRFI1 ERBB receptor feedback inhibitor 1 0.0441574
KTN1 kinectin 1 (kinesin receptor) 0.0422158
NUP58 nucleoporin 58 0.0399446
CD44 CD44 molecule (Indian blood group) 0.0393589
UBA6 ubiquitin-like modifier activating enzyme 6 0.0390363
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0388276
PBX3 pre-B-cell leukemia homeobox 3 0.0372693
JUN jun proto-oncogene 0.0362755
KMT2E lysine (K)-specific methyltransferase 2E 0.0353801
PTMA prothymosin, alpha 0.0352917
ELL2 elongation factor, RNA polymerase II, 2 0.0348734
FN1 fibronectin 1 0.0347127
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0338348
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0337925
PDIA3 protein disulfide isomerase family A, member 3 0.0337426
MXI1 MAX interactor 1, dimerization protein 0.0337273
KDM2A lysine (K)-specific demethylase 2A 0.033199
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0330794
P4HB prolyl 4-hydroxylase, beta polypeptide 0.032448
LIMS1 LIM and senescent cell antigen-like domains 1 0.0322118
CANX calnexin 0.0316931
MYH9 myosin, heavy chain 9, non-muscle 0.0312838
MAP2K1 mitogen-activated protein kinase kinase 1 0.0310425
TPM3 tropomyosin 3 0.0307119
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0303077
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0300267
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0295477
FMNL2 formin-like 2 0.0291219
SAMD4A sterile alpha motif domain containing 4A 0.0285936
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0285494
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0285219
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0278416
WDR45B WD repeat domain 45B 0.0277814
KDM3A lysine (K)-specific demethylase 3A 0.0277049
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0268068
HELZ helicase with zinc finger 0.0267911
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0266612
RNF145 ring finger protein 145 0.0264301
ESYT2 extended synaptotagmin-like protein 2 0.0262032
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0254086
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0252057
MYO1B myosin IB 0.024758
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0246662
HILPDA hypoxia inducible lipid droplet-associated 0.0245826
GOLGA4 golgin A4 0.0244879
ATF3 activating transcription factor 3 0.0242429
ZFAND3 zinc finger, AN1-type domain 3 0.023561
SCAF11 SR-related CTD-associated factor 11 0.0231331
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0223338
TMOD3 tropomodulin 3 (ubiquitous) 0.0218148
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0215059
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 0.0212586
MYOF myoferlin 0.0211983
PICALM phosphatidylinositol binding clathrin assembly protein 0.0211085
TPM4 tropomyosin 4 0.0210466
MED13 mediator complex subunit 13 0.0207139
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0206459
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.020636
ZNF292 zinc finger protein 292 0.0205745
USP3 ubiquitin specific peptidase 3 0.020227
ZNF148 zinc finger protein 148 0.0202119
FRMD6 FERM domain containing 6 0.0201679
TSC22D2 TSC22 domain family, member 2 0.0201488
MSN moesin 0.0201416
HOOK2 hook microtubule-tethering protein 2 0.0199899
ADAM9 ADAM metallopeptidase domain 9 0.0199471
ZNF207 zinc finger protein 207 0.0196612
TPR translocated promoter region, nuclear basket protein 0.0194387
COPA coatomer protein complex, subunit alpha 0.0190853
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0190165
KIF13A kinesin family member 13A 0.0189675
PCBP2 poly(rC) binding protein 2 0.0188671
RAB6A RAB6A, member RAS oncogene family 0.0188666
SEPTIN7 septin 7 0.0188301
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0187764
ERBIN erbb2 interacting protein 0.0187333
WAC WW domain containing adaptor with coiled-coil 0.0185509
FNBP1L formin binding protein 1-like 0.0184784
ARHGAP21 Rho GTPase activating protein 21 0.0184744
KMT2C lysine (K)-specific methyltransferase 2C 0.0183993
BIRC6 baculoviral IAP repeat containing 6 0.0183861
ANXA2 annexin A2 0.0182918
LMAN1 lectin, mannose-binding, 1 0.0182599

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.302393
TMSB10 thymosin beta 10 -0.163934
FTL ferritin, light polypeptide -0.120639
MT2A metallothionein 2A -0.112504
ASPH aspartate beta-hydroxylase -0.11078
GPC6 glypican 6 -0.109811
PRKG1 protein kinase, cGMP-dependent, type I -0.105476
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0973508
RPL23 ribosomal protein L23 -0.0903301
TPT1 tumor protein, translationally-controlled 1 -0.0877696
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0856585
RPS3 ribosomal protein S3 -0.0829293
RPL12 ribosomal protein L12 -0.0789802
KIAA1217 KIAA1217 -0.0754743
SAMD3 sterile alpha motif domain containing 3 -0.0736337
HMGA2 high mobility group AT-hook 2 -0.0715494
LSAMP limbic system-associated membrane protein -0.0661105
RPS19 ribosomal protein S19 -0.0653601
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0629066
PTPRG protein tyrosine phosphatase, receptor type, G -0.0574339
PHACTR1 phosphatase and actin regulator 1 -0.0573512
RPS12 ribosomal protein S12 -0.0569275
RPL37A ribosomal protein L37a -0.0539828
RPL31 ribosomal protein L31 -0.0538545
NTM neurotrimin -0.0535052
RPL35A ribosomal protein L35a -0.0534759
RPL19 ribosomal protein L19 -0.0517202
EXT1 exostosin glycosyltransferase 1 -0.0513593
RPS24 ribosomal protein S24 -0.051213
RPL9 ribosomal protein L9 -0.0494145
RPLP2 ribosomal protein, large, P2 -0.049169
KIAA1549L KIAA1549-like -0.0480393
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0462826
DSCAM Down syndrome cell adhesion molecule -0.0459864
RPL32 ribosomal protein L32 -0.0458216
RPS17 ribosomal protein S17 -0.0453862
YBX3 Y box binding protein 3 -0.0445858
RPL26 ribosomal protein L26 -0.0442652
RPLP1 ribosomal protein, large, P1 -0.0441195
NABP1 nucleic acid binding protein 1 -0.0436
ACTG1 actin gamma 1 -0.0422098
RPLP0 ribosomal protein, large, P0 -0.0421085
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.0414069
ESM1 endothelial cell-specific molecule 1 -0.0411735
CDH13 cadherin 13 -0.0407765
RPL30 ribosomal protein L30 -0.0400409
KISS1 KiSS-1 metastasis-suppressor -0.0398295
CFAP251 cilia and flagella associated protein 251 -0.0396177
CDK14 cyclin-dependent kinase 14 -0.039451
RPS23 ribosomal protein S23 -0.0390618
SDCCAG8 serologically defined colon cancer antigen 8 -0.0386234
NACA nascent polypeptide-associated complex alpha subunit -0.0385433
ZNF804A zinc finger protein 804A -0.0383786
RPL36 ribosomal protein L36 -0.0383019
RPL11 ribosomal protein L11 -0.0383011
ANTXR2 anthrax toxin receptor 2 -0.0380466
EIF1 eukaryotic translation initiation factor 1 -0.0379172
RPL36A ribosomal protein L36a -0.0375818
RPS27A ribosomal protein S27a -0.0360071
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0359307
RPS25 ribosomal protein S25 -0.0358476
TM4SF1 transmembrane 4 L six family member 1 -0.0356561
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0353338
TPI1 triosephosphate isomerase 1 -0.0346354
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.03435
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0342544
ENKUR enkurin, TRPC channel interacting protein -0.0338051
PDE4D phosphodiesterase 4D, cAMP-specific -0.033198
MARCHF4 membrane associated ring-CH-type finger 4 -0.0328344
DOCK4 dedicator of cytokinesis 4 -0.032714
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0310846
RPS13 ribosomal protein S13 -0.0308757
DPYD dihydropyrimidine dehydrogenase -0.0308727
MSR1 macrophage scavenger receptor 1 -0.0306848
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0306665
INTS6 integrator complex subunit 6 -0.0305429
AEBP2 AE binding protein 2 -0.0305001
RPL27 ribosomal protein L27 -0.0304446
WNT2B wingless-type MMTV integration site family, member 2B -0.0301883
RPL35 ribosomal protein L35 -0.0298619
RPS21 ribosomal protein S21 -0.0296955
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0296084
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0294599
PFN1 profilin 1 -0.0293136
LOC112694756 uncharaterized LOC112694756 -0.0291254
RPL37 ribosomal protein L37 -0.0288459
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0287276
VCL vinculin -0.0286314
RPS8 ribosomal protein S8 -0.0286234
MYL12B myosin, light chain 12B, regulatory -0.0283702
RPL13A ribosomal protein L13a -0.0281881
PTCHD4 patched domain containing 4 -0.0281613
RPL34 ribosomal protein L34 -0.028089
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0278955
RPS4X ribosomal protein S4, X-linked -0.0278377
MBD5 methyl-CpG binding domain protein 5 -0.0275153
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0265997
RPL21 ribosomal protein L21 -0.0264889
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0263322
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.026148