Vinblastine (sulfate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.135973
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0861407
TXNRD1 thioredoxin reductase 1 0.0551043
ASPH aspartate beta-hydroxylase 0.0481423
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0454391
RPL13A ribosomal protein L13a 0.0413418
MKI67 marker of proliferation Ki-67 0.0395219
MT2A metallothionein 2A 0.037542
PRELID2 PRELI domain containing 2 0.0373636
FAT1 FAT atypical cadherin 1 0.033879
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0328852
SPTBN1 spectrin, beta, non-erythrocytic 1 0.031288
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0308446
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0303857
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.030295
SMC4 structural maintenance of chromosomes 4 0.0300248
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0296021
CENPF centromere protein F, 350/400kDa 0.0293761
EIF1 eukaryotic translation initiation factor 1 0.0287505
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0282784
PKP2 plakophilin 2 0.0281566
KLF5 Kruppel-like factor 5 (intestinal) 0.0272546
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0261394
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0247192
EREG epiregulin 0.0245992
ARHGAP29 Rho GTPase activating protein 29 0.0228008
GOLM2 golgi membrane protein 2 0.0220996
RPLP0 ribosomal protein, large, P0 0.0219815
ENO1 enolase 1, (alpha) 0.0212322
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0204432
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0200351
DIAPH3 diaphanous-related formin 3 0.0196689
VCL vinculin 0.0196665
GARS1 glycyl-tRNA synthetase 1 0.0193758
HMGB2 high mobility group box 2 0.0192421
EXT1 exostosin glycosyltransferase 1 0.0185312
PHF3 PHD finger protein 3 0.0184647
ACTG1 actin gamma 1 0.0180354
CXADR coxsackie virus and adenovirus receptor 0.0177591
EGR1 early growth response 1 0.0175234
ANLN anillin, actin binding protein 0.0169054
ATXN1 ataxin 1 0.0166529
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.016481
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0162682
RAD21 RAD21 homolog (S. pombe) 0.0162263
CCPG1 cell cycle progression 1 0.016164
IER3 immediate early response 3 0.0158884
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0157896
ERRFI1 ERBB receptor feedback inhibitor 1 0.0157448
BZW1 basic leucine zipper and W2 domains 1 0.0155826
MT1E metallothionein 1E 0.0154659
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0153338
SEC24D SEC24 family member D 0.0152109
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0150531
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0145271
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0142762
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.014175
KNL1 kinetochore scaffold 1 0.0140751
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0140488
NAP1L1 nucleosome assembly protein 1-like 1 0.0140465
CENPE centromere protein E, 312kDa 0.0138752
PDZD8 PDZ domain containing 8 0.0137479
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0135838
EFNA5 ephrin-A5 0.013483
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0134415
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0132436
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0130675
GOLGB1 golgin B1 0.0128421
MT1X metallothionein 1X 0.012694
ARL15 ADP-ribosylation factor-like 15 0.0126568
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0125906
WWOX WW domain containing oxidoreductase 0.0124206
MLEC malectin 0.0123984
MYO9A myosin IXA 0.0123809
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0123437
TC2N tandem C2 domains, nuclear 0.01234
STRBP spermatid perinuclear RNA binding protein 0.0123025
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0122637
EEA1 early endosome antigen 1 0.0122402
KIF20B kinesin family member 20B 0.0121323
IFNGR1 interferon gamma receptor 1 0.0121128
CKAP2 cytoskeleton associated protein 2 0.0120015
PRC1 protein regulator of cytokinesis 1 0.0118647
NAMPT nicotinamide phosphoribosyltransferase 0.0117822
TMEM263 transmembrane protein 263 0.0117439
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0117388
SUCO SUN domain containing ossification factor 0.0117261
DEK DEK proto-oncogene 0.0117232
RPL41 ribosomal protein L41 0.0115732
SGO2 shugoshin 2 0.0115502
RPL7 ribosomal protein L7 0.0114026
NCOA7 nuclear receptor coactivator 7 0.0113406
AREG amphiregulin 0.0113039
MB21D2 Mab-21 domain containing 2 0.01125
IL18 interleukin 18 0.0111861
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0111787
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0111512
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0111171
SERINC5 serine incorporator 5 0.0110831
ZNF770 zinc finger protein 770 0.0110231

decreased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 -0.153127
TMSB10 thymosin beta 10 -0.137043
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.108281
EZR ezrin -0.100918
RPS19 ribosomal protein S19 -0.0956535
F3 coagulation factor III (thromboplastin, tissue factor) -0.0900944
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0885131
RPLP1 ribosomal protein, large, P1 -0.0879174
FLNB filamin B, beta -0.0869093
MSI2 musashi RNA-binding protein 2 -0.086114
GMDS GDP-mannose 4,6-dehydratase -0.0851981
CALB1 calbindin 1, 28kDa -0.0807556
MPRIP myosin phosphatase Rho interacting protein -0.0780004
UBE2H ubiquitin-conjugating enzyme E2H -0.073627
RPL31 ribosomal protein L31 -0.0724418
ESYT2 extended synaptotagmin-like protein 2 -0.0719963
RPLP2 ribosomal protein, large, P2 -0.0719177
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.071877
RPS12 ribosomal protein S12 -0.0706969
THSD4 thrombospondin, type I, domain containing 4 -0.0706896
RPL36 ribosomal protein L36 -0.0704371
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0679395
RPL37A ribosomal protein L37a -0.0676261
AKAP13 A kinase (PRKA) anchor protein 13 -0.065396
RPS8 ribosomal protein S8 -0.0652737
RPS14 ribosomal protein S14 -0.0604303
DIAPH1 diaphanous-related formin 1 -0.0594071
CLDN4 claudin 4 -0.0583044
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0575288
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0569739
FRMD5 FERM domain containing 5 -0.0560535
RPS25 ribosomal protein S25 -0.0557255
POTEF POTE ankyrin domain family, member F -0.0552811
HLA-B major histocompatibility complex, class I, B -0.0527738
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0506123
ANXA11 annexin A11 -0.0505748
RPS27 ribosomal protein S27 -0.0500572
IFI27 interferon, alpha-inducible protein 27 -0.0494022
JMJD1C jumonji domain containing 1C -0.0487574
PKM pyruvate kinase, muscle -0.0484109
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0480011
RPS21 ribosomal protein S21 -0.0472297
RPS17 ribosomal protein S17 -0.0448826
CUX1 cut-like homeobox 1 -0.0448418
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0445957
ITGB4 integrin, beta 4 -0.0441821
S100A6 S100 calcium binding protein A6 -0.0438446
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0438417
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0431063
NPSR1 neuropeptide S receptor 1 -0.0429342
RPL36A ribosomal protein L36a -0.0428668
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -0.0428235
RPL34 ribosomal protein L34 -0.0426402
RPL18 ribosomal protein L18 -0.042388
AOPEP aminopeptidase O (putative) -0.0421383
RPS13 ribosomal protein S13 -0.0420387
RPL28 ribosomal protein L28 -0.0419222
SLK STE20-like kinase -0.0416356
MX1 MX dynamin-like GTPase 1 -0.0413176
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0412996
FOXO3 forkhead box O3 -0.0409
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0408418
ACTN4 actinin, alpha 4 -0.0405163
MCU mitochondrial calcium uniporter -0.0402348
TSPAN8 tetraspanin 8 -0.0401174
COBL cordon-bleu WH2 repeat protein -0.0399695
TPM1 tropomyosin 1 (alpha) -0.0397554
RREB1 ras responsive element binding protein 1 -0.039677
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.03865
SVIL supervillin -0.0385223
RAP1B RAP1B, member of RAS oncogene family -0.0379076
PARD3 par-3 family cell polarity regulator -0.0375725
RPL8 ribosomal protein L8 -0.0374507
SLMAP sarcolemma associated protein -0.0373592
MYH14 myosin, heavy chain 14, non-muscle -0.0369619
RBM25 RNA binding motif protein 25 -0.0367337
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0367099
S100A11 S100 calcium binding protein A11 -0.0366804
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0365304
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0363217
ITGA6 integrin, alpha 6 -0.0362158
MAML2 mastermind-like 2 (Drosophila) -0.0355823
FBXO11 F-box protein 11 -0.0355115
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0352293
KRT19 keratin 19, type I -0.0349855
CD9 CD9 molecule -0.0347957
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0340204
ISG15 ISG15 ubiquitin-like modifier -0.0334541
PIAS1 protein inhibitor of activated STAT, 1 -0.0333561
TMCC1 transmembrane and coiled-coil domain family 1 -0.032971
RCOR1 REST corepressor 1 -0.0329658
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0329289
MUC2 mucin 2, oligomeric mucus/gel-forming -0.0328262
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0325468
TBL1X transducin (beta)-like 1X-linked -0.0325428
BACE2 beta-site APP-cleaving enzyme 2 -0.0319776
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0315657
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0315469
JUP junction plakoglobin -0.0313636
BCL2L1 BCL2-like 1 -0.0313566